Amino acid dipepetide frequency for Candidatus Similichlamydia laticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.859AlaAla: 3.859 ± 0.162
1.448AlaCys: 1.448 ± 0.084
2.398AlaAsp: 2.398 ± 0.122
3.541AlaGlu: 3.541 ± 0.137
3.841AlaPhe: 3.841 ± 0.133
3.274AlaGly: 3.274 ± 0.135
1.564AlaHis: 1.564 ± 0.089
4.009AlaIle: 4.009 ± 0.118
3.171AlaLys: 3.171 ± 0.114
9.487AlaLeu: 9.487 ± 0.245
1.418AlaMet: 1.418 ± 0.079
1.714AlaAsn: 1.714 ± 0.085
2.441AlaPro: 2.441 ± 0.097
2.965AlaGln: 2.965 ± 0.135
3.631AlaArg: 3.631 ± 0.153
5.367AlaSer: 5.367 ± 0.173
2.776AlaThr: 2.776 ± 0.106
4.125AlaVal: 4.125 ± 0.145
0.657AlaTrp: 0.657 ± 0.049
1.624AlaTyr: 1.624 ± 0.1
0.0AlaXaa: 0.0 ± 0.0
Cys
1.126CysAla: 1.126 ± 0.063
0.58CysCys: 0.58 ± 0.056
0.722CysAsp: 0.722 ± 0.057
0.851CysGlu: 0.851 ± 0.07
1.646CysPhe: 1.646 ± 0.096
1.121CysGly: 1.121 ± 0.073
0.593CysHis: 0.593 ± 0.048
1.036CysIle: 1.036 ± 0.075
0.748CysLys: 0.748 ± 0.057
3.197CysLeu: 3.197 ± 0.146
0.348CysMet: 0.348 ± 0.041
0.37CysAsn: 0.37 ± 0.039
1.066CysPro: 1.066 ± 0.073
0.739CysGln: 0.739 ± 0.055
0.945CysArg: 0.945 ± 0.062
2.204CysSer: 2.204 ± 0.119
0.791CysThr: 0.791 ± 0.063
1.121CysVal: 1.121 ± 0.074
0.318CysTrp: 0.318 ± 0.033
0.477CysTyr: 0.477 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
2.651AspAla: 2.651 ± 0.116
0.73AspCys: 0.73 ± 0.057
1.487AspAsp: 1.487 ± 0.1
2.522AspGlu: 2.522 ± 0.121
2.428AspPhe: 2.428 ± 0.102
2.204AspGly: 2.204 ± 0.095
1.13AspHis: 1.13 ± 0.067
2.295AspIle: 2.295 ± 0.1
1.775AspLys: 1.775 ± 0.082
6.621AspLeu: 6.621 ± 0.181
0.825AspMet: 0.825 ± 0.054
0.855AspAsn: 0.855 ± 0.1
2.767AspPro: 2.767 ± 0.098
2.045AspGln: 2.045 ± 0.094
2.827AspArg: 2.827 ± 0.13
2.926AspSer: 2.926 ± 0.131
1.921AspThr: 1.921 ± 0.167
2.617AspVal: 2.617 ± 0.124
0.687AspTrp: 0.687 ± 0.054
1.139AspTyr: 1.139 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
4.847GluAla: 4.847 ± 0.157
0.851GluCys: 0.851 ± 0.058
3.115GluAsp: 3.115 ± 0.13
7.756GluGlu: 7.756 ± 0.235
2.221GluPhe: 2.221 ± 0.114
4.851GluGly: 4.851 ± 0.147
1.525GluHis: 1.525 ± 0.082
4.301GluIle: 4.301 ± 0.151
5.324GluLys: 5.324 ± 0.172
6.381GluLeu: 6.381 ± 0.176
1.74GluMet: 1.74 ± 0.09
2.389GluAsn: 2.389 ± 0.101
2.037GluPro: 2.037 ± 0.095
3.343GluGln: 3.343 ± 0.134
4.761GluArg: 4.761 ± 0.175
4.37GluSer: 4.37 ± 0.135
3.541GluThr: 3.541 ± 0.127
4.529GluVal: 4.529 ± 0.163
1.018GluTrp: 1.018 ± 0.069
1.13GluTyr: 1.13 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
3.128PheAla: 3.128 ± 0.149
1.495PheCys: 1.495 ± 0.088
2.466PheAsp: 2.466 ± 0.111
3.059PheGlu: 3.059 ± 0.128
4.542PhePhe: 4.542 ± 0.18
3.145PheGly: 3.145 ± 0.122
1.22PheHis: 1.22 ± 0.076
2.621PheIle: 2.621 ± 0.111
1.912PheLys: 1.912 ± 0.088
8.314PheLeu: 8.314 ± 0.24
0.795PheMet: 0.795 ± 0.058
1.216PheAsn: 1.216 ± 0.068
2.763PhePro: 2.763 ± 0.128
2.269PheGln: 2.269 ± 0.09
2.939PheArg: 2.939 ± 0.109
6.179PheSer: 6.179 ± 0.179
1.792PheThr: 1.792 ± 0.105
3.403PheVal: 3.403 ± 0.11
1.014PheTrp: 1.014 ± 0.082
1.47PheTyr: 1.47 ± 0.09
0.0PheXaa: 0.0 ± 0.0
Gly
3.627GlyAla: 3.627 ± 0.145
1.263GlyCys: 1.263 ± 0.079
2.557GlyAsp: 2.557 ± 0.11
4.134GlyGlu: 4.134 ± 0.14
3.356GlyPhe: 3.356 ± 0.126
4.108GlyGly: 4.108 ± 0.239
1.659GlyHis: 1.659 ± 0.085
4.112GlyIle: 4.112 ± 0.149
3.992GlyLys: 3.992 ± 0.161
7.498GlyLeu: 7.498 ± 0.176
1.646GlyMet: 1.646 ± 0.079
1.753GlyAsn: 1.753 ± 0.089
2.153GlyPro: 2.153 ± 0.102
2.389GlyGln: 2.389 ± 0.11
3.283GlyArg: 3.283 ± 0.156
5.109GlySer: 5.109 ± 0.153
3.175GlyThr: 3.175 ± 0.13
4.121GlyVal: 4.121 ± 0.156
0.846GlyTrp: 0.846 ± 0.07
1.538GlyTyr: 1.538 ± 0.085
0.0GlyXaa: 0.0 ± 0.0
His
1.71HisAla: 1.71 ± 0.083
0.464HisCys: 0.464 ± 0.044
0.941HisAsp: 0.941 ± 0.056
1.126HisGlu: 1.126 ± 0.072
1.745HisPhe: 1.745 ± 0.089
1.156HisGly: 1.156 ± 0.064
0.683HisHis: 0.683 ± 0.058
1.263HisIle: 1.263 ± 0.067
0.907HisLys: 0.907 ± 0.069
3.622HisLeu: 3.622 ± 0.153
0.443HisMet: 0.443 ± 0.041
0.657HisAsn: 0.657 ± 0.053
1.564HisPro: 1.564 ± 0.104
1.005HisGln: 1.005 ± 0.063
1.431HisArg: 1.431 ± 0.075
1.766HisSer: 1.766 ± 0.093
0.958HisThr: 0.958 ± 0.066
1.564HisVal: 1.564 ± 0.093
0.365HisTrp: 0.365 ± 0.036
0.782HisTyr: 0.782 ± 0.049
0.0HisXaa: 0.0 ± 0.0
Ile
3.652IleAla: 3.652 ± 0.141
1.375IleCys: 1.375 ± 0.068
2.57IleAsp: 2.57 ± 0.114
4.159IleGlu: 4.159 ± 0.123
2.544IlePhe: 2.544 ± 0.109
4.022IleGly: 4.022 ± 0.161
1.517IleHis: 1.517 ± 0.08
2.389IleIle: 2.389 ± 0.128
2.621IleLys: 2.621 ± 0.117
7.042IleLeu: 7.042 ± 0.189
0.911IleMet: 0.911 ± 0.06
1.409IleAsn: 1.409 ± 0.099
3.261IlePro: 3.261 ± 0.126
2.711IleGln: 2.711 ± 0.114
3.764IleArg: 3.764 ± 0.128
4.619IleSer: 4.619 ± 0.152
2.6IleThr: 2.6 ± 0.152
3.352IleVal: 3.352 ± 0.133
0.812IleTrp: 0.812 ± 0.061
1.345IleTyr: 1.345 ± 0.074
0.0IleXaa: 0.0 ± 0.0
Lys
3.442LysAla: 3.442 ± 0.139
0.593LysCys: 0.593 ± 0.048
2.406LysAsp: 2.406 ± 0.102
5.448LysGlu: 5.448 ± 0.186
1.392LysPhe: 1.392 ± 0.073
4.202LysGly: 4.202 ± 0.162
1.014LysHis: 1.014 ± 0.065
3.364LysIle: 3.364 ± 0.125
5.139LysLys: 5.139 ± 0.176
4.421LysLeu: 4.421 ± 0.16
1.508LysMet: 1.508 ± 0.082
2.067LysAsn: 2.067 ± 0.106
1.598LysPro: 1.598 ± 0.098
2.376LysGln: 2.376 ± 0.123
4.03LysArg: 4.03 ± 0.138
3.532LysSer: 3.532 ± 0.136
3.128LysThr: 3.128 ± 0.127
3.025LysVal: 3.025 ± 0.119
0.756LysTrp: 0.756 ± 0.056
0.907LysTyr: 0.907 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
8.791LeuAla: 8.791 ± 0.208
2.552LeuCys: 2.552 ± 0.11
5.831LeuAsp: 5.831 ± 0.148
9.169LeuGlu: 9.169 ± 0.217
8.117LeuPhe: 8.117 ± 0.267
7.317LeuGly: 7.317 ± 0.188
2.956LeuHis: 2.956 ± 0.122
6.342LeuIle: 6.342 ± 0.191
6.351LeuLys: 6.351 ± 0.192
15.997LeuLeu: 15.997 ± 0.335
2.088LeuMet: 2.088 ± 0.098
3.364LeuAsn: 3.364 ± 0.127
5.685LeuPro: 5.685 ± 0.183
5.182LeuGln: 5.182 ± 0.179
7.03LeuArg: 7.03 ± 0.182
11.838LeuSer: 11.838 ± 0.249
5.251LeuThr: 5.251 ± 0.243
7.386LeuVal: 7.386 ± 0.172
1.349LeuTrp: 1.349 ± 0.082
2.93LeuTyr: 2.93 ± 0.118
0.0LeuXaa: 0.0 ± 0.0
Met
1.332MetAla: 1.332 ± 0.076
0.309MetCys: 0.309 ± 0.037
0.864MetAsp: 0.864 ± 0.063
1.371MetGlu: 1.371 ± 0.067
0.795MetPhe: 0.795 ± 0.068
1.71MetGly: 1.71 ± 0.081
0.494MetHis: 0.494 ± 0.052
1.117MetIle: 1.117 ± 0.067
1.147MetLys: 1.147 ± 0.069
1.852MetLeu: 1.852 ± 0.091
0.464MetMet: 0.464 ± 0.046
0.683MetAsn: 0.683 ± 0.052
0.932MetPro: 0.932 ± 0.064
0.988MetGln: 0.988 ± 0.071
1.465MetArg: 1.465 ± 0.086
1.779MetSer: 1.779 ± 0.091
1.276MetThr: 1.276 ± 0.077
1.259MetVal: 1.259 ± 0.072
0.163MetTrp: 0.163 ± 0.025
0.378MetTyr: 0.378 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
1.749AsnAla: 1.749 ± 0.087
0.498AsnCys: 0.498 ± 0.05
1.053AsnAsp: 1.053 ± 0.078
1.71AsnGlu: 1.71 ± 0.089
1.474AsnPhe: 1.474 ± 0.076
1.891AsnGly: 1.891 ± 0.083
0.64AsnHis: 0.64 ± 0.06
1.624AsnIle: 1.624 ± 0.086
1.482AsnLys: 1.482 ± 0.08
3.76AsnLeu: 3.76 ± 0.127
0.627AsnMet: 0.627 ± 0.055
0.748AsnAsn: 0.748 ± 0.056
1.551AsnPro: 1.551 ± 0.085
1.353AsnGln: 1.353 ± 0.068
2.062AsnArg: 2.062 ± 0.088
1.869AsnSer: 1.869 ± 0.119
1.353AsnThr: 1.353 ± 0.117
1.59AsnVal: 1.59 ± 0.087
0.524AsnTrp: 0.524 ± 0.047
0.739AsnTyr: 0.739 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
2.131ProAla: 2.131 ± 0.099
0.885ProCys: 0.885 ± 0.069
1.921ProAsp: 1.921 ± 0.09
3.102ProGlu: 3.102 ± 0.127
3.055ProPhe: 3.055 ± 0.136
2.651ProGly: 2.651 ± 0.113
1.199ProHis: 1.199 ± 0.076
2.655ProIle: 2.655 ± 0.116
2.303ProLys: 2.303 ± 0.109
5.556ProLeu: 5.556 ± 0.165
0.761ProMet: 0.761 ± 0.058
1.392ProAsn: 1.392 ± 0.088
2.333ProPro: 2.333 ± 0.117
1.616ProGln: 1.616 ± 0.086
1.977ProArg: 1.977 ± 0.083
4.305ProSer: 4.305 ± 0.14
1.942ProThr: 1.942 ± 0.111
2.746ProVal: 2.746 ± 0.112
0.511ProTrp: 0.511 ± 0.048
1.319ProTyr: 1.319 ± 0.084
0.0ProXaa: 0.0 ± 0.0
Gln
3.253GlnAla: 3.253 ± 0.122
0.43GlnCys: 0.43 ± 0.039
2.015GlnAsp: 2.015 ± 0.101
3.94GlnGlu: 3.94 ± 0.127
1.68GlnPhe: 1.68 ± 0.078
2.505GlnGly: 2.505 ± 0.105
0.846GlnHis: 0.846 ± 0.062
2.681GlnIle: 2.681 ± 0.107
3.102GlnLys: 3.102 ± 0.123
4.542GlnLeu: 4.542 ± 0.132
0.915GlnMet: 0.915 ± 0.068
1.555GlnAsn: 1.555 ± 0.09
1.272GlnPro: 1.272 ± 0.081
1.869GlnGln: 1.869 ± 0.095
2.423GlnArg: 2.423 ± 0.108
2.879GlnSer: 2.879 ± 0.102
2.062GlnThr: 2.062 ± 0.092
2.909GlnVal: 2.909 ± 0.116
0.546GlnTrp: 0.546 ± 0.054
0.752GlnTyr: 0.752 ± 0.06
0.0GlnXaa: 0.0 ± 0.0
Arg
3.833ArgAla: 3.833 ± 0.144
1.164ArgCys: 1.164 ± 0.071
2.57ArgAsp: 2.57 ± 0.103
4.327ArgGlu: 4.327 ± 0.139
3.266ArgPhe: 3.266 ± 0.123
3.459ArgGly: 3.459 ± 0.13
1.487ArgHis: 1.487 ± 0.078
3.751ArgIle: 3.751 ± 0.135
3.682ArgLys: 3.682 ± 0.129
7.18ArgLeu: 7.18 ± 0.202
1.319ArgMet: 1.319 ± 0.078
1.809ArgAsn: 1.809 ± 0.089
1.989ArgPro: 1.989 ± 0.098
2.471ArgGln: 2.471 ± 0.103
3.863ArgArg: 3.863 ± 0.162
4.606ArgSer: 4.606 ± 0.151
2.724ArgThr: 2.724 ± 0.109
3.987ArgVal: 3.987 ± 0.14
0.67ArgTrp: 0.67 ± 0.05
1.564ArgTyr: 1.564 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
4.533SerAla: 4.533 ± 0.143
2.007SerCys: 2.007 ± 0.118
3.197SerAsp: 3.197 ± 0.107
4.688SerGlu: 4.688 ± 0.162
5.723SerPhe: 5.723 ± 0.171
5.491SerGly: 5.491 ± 0.162
1.955SerHis: 1.955 ± 0.103
4.641SerIle: 4.641 ± 0.15
3.906SerLys: 3.906 ± 0.139
11.365SerLeu: 11.365 ± 0.275
1.547SerMet: 1.547 ± 0.073
2.148SerAsn: 2.148 ± 0.103
4.078SerPro: 4.078 ± 0.148
3.132SerGln: 3.132 ± 0.117
4.684SerArg: 4.684 ± 0.168
8.422SerSer: 8.422 ± 0.255
3.584SerThr: 3.584 ± 0.156
5.435SerVal: 5.435 ± 0.162
1.379SerTrp: 1.379 ± 0.091
2.243SerTyr: 2.243 ± 0.098
0.0SerXaa: 0.0 ± 0.0
Thr
3.111ThrAla: 3.111 ± 0.169
1.169ThrCys: 1.169 ± 0.07
1.985ThrAsp: 1.985 ± 0.173
2.918ThrGlu: 2.918 ± 0.125
2.492ThrPhe: 2.492 ± 0.117
2.87ThrGly: 2.87 ± 0.12
1.117ThrHis: 1.117 ± 0.072
2.737ThrIle: 2.737 ± 0.124
2.191ThrLys: 2.191 ± 0.102
5.788ThrLeu: 5.788 ± 0.18
0.851ThrMet: 0.851 ± 0.062
1.396ThrAsn: 1.396 ± 0.103
2.32ThrPro: 2.32 ± 0.127
1.693ThrGln: 1.693 ± 0.102
2.389ThrArg: 2.389 ± 0.12
3.846ThrSer: 3.846 ± 0.196
2.767ThrThr: 2.767 ± 0.329
2.9ThrVal: 2.9 ± 0.118
0.726ThrTrp: 0.726 ± 0.069
1.276ThrTyr: 1.276 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
4.052ValAla: 4.052 ± 0.147
1.379ValCys: 1.379 ± 0.087
2.771ValAsp: 2.771 ± 0.121
4.035ValGlu: 4.035 ± 0.148
3.528ValPhe: 3.528 ± 0.135
3.798ValGly: 3.798 ± 0.152
1.607ValHis: 1.607 ± 0.083
3.394ValIle: 3.394 ± 0.13
2.505ValLys: 2.505 ± 0.104
8.336ValLeu: 8.336 ± 0.198
1.336ValMet: 1.336 ± 0.063
1.474ValAsn: 1.474 ± 0.085
2.922ValPro: 2.922 ± 0.111
2.492ValGln: 2.492 ± 0.115
3.987ValArg: 3.987 ± 0.146
5.573ValSer: 5.573 ± 0.16
2.969ValThr: 2.969 ± 0.125
4.202ValVal: 4.202 ± 0.182
0.786ValTrp: 0.786 ± 0.064
1.276ValTyr: 1.276 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.864TrpAla: 0.864 ± 0.065
0.232TrpCys: 0.232 ± 0.032
0.679TrpAsp: 0.679 ± 0.059
0.855TrpGlu: 0.855 ± 0.06
0.503TrpPhe: 0.503 ± 0.053
1.014TrpGly: 1.014 ± 0.072
0.305TrpHis: 0.305 ± 0.037
1.199TrpIle: 1.199 ± 0.08
1.121TrpLys: 1.121 ± 0.065
1.405TrpLeu: 1.405 ± 0.074
0.348TrpMet: 0.348 ± 0.04
0.709TrpAsn: 0.709 ± 0.177
0.46TrpPro: 0.46 ± 0.039
0.46TrpGln: 0.46 ± 0.044
0.619TrpArg: 0.619 ± 0.049
1.139TrpSer: 1.139 ± 0.08
0.687TrpThr: 0.687 ± 0.06
0.645TrpVal: 0.645 ± 0.063
0.193TrpTrp: 0.193 ± 0.027
0.254TrpTyr: 0.254 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.62TyrAla: 1.62 ± 0.084
0.571TyrCys: 0.571 ± 0.058
0.907TyrAsp: 0.907 ± 0.058
1.319TyrGlu: 1.319 ± 0.075
1.396TyrPhe: 1.396 ± 0.075
1.525TyrGly: 1.525 ± 0.075
0.64TyrHis: 0.64 ± 0.05
1.143TyrIle: 1.143 ± 0.08
0.971TyrLys: 0.971 ± 0.082
3.162TyrLeu: 3.162 ± 0.116
0.486TyrMet: 0.486 ± 0.04
0.589TyrAsn: 0.589 ± 0.043
1.169TyrPro: 1.169 ± 0.077
1.083TyrGln: 1.083 ± 0.069
1.611TyrArg: 1.611 ± 0.086
1.83TyrSer: 1.83 ± 0.099
1.246TyrThr: 1.246 ± 0.073
1.508TyrVal: 1.508 ± 0.09
0.365TyrTrp: 0.365 ± 0.042
0.55TyrTyr: 0.55 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 750 proteins (232731 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski