Amino acid dipepetide frequency for Klebsiella phage Soft

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.137AlaAla: 13.137 ± 1.36
1.081AlaCys: 1.081 ± 0.307
6.055AlaAsp: 6.055 ± 0.591
7.244AlaGlu: 7.244 ± 0.729
3.73AlaPhe: 3.73 ± 0.512
7.514AlaGly: 7.514 ± 0.579
1.243AlaHis: 1.243 ± 0.242
6.001AlaIle: 6.001 ± 0.545
6.595AlaLys: 6.595 ± 0.801
8.001AlaLeu: 8.001 ± 0.613
3.298AlaMet: 3.298 ± 0.415
4.379AlaAsn: 4.379 ± 0.533
3.568AlaPro: 3.568 ± 0.44
4.865AlaGln: 4.865 ± 0.592
5.082AlaArg: 5.082 ± 0.521
4.703AlaSer: 4.703 ± 0.611
4.974AlaThr: 4.974 ± 0.621
7.136AlaVal: 7.136 ± 0.765
1.73AlaTrp: 1.73 ± 0.342
3.622AlaTyr: 3.622 ± 0.446
0.0AlaXaa: 0.0 ± 0.0
Cys
1.027CysAla: 1.027 ± 0.217
0.162CysCys: 0.162 ± 0.091
0.703CysAsp: 0.703 ± 0.215
0.541CysGlu: 0.541 ± 0.199
0.541CysPhe: 0.541 ± 0.156
0.973CysGly: 0.973 ± 0.273
0.324CysHis: 0.324 ± 0.115
0.595CysIle: 0.595 ± 0.197
0.703CysLys: 0.703 ± 0.2
0.595CysLeu: 0.595 ± 0.225
0.27CysMet: 0.27 ± 0.144
0.541CysAsn: 0.541 ± 0.17
0.541CysPro: 0.541 ± 0.227
0.378CysGln: 0.378 ± 0.137
1.189CysArg: 1.189 ± 0.276
0.757CysSer: 0.757 ± 0.253
0.541CysThr: 0.541 ± 0.152
0.595CysVal: 0.595 ± 0.19
0.108CysTrp: 0.108 ± 0.08
0.27CysTyr: 0.27 ± 0.114
0.0CysXaa: 0.0 ± 0.0
Asp
6.487AspAla: 6.487 ± 0.621
0.432AspCys: 0.432 ± 0.176
5.244AspAsp: 5.244 ± 0.634
4.703AspGlu: 4.703 ± 0.535
2.433AspPhe: 2.433 ± 0.379
5.082AspGly: 5.082 ± 0.421
0.649AspHis: 0.649 ± 0.211
3.622AspIle: 3.622 ± 0.382
2.595AspLys: 2.595 ± 0.321
4.811AspLeu: 4.811 ± 0.561
1.838AspMet: 1.838 ± 0.232
2.325AspAsn: 2.325 ± 0.36
3.568AspPro: 3.568 ± 0.38
1.838AspGln: 1.838 ± 0.266
3.406AspArg: 3.406 ± 0.449
3.027AspSer: 3.027 ± 0.459
3.46AspThr: 3.46 ± 0.341
4.271AspVal: 4.271 ± 0.457
1.676AspTrp: 1.676 ± 0.343
2.379AspTyr: 2.379 ± 0.422
0.0AspXaa: 0.0 ± 0.0
Glu
6.055GluAla: 6.055 ± 0.502
0.541GluCys: 0.541 ± 0.196
3.622GluAsp: 3.622 ± 0.467
4.703GluGlu: 4.703 ± 0.737
2.325GluPhe: 2.325 ± 0.484
3.73GluGly: 3.73 ± 0.431
0.649GluHis: 0.649 ± 0.175
3.46GluIle: 3.46 ± 0.507
3.784GluLys: 3.784 ± 0.625
4.703GluLeu: 4.703 ± 0.648
2.108GluMet: 2.108 ± 0.442
2.487GluAsn: 2.487 ± 0.421
1.676GluPro: 1.676 ± 0.304
1.946GluGln: 1.946 ± 0.416
3.622GluArg: 3.622 ± 0.477
3.19GluSer: 3.19 ± 0.393
2.271GluThr: 2.271 ± 0.368
4.919GluVal: 4.919 ± 0.553
1.189GluTrp: 1.189 ± 0.224
2.433GluTyr: 2.433 ± 0.383
0.0GluXaa: 0.0 ± 0.0
Phe
4.0PheAla: 4.0 ± 0.443
0.487PheCys: 0.487 ± 0.15
2.541PheAsp: 2.541 ± 0.405
1.784PheGlu: 1.784 ± 0.258
1.46PhePhe: 1.46 ± 0.309
2.595PheGly: 2.595 ± 0.395
0.378PheHis: 0.378 ± 0.134
2.379PheIle: 2.379 ± 0.328
1.73PheLys: 1.73 ± 0.371
2.649PheLeu: 2.649 ± 0.404
0.973PheMet: 0.973 ± 0.264
1.784PheAsn: 1.784 ± 0.436
1.946PhePro: 1.946 ± 0.302
1.135PheGln: 1.135 ± 0.197
2.271PheArg: 2.271 ± 0.404
2.325PheSer: 2.325 ± 0.354
2.595PheThr: 2.595 ± 0.467
1.946PheVal: 1.946 ± 0.349
0.595PheTrp: 0.595 ± 0.181
0.811PheTyr: 0.811 ± 0.201
0.0PheXaa: 0.0 ± 0.0
Gly
6.649GlyAla: 6.649 ± 0.666
1.297GlyCys: 1.297 ± 0.356
4.595GlyAsp: 4.595 ± 0.5
4.541GlyGlu: 4.541 ± 0.49
2.271GlyPhe: 2.271 ± 0.355
5.46GlyGly: 5.46 ± 0.641
1.73GlyHis: 1.73 ± 0.383
3.622GlyIle: 3.622 ± 0.363
4.703GlyLys: 4.703 ± 0.558
6.217GlyLeu: 6.217 ± 0.735
2.271GlyMet: 2.271 ± 0.334
2.757GlyAsn: 2.757 ± 0.401
2.054GlyPro: 2.054 ± 0.291
2.433GlyGln: 2.433 ± 0.301
4.811GlyArg: 4.811 ± 0.471
4.379GlySer: 4.379 ± 0.587
4.0GlyThr: 4.0 ± 0.481
5.19GlyVal: 5.19 ± 0.447
1.784GlyTrp: 1.784 ± 0.324
3.46GlyTyr: 3.46 ± 0.423
0.0GlyXaa: 0.0 ± 0.0
His
1.135HisAla: 1.135 ± 0.265
0.432HisCys: 0.432 ± 0.139
0.757HisAsp: 0.757 ± 0.164
0.973HisGlu: 0.973 ± 0.301
0.595HisPhe: 0.595 ± 0.183
1.46HisGly: 1.46 ± 0.319
0.216HisHis: 0.216 ± 0.109
1.243HisIle: 1.243 ± 0.283
0.919HisLys: 0.919 ± 0.209
1.514HisLeu: 1.514 ± 0.331
0.487HisMet: 0.487 ± 0.202
0.703HisAsn: 0.703 ± 0.217
0.757HisPro: 0.757 ± 0.222
0.162HisGln: 0.162 ± 0.077
1.243HisArg: 1.243 ± 0.286
0.811HisSer: 0.811 ± 0.217
0.757HisThr: 0.757 ± 0.187
0.973HisVal: 0.973 ± 0.261
0.216HisTrp: 0.216 ± 0.098
0.865HisTyr: 0.865 ± 0.195
0.0HisXaa: 0.0 ± 0.0
Ile
5.784IleAla: 5.784 ± 0.535
0.432IleCys: 0.432 ± 0.16
4.0IleAsp: 4.0 ± 0.406
2.865IleGlu: 2.865 ± 0.33
1.622IlePhe: 1.622 ± 0.333
4.541IleGly: 4.541 ± 0.584
1.081IleHis: 1.081 ± 0.301
3.838IleIle: 3.838 ± 0.434
3.46IleLys: 3.46 ± 0.384
2.919IleLeu: 2.919 ± 0.414
0.919IleMet: 0.919 ± 0.212
2.379IleAsn: 2.379 ± 0.324
2.325IlePro: 2.325 ± 0.389
1.243IleGln: 1.243 ± 0.263
4.271IleArg: 4.271 ± 0.561
3.19IleSer: 3.19 ± 0.339
3.406IleThr: 3.406 ± 0.455
3.838IleVal: 3.838 ± 0.482
0.487IleTrp: 0.487 ± 0.168
1.568IleTyr: 1.568 ± 0.332
0.0IleXaa: 0.0 ± 0.0
Lys
6.595LysAla: 6.595 ± 0.701
0.595LysCys: 0.595 ± 0.202
2.973LysAsp: 2.973 ± 0.426
2.919LysGlu: 2.919 ± 0.538
1.892LysPhe: 1.892 ± 0.311
4.0LysGly: 4.0 ± 0.429
1.351LysHis: 1.351 ± 0.282
2.757LysIle: 2.757 ± 0.422
3.568LysLys: 3.568 ± 0.53
3.298LysLeu: 3.298 ± 0.372
1.784LysMet: 1.784 ± 0.335
2.811LysAsn: 2.811 ± 0.409
2.595LysPro: 2.595 ± 0.285
1.676LysGln: 1.676 ± 0.367
3.946LysArg: 3.946 ± 0.607
2.919LysSer: 2.919 ± 0.435
4.217LysThr: 4.217 ± 0.567
3.568LysVal: 3.568 ± 0.507
1.297LysTrp: 1.297 ± 0.332
1.568LysTyr: 1.568 ± 0.301
0.0LysXaa: 0.0 ± 0.0
Leu
7.352LeuAla: 7.352 ± 0.66
1.189LeuCys: 1.189 ± 0.261
4.811LeuAsp: 4.811 ± 0.506
3.946LeuGlu: 3.946 ± 0.535
2.703LeuPhe: 2.703 ± 0.42
4.595LeuGly: 4.595 ± 0.673
0.649LeuHis: 0.649 ± 0.201
4.0LeuIle: 4.0 ± 0.465
4.163LeuLys: 4.163 ± 0.477
5.136LeuLeu: 5.136 ± 0.556
2.811LeuMet: 2.811 ± 0.442
3.946LeuAsn: 3.946 ± 0.584
3.406LeuPro: 3.406 ± 0.486
3.135LeuGln: 3.135 ± 0.567
5.406LeuArg: 5.406 ± 0.491
4.163LeuSer: 4.163 ± 0.482
5.082LeuThr: 5.082 ± 0.583
4.703LeuVal: 4.703 ± 0.366
1.46LeuTrp: 1.46 ± 0.213
2.216LeuTyr: 2.216 ± 0.336
0.0LeuXaa: 0.0 ± 0.0
Met
3.244MetAla: 3.244 ± 0.387
0.378MetCys: 0.378 ± 0.172
1.622MetAsp: 1.622 ± 0.298
1.568MetGlu: 1.568 ± 0.26
0.757MetPhe: 0.757 ± 0.209
1.784MetGly: 1.784 ± 0.289
0.649MetHis: 0.649 ± 0.165
1.297MetIle: 1.297 ± 0.247
2.595MetLys: 2.595 ± 0.413
2.108MetLeu: 2.108 ± 0.38
0.649MetMet: 0.649 ± 0.202
1.514MetAsn: 1.514 ± 0.242
1.135MetPro: 1.135 ± 0.253
0.973MetGln: 0.973 ± 0.184
2.216MetArg: 2.216 ± 0.303
2.054MetSer: 2.054 ± 0.341
2.216MetThr: 2.216 ± 0.322
2.325MetVal: 2.325 ± 0.322
0.378MetTrp: 0.378 ± 0.125
0.811MetTyr: 0.811 ± 0.174
0.0MetXaa: 0.0 ± 0.0
Asn
5.136AsnAla: 5.136 ± 0.567
0.27AsnCys: 0.27 ± 0.105
2.162AsnAsp: 2.162 ± 0.299
1.946AsnGlu: 1.946 ± 0.423
1.351AsnPhe: 1.351 ± 0.268
4.757AsnGly: 4.757 ± 0.478
0.703AsnHis: 0.703 ± 0.272
2.595AsnIle: 2.595 ± 0.378
2.0AsnLys: 2.0 ± 0.392
2.865AsnLeu: 2.865 ± 0.363
1.406AsnMet: 1.406 ± 0.24
1.568AsnAsn: 1.568 ± 0.32
2.649AsnPro: 2.649 ± 0.286
1.081AsnGln: 1.081 ± 0.228
2.865AsnArg: 2.865 ± 0.435
2.325AsnSer: 2.325 ± 0.371
2.487AsnThr: 2.487 ± 0.414
2.216AsnVal: 2.216 ± 0.433
1.189AsnTrp: 1.189 ± 0.284
1.892AsnTyr: 1.892 ± 0.317
0.0AsnXaa: 0.0 ± 0.0
Pro
4.433ProAla: 4.433 ± 0.707
0.541ProCys: 0.541 ± 0.199
4.217ProAsp: 4.217 ± 0.598
3.406ProGlu: 3.406 ± 0.415
1.73ProPhe: 1.73 ± 0.279
3.514ProGly: 3.514 ± 0.448
1.189ProHis: 1.189 ± 0.271
1.351ProIle: 1.351 ± 0.262
1.568ProLys: 1.568 ± 0.337
2.811ProLeu: 2.811 ± 0.297
1.135ProMet: 1.135 ± 0.312
1.784ProAsn: 1.784 ± 0.318
1.784ProPro: 1.784 ± 0.333
1.406ProGln: 1.406 ± 0.261
2.054ProArg: 2.054 ± 0.346
2.541ProSer: 2.541 ± 0.351
2.433ProThr: 2.433 ± 0.355
3.19ProVal: 3.19 ± 0.403
0.757ProTrp: 0.757 ± 0.2
1.676ProTyr: 1.676 ± 0.33
0.0ProXaa: 0.0 ± 0.0
Gln
4.163GlnAla: 4.163 ± 0.778
0.108GlnCys: 0.108 ± 0.07
1.46GlnAsp: 1.46 ± 0.224
1.676GlnGlu: 1.676 ± 0.257
1.189GlnPhe: 1.189 ± 0.237
1.838GlnGly: 1.838 ± 0.336
0.487GlnHis: 0.487 ± 0.159
1.676GlnIle: 1.676 ± 0.319
1.46GlnLys: 1.46 ± 0.34
2.919GlnLeu: 2.919 ± 0.461
1.622GlnMet: 1.622 ± 0.264
1.406GlnAsn: 1.406 ± 0.251
1.297GlnPro: 1.297 ± 0.231
1.838GlnGln: 1.838 ± 0.746
2.649GlnArg: 2.649 ± 0.388
1.838GlnSer: 1.838 ± 0.351
2.0GlnThr: 2.0 ± 0.226
2.379GlnVal: 2.379 ± 0.332
0.811GlnTrp: 0.811 ± 0.237
1.189GlnTyr: 1.189 ± 0.282
0.0GlnXaa: 0.0 ± 0.0
Arg
6.541ArgAla: 6.541 ± 0.637
0.919ArgCys: 0.919 ± 0.237
4.379ArgAsp: 4.379 ± 0.55
3.784ArgGlu: 3.784 ± 0.487
2.379ArgPhe: 2.379 ± 0.417
4.217ArgGly: 4.217 ± 0.38
1.351ArgHis: 1.351 ± 0.287
3.244ArgIle: 3.244 ± 0.429
4.0ArgLys: 4.0 ± 0.424
4.974ArgLeu: 4.974 ± 0.579
1.568ArgMet: 1.568 ± 0.325
3.244ArgAsn: 3.244 ± 0.426
2.811ArgPro: 2.811 ± 0.351
2.325ArgGln: 2.325 ± 0.358
4.487ArgArg: 4.487 ± 0.72
2.216ArgSer: 2.216 ± 0.336
2.973ArgThr: 2.973 ± 0.507
5.028ArgVal: 5.028 ± 0.539
0.919ArgTrp: 0.919 ± 0.215
2.108ArgTyr: 2.108 ± 0.338
0.0ArgXaa: 0.0 ± 0.0
Ser
5.568SerAla: 5.568 ± 0.609
0.649SerCys: 0.649 ± 0.199
3.676SerAsp: 3.676 ± 0.524
2.108SerGlu: 2.108 ± 0.286
2.108SerPhe: 2.108 ± 0.381
4.974SerGly: 4.974 ± 0.55
0.649SerHis: 0.649 ± 0.153
2.865SerIle: 2.865 ± 0.413
2.919SerLys: 2.919 ± 0.432
4.865SerLeu: 4.865 ± 0.477
1.784SerMet: 1.784 ± 0.318
1.892SerAsn: 1.892 ± 0.244
2.379SerPro: 2.379 ± 0.465
1.514SerGln: 1.514 ± 0.256
3.514SerArg: 3.514 ± 0.378
3.027SerSer: 3.027 ± 0.494
2.325SerThr: 2.325 ± 0.422
4.649SerVal: 4.649 ± 0.443
0.865SerTrp: 0.865 ± 0.209
1.676SerTyr: 1.676 ± 0.315
0.0SerXaa: 0.0 ± 0.0
Thr
5.46ThrAla: 5.46 ± 0.781
0.487ThrCys: 0.487 ± 0.141
3.514ThrAsp: 3.514 ± 0.516
2.811ThrGlu: 2.811 ± 0.398
2.325ThrPhe: 2.325 ± 0.461
4.217ThrGly: 4.217 ± 0.489
0.703ThrHis: 0.703 ± 0.173
2.487ThrIle: 2.487 ± 0.459
3.19ThrLys: 3.19 ± 0.366
5.352ThrLeu: 5.352 ± 0.496
1.514ThrMet: 1.514 ± 0.248
2.054ThrAsn: 2.054 ± 0.3
2.973ThrPro: 2.973 ± 0.417
1.892ThrGln: 1.892 ± 0.384
3.244ThrArg: 3.244 ± 0.352
3.027ThrSer: 3.027 ± 0.393
3.892ThrThr: 3.892 ± 0.661
5.622ThrVal: 5.622 ± 0.55
1.297ThrTrp: 1.297 ± 0.268
1.46ThrTyr: 1.46 ± 0.233
0.0ThrXaa: 0.0 ± 0.0
Val
6.109ValAla: 6.109 ± 0.619
0.703ValCys: 0.703 ± 0.236
3.892ValAsp: 3.892 ± 0.411
4.811ValGlu: 4.811 ± 0.409
2.703ValPhe: 2.703 ± 0.365
4.865ValGly: 4.865 ± 0.517
1.243ValHis: 1.243 ± 0.264
4.325ValIle: 4.325 ± 0.529
3.946ValLys: 3.946 ± 0.508
5.028ValLeu: 5.028 ± 0.601
2.811ValMet: 2.811 ± 0.418
3.46ValAsn: 3.46 ± 0.371
2.973ValPro: 2.973 ± 0.526
2.108ValGln: 2.108 ± 0.327
3.784ValArg: 3.784 ± 0.387
4.649ValSer: 4.649 ± 0.576
5.028ValThr: 5.028 ± 0.474
4.703ValVal: 4.703 ± 0.485
1.297ValTrp: 1.297 ± 0.289
1.838ValTyr: 1.838 ± 0.302
0.0ValXaa: 0.0 ± 0.0
Trp
2.054TrpAla: 2.054 ± 0.291
0.324TrpCys: 0.324 ± 0.152
1.514TrpAsp: 1.514 ± 0.303
0.919TrpGlu: 0.919 ± 0.274
1.243TrpPhe: 1.243 ± 0.262
0.919TrpGly: 0.919 ± 0.213
0.378TrpHis: 0.378 ± 0.174
1.081TrpIle: 1.081 ± 0.25
1.243TrpLys: 1.243 ± 0.177
1.406TrpLeu: 1.406 ± 0.302
0.27TrpMet: 0.27 ± 0.102
0.649TrpAsn: 0.649 ± 0.175
1.406TrpPro: 1.406 ± 0.289
0.595TrpGln: 0.595 ± 0.175
1.135TrpArg: 1.135 ± 0.29
1.081TrpSer: 1.081 ± 0.238
1.027TrpThr: 1.027 ± 0.314
1.135TrpVal: 1.135 ± 0.232
0.487TrpTrp: 0.487 ± 0.162
0.324TrpTyr: 0.324 ± 0.117
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.027TyrAla: 3.027 ± 0.311
0.324TyrCys: 0.324 ± 0.146
2.108TyrAsp: 2.108 ± 0.346
2.162TyrGlu: 2.162 ± 0.351
1.027TyrPhe: 1.027 ± 0.202
3.19TyrGly: 3.19 ± 0.454
0.595TyrHis: 0.595 ± 0.178
1.73TyrIle: 1.73 ± 0.391
1.189TyrLys: 1.189 ± 0.217
2.703TyrLeu: 2.703 ± 0.441
0.703TyrMet: 0.703 ± 0.199
1.784TyrAsn: 1.784 ± 0.316
1.676TyrPro: 1.676 ± 0.276
1.46TyrGln: 1.46 ± 0.308
2.271TyrArg: 2.271 ± 0.288
1.784TyrSer: 1.784 ± 0.305
1.838TyrThr: 1.838 ± 0.253
1.946TyrVal: 1.946 ± 0.323
0.649TyrTrp: 0.649 ± 0.184
1.351TyrTyr: 1.351 ± 0.271
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 87 proteins (18499 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski