Amino acid dipepetide frequency for Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.712AlaAla: 4.712 ± 0.116
0.455AlaCys: 0.455 ± 0.031
3.731AlaAsp: 3.731 ± 0.084
4.033AlaGlu: 4.033 ± 0.105
3.159AlaPhe: 3.159 ± 0.087
4.604AlaGly: 4.604 ± 0.093
1.164AlaHis: 1.164 ± 0.049
6.239AlaIle: 6.239 ± 0.104
5.357AlaLys: 5.357 ± 0.121
6.889AlaLeu: 6.889 ± 0.121
1.815AlaMet: 1.815 ± 0.062
3.184AlaAsn: 3.184 ± 0.076
1.841AlaPro: 1.841 ± 0.068
2.728AlaGln: 2.728 ± 0.077
2.579AlaArg: 2.579 ± 0.07
4.459AlaSer: 4.459 ± 0.147
4.059AlaThr: 4.059 ± 0.091
4.751AlaVal: 4.751 ± 0.099
0.535AlaTrp: 0.535 ± 0.036
2.744AlaTyr: 2.744 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.308CysAla: 0.308 ± 0.022
0.065CysCys: 0.065 ± 0.01
0.344CysAsp: 0.344 ± 0.026
0.235CysGlu: 0.235 ± 0.021
0.336CysPhe: 0.336 ± 0.021
0.504CysGly: 0.504 ± 0.035
0.195CysHis: 0.195 ± 0.018
0.361CysIle: 0.361 ± 0.025
0.248CysLys: 0.248 ± 0.022
0.702CysLeu: 0.702 ± 0.037
0.141CysMet: 0.141 ± 0.014
0.217CysAsn: 0.217 ± 0.02
0.272CysPro: 0.272 ± 0.026
0.418CysGln: 0.418 ± 0.031
0.232CysArg: 0.232 ± 0.022
0.368CysSer: 0.368 ± 0.026
0.251CysThr: 0.251 ± 0.021
0.347CysVal: 0.347 ± 0.02
0.042CysTrp: 0.042 ± 0.008
0.227CysTyr: 0.227 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.399AspAla: 3.399 ± 0.085
0.347AspCys: 0.347 ± 0.022
3.039AspAsp: 3.039 ± 0.09
3.612AspGlu: 3.612 ± 0.079
3.214AspPhe: 3.214 ± 0.08
3.529AspGly: 3.529 ± 0.085
0.989AspHis: 0.989 ± 0.044
5.237AspIle: 5.237 ± 0.089
4.527AspLys: 4.527 ± 0.103
5.558AspLeu: 5.558 ± 0.099
1.582AspMet: 1.582 ± 0.05
2.887AspAsn: 2.887 ± 0.073
1.592AspPro: 1.592 ± 0.067
1.846AspGln: 1.846 ± 0.056
1.995AspArg: 1.995 ± 0.062
3.375AspSer: 3.375 ± 0.071
2.796AspThr: 2.796 ± 0.071
3.459AspVal: 3.459 ± 0.085
0.546AspTrp: 0.546 ± 0.033
2.908AspTyr: 2.908 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
4.842GluAla: 4.842 ± 0.117
0.284GluCys: 0.284 ± 0.022
3.516GluAsp: 3.516 ± 0.093
5.278GluGlu: 5.278 ± 0.11
2.506GluPhe: 2.506 ± 0.064
3.477GluGly: 3.477 ± 0.083
1.323GluHis: 1.323 ± 0.052
4.95GluIle: 4.95 ± 0.09
5.72GluLys: 5.72 ± 0.113
6.5GluLeu: 6.5 ± 0.108
1.811GluMet: 1.811 ± 0.054
3.723GluAsn: 3.723 ± 0.075
1.407GluPro: 1.407 ± 0.051
2.618GluGln: 2.618 ± 0.08
2.921GluArg: 2.921 ± 0.07
3.419GluSer: 3.419 ± 0.078
3.803GluThr: 3.803 ± 0.087
4.508GluVal: 4.508 ± 0.092
0.584GluTrp: 0.584 ± 0.032
1.969GluTyr: 1.969 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
3.047PheAla: 3.047 ± 0.083
0.289PheCys: 0.289 ± 0.022
3.059PheAsp: 3.059 ± 0.069
3.013PheGlu: 3.013 ± 0.083
2.107PhePhe: 2.107 ± 0.075
3.208PheGly: 3.208 ± 0.087
0.801PheHis: 0.801 ± 0.038
3.566PheIle: 3.566 ± 0.093
2.926PheLys: 2.926 ± 0.063
4.591PheLeu: 4.591 ± 0.107
1.112PheMet: 1.112 ± 0.044
2.206PheAsn: 2.206 ± 0.062
1.47PhePro: 1.47 ± 0.046
1.522PheGln: 1.522 ± 0.057
1.483PheArg: 1.483 ± 0.052
3.438PheSer: 3.438 ± 0.084
2.435PheThr: 2.435 ± 0.07
3.119PheVal: 3.119 ± 0.074
0.452PheTrp: 0.452 ± 0.029
1.867PheTyr: 1.867 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
4.325GlyAla: 4.325 ± 0.093
0.439GlyCys: 0.439 ± 0.03
3.333GlyAsp: 3.333 ± 0.086
3.435GlyGlu: 3.435 ± 0.081
3.24GlyPhe: 3.24 ± 0.084
4.069GlyGly: 4.069 ± 0.1
1.371GlyHis: 1.371 ± 0.047
5.563GlyIle: 5.563 ± 0.113
4.845GlyLys: 4.845 ± 0.104
6.463GlyLeu: 6.463 ± 0.103
1.767GlyMet: 1.767 ± 0.069
2.872GlyAsn: 2.872 ± 0.069
1.362GlyPro: 1.362 ± 0.043
2.705GlyGln: 2.705 ± 0.07
2.542GlyArg: 2.542 ± 0.065
3.702GlySer: 3.702 ± 0.086
3.586GlyThr: 3.586 ± 0.087
4.419GlyVal: 4.419 ± 0.087
0.622GlyTrp: 0.622 ± 0.039
2.73GlyTyr: 2.73 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.031HisAla: 1.031 ± 0.045
0.138HisCys: 0.138 ± 0.015
1.06HisAsp: 1.06 ± 0.041
1.01HisGlu: 1.01 ± 0.042
1.185HisPhe: 1.185 ± 0.047
1.17HisGly: 1.17 ± 0.051
0.616HisHis: 0.616 ± 0.037
1.618HisIle: 1.618 ± 0.053
1.24HisLys: 1.24 ± 0.044
2.229HisLeu: 2.229 ± 0.067
0.494HisMet: 0.494 ± 0.024
0.877HisAsn: 0.877 ± 0.041
0.804HisPro: 0.804 ± 0.037
0.968HisGln: 0.968 ± 0.042
0.81HisArg: 0.81 ± 0.039
1.208HisSer: 1.208 ± 0.042
0.955HisThr: 0.955 ± 0.039
1.172HisVal: 1.172 ± 0.041
0.144HisTrp: 0.144 ± 0.015
1.08HisTyr: 1.08 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
6.038IleAla: 6.038 ± 0.109
0.582IleCys: 0.582 ± 0.035
4.613IleAsp: 4.613 ± 0.079
5.208IleGlu: 5.208 ± 0.105
3.625IlePhe: 3.625 ± 0.093
5.161IleGly: 5.161 ± 0.106
1.297IleHis: 1.297 ± 0.047
6.192IleIle: 6.192 ± 0.113
5.304IleLys: 5.304 ± 0.088
7.837IleLeu: 7.837 ± 0.158
1.935IleMet: 1.935 ± 0.057
3.949IleAsn: 3.949 ± 0.084
3.005IlePro: 3.005 ± 0.069
2.511IleGln: 2.511 ± 0.057
2.856IleArg: 2.856 ± 0.079
5.73IleSer: 5.73 ± 0.1
4.54IleThr: 4.54 ± 0.087
5.236IleVal: 5.236 ± 0.095
0.613IleTrp: 0.613 ± 0.032
2.683IleTyr: 2.683 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
5.218LysAla: 5.218 ± 0.106
0.3LysCys: 0.3 ± 0.023
4.326LysAsp: 4.326 ± 0.095
6.221LysGlu: 6.221 ± 0.113
2.172LysPhe: 2.172 ± 0.053
4.21LysGly: 4.21 ± 0.093
1.451LysHis: 1.451 ± 0.052
5.121LysIle: 5.121 ± 0.1
5.808LysLys: 5.808 ± 0.121
6.403LysLeu: 6.403 ± 0.104
2.208LysMet: 2.208 ± 0.058
3.973LysAsn: 3.973 ± 0.093
2.357LysPro: 2.357 ± 0.095
3.169LysGln: 3.169 ± 0.081
3.195LysArg: 3.195 ± 0.085
4.537LysSer: 4.537 ± 0.082
4.427LysThr: 4.427 ± 0.089
5.085LysVal: 5.085 ± 0.107
0.669LysTrp: 0.669 ± 0.034
2.54LysTyr: 2.54 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
7.928LeuAla: 7.928 ± 0.109
0.558LeuCys: 0.558 ± 0.03
5.712LeuAsp: 5.712 ± 0.108
6.805LeuGlu: 6.805 ± 0.119
4.42LeuPhe: 4.42 ± 0.096
6.43LeuGly: 6.43 ± 0.12
1.602LeuHis: 1.602 ± 0.058
7.372LeuIle: 7.372 ± 0.139
7.11LeuLys: 7.11 ± 0.115
9.984LeuLeu: 9.984 ± 0.168
2.53LeuMet: 2.53 ± 0.066
4.488LeuAsn: 4.488 ± 0.095
3.764LeuPro: 3.764 ± 0.1
3.318LeuGln: 3.318 ± 0.083
3.623LeuArg: 3.623 ± 0.089
7.873LeuSer: 7.873 ± 0.117
6.122LeuThr: 6.122 ± 0.096
6.562LeuVal: 6.562 ± 0.12
0.684LeuTrp: 0.684 ± 0.034
3.056LeuTyr: 3.056 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
1.961MetAla: 1.961 ± 0.057
0.123MetCys: 0.123 ± 0.015
1.352MetAsp: 1.352 ± 0.048
1.425MetGlu: 1.425 ± 0.048
0.883MetPhe: 0.883 ± 0.033
1.639MetGly: 1.639 ± 0.052
0.392MetHis: 0.392 ± 0.028
2.229MetIle: 2.229 ± 0.068
1.999MetLys: 1.999 ± 0.053
2.333MetLeu: 2.333 ± 0.07
0.726MetMet: 0.726 ± 0.036
1.232MetAsn: 1.232 ± 0.051
0.849MetPro: 0.849 ± 0.036
0.88MetGln: 0.88 ± 0.038
0.995MetArg: 0.995 ± 0.045
1.948MetSer: 1.948 ± 0.068
2.14MetThr: 2.14 ± 0.056
1.757MetVal: 1.757 ± 0.061
0.149MetTrp: 0.149 ± 0.015
0.597MetTyr: 0.597 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.908AsnAla: 2.908 ± 0.08
0.313AsnCys: 0.313 ± 0.022
2.603AsnAsp: 2.603 ± 0.08
2.639AsnGlu: 2.639 ± 0.073
2.133AsnPhe: 2.133 ± 0.061
3.328AsnGly: 3.328 ± 0.081
1.405AsnHis: 1.405 ± 0.044
3.851AsnIle: 3.851 ± 0.083
3.376AsnLys: 3.376 ± 0.079
4.97AsnLeu: 4.97 ± 0.094
1.229AsnMet: 1.229 ± 0.045
2.521AsnAsn: 2.521 ± 0.072
2.172AsnPro: 2.172 ± 0.063
2.602AsnGln: 2.602 ± 0.07
2.143AsnArg: 2.143 ± 0.057
2.97AsnSer: 2.97 ± 0.078
2.469AsnThr: 2.469 ± 0.066
2.911AsnVal: 2.911 ± 0.074
0.537AsnTrp: 0.537 ± 0.029
2.161AsnTyr: 2.161 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
1.94ProAla: 1.94 ± 0.073
0.13ProCys: 0.13 ± 0.016
1.927ProAsp: 1.927 ± 0.074
2.44ProGlu: 2.44 ± 0.072
1.58ProPhe: 1.58 ± 0.048
1.627ProGly: 1.627 ± 0.054
0.681ProHis: 0.681 ± 0.036
2.579ProIle: 2.579 ± 0.063
2.626ProLys: 2.626 ± 0.086
2.929ProLeu: 2.929 ± 0.071
0.744ProMet: 0.744 ± 0.036
1.828ProAsn: 1.828 ± 0.057
0.537ProPro: 0.537 ± 0.031
1.255ProGln: 1.255 ± 0.044
1.039ProArg: 1.039 ± 0.05
2.162ProSer: 2.162 ± 0.066
1.927ProThr: 1.927 ± 0.06
2.36ProVal: 2.36 ± 0.066
0.24ProTrp: 0.24 ± 0.021
1.321ProTyr: 1.321 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
3.135GlnAla: 3.135 ± 0.073
0.148GlnCys: 0.148 ± 0.015
1.944GlnAsp: 1.944 ± 0.058
3.103GlnGlu: 3.103 ± 0.08
1.783GlnPhe: 1.783 ± 0.062
2.17GlnGly: 2.17 ± 0.059
0.702GlnHis: 0.702 ± 0.037
2.759GlnIle: 2.759 ± 0.068
3.294GlnLys: 3.294 ± 0.079
4.304GlnLeu: 4.304 ± 0.094
1.01GlnMet: 1.01 ± 0.042
1.9GlnAsn: 1.9 ± 0.06
1.073GlnPro: 1.073 ± 0.043
1.469GlnGln: 1.469 ± 0.06
1.542GlnArg: 1.542 ± 0.061
2.42GlnSer: 2.42 ± 0.061
2.303GlnThr: 2.303 ± 0.067
2.916GlnVal: 2.916 ± 0.066
0.336GlnTrp: 0.336 ± 0.022
1.448GlnTyr: 1.448 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.388ArgAla: 2.388 ± 0.071
0.224ArgCys: 0.224 ± 0.024
2.179ArgAsp: 2.179 ± 0.056
2.767ArgGlu: 2.767 ± 0.078
1.833ArgPhe: 1.833 ± 0.055
2.258ArgGly: 2.258 ± 0.075
0.913ArgHis: 0.913 ± 0.04
2.989ArgIle: 2.989 ± 0.073
2.885ArgLys: 2.885 ± 0.079
4.085ArgLeu: 4.085 ± 0.085
1.034ArgMet: 1.034 ± 0.043
1.783ArgAsn: 1.783 ± 0.055
1.217ArgPro: 1.217 ± 0.048
2.007ArgGln: 2.007 ± 0.064
1.927ArgArg: 1.927 ± 0.073
1.961ArgSer: 1.961 ± 0.059
1.952ArgThr: 1.952 ± 0.057
2.516ArgVal: 2.516 ± 0.073
0.308ArgTrp: 0.308 ± 0.019
1.595ArgTyr: 1.595 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
3.871SerAla: 3.871 ± 0.139
0.339SerCys: 0.339 ± 0.025
3.824SerAsp: 3.824 ± 0.087
3.775SerGlu: 3.775 ± 0.085
3.253SerPhe: 3.253 ± 0.086
4.628SerGly: 4.628 ± 0.093
1.48SerHis: 1.48 ± 0.054
5.006SerIle: 5.006 ± 0.088
4.686SerLys: 4.686 ± 0.099
6.839SerLeu: 6.839 ± 0.132
1.444SerMet: 1.444 ± 0.056
3.245SerAsn: 3.245 ± 0.077
1.979SerPro: 1.979 ± 0.05
3.179SerGln: 3.179 ± 0.079
2.564SerArg: 2.564 ± 0.068
4.44SerSer: 4.44 ± 0.117
3.505SerThr: 3.505 ± 0.125
4.258SerVal: 4.258 ± 0.093
0.582SerTrp: 0.582 ± 0.033
2.605SerTyr: 2.605 ± 0.077
0.0SerXaa: 0.0 ± 0.0
Thr
3.983ThrAla: 3.983 ± 0.094
0.329ThrCys: 0.329 ± 0.023
3.067ThrAsp: 3.067 ± 0.069
3.247ThrGlu: 3.247 ± 0.076
2.78ThrPhe: 2.78 ± 0.073
3.965ThrGly: 3.965 ± 0.079
1.104ThrHis: 1.104 ± 0.045
4.809ThrIle: 4.809 ± 0.08
3.905ThrLys: 3.905 ± 0.088
5.68ThrLeu: 5.68 ± 0.094
1.237ThrMet: 1.237 ± 0.045
2.722ThrAsn: 2.722 ± 0.081
2.344ThrPro: 2.344 ± 0.082
1.958ThrGln: 1.958 ± 0.058
1.875ThrArg: 1.875 ± 0.055
3.748ThrSer: 3.748 ± 0.128
3.244ThrThr: 3.244 ± 0.077
4.458ThrVal: 4.458 ± 0.122
0.509ThrTrp: 0.509 ± 0.035
2.42ThrTyr: 2.42 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
5.166ValAla: 5.166 ± 0.105
0.426ValCys: 0.426 ± 0.027
4.031ValAsp: 4.031 ± 0.11
4.283ValGlu: 4.283 ± 0.108
2.918ValPhe: 2.918 ± 0.079
4.398ValGly: 4.398 ± 0.088
1.075ValHis: 1.075 ± 0.041
5.218ValIle: 5.218 ± 0.106
4.673ValLys: 4.673 ± 0.095
6.469ValLeu: 6.469 ± 0.108
1.692ValMet: 1.692 ± 0.055
3.242ValAsn: 3.242 ± 0.079
2.282ValPro: 2.282 ± 0.069
1.981ValGln: 1.981 ± 0.059
2.464ValArg: 2.464 ± 0.069
4.831ValSer: 4.831 ± 0.083
4.501ValThr: 4.501 ± 0.107
4.814ValVal: 4.814 ± 0.124
0.537ValTrp: 0.537 ± 0.03
2.282ValTyr: 2.282 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.493TrpAla: 0.493 ± 0.029
0.042TrpCys: 0.042 ± 0.007
0.431TrpAsp: 0.431 ± 0.026
0.519TrpGlu: 0.519 ± 0.029
0.439TrpPhe: 0.439 ± 0.031
0.588TrpGly: 0.588 ± 0.03
0.204TrpHis: 0.204 ± 0.019
0.621TrpIle: 0.621 ± 0.036
0.543TrpLys: 0.543 ± 0.03
0.973TrpLeu: 0.973 ± 0.044
0.246TrpMet: 0.246 ± 0.021
0.493TrpAsn: 0.493 ± 0.029
0.154TrpPro: 0.154 ± 0.017
0.426TrpGln: 0.426 ± 0.029
0.353TrpArg: 0.353 ± 0.027
0.566TrpSer: 0.566 ± 0.033
0.485TrpThr: 0.485 ± 0.032
0.47TrpVal: 0.47 ± 0.025
0.113TrpTrp: 0.113 ± 0.014
0.371TrpTyr: 0.371 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.347TyrAla: 2.347 ± 0.062
0.284TyrCys: 0.284 ± 0.023
2.347TyrAsp: 2.347 ± 0.071
2.112TyrGlu: 2.112 ± 0.065
2.143TyrPhe: 2.143 ± 0.057
2.427TyrGly: 2.427 ± 0.055
1.047TyrHis: 1.047 ± 0.046
2.634TyrIle: 2.634 ± 0.07
2.316TyrLys: 2.316 ± 0.067
4.205TyrLeu: 4.205 ± 0.08
0.849TyrMet: 0.849 ± 0.035
1.898TyrAsn: 1.898 ± 0.056
1.391TyrPro: 1.391 ± 0.051
2.196TyrGln: 2.196 ± 0.072
1.681TyrArg: 1.681 ± 0.052
2.347TyrSer: 2.347 ± 0.057
1.884TyrThr: 1.884 ± 0.057
2.166TyrVal: 2.166 ± 0.06
0.329TyrTrp: 0.329 ± 0.022
1.79TyrTyr: 1.79 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2105 proteins (616913 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski