Amino acid dipepetide frequency for Paraburkholderia xenovorans (strain LB400)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.565AlaAla: 17.565 ± 0.132	1.349AlaCys: 1.349 ± 0.024	6.423AlaAsp: 6.423 ± 0.053	5.946AlaGlu: 5.946 ± 0.057	4.318AlaPhe: 4.318 ± 0.048	10.685AlaGly: 10.685 ± 0.076	2.831AlaHis: 2.831 ± 0.031	5.726AlaIle: 5.726 ± 0.053	3.421AlaLys: 3.421 ± 0.05	13.876AlaLeu: 13.876 ± 0.078	3.158AlaMet: 3.158 ± 0.035	3.404AlaAsn: 3.404 ± 0.066	5.798AlaPro: 5.798 ± 0.054	5.312AlaGln: 5.312 ± 0.053	9.033AlaArg: 9.033 ± 0.082	7.559AlaSer: 7.559 ± 0.064	6.464AlaThr: 6.464 ± 0.059	8.827AlaVal: 8.827 ± 0.073	1.659AlaTrp: 1.659 ± 0.027	2.694AlaTyr: 2.694 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.262CysAla: 1.262 ± 0.025	0.151CysCys: 0.151 ± 0.008	0.535CysAsp: 0.535 ± 0.013	0.525CysGlu: 0.525 ± 0.015	0.359CysPhe: 0.359 ± 0.012	1.036CysGly: 1.036 ± 0.019	0.261CysHis: 0.261 ± 0.009	0.426CysIle: 0.426 ± 0.012	0.218CysLys: 0.218 ± 0.009	0.827CysLeu: 0.827 ± 0.017	0.209CysMet: 0.209 ± 0.009	0.263CysAsn: 0.263 ± 0.008	0.456CysPro: 0.456 ± 0.013	0.231CysGln: 0.231 ± 0.009	0.678CysArg: 0.678 ± 0.015	0.571CysSer: 0.571 ± 0.014	0.52CysThr: 0.52 ± 0.013	0.837CysVal: 0.837 ± 0.019	0.124CysTrp: 0.124 ± 0.006	0.225CysTyr: 0.225 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.177AspAla: 7.177 ± 0.063	0.47AspCys: 0.47 ± 0.013	2.953AspAsp: 2.953 ± 0.039	3.309AspGlu: 3.309 ± 0.039	1.984AspPhe: 1.984 ± 0.027	4.447AspGly: 4.447 ± 0.043	1.172AspHis: 1.172 ± 0.019	2.499AspIle: 2.499 ± 0.031	1.432AspLys: 1.432 ± 0.031	5.054AspLeu: 5.054 ± 0.044	1.207AspMet: 1.207 ± 0.024	1.333AspAsn: 1.333 ± 0.023	2.896AspPro: 2.896 ± 0.034	1.571AspGln: 1.571 ± 0.025	3.399AspArg: 3.399 ± 0.037	2.607AspSer: 2.607 ± 0.034	2.836AspThr: 2.836 ± 0.031	4.183AspVal: 4.183 ± 0.048	0.859AspTrp: 0.859 ± 0.016	1.535AspTyr: 1.535 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.416GluAla: 6.416 ± 0.059	0.396GluCys: 0.396 ± 0.011	2.099GluAsp: 2.099 ± 0.034	2.385GluGlu: 2.385 ± 0.042	1.779GluPhe: 1.779 ± 0.027	3.365GluGly: 3.365 ± 0.039	1.386GluHis: 1.386 ± 0.021	2.725GluIle: 2.725 ± 0.033	1.74GluLys: 1.74 ± 0.031	5.428GluLeu: 5.428 ± 0.057	1.184GluMet: 1.184 ± 0.023	1.407GluAsn: 1.407 ± 0.022	2.552GluPro: 2.552 ± 0.035	2.359GluGln: 2.359 ± 0.028	4.832GluArg: 4.832 ± 0.054	2.624GluSer: 2.624 ± 0.03	2.814GluThr: 2.814 ± 0.036	3.496GluVal: 3.496 ± 0.037	0.731GluTrp: 0.731 ± 0.015	1.145GluTyr: 1.145 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.649PheAla: 4.649 ± 0.055	0.444PheCys: 0.444 ± 0.014	2.645PheAsp: 2.645 ± 0.034	2.029PheGlu: 2.029 ± 0.031	1.455PhePhe: 1.455 ± 0.027	3.733PheGly: 3.733 ± 0.049	0.772PheHis: 0.772 ± 0.017	1.61PheIle: 1.61 ± 0.027	0.937PheLys: 0.937 ± 0.02	2.957PheLeu: 2.957 ± 0.043	0.792PheMet: 0.792 ± 0.018	1.232PheAsn: 1.232 ± 0.022	1.584PhePro: 1.584 ± 0.027	1.018PheGln: 1.018 ± 0.019	2.131PheArg: 2.131 ± 0.03	2.384PheSer: 2.384 ± 0.031	2.018PheThr: 2.018 ± 0.027	3.106PheVal: 3.106 ± 0.034	0.511PheTrp: 0.511 ± 0.013	0.972PheTyr: 0.972 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.508GlyAla: 9.508 ± 0.079	0.871GlyCys: 0.871 ± 0.021	3.871GlyAsp: 3.871 ± 0.042	4.332GlyGlu: 4.332 ± 0.041	3.442GlyPhe: 3.442 ± 0.041	7.091GlyGly: 7.091 ± 0.085	1.941GlyHis: 1.941 ± 0.023	4.348GlyIle: 4.348 ± 0.046	3.206GlyLys: 3.206 ± 0.045	7.979GlyLeu: 7.979 ± 0.064	2.21GlyMet: 2.21 ± 0.029	2.551GlyAsn: 2.551 ± 0.045	2.96GlyPro: 2.96 ± 0.03	2.762GlyGln: 2.762 ± 0.035	5.33GlyArg: 5.33 ± 0.058	4.915GlySer: 4.915 ± 0.063	4.791GlyThr: 4.791 ± 0.063	6.775GlyVal: 6.775 ± 0.052	1.399GlyTrp: 1.399 ± 0.022	2.474GlyTyr: 2.474 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	3.166HisAla: 3.166 ± 0.033	0.278HisCys: 0.278 ± 0.01	1.356HisAsp: 1.356 ± 0.025	1.246HisGlu: 1.246 ± 0.021	0.96HisPhe: 0.96 ± 0.021	2.159HisGly: 2.159 ± 0.03	0.661HisHis: 0.661 ± 0.017	0.954HisIle: 0.954 ± 0.019	0.519HisLys: 0.519 ± 0.014	2.169HisLeu: 2.169 ± 0.03	0.536HisMet: 0.536 ± 0.013	0.537HisAsn: 0.537 ± 0.014	1.421HisPro: 1.421 ± 0.025	0.682HisGln: 0.682 ± 0.015	1.565HisArg: 1.565 ± 0.023	1.15HisSer: 1.15 ± 0.02	1.111HisThr: 1.111 ± 0.02	1.774HisVal: 1.774 ± 0.025	0.398HisTrp: 0.398 ± 0.012	0.684HisTyr: 0.684 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.928IleAla: 6.928 ± 0.059	0.472IleCys: 0.472 ± 0.013	3.378IleAsp: 3.378 ± 0.037	3.205IleGlu: 3.205 ± 0.04	1.506IlePhe: 1.506 ± 0.027	4.85IleGly: 4.85 ± 0.054	0.962IleHis: 0.962 ± 0.02	1.597IleIle: 1.597 ± 0.029	1.295IleLys: 1.295 ± 0.025	3.396IleLeu: 3.396 ± 0.044	0.729IleMet: 0.729 ± 0.016	1.463IleAsn: 1.463 ± 0.025	2.099IlePro: 2.099 ± 0.028	1.264IleGln: 1.264 ± 0.023	2.951IleArg: 2.951 ± 0.03	2.614IleSer: 2.614 ± 0.035	2.466IleThr: 2.466 ± 0.037	4.338IleVal: 4.338 ± 0.045	0.526IleTrp: 0.526 ± 0.014	1.094IleTyr: 1.094 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.408LysAla: 3.408 ± 0.049	0.174LysCys: 0.174 ± 0.008	1.433LysAsp: 1.433 ± 0.025	1.368LysGlu: 1.368 ± 0.031	0.879LysPhe: 0.879 ± 0.018	2.091LysGly: 2.091 ± 0.028	0.646LysHis: 0.646 ± 0.017	1.528LysIle: 1.528 ± 0.029	1.191LysLys: 1.191 ± 0.03	3.251LysLeu: 3.251 ± 0.035	0.741LysMet: 0.741 ± 0.016	0.843LysAsn: 0.843 ± 0.019	1.904LysPro: 1.904 ± 0.031	1.225LysGln: 1.225 ± 0.026	2.318LysArg: 2.318 ± 0.032	1.709LysSer: 1.709 ± 0.028	1.788LysThr: 1.788 ± 0.03	2.287LysVal: 2.287 ± 0.034	0.371LysTrp: 0.371 ± 0.011	0.692LysTyr: 0.692 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.665LeuAla: 13.665 ± 0.077	1.073LeuCys: 1.073 ± 0.02	5.823LeuAsp: 5.823 ± 0.054	4.952LeuGlu: 4.952 ± 0.047	3.614LeuPhe: 3.614 ± 0.051	8.149LeuGly: 8.149 ± 0.063	2.282LeuHis: 2.282 ± 0.027	4.749LeuIle: 4.749 ± 0.05	3.334LeuLys: 3.334 ± 0.04	10.007LeuLeu: 10.007 ± 0.095	2.203LeuMet: 2.203 ± 0.032	2.858LeuAsn: 2.858 ± 0.036	5.727LeuPro: 5.727 ± 0.058	3.395LeuGln: 3.395 ± 0.037	7.122LeuArg: 7.122 ± 0.065	6.403LeuSer: 6.403 ± 0.057	5.636LeuThr: 5.636 ± 0.05	7.279LeuVal: 7.279 ± 0.063	1.119LeuTrp: 1.119 ± 0.022	2.202LeuTyr: 2.202 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.408MetAla: 2.408 ± 0.032	0.189MetCys: 0.189 ± 0.009	0.924MetAsp: 0.924 ± 0.018	0.891MetGlu: 0.891 ± 0.019	0.775MetPhe: 0.775 ± 0.018	1.535MetGly: 1.535 ± 0.026	0.568MetHis: 0.568 ± 0.015	1.125MetIle: 1.125 ± 0.022	0.997MetLys: 0.997 ± 0.02	2.624MetLeu: 2.624 ± 0.035	0.557MetMet: 0.557 ± 0.015	0.907MetAsn: 0.907 ± 0.017	1.479MetPro: 1.479 ± 0.027	1.003MetGln: 1.003 ± 0.021	1.811MetArg: 1.811 ± 0.026	1.801MetSer: 1.801 ± 0.027	1.654MetThr: 1.654 ± 0.025	1.492MetVal: 1.492 ± 0.025	0.212MetTrp: 0.212 ± 0.009	0.405MetTyr: 0.405 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.713AsnAla: 3.713 ± 0.049	0.262AsnCys: 0.262 ± 0.009	1.476AsnAsp: 1.476 ± 0.024	1.341AsnGlu: 1.341 ± 0.024	1.008AsnPhe: 1.008 ± 0.022	2.811AsnGly: 2.811 ± 0.042	0.575AsnHis: 0.575 ± 0.016	1.278AsnIle: 1.278 ± 0.03	0.663AsnLys: 0.663 ± 0.016	2.824AsnLeu: 2.824 ± 0.04	0.611AsnMet: 0.611 ± 0.015	0.906AsnAsn: 0.906 ± 0.039	1.864AsnPro: 1.864 ± 0.026	0.961AsnGln: 0.961 ± 0.022	1.919AsnArg: 1.919 ± 0.026	1.531AsnSer: 1.531 ± 0.044	1.548AsnThr: 1.548 ± 0.04	2.408AsnVal: 2.408 ± 0.059	0.424AsnTrp: 0.424 ± 0.014	0.747AsnTyr: 0.747 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	6.651ProAla: 6.651 ± 0.063	0.367ProCys: 0.367 ± 0.013	3.232ProAsp: 3.232 ± 0.04	2.886ProGlu: 2.886 ± 0.036	1.947ProPhe: 1.947 ± 0.031	4.247ProGly: 4.247 ± 0.041	1.285ProHis: 1.285 ± 0.024	2.009ProIle: 2.009 ± 0.026	1.362ProLys: 1.362 ± 0.025	5.239ProLeu: 5.239 ± 0.054	1.117ProMet: 1.117 ± 0.022	1.44ProAsn: 1.44 ± 0.023	2.489ProPro: 2.489 ± 0.043	1.972ProGln: 1.972 ± 0.028	3.021ProArg: 3.021 ± 0.037	2.865ProSer: 2.865 ± 0.033	2.564ProThr: 2.564 ± 0.033	4.354ProVal: 4.354 ± 0.041	0.667ProTrp: 0.667 ± 0.018	1.257ProTyr: 1.257 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.492GlnAla: 4.492 ± 0.05	0.301GlnCys: 0.301 ± 0.011	1.355GlnAsp: 1.355 ± 0.022	1.337GlnGlu: 1.337 ± 0.023	1.293GlnPhe: 1.293 ± 0.023	2.467GlnGly: 2.467 ± 0.031	0.933GlnHis: 0.933 ± 0.019	2.016GlnIle: 2.016 ± 0.026	1.111GlnLys: 1.111 ± 0.022	3.878GlnLeu: 3.878 ± 0.041	1.009GlnMet: 1.009 ± 0.021	0.973GlnAsn: 0.973 ± 0.022	2.091GlnPro: 2.091 ± 0.03	1.909GlnGln: 1.909 ± 0.037	3.004GlnArg: 3.004 ± 0.035	2.117GlnSer: 2.117 ± 0.035	2.107GlnThr: 2.107 ± 0.034	2.521GlnVal: 2.521 ± 0.031	0.56GlnTrp: 0.56 ± 0.012	0.952GlnTyr: 0.952 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.093ArgAla: 8.093 ± 0.068	0.69ArgCys: 0.69 ± 0.016	3.737ArgAsp: 3.737 ± 0.04	4.3ArgGlu: 4.3 ± 0.043	2.993ArgPhe: 2.993 ± 0.037	4.687ArgGly: 4.687 ± 0.044	1.917ArgHis: 1.917 ± 0.03	3.746ArgIle: 3.746 ± 0.04	2.192ArgLys: 2.192 ± 0.028	7.365ArgLeu: 7.365 ± 0.067	1.803ArgMet: 1.803 ± 0.026	2.015ArgAsn: 2.015 ± 0.028	3.152ArgPro: 3.152 ± 0.034	2.634ArgGln: 2.634 ± 0.032	5.556ArgArg: 5.556 ± 0.051	3.793ArgSer: 3.793 ± 0.041	3.585ArgThr: 3.585 ± 0.039	5.241ArgVal: 5.241 ± 0.047	1.084ArgTrp: 1.084 ± 0.022	2.034ArgTyr: 2.034 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.194SerAla: 7.194 ± 0.069	0.495SerCys: 0.495 ± 0.014	2.774SerAsp: 2.774 ± 0.036	2.6SerGlu: 2.6 ± 0.031	2.268SerPhe: 2.268 ± 0.029	5.745SerGly: 5.745 ± 0.061	1.313SerHis: 1.313 ± 0.021	2.823SerIle: 2.823 ± 0.032	1.62SerLys: 1.62 ± 0.026	5.925SerLeu: 5.925 ± 0.049	1.453SerMet: 1.453 ± 0.023	1.77SerAsn: 1.77 ± 0.041	2.971SerPro: 2.971 ± 0.038	1.951SerGln: 1.951 ± 0.029	3.937SerArg: 3.937 ± 0.038	3.652SerSer: 3.652 ± 0.047	3.31SerThr: 3.31 ± 0.048	4.622SerVal: 4.622 ± 0.048	0.742SerTrp: 0.742 ± 0.016	1.389SerTyr: 1.389 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.228ThrAla: 6.228 ± 0.062	0.475ThrCys: 0.475 ± 0.016	2.727ThrAsp: 2.727 ± 0.037	2.328ThrGlu: 2.328 ± 0.028	1.99ThrPhe: 1.99 ± 0.029	4.938ThrGly: 4.938 ± 0.06	1.307ThrHis: 1.307 ± 0.021	2.595ThrIle: 2.595 ± 0.035	1.186ThrLys: 1.186 ± 0.021	6.484ThrLeu: 6.484 ± 0.052	1.178ThrMet: 1.178 ± 0.022	1.489ThrAsn: 1.489 ± 0.055	3.591ThrPro: 3.591 ± 0.044	2.043ThrGln: 2.043 ± 0.03	3.752ThrArg: 3.752 ± 0.044	3.145ThrSer: 3.145 ± 0.047	3.029ThrThr: 3.029 ± 0.048	4.425ThrVal: 4.425 ± 0.044	0.689ThrTrp: 0.689 ± 0.016	1.294ThrTyr: 1.294 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	9.527ValAla: 9.527 ± 0.076	0.83ValCys: 0.83 ± 0.019	4.186ValAsp: 4.186 ± 0.041	4.15ValGlu: 4.15 ± 0.041	2.857ValPhe: 2.857 ± 0.036	5.591ValGly: 5.591 ± 0.05	1.575ValHis: 1.575 ± 0.026	3.807ValIle: 3.807 ± 0.044	2.373ValLys: 2.373 ± 0.035	7.865ValLeu: 7.865 ± 0.064	1.868ValMet: 1.868 ± 0.028	2.338ValAsn: 2.338 ± 0.051	3.986ValPro: 3.986 ± 0.038	2.513ValGln: 2.513 ± 0.032	5.136ValArg: 5.136 ± 0.058	4.9ValSer: 4.9 ± 0.056	4.611ValThr: 4.611 ± 0.041	6.26ValVal: 6.26 ± 0.057	0.961ValTrp: 0.961 ± 0.019	1.689ValTyr: 1.689 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.17TrpAla: 1.17 ± 0.024	0.147TrpCys: 0.147 ± 0.008	0.605TrpAsp: 0.605 ± 0.015	0.495TrpGlu: 0.495 ± 0.011	0.545TrpPhe: 0.545 ± 0.015	0.902TrpGly: 0.902 ± 0.02	0.398TrpHis: 0.398 ± 0.013	0.709TrpIle: 0.709 ± 0.017	0.445TrpLys: 0.445 ± 0.011	1.9TrpLeu: 1.9 ± 0.03	0.342TrpMet: 0.342 ± 0.011	0.469TrpAsn: 0.469 ± 0.012	0.678TrpPro: 0.678 ± 0.016	0.692TrpGln: 0.692 ± 0.015	1.191TrpArg: 1.191 ± 0.023	0.829TrpSer: 0.829 ± 0.02	0.719TrpThr: 0.719 ± 0.016	0.897TrpVal: 0.897 ± 0.017	0.223TrpTrp: 0.223 ± 0.009	0.298TrpTyr: 0.298 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.828TyrAla: 2.828 ± 0.031	0.281TyrCys: 0.281 ± 0.011	1.391TyrAsp: 1.391 ± 0.025	1.236TyrGlu: 1.236 ± 0.026	1.005TyrPhe: 1.005 ± 0.023	2.23TyrGly: 2.23 ± 0.031	0.54TyrHis: 0.54 ± 0.015	0.863TyrIle: 0.863 ± 0.017	0.605TyrLys: 0.605 ± 0.017	2.544TyrLeu: 2.544 ± 0.03	0.448TyrMet: 0.448 ± 0.013	0.671TyrAsn: 0.671 ± 0.018	1.271TyrPro: 1.271 ± 0.021	0.932TyrGln: 0.932 ± 0.021	1.936TyrArg: 1.936 ± 0.026	1.386TyrSer: 1.386 ± 0.025	1.322TyrThr: 1.322 ± 0.026	1.9TyrVal: 1.9 ± 0.027	0.394TyrTrp: 0.394 ± 0.013	0.658TyrTyr: 0.658 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8591 proteins (2754203 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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