Amino acid dipepetide frequency for Colwellia sp. PAMC 20917

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.26AlaAla: 6.26 ± 0.094
0.906AlaCys: 0.906 ± 0.03
4.666AlaAsp: 4.666 ± 0.087
5.148AlaGlu: 5.148 ± 0.095
3.291AlaPhe: 3.291 ± 0.057
5.295AlaGly: 5.295 ± 0.098
1.538AlaHis: 1.538 ± 0.034
6.429AlaIle: 6.429 ± 0.083
5.383AlaLys: 5.383 ± 0.082
9.066AlaLeu: 9.066 ± 0.11
2.197AlaMet: 2.197 ± 0.049
4.073AlaAsn: 4.073 ± 0.061
2.433AlaPro: 2.433 ± 0.048
3.57AlaGln: 3.57 ± 0.065
2.868AlaArg: 2.868 ± 0.064
5.154AlaSer: 5.154 ± 0.089
4.342AlaThr: 4.342 ± 0.067
5.149AlaVal: 5.149 ± 0.084
0.824AlaTrp: 0.824 ± 0.028
2.248AlaTyr: 2.248 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.687CysAla: 0.687 ± 0.025
0.155CysCys: 0.155 ± 0.013
0.569CysAsp: 0.569 ± 0.024
0.527CysGlu: 0.527 ± 0.021
0.482CysPhe: 0.482 ± 0.019
0.809CysGly: 0.809 ± 0.031
0.347CysHis: 0.347 ± 0.024
0.62CysIle: 0.62 ± 0.024
0.509CysLys: 0.509 ± 0.02
1.017CysLeu: 1.017 ± 0.03
0.183CysMet: 0.183 ± 0.012
0.368CysAsn: 0.368 ± 0.019
0.424CysPro: 0.424 ± 0.023
0.598CysGln: 0.598 ± 0.025
0.414CysArg: 0.414 ± 0.018
0.731CysSer: 0.731 ± 0.024
0.446CysThr: 0.446 ± 0.016
0.542CysVal: 0.542 ± 0.02
0.129CysTrp: 0.129 ± 0.011
0.35CysTyr: 0.35 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.038AspAla: 4.038 ± 0.085
0.583AspCys: 0.583 ± 0.025
3.599AspAsp: 3.599 ± 0.106
3.944AspGlu: 3.944 ± 0.065
2.85AspPhe: 2.85 ± 0.05
3.747AspGly: 3.747 ± 0.173
1.107AspHis: 1.107 ± 0.033
4.985AspIle: 4.985 ± 0.071
3.84AspLys: 3.84 ± 0.065
5.173AspLeu: 5.173 ± 0.076
1.235AspMet: 1.235 ± 0.036
3.266AspAsn: 3.266 ± 0.094
1.729AspPro: 1.729 ± 0.045
1.867AspGln: 1.867 ± 0.045
1.868AspArg: 1.868 ± 0.046
3.465AspSer: 3.465 ± 0.075
2.773AspThr: 2.773 ± 0.128
3.769AspVal: 3.769 ± 0.068
0.702AspTrp: 0.702 ± 0.024
2.059AspTyr: 2.059 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
4.158GluAla: 4.158 ± 0.063
0.437GluCys: 0.437 ± 0.019
2.807GluAsp: 2.807 ± 0.067
3.195GluGlu: 3.195 ± 0.064
2.535GluPhe: 2.535 ± 0.038
3.144GluGly: 3.144 ± 0.068
1.514GluHis: 1.514 ± 0.034
4.348GluIle: 4.348 ± 0.065
4.364GluLys: 4.364 ± 0.068
6.708GluLeu: 6.708 ± 0.071
1.486GluMet: 1.486 ± 0.041
3.518GluAsn: 3.518 ± 0.061
1.578GluPro: 1.578 ± 0.054
3.984GluGln: 3.984 ± 0.066
2.571GluArg: 2.571 ± 0.053
3.67GluSer: 3.67 ± 0.061
3.047GluThr: 3.047 ± 0.062
3.98GluVal: 3.98 ± 0.065
0.551GluTrp: 0.551 ± 0.025
1.74GluTyr: 1.74 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.37PheAla: 3.37 ± 0.058
0.509PheCys: 0.509 ± 0.022
2.953PheAsp: 2.953 ± 0.059
2.645PheGlu: 2.645 ± 0.048
1.922PhePhe: 1.922 ± 0.041
2.959PheGly: 2.959 ± 0.052
0.796PheHis: 0.796 ± 0.028
3.629PheIle: 3.629 ± 0.063
2.364PheLys: 2.364 ± 0.044
3.495PheLeu: 3.495 ± 0.063
0.948PheMet: 0.948 ± 0.03
2.527PheAsn: 2.527 ± 0.058
1.389PhePro: 1.389 ± 0.04
1.313PheGln: 1.313 ± 0.035
1.352PheArg: 1.352 ± 0.035
4.021PheSer: 4.021 ± 0.064
2.922PheThr: 2.922 ± 0.083
2.653PheVal: 2.653 ± 0.053
0.523PheTrp: 0.523 ± 0.022
1.539PheTyr: 1.539 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
4.661GlyAla: 4.661 ± 0.098
0.792GlyCys: 0.792 ± 0.031
3.735GlyAsp: 3.735 ± 0.11
3.919GlyGlu: 3.919 ± 0.061
3.193GlyPhe: 3.193 ± 0.055
4.305GlyGly: 4.305 ± 0.084
1.412GlyHis: 1.412 ± 0.037
4.763GlyIle: 4.763 ± 0.068
3.987GlyLys: 3.987 ± 0.064
6.375GlyLeu: 6.375 ± 0.099
1.677GlyMet: 1.677 ± 0.041
2.82GlyAsn: 2.82 ± 0.091
1.346GlyPro: 1.346 ± 0.048
2.503GlyGln: 2.503 ± 0.045
2.45GlyArg: 2.45 ± 0.045
3.963GlySer: 3.963 ± 0.079
3.316GlyThr: 3.316 ± 0.077
4.543GlyVal: 4.543 ± 0.071
0.753GlyTrp: 0.753 ± 0.027
2.41GlyTyr: 2.41 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.423HisAla: 1.423 ± 0.029
0.329HisCys: 0.329 ± 0.017
1.08HisAsp: 1.08 ± 0.034
1.067HisGlu: 1.067 ± 0.025
1.097HisPhe: 1.097 ± 0.034
1.368HisGly: 1.368 ± 0.038
0.641HisHis: 0.641 ± 0.022
1.454HisIle: 1.454 ± 0.04
1.112HisLys: 1.112 ± 0.029
2.286HisLeu: 2.286 ± 0.051
0.427HisMet: 0.427 ± 0.018
1.012HisAsn: 1.012 ± 0.03
0.974HisPro: 0.974 ± 0.028
1.347HisGln: 1.347 ± 0.028
0.88HisArg: 0.88 ± 0.028
1.414HisSer: 1.414 ± 0.036
0.94HisThr: 0.94 ± 0.031
1.201HisVal: 1.201 ± 0.033
0.332HisTrp: 0.332 ± 0.017
0.818HisTyr: 0.818 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.836IleAla: 6.836 ± 0.074
0.737IleCys: 0.737 ± 0.027
4.894IleAsp: 4.894 ± 0.068
5.091IleGlu: 5.091 ± 0.063
2.871IlePhe: 2.871 ± 0.051
4.629IleGly: 4.629 ± 0.065
1.309IleHis: 1.309 ± 0.035
5.133IleIle: 5.133 ± 0.084
4.726IleLys: 4.726 ± 0.058
5.986IleLeu: 5.986 ± 0.088
1.347IleMet: 1.347 ± 0.038
4.551IleAsn: 4.551 ± 0.071
2.575IlePro: 2.575 ± 0.045
2.187IleGln: 2.187 ± 0.046
2.677IleArg: 2.677 ± 0.053
5.829IleSer: 5.829 ± 0.075
4.711IleThr: 4.711 ± 0.069
4.406IleVal: 4.406 ± 0.061
0.624IleTrp: 0.624 ± 0.023
2.031IleTyr: 2.031 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
5.13LysAla: 5.13 ± 0.08
0.382LysCys: 0.382 ± 0.022
3.144LysAsp: 3.144 ± 0.056
3.668LysGlu: 3.668 ± 0.079
2.056LysPhe: 2.056 ± 0.039
3.414LysGly: 3.414 ± 0.058
1.383LysHis: 1.383 ± 0.039
4.401LysIle: 4.401 ± 0.067
4.156LysLys: 4.156 ± 0.08
6.127LysLeu: 6.127 ± 0.086
1.578LysMet: 1.578 ± 0.033
3.494LysAsn: 3.494 ± 0.062
2.31LysPro: 2.31 ± 0.048
3.135LysGln: 3.135 ± 0.06
2.637LysArg: 2.637 ± 0.05
4.144LysSer: 4.144 ± 0.067
3.616LysThr: 3.616 ± 0.062
4.23LysVal: 4.23 ± 0.058
0.562LysTrp: 0.562 ± 0.021
1.847LysTyr: 1.847 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
9.879LeuAla: 9.879 ± 0.105
0.954LeuCys: 0.954 ± 0.028
5.379LeuAsp: 5.379 ± 0.076
5.251LeuGlu: 5.251 ± 0.072
4.427LeuPhe: 4.427 ± 0.081
6.241LeuGly: 6.241 ± 0.089
1.95LeuHis: 1.95 ± 0.044
7.051LeuIle: 7.051 ± 0.102
6.017LeuLys: 6.017 ± 0.087
10.824LeuLeu: 10.824 ± 0.147
2.539LeuMet: 2.539 ± 0.048
5.301LeuAsn: 5.301 ± 0.082
4.403LeuPro: 4.403 ± 0.06
3.446LeuGln: 3.446 ± 0.064
3.71LeuArg: 3.71 ± 0.061
8.508LeuSer: 8.508 ± 0.098
7.001LeuThr: 7.001 ± 0.152
6.63LeuVal: 6.63 ± 0.085
1.01LeuTrp: 1.01 ± 0.04
2.683LeuTyr: 2.683 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.18MetAla: 2.18 ± 0.049
0.194MetCys: 0.194 ± 0.012
1.067MetAsp: 1.067 ± 0.037
1.056MetGlu: 1.056 ± 0.026
0.896MetPhe: 0.896 ± 0.028
1.459MetGly: 1.459 ± 0.038
0.42MetHis: 0.42 ± 0.019
1.459MetIle: 1.459 ± 0.036
1.515MetLys: 1.515 ± 0.037
2.515MetLeu: 2.515 ± 0.05
0.702MetMet: 0.702 ± 0.026
1.213MetAsn: 1.213 ± 0.028
1.153MetPro: 1.153 ± 0.033
0.94MetGln: 0.94 ± 0.028
0.98MetArg: 0.98 ± 0.029
1.936MetSer: 1.936 ± 0.042
1.532MetThr: 1.532 ± 0.032
1.515MetVal: 1.515 ± 0.039
0.211MetTrp: 0.211 ± 0.014
0.504MetTyr: 0.504 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.904AsnAla: 3.904 ± 0.096
0.496AsnCys: 0.496 ± 0.021
3.107AsnAsp: 3.107 ± 0.094
3.168AsnGlu: 3.168 ± 0.047
2.155AsnPhe: 2.155 ± 0.058
3.292AsnGly: 3.292 ± 0.074
1.048AsnHis: 1.048 ± 0.03
4.193AsnIle: 4.193 ± 0.063
3.768AsnLys: 3.768 ± 0.069
4.535AsnLeu: 4.535 ± 0.081
1.084AsnMet: 1.084 ± 0.03
3.392AsnAsn: 3.392 ± 0.08
1.861AsnPro: 1.861 ± 0.041
2.195AsnGln: 2.195 ± 0.051
1.932AsnArg: 1.932 ± 0.04
3.435AsnSer: 3.435 ± 0.067
2.904AsnThr: 2.904 ± 0.081
3.191AsnVal: 3.191 ± 0.065
0.619AsnTrp: 0.619 ± 0.023
1.747AsnTyr: 1.747 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
2.595ProAla: 2.595 ± 0.057
0.278ProCys: 0.278 ± 0.017
2.006ProAsp: 2.006 ± 0.046
2.679ProGlu: 2.679 ± 0.055
1.619ProPhe: 1.619 ± 0.038
1.896ProGly: 1.896 ± 0.044
0.711ProHis: 0.711 ± 0.023
2.552ProIle: 2.552 ± 0.045
2.092ProLys: 2.092 ± 0.049
3.867ProLeu: 3.867 ± 0.063
0.848ProMet: 0.848 ± 0.025
1.674ProAsn: 1.674 ± 0.048
0.898ProPro: 0.898 ± 0.032
1.383ProGln: 1.383 ± 0.034
1.081ProArg: 1.081 ± 0.031
2.288ProSer: 2.288 ± 0.045
1.917ProThr: 1.917 ± 0.043
2.619ProVal: 2.619 ± 0.092
0.409ProTrp: 0.409 ± 0.018
1.164ProTyr: 1.164 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.215GlnAla: 4.215 ± 0.07
0.419GlnCys: 0.419 ± 0.02
1.953GlnAsp: 1.953 ± 0.043
2.323GlnGlu: 2.323 ± 0.051
1.666GlnPhe: 1.666 ± 0.037
2.836GlnGly: 2.836 ± 0.053
1.161GlnHis: 1.161 ± 0.031
2.563GlnIle: 2.563 ± 0.047
2.46GlnLys: 2.46 ± 0.043
5.245GlnLeu: 5.245 ± 0.077
0.982GlnMet: 0.982 ± 0.027
1.678GlnAsn: 1.678 ± 0.037
1.477GlnPro: 1.477 ± 0.036
3.426GlnGln: 3.426 ± 0.08
2.023GlnArg: 2.023 ± 0.045
2.828GlnSer: 2.828 ± 0.054
2.185GlnThr: 2.185 ± 0.046
3.061GlnVal: 3.061 ± 0.057
0.624GlnTrp: 0.624 ± 0.021
1.398GlnTyr: 1.398 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.774ArgAla: 2.774 ± 0.057
0.368ArgCys: 0.368 ± 0.019
2.031ArgAsp: 2.031 ± 0.04
2.345ArgGlu: 2.345 ± 0.051
1.946ArgPhe: 1.946 ± 0.041
2.178ArgGly: 2.178 ± 0.047
0.892ArgHis: 0.892 ± 0.028
2.829ArgIle: 2.829 ± 0.052
2.289ArgLys: 2.289 ± 0.053
4.311ArgLeu: 4.311 ± 0.063
0.949ArgMet: 0.949 ± 0.035
1.881ArgAsn: 1.881 ± 0.042
1.229ArgPro: 1.229 ± 0.033
1.771ArgGln: 1.771 ± 0.04
1.691ArgArg: 1.691 ± 0.039
2.289ArgSer: 2.289 ± 0.042
1.847ArgThr: 1.847 ± 0.041
2.564ArgVal: 2.564 ± 0.052
0.519ArgTrp: 0.519 ± 0.017
1.533ArgTyr: 1.533 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
5.747SerAla: 5.747 ± 0.083
0.724SerCys: 0.724 ± 0.026
3.899SerAsp: 3.899 ± 0.078
3.986SerGlu: 3.986 ± 0.067
3.404SerPhe: 3.404 ± 0.065
4.811SerGly: 4.811 ± 0.069
1.561SerHis: 1.561 ± 0.039
4.929SerIle: 4.929 ± 0.071
3.858SerLys: 3.858 ± 0.066
7.577SerLeu: 7.577 ± 0.099
1.639SerMet: 1.639 ± 0.042
3.215SerAsn: 3.215 ± 0.063
2.385SerPro: 2.385 ± 0.045
3.093SerGln: 3.093 ± 0.054
2.635SerArg: 2.635 ± 0.048
5.009SerSer: 5.009 ± 0.094
3.872SerThr: 3.872 ± 0.065
4.703SerVal: 4.703 ± 0.076
0.778SerTrp: 0.778 ± 0.029
2.34SerTyr: 2.34 ± 0.08
0.0SerXaa: 0.0 ± 0.0
Thr
4.633ThrAla: 4.633 ± 0.102
0.485ThrCys: 0.485 ± 0.02
3.439ThrAsp: 3.439 ± 0.094
3.325ThrGlu: 3.325 ± 0.057
2.465ThrPhe: 2.465 ± 0.062
3.917ThrGly: 3.917 ± 0.08
1.154ThrHis: 1.154 ± 0.036
4.076ThrIle: 4.076 ± 0.093
2.94ThrLys: 2.94 ± 0.051
6.646ThrLeu: 6.646 ± 0.122
1.137ThrMet: 1.137 ± 0.027
2.515ThrAsn: 2.515 ± 0.069
2.584ThrPro: 2.584 ± 0.095
2.349ThrGln: 2.349 ± 0.05
2.019ThrArg: 2.019 ± 0.044
3.723ThrSer: 3.723 ± 0.061
3.301ThrThr: 3.301 ± 0.072
3.922ThrVal: 3.922 ± 0.176
0.583ThrTrp: 0.583 ± 0.022
1.61ThrTyr: 1.61 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
5.553ValAla: 5.553 ± 0.067
0.635ValCys: 0.635 ± 0.025
4.144ValAsp: 4.144 ± 0.057
4.154ValGlu: 4.154 ± 0.056
2.807ValPhe: 2.807 ± 0.053
4.022ValGly: 4.022 ± 0.067
1.168ValHis: 1.168 ± 0.032
5.187ValIle: 5.187 ± 0.076
3.925ValLys: 3.925 ± 0.063
6.305ValLeu: 6.305 ± 0.085
1.675ValMet: 1.675 ± 0.04
3.724ValAsn: 3.724 ± 0.072
2.163ValPro: 2.163 ± 0.055
1.976ValGln: 1.976 ± 0.038
2.334ValArg: 2.334 ± 0.051
4.751ValSer: 4.751 ± 0.069
4.119ValThr: 4.119 ± 0.203
4.643ValVal: 4.643 ± 0.065
0.62ValTrp: 0.62 ± 0.023
1.753ValTyr: 1.753 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
0.682TrpAla: 0.682 ± 0.023
0.131TrpCys: 0.131 ± 0.011
0.466TrpAsp: 0.466 ± 0.022
0.421TrpGlu: 0.421 ± 0.021
0.557TrpPhe: 0.557 ± 0.022
0.657TrpGly: 0.657 ± 0.03
0.343TrpHis: 0.343 ± 0.016
0.587TrpIle: 0.587 ± 0.026
0.443TrpLys: 0.443 ± 0.019
1.643TrpLeu: 1.643 ± 0.035
0.228TrpMet: 0.228 ± 0.013
0.405TrpAsn: 0.405 ± 0.02
0.399TrpPro: 0.399 ± 0.021
1.145TrpGln: 1.145 ± 0.035
0.562TrpArg: 0.562 ± 0.021
0.684TrpSer: 0.684 ± 0.026
0.442TrpThr: 0.442 ± 0.025
0.686TrpVal: 0.686 ± 0.026
0.146TrpTrp: 0.146 ± 0.011
0.322TrpTyr: 0.322 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.114TyrAla: 2.114 ± 0.045
0.395TyrCys: 0.395 ± 0.019
1.663TyrAsp: 1.663 ± 0.043
1.421TyrGlu: 1.421 ± 0.035
1.591TyrPhe: 1.591 ± 0.039
1.947TyrGly: 1.947 ± 0.046
0.747TyrHis: 0.747 ± 0.028
1.963TyrIle: 1.963 ± 0.043
1.666TyrLys: 1.666 ± 0.039
3.502TyrLeu: 3.502 ± 0.056
0.581TyrMet: 0.581 ± 0.02
1.399TyrAsn: 1.399 ± 0.039
1.267TyrPro: 1.267 ± 0.033
2.295TyrGln: 2.295 ± 0.044
1.551TyrArg: 1.551 ± 0.038
2.324TyrSer: 2.324 ± 0.054
1.591TyrThr: 1.591 ± 0.082
1.65TyrVal: 1.65 ± 0.041
0.432TyrTrp: 0.432 ± 0.019
1.106TyrTyr: 1.106 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3764 proteins (1268406 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski