Amino acid dipepetide frequency for Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.255AlaAla: 20.255 ± 0.193	1.184AlaCys: 1.184 ± 0.036	7.461AlaAsp: 7.461 ± 0.083	7.775AlaGlu: 7.775 ± 0.094	4.907AlaPhe: 4.907 ± 0.069	11.802AlaGly: 11.802 ± 0.117	2.321AlaHis: 2.321 ± 0.047	5.734AlaIle: 5.734 ± 0.081	5.187AlaLys: 5.187 ± 0.079	14.762AlaLeu: 14.762 ± 0.17	3.572AlaMet: 3.572 ± 0.049	2.939AlaAsn: 2.939 ± 0.059	7.479AlaPro: 7.479 ± 0.099	4.786AlaGln: 4.786 ± 0.074	10.263AlaArg: 10.263 ± 0.108	6.677AlaSer: 6.677 ± 0.086	6.209AlaThr: 6.209 ± 0.095	9.701AlaVal: 9.701 ± 0.114	2.015AlaTrp: 2.015 ± 0.043	2.869AlaTyr: 2.869 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.043CysAla: 1.043 ± 0.03	0.087CysCys: 0.087 ± 0.01	0.503CysAsp: 0.503 ± 0.023	0.402CysGlu: 0.402 ± 0.019	0.279CysPhe: 0.279 ± 0.014	0.849CysGly: 0.849 ± 0.028	0.156CysHis: 0.156 ± 0.011	0.26CysIle: 0.26 ± 0.016	0.187CysLys: 0.187 ± 0.012	0.669CysLeu: 0.669 ± 0.021	0.129CysMet: 0.129 ± 0.01	0.164CysAsn: 0.164 ± 0.014	0.39CysPro: 0.39 ± 0.017	0.216CysGln: 0.216 ± 0.013	0.52CysArg: 0.52 ± 0.019	0.406CysSer: 0.406 ± 0.018	0.279CysThr: 0.279 ± 0.014	0.641CysVal: 0.641 ± 0.023	0.098CysTrp: 0.098 ± 0.009	0.168CysTyr: 0.168 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.605AspAla: 7.605 ± 0.089	0.413AspCys: 0.413 ± 0.018	3.17AspAsp: 3.17 ± 0.057	3.208AspGlu: 3.208 ± 0.058	2.209AspPhe: 2.209 ± 0.048	5.486AspGly: 5.486 ± 0.068	1.324AspHis: 1.324 ± 0.035	2.508AspIle: 2.508 ± 0.051	1.958AspLys: 1.958 ± 0.046	6.506AspLeu: 6.506 ± 0.078	1.169AspMet: 1.169 ± 0.03	1.169AspAsn: 1.169 ± 0.034	3.873AspPro: 3.873 ± 0.056	2.058AspGln: 2.058 ± 0.044	4.353AspArg: 4.353 ± 0.069	1.986AspSer: 1.986 ± 0.041	2.373AspThr: 2.373 ± 0.049	4.078AspVal: 4.078 ± 0.057	0.998AspTrp: 0.998 ± 0.029	1.502AspTyr: 1.502 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.678GluAla: 8.678 ± 0.127	0.228GluCys: 0.228 ± 0.014	2.79GluAsp: 2.79 ± 0.049	2.588GluGlu: 2.588 ± 0.045	1.46GluPhe: 1.46 ± 0.036	4.816GluGly: 4.816 ± 0.073	1.018GluHis: 1.018 ± 0.03	3.0GluIle: 3.0 ± 0.054	2.02GluLys: 2.02 ± 0.044	4.701GluLeu: 4.701 ± 0.067	1.227GluMet: 1.227 ± 0.037	1.309GluAsn: 1.309 ± 0.036	2.677GluPro: 2.677 ± 0.055	1.972GluGln: 1.972 ± 0.043	4.791GluArg: 4.791 ± 0.075	2.117GluSer: 2.117 ± 0.05	3.478GluThr: 3.478 ± 0.046	3.769GluVal: 3.769 ± 0.061	0.576GluTrp: 0.576 ± 0.023	0.832GluTyr: 0.832 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.584PheAla: 4.584 ± 0.072	0.333PheCys: 0.333 ± 0.017	2.7PheAsp: 2.7 ± 0.048	2.249PheGlu: 2.249 ± 0.04	1.235PhePhe: 1.235 ± 0.032	3.536PheGly: 3.536 ± 0.06	0.683PheHis: 0.683 ± 0.027	1.416PheIle: 1.416 ± 0.037	1.206PheLys: 1.206 ± 0.033	2.954PheLeu: 2.954 ± 0.054	0.761PheMet: 0.761 ± 0.025	1.108PheAsn: 1.108 ± 0.038	1.469PhePro: 1.469 ± 0.035	1.139PheGln: 1.139 ± 0.035	1.976PheArg: 1.976 ± 0.04	2.055PheSer: 2.055 ± 0.047	2.023PheThr: 2.023 ± 0.039	2.677PheVal: 2.677 ± 0.048	0.542PheTrp: 0.542 ± 0.025	0.825PheTyr: 0.825 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	11.454GlyAla: 11.454 ± 0.12	0.746GlyCys: 0.746 ± 0.029	5.05GlyAsp: 5.05 ± 0.072	5.177GlyGlu: 5.177 ± 0.076	3.727GlyPhe: 3.727 ± 0.061	8.649GlyGly: 8.649 ± 0.115	1.684GlyHis: 1.684 ± 0.043	2.686GlyIle: 2.686 ± 0.047	3.531GlyLys: 3.531 ± 0.066	9.967GlyLeu: 9.967 ± 0.113	2.064GlyMet: 2.064 ± 0.044	1.558GlyAsn: 1.558 ± 0.044	4.193GlyPro: 4.193 ± 0.058	3.352GlyGln: 3.352 ± 0.06	6.747GlyArg: 6.747 ± 0.093	4.044GlySer: 4.044 ± 0.074	3.2GlyThr: 3.2 ± 0.064	8.163GlyVal: 8.163 ± 0.085	1.543GlyTrp: 1.543 ± 0.044	2.206GlyTyr: 2.206 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.341HisAla: 2.341 ± 0.045	0.17HisCys: 0.17 ± 0.012	1.104HisAsp: 1.104 ± 0.03	0.945HisGlu: 0.945 ± 0.031	0.643HisPhe: 0.643 ± 0.021	1.814HisGly: 1.814 ± 0.04	0.505HisHis: 0.505 ± 0.021	0.693HisIle: 0.693 ± 0.024	0.467HisLys: 0.467 ± 0.021	1.807HisLeu: 1.807 ± 0.04	0.423HisMet: 0.423 ± 0.017	0.386HisAsn: 0.386 ± 0.018	1.294HisPro: 1.294 ± 0.034	0.583HisGln: 0.583 ± 0.021	1.408HisArg: 1.408 ± 0.041	0.672HisSer: 0.672 ± 0.027	0.674HisThr: 0.674 ± 0.023	1.297HisVal: 1.297 ± 0.036	0.278HisTrp: 0.278 ± 0.013	0.464HisTyr: 0.464 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.567IleAla: 6.567 ± 0.077	0.386IleCys: 0.386 ± 0.019	3.175IleAsp: 3.175 ± 0.053	3.002IleGlu: 3.002 ± 0.058	1.3IlePhe: 1.3 ± 0.034	4.206IleGly: 4.206 ± 0.069	0.745IleHis: 0.745 ± 0.025	1.646IleIle: 1.646 ± 0.043	1.419IleLys: 1.419 ± 0.038	3.811IleLeu: 3.811 ± 0.064	0.784IleMet: 0.784 ± 0.025	1.196IleAsn: 1.196 ± 0.035	1.967IlePro: 1.967 ± 0.042	1.282IleGln: 1.282 ± 0.034	2.622IleArg: 2.622 ± 0.048	2.318IleSer: 2.318 ± 0.051	2.403IleThr: 2.403 ± 0.049	3.479IleVal: 3.479 ± 0.067	0.546IleTrp: 0.546 ± 0.02	0.879IleTyr: 0.879 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	5.631LysAla: 5.631 ± 0.076	0.125LysCys: 0.125 ± 0.01	1.893LysAsp: 1.893 ± 0.051	1.296LysGlu: 1.296 ± 0.035	0.947LysPhe: 0.947 ± 0.027	3.142LysGly: 3.142 ± 0.067	0.519LysHis: 0.519 ± 0.022	1.728LysIle: 1.728 ± 0.042	1.255LysLys: 1.255 ± 0.042	3.33LysLeu: 3.33 ± 0.052	0.726LysMet: 0.726 ± 0.022	0.873LysAsn: 0.873 ± 0.028	2.47LysPro: 2.47 ± 0.049	0.921LysGln: 0.921 ± 0.028	2.41LysArg: 2.41 ± 0.05	1.816LysSer: 1.816 ± 0.043	2.331LysThr: 2.331 ± 0.047	2.865LysVal: 2.865 ± 0.06	0.336LysTrp: 0.336 ± 0.017	0.559LysTyr: 0.559 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.712LeuAla: 14.712 ± 0.147	0.754LeuCys: 0.754 ± 0.026	6.189LeuAsp: 6.189 ± 0.079	5.35LeuGlu: 5.35 ± 0.083	3.318LeuPhe: 3.318 ± 0.056	8.41LeuGly: 8.41 ± 0.091	1.672LeuHis: 1.672 ± 0.043	4.754LeuIle: 4.754 ± 0.079	4.209LeuLys: 4.209 ± 0.066	8.694LeuLeu: 8.694 ± 0.115	2.258LeuMet: 2.258 ± 0.045	2.58LeuAsn: 2.58 ± 0.056	5.056LeuPro: 5.056 ± 0.076	2.602LeuGln: 2.602 ± 0.05	6.706LeuArg: 6.706 ± 0.088	6.505LeuSer: 6.505 ± 0.12	5.908LeuThr: 5.908 ± 0.104	7.192LeuVal: 7.192 ± 0.093	1.204LeuTrp: 1.204 ± 0.035	1.957LeuTyr: 1.957 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.201MetAla: 3.201 ± 0.047	0.139MetCys: 0.139 ± 0.01	1.203MetAsp: 1.203 ± 0.028	0.908MetGlu: 0.908 ± 0.028	0.671MetPhe: 0.671 ± 0.025	1.921MetGly: 1.921 ± 0.043	0.34MetHis: 0.34 ± 0.019	1.187MetIle: 1.187 ± 0.035	0.904MetLys: 0.904 ± 0.028	2.097MetLeu: 2.097 ± 0.044	0.561MetMet: 0.561 ± 0.021	0.678MetAsn: 0.678 ± 0.025	1.199MetPro: 1.199 ± 0.033	0.614MetGln: 0.614 ± 0.022	1.699MetArg: 1.699 ± 0.036	1.572MetSer: 1.572 ± 0.037	1.806MetThr: 1.806 ± 0.033	1.524MetVal: 1.524 ± 0.037	0.197MetTrp: 0.197 ± 0.013	0.231MetTyr: 0.231 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.114AsnAla: 3.114 ± 0.056	0.192AsnCys: 0.192 ± 0.013	1.316AsnAsp: 1.316 ± 0.038	0.984AsnGlu: 0.984 ± 0.03	0.854AsnPhe: 0.854 ± 0.031	2.261AsnGly: 2.261 ± 0.051	0.441AsnHis: 0.441 ± 0.019	1.108AsnIle: 1.108 ± 0.038	0.634AsnLys: 0.634 ± 0.027	2.56AsnLeu: 2.56 ± 0.057	0.502AsnMet: 0.502 ± 0.022	0.62AsnAsn: 0.62 ± 0.028	1.711AsnPro: 1.711 ± 0.043	0.749AsnGln: 0.749 ± 0.03	1.616AsnArg: 1.616 ± 0.04	1.063AsnSer: 1.063 ± 0.037	1.233AsnThr: 1.233 ± 0.041	1.775AsnVal: 1.775 ± 0.045	0.343AsnTrp: 0.343 ± 0.017	0.643AsnTyr: 0.643 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.331ProAla: 7.331 ± 0.108	0.374ProCys: 0.374 ± 0.023	3.6ProAsp: 3.6 ± 0.059	3.57ProGlu: 3.57 ± 0.06	2.008ProPhe: 2.008 ± 0.045	4.935ProGly: 4.935 ± 0.066	0.951ProHis: 0.951 ± 0.029	2.297ProIle: 2.297 ± 0.041	1.953ProLys: 1.953 ± 0.045	4.869ProLeu: 4.869 ± 0.076	1.229ProMet: 1.229 ± 0.033	1.373ProAsn: 1.373 ± 0.037	3.319ProPro: 3.319 ± 0.085	1.676ProGln: 1.676 ± 0.038	3.376ProArg: 3.376 ± 0.061	2.971ProSer: 2.971 ± 0.053	2.92ProThr: 2.92 ± 0.051	4.221ProVal: 4.221 ± 0.057	0.766ProTrp: 0.766 ± 0.025	1.105ProTyr: 1.105 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.897GlnAla: 4.897 ± 0.065	0.153GlnCys: 0.153 ± 0.011	1.59GlnAsp: 1.59 ± 0.04	1.351GlnGlu: 1.351 ± 0.035	1.016GlnPhe: 1.016 ± 0.026	2.98GlnGly: 2.98 ± 0.057	0.587GlnHis: 0.587 ± 0.023	1.646GlnIle: 1.646 ± 0.065	1.041GlnLys: 1.041 ± 0.03	2.821GlnLeu: 2.821 ± 0.076	0.765GlnMet: 0.765 ± 0.026	0.742GlnAsn: 0.742 ± 0.027	1.789GlnPro: 1.789 ± 0.043	1.088GlnGln: 1.088 ± 0.037	2.501GlnArg: 2.501 ± 0.049	1.665GlnSer: 1.665 ± 0.04	2.017GlnThr: 2.017 ± 0.045	2.562GlnVal: 2.562 ± 0.086	0.388GlnTrp: 0.388 ± 0.017	0.517GlnTyr: 0.517 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.176ArgAla: 9.176 ± 0.114	0.518ArgCys: 0.518 ± 0.021	4.121ArgAsp: 4.121 ± 0.063	4.028ArgGlu: 4.028 ± 0.062	2.89ArgPhe: 2.89 ± 0.051	5.442ArgGly: 5.442 ± 0.069	1.417ArgHis: 1.417 ± 0.034	3.403ArgIle: 3.403 ± 0.053	2.383ArgLys: 2.383 ± 0.048	8.473ArgLeu: 8.473 ± 0.105	1.801ArgMet: 1.801 ± 0.039	1.511ArgAsn: 1.511 ± 0.035	4.207ArgPro: 4.207 ± 0.069	2.575ArgGln: 2.575 ± 0.051	6.611ArgArg: 6.611 ± 0.115	3.409ArgSer: 3.409 ± 0.057	3.373ArgThr: 3.373 ± 0.061	4.965ArgVal: 4.965 ± 0.067	1.163ArgTrp: 1.163 ± 0.034	1.713ArgTyr: 1.713 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.616SerAla: 6.616 ± 0.089	0.337SerCys: 0.337 ± 0.018	2.857SerAsp: 2.857 ± 0.054	2.387SerGlu: 2.387 ± 0.045	1.973SerPhe: 1.973 ± 0.04	5.067SerGly: 5.067 ± 0.065	0.859SerHis: 0.859 ± 0.03	2.218SerIle: 2.218 ± 0.044	1.607SerLys: 1.607 ± 0.041	5.223SerLeu: 5.223 ± 0.067	1.11SerMet: 1.11 ± 0.031	1.285SerAsn: 1.285 ± 0.038	3.172SerPro: 3.172 ± 0.056	1.644SerGln: 1.644 ± 0.041	3.677SerArg: 3.677 ± 0.06	2.745SerSer: 2.745 ± 0.055	2.693SerThr: 2.693 ± 0.068	3.688SerVal: 3.688 ± 0.056	0.751SerTrp: 0.751 ± 0.027	1.135SerTyr: 1.135 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.67ThrAla: 6.67 ± 0.096	0.371ThrCys: 0.371 ± 0.017	2.673ThrAsp: 2.673 ± 0.048	2.238ThrGlu: 2.238 ± 0.045	1.945ThrPhe: 1.945 ± 0.039	5.036ThrGly: 5.036 ± 0.08	0.938ThrHis: 0.938 ± 0.03	2.333ThrIle: 2.333 ± 0.052	1.505ThrLys: 1.505 ± 0.042	5.829ThrLeu: 5.829 ± 0.073	0.989ThrMet: 0.989 ± 0.029	1.268ThrAsn: 1.268 ± 0.052	3.918ThrPro: 3.918 ± 0.058	1.682ThrGln: 1.682 ± 0.146	3.312ThrArg: 3.312 ± 0.049	2.586ThrSer: 2.586 ± 0.057	2.964ThrThr: 2.964 ± 0.131	4.136ThrVal: 4.136 ± 0.062	0.731ThrTrp: 0.731 ± 0.028	1.208ThrTyr: 1.208 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.958ValAla: 9.958 ± 0.101	0.647ValCys: 0.647 ± 0.026	4.382ValAsp: 4.382 ± 0.065	4.907ValGlu: 4.907 ± 0.071	2.74ValPhe: 2.74 ± 0.05	6.248ValGly: 6.248 ± 0.076	1.223ValHis: 1.223 ± 0.038	3.704ValIle: 3.704 ± 0.068	2.477ValLys: 2.477 ± 0.048	7.387ValLeu: 7.387 ± 0.101	1.804ValMet: 1.804 ± 0.038	1.918ValAsn: 1.918 ± 0.045	2.905ValPro: 2.905 ± 0.051	2.122ValGln: 2.122 ± 0.04	5.375ValArg: 5.375 ± 0.075	4.447ValSer: 4.447 ± 0.056	4.496ValThr: 4.496 ± 0.064	6.232ValVal: 6.232 ± 0.089	1.051ValTrp: 1.051 ± 0.029	1.46ValTyr: 1.46 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.386TrpAla: 1.386 ± 0.033	0.106TrpCys: 0.106 ± 0.009	0.691TrpAsp: 0.691 ± 0.025	0.523TrpGlu: 0.523 ± 0.023	0.551TrpPhe: 0.551 ± 0.022	1.029TrpGly: 1.029 ± 0.029	0.207TrpHis: 0.207 ± 0.014	0.683TrpIle: 0.683 ± 0.025	0.559TrpLys: 0.559 ± 0.021	1.609TrpLeu: 1.609 ± 0.047	0.368TrpMet: 0.368 ± 0.017	0.447TrpAsn: 0.447 ± 0.021	0.747TrpPro: 0.747 ± 0.025	0.369TrpGln: 0.369 ± 0.019	1.529TrpArg: 1.529 ± 0.042	0.983TrpSer: 0.983 ± 0.032	0.981TrpThr: 0.981 ± 0.03	0.836TrpVal: 0.836 ± 0.027	0.262TrpTrp: 0.262 ± 0.016	0.259TrpTyr: 0.259 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.677TyrAla: 2.677 ± 0.051	0.185TyrCys: 0.185 ± 0.014	1.479TyrAsp: 1.479 ± 0.04	1.156TyrGlu: 1.156 ± 0.033	0.8TyrPhe: 0.8 ± 0.026	2.112TyrGly: 2.112 ± 0.044	0.377TyrHis: 0.377 ± 0.019	0.726TyrIle: 0.726 ± 0.024	0.673TyrLys: 0.673 ± 0.026	1.961TyrLeu: 1.961 ± 0.04	0.411TyrMet: 0.411 ± 0.018	0.596TyrAsn: 0.596 ± 0.025	1.009TyrPro: 1.009 ± 0.028	0.687TyrGln: 0.687 ± 0.023	1.686TyrArg: 1.686 ± 0.038	1.005TyrSer: 1.005 ± 0.031	0.971TyrThr: 0.971 ± 0.034	1.681TyrVal: 1.681 ± 0.037	0.338TyrTrp: 0.338 ± 0.017	0.516TyrTyr: 0.516 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3720 proteins (1205719 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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