Amino acid dipepetide frequency for Morganella phage vB_MmoP_MP2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.175AlaAla: 7.175 ± 0.713
0.667AlaCys: 0.667 ± 0.273
5.59AlaAsp: 5.59 ± 0.677
5.757AlaGlu: 5.757 ± 0.709
2.753AlaPhe: 2.753 ± 0.494
6.758AlaGly: 6.758 ± 0.74
1.335AlaHis: 1.335 ± 0.229
4.672AlaIle: 4.672 ± 0.652
5.924AlaLys: 5.924 ± 0.771
7.926AlaLeu: 7.926 ± 1.177
3.504AlaMet: 3.504 ± 0.513
3.671AlaAsn: 3.671 ± 0.544
2.837AlaPro: 2.837 ± 0.565
4.005AlaGln: 4.005 ± 0.665
4.922AlaArg: 4.922 ± 0.677
4.422AlaSer: 4.422 ± 0.569
4.422AlaThr: 4.422 ± 0.567
5.59AlaVal: 5.59 ± 0.561
1.085AlaTrp: 1.085 ± 0.309
2.92AlaTyr: 2.92 ± 0.439
0.0AlaXaa: 0.0 ± 0.0
Cys
0.834CysAla: 0.834 ± 0.273
0.083CysCys: 0.083 ± 0.097
0.918CysAsp: 0.918 ± 0.341
0.834CysGlu: 0.834 ± 0.355
0.501CysPhe: 0.501 ± 0.215
0.834CysGly: 0.834 ± 0.279
0.334CysHis: 0.334 ± 0.171
0.167CysIle: 0.167 ± 0.111
0.501CysLys: 0.501 ± 0.282
0.501CysLeu: 0.501 ± 0.195
0.25CysMet: 0.25 ± 0.16
0.417CysAsn: 0.417 ± 0.192
0.667CysPro: 0.667 ± 0.216
0.667CysGln: 0.667 ± 0.261
0.334CysArg: 0.334 ± 0.182
0.584CysSer: 0.584 ± 0.198
0.501CysThr: 0.501 ± 0.218
0.501CysVal: 0.501 ± 0.175
0.083CysTrp: 0.083 ± 0.08
0.167CysTyr: 0.167 ± 0.124
0.0CysXaa: 0.0 ± 0.0
Asp
4.839AspAla: 4.839 ± 0.663
0.834AspCys: 0.834 ± 0.29
5.423AspAsp: 5.423 ± 1.175
4.172AspGlu: 4.172 ± 0.725
2.253AspPhe: 2.253 ± 0.522
5.673AspGly: 5.673 ± 0.719
0.751AspHis: 0.751 ± 0.235
3.838AspIle: 3.838 ± 0.509
4.338AspLys: 4.338 ± 0.422
4.172AspLeu: 4.172 ± 0.476
1.752AspMet: 1.752 ± 0.317
2.92AspAsn: 2.92 ± 0.436
2.503AspPro: 2.503 ± 0.418
1.502AspGln: 1.502 ± 0.389
3.004AspArg: 3.004 ± 0.44
3.671AspSer: 3.671 ± 0.585
3.504AspThr: 3.504 ± 0.487
4.088AspVal: 4.088 ± 0.588
1.001AspTrp: 1.001 ± 0.266
2.253AspTyr: 2.253 ± 0.439
0.0AspXaa: 0.0 ± 0.0
Glu
7.592GluAla: 7.592 ± 0.855
0.667GluCys: 0.667 ± 0.238
4.422GluAsp: 4.422 ± 0.561
6.758GluGlu: 6.758 ± 0.979
2.419GluPhe: 2.419 ± 0.332
4.338GluGly: 4.338 ± 0.563
1.669GluHis: 1.669 ± 0.349
4.255GluIle: 4.255 ± 0.598
3.588GluLys: 3.588 ± 0.556
6.508GluLeu: 6.508 ± 0.76
2.169GluMet: 2.169 ± 0.368
3.004GluAsn: 3.004 ± 0.635
2.086GluPro: 2.086 ± 0.557
3.504GluGln: 3.504 ± 0.705
3.838GluArg: 3.838 ± 0.558
5.173GluSer: 5.173 ± 0.57
3.671GluThr: 3.671 ± 0.439
4.839GluVal: 4.839 ± 0.649
1.335GluTrp: 1.335 ± 0.497
3.337GluTyr: 3.337 ± 0.444
0.0GluXaa: 0.0 ± 0.0
Phe
2.753PheAla: 2.753 ± 0.459
0.334PheCys: 0.334 ± 0.185
2.419PheAsp: 2.419 ± 0.458
1.669PheGlu: 1.669 ± 0.322
0.918PhePhe: 0.918 ± 0.261
3.087PheGly: 3.087 ± 0.57
1.168PheHis: 1.168 ± 0.313
2.419PheIle: 2.419 ± 0.548
2.92PheLys: 2.92 ± 0.544
2.503PheLeu: 2.503 ± 0.417
1.418PheMet: 1.418 ± 0.29
2.503PheAsn: 2.503 ± 0.479
1.752PhePro: 1.752 ± 0.354
0.584PheGln: 0.584 ± 0.213
1.919PheArg: 1.919 ± 0.297
2.002PheSer: 2.002 ± 0.358
3.421PheThr: 3.421 ± 0.578
2.086PheVal: 2.086 ± 0.439
0.417PheTrp: 0.417 ± 0.164
0.918PheTyr: 0.918 ± 0.278
0.0PheXaa: 0.0 ± 0.0
Gly
6.758GlyAla: 6.758 ± 0.679
0.584GlyCys: 0.584 ± 0.203
5.59GlyAsp: 5.59 ± 0.643
5.34GlyGlu: 5.34 ± 0.741
4.005GlyPhe: 4.005 ± 0.39
6.341GlyGly: 6.341 ± 0.839
1.001GlyHis: 1.001 ± 0.261
4.255GlyIle: 4.255 ± 0.587
6.174GlyLys: 6.174 ± 0.71
5.59GlyLeu: 5.59 ± 0.801
2.169GlyMet: 2.169 ± 0.573
2.837GlyAsn: 2.837 ± 0.482
0.0GlyPro: 0.0 ± 0.0
1.835GlyGln: 1.835 ± 0.512
4.005GlyArg: 4.005 ± 0.612
5.006GlySer: 5.006 ± 0.838
3.921GlyThr: 3.921 ± 0.59
3.921GlyVal: 3.921 ± 0.585
1.835GlyTrp: 1.835 ± 0.382
3.254GlyTyr: 3.254 ± 0.471
0.0GlyXaa: 0.0 ± 0.0
His
0.751HisAla: 0.751 ± 0.24
0.501HisCys: 0.501 ± 0.19
1.251HisAsp: 1.251 ± 0.339
1.585HisGlu: 1.585 ± 0.325
0.667HisPhe: 0.667 ± 0.244
1.335HisGly: 1.335 ± 0.327
0.25HisHis: 0.25 ± 0.148
1.168HisIle: 1.168 ± 0.263
1.001HisLys: 1.001 ± 0.223
1.585HisLeu: 1.585 ± 0.378
0.667HisMet: 0.667 ± 0.182
0.834HisAsn: 0.834 ± 0.265
0.501HisPro: 0.501 ± 0.171
0.501HisGln: 0.501 ± 0.203
0.417HisArg: 0.417 ± 0.161
0.667HisSer: 0.667 ± 0.178
1.168HisThr: 1.168 ± 0.34
1.251HisVal: 1.251 ± 0.412
0.334HisTrp: 0.334 ± 0.165
1.001HisTyr: 1.001 ± 0.284
0.0HisXaa: 0.0 ± 0.0
Ile
4.255IleAla: 4.255 ± 0.534
0.584IleCys: 0.584 ± 0.25
4.172IleAsp: 4.172 ± 0.583
4.338IleGlu: 4.338 ± 0.64
1.585IlePhe: 1.585 ± 0.413
4.589IleGly: 4.589 ± 0.542
0.751IleHis: 0.751 ± 0.189
3.087IleIle: 3.087 ± 0.584
2.92IleLys: 2.92 ± 0.402
3.254IleLeu: 3.254 ± 0.464
1.835IleMet: 1.835 ± 0.363
2.336IleAsn: 2.336 ± 0.382
2.086IlePro: 2.086 ± 0.437
1.585IleGln: 1.585 ± 0.304
3.421IleArg: 3.421 ± 0.435
3.421IleSer: 3.421 ± 0.543
3.17IleThr: 3.17 ± 0.558
2.67IleVal: 2.67 ± 0.471
0.501IleTrp: 0.501 ± 0.251
2.586IleTyr: 2.586 ± 0.379
0.0IleXaa: 0.0 ± 0.0
Lys
7.509LysAla: 7.509 ± 0.763
0.667LysCys: 0.667 ± 0.267
3.838LysAsp: 3.838 ± 0.496
5.173LysGlu: 5.173 ± 0.693
3.337LysPhe: 3.337 ± 0.506
5.84LysGly: 5.84 ± 0.865
1.919LysHis: 1.919 ± 0.451
1.669LysIle: 1.669 ± 0.348
4.338LysLys: 4.338 ± 0.611
5.34LysLeu: 5.34 ± 0.791
2.586LysMet: 2.586 ± 0.427
2.67LysAsn: 2.67 ± 0.317
2.503LysPro: 2.503 ± 0.561
2.837LysGln: 2.837 ± 0.626
3.921LysArg: 3.921 ± 0.624
3.921LysSer: 3.921 ± 0.579
2.753LysThr: 2.753 ± 0.508
5.757LysVal: 5.757 ± 0.753
0.751LysTrp: 0.751 ± 0.261
1.919LysTyr: 1.919 ± 0.32
0.0LysXaa: 0.0 ± 0.0
Leu
6.674LeuAla: 6.674 ± 1.086
0.501LeuCys: 0.501 ± 0.221
4.255LeuAsp: 4.255 ± 0.533
6.674LeuGlu: 6.674 ± 0.852
2.253LeuPhe: 2.253 ± 0.446
4.839LeuGly: 4.839 ± 0.748
1.001LeuHis: 1.001 ± 0.246
3.504LeuIle: 3.504 ± 0.53
6.758LeuLys: 6.758 ± 0.732
6.174LeuLeu: 6.174 ± 0.697
1.502LeuMet: 1.502 ± 0.366
5.423LeuAsn: 5.423 ± 0.64
3.337LeuPro: 3.337 ± 0.524
4.005LeuGln: 4.005 ± 0.858
4.922LeuArg: 4.922 ± 0.626
4.672LeuSer: 4.672 ± 0.625
3.921LeuThr: 3.921 ± 0.64
4.505LeuVal: 4.505 ± 0.732
1.418LeuTrp: 1.418 ± 0.42
2.253LeuTyr: 2.253 ± 0.432
0.0LeuXaa: 0.0 ± 0.0
Met
2.92MetAla: 2.92 ± 0.457
0.417MetCys: 0.417 ± 0.178
1.502MetAsp: 1.502 ± 0.341
1.919MetGlu: 1.919 ± 0.321
1.335MetPhe: 1.335 ± 0.306
1.502MetGly: 1.502 ± 0.298
0.667MetHis: 0.667 ± 0.261
1.502MetIle: 1.502 ± 0.354
1.919MetLys: 1.919 ± 0.357
3.254MetLeu: 3.254 ± 0.552
0.751MetMet: 0.751 ± 0.334
1.251MetAsn: 1.251 ± 0.363
1.669MetPro: 1.669 ± 0.397
1.001MetGln: 1.001 ± 0.301
1.335MetArg: 1.335 ± 0.262
2.336MetSer: 2.336 ± 0.379
2.002MetThr: 2.002 ± 0.358
2.336MetVal: 2.336 ± 0.468
0.334MetTrp: 0.334 ± 0.168
1.335MetTyr: 1.335 ± 0.351
0.0MetXaa: 0.0 ± 0.0
Asn
3.588AsnAla: 3.588 ± 0.556
0.501AsnCys: 0.501 ± 0.196
3.087AsnAsp: 3.087 ± 0.562
2.92AsnGlu: 2.92 ± 0.503
1.168AsnPhe: 1.168 ± 0.237
4.422AsnGly: 4.422 ± 0.904
0.751AsnHis: 0.751 ± 0.254
2.92AsnIle: 2.92 ± 0.503
2.419AsnLys: 2.419 ± 0.456
3.254AsnLeu: 3.254 ± 0.577
1.418AsnMet: 1.418 ± 0.399
1.335AsnAsn: 1.335 ± 0.324
3.337AsnPro: 3.337 ± 0.446
1.585AsnGln: 1.585 ± 0.324
2.67AsnArg: 2.67 ± 0.616
2.169AsnSer: 2.169 ± 0.625
2.586AsnThr: 2.586 ± 0.407
3.17AsnVal: 3.17 ± 0.504
0.417AsnTrp: 0.417 ± 0.174
2.002AsnTyr: 2.002 ± 0.451
0.0AsnXaa: 0.0 ± 0.0
Pro
3.421ProAla: 3.421 ± 0.537
0.417ProCys: 0.417 ± 0.172
2.837ProAsp: 2.837 ± 0.53
4.338ProGlu: 4.338 ± 0.639
1.251ProPhe: 1.251 ± 0.267
0.417ProGly: 0.417 ± 0.14
0.667ProHis: 0.667 ± 0.204
1.418ProIle: 1.418 ± 0.362
2.92ProLys: 2.92 ± 0.437
3.004ProLeu: 3.004 ± 0.585
1.168ProMet: 1.168 ± 0.33
2.253ProAsn: 2.253 ± 0.382
0.918ProPro: 0.918 ± 0.279
1.335ProGln: 1.335 ± 0.32
1.168ProArg: 1.168 ± 0.304
2.419ProSer: 2.419 ± 0.405
2.086ProThr: 2.086 ± 0.437
2.086ProVal: 2.086 ± 0.336
0.667ProTrp: 0.667 ± 0.19
1.752ProTyr: 1.752 ± 0.403
0.0ProXaa: 0.0 ± 0.0
Gln
4.338GlnAla: 4.338 ± 0.747
0.167GlnCys: 0.167 ± 0.112
2.253GlnAsp: 2.253 ± 0.415
2.086GlnGlu: 2.086 ± 0.368
2.086GlnPhe: 2.086 ± 0.4
2.67GlnGly: 2.67 ± 0.55
0.501GlnHis: 0.501 ± 0.181
1.919GlnIle: 1.919 ± 0.409
2.419GlnLys: 2.419 ± 0.455
3.421GlnLeu: 3.421 ± 0.662
0.918GlnMet: 0.918 ± 0.227
1.669GlnAsn: 1.669 ± 0.359
1.335GlnPro: 1.335 ± 0.273
1.919GlnGln: 1.919 ± 0.636
1.919GlnArg: 1.919 ± 0.593
2.253GlnSer: 2.253 ± 0.348
2.169GlnThr: 2.169 ± 0.449
1.835GlnVal: 1.835 ± 0.418
0.918GlnTrp: 0.918 ± 0.261
1.085GlnTyr: 1.085 ± 0.284
0.0GlnXaa: 0.0 ± 0.0
Arg
4.088ArgAla: 4.088 ± 0.618
0.584ArgCys: 0.584 ± 0.216
3.004ArgAsp: 3.004 ± 0.551
4.505ArgGlu: 4.505 ± 0.669
1.835ArgPhe: 1.835 ± 0.354
3.504ArgGly: 3.504 ± 0.604
1.085ArgHis: 1.085 ± 0.239
3.254ArgIle: 3.254 ± 0.52
5.173ArgLys: 5.173 ± 0.932
3.421ArgLeu: 3.421 ± 0.422
1.585ArgMet: 1.585 ± 0.312
2.753ArgAsn: 2.753 ± 0.479
1.585ArgPro: 1.585 ± 0.246
1.919ArgGln: 1.919 ± 0.397
2.086ArgArg: 2.086 ± 0.447
3.504ArgSer: 3.504 ± 0.668
2.753ArgThr: 2.753 ± 0.485
2.586ArgVal: 2.586 ± 0.423
0.751ArgTrp: 0.751 ± 0.211
1.835ArgTyr: 1.835 ± 0.315
0.0ArgXaa: 0.0 ± 0.0
Ser
4.756SerAla: 4.756 ± 0.717
0.667SerCys: 0.667 ± 0.231
3.921SerAsp: 3.921 ± 0.666
3.671SerGlu: 3.671 ± 0.637
2.586SerPhe: 2.586 ± 0.388
5.089SerGly: 5.089 ± 0.635
1.001SerHis: 1.001 ± 0.262
2.92SerIle: 2.92 ± 0.515
4.589SerLys: 4.589 ± 0.574
4.255SerLeu: 4.255 ± 0.624
2.253SerMet: 2.253 ± 0.527
2.586SerAsn: 2.586 ± 0.534
2.253SerPro: 2.253 ± 0.353
2.753SerGln: 2.753 ± 0.54
3.087SerArg: 3.087 ± 0.425
3.004SerSer: 3.004 ± 0.533
3.087SerThr: 3.087 ± 0.389
4.255SerVal: 4.255 ± 0.313
1.001SerTrp: 1.001 ± 0.234
2.92SerTyr: 2.92 ± 0.7
0.0SerXaa: 0.0 ± 0.0
Thr
3.838ThrAla: 3.838 ± 0.62
0.334ThrCys: 0.334 ± 0.231
2.837ThrAsp: 2.837 ± 0.5
4.756ThrGlu: 4.756 ± 0.484
2.253ThrPhe: 2.253 ± 0.386
4.672ThrGly: 4.672 ± 0.58
0.751ThrHis: 0.751 ± 0.224
4.338ThrIle: 4.338 ± 0.664
3.838ThrLys: 3.838 ± 0.518
4.922ThrLeu: 4.922 ± 0.564
1.919ThrMet: 1.919 ± 0.46
1.835ThrAsn: 1.835 ± 0.362
3.254ThrPro: 3.254 ± 0.449
1.919ThrGln: 1.919 ± 0.49
2.086ThrArg: 2.086 ± 0.288
2.837ThrSer: 2.837 ± 0.557
2.92ThrThr: 2.92 ± 0.551
3.671ThrVal: 3.671 ± 0.478
0.751ThrTrp: 0.751 ± 0.203
2.253ThrTyr: 2.253 ± 0.321
0.0ThrXaa: 0.0 ± 0.0
Val
5.006ValAla: 5.006 ± 0.644
0.417ValCys: 0.417 ± 0.16
2.419ValAsp: 2.419 ± 0.558
4.756ValGlu: 4.756 ± 0.539
2.586ValPhe: 2.586 ± 0.471
4.589ValGly: 4.589 ± 0.695
1.251ValHis: 1.251 ± 0.29
3.921ValIle: 3.921 ± 0.588
4.589ValLys: 4.589 ± 0.633
4.505ValLeu: 4.505 ± 0.527
1.585ValMet: 1.585 ± 0.375
3.17ValAsn: 3.17 ± 0.588
2.419ValPro: 2.419 ± 0.452
2.837ValGln: 2.837 ± 0.371
3.17ValArg: 3.17 ± 0.493
4.255ValSer: 4.255 ± 0.552
4.756ValThr: 4.756 ± 0.578
4.422ValVal: 4.422 ± 0.717
0.751ValTrp: 0.751 ± 0.223
2.586ValTyr: 2.586 ± 0.507
0.0ValXaa: 0.0 ± 0.0
Trp
1.085TrpAla: 1.085 ± 0.27
0.25TrpCys: 0.25 ± 0.17
0.751TrpAsp: 0.751 ± 0.238
1.168TrpGlu: 1.168 ± 0.312
0.667TrpPhe: 0.667 ± 0.24
1.001TrpGly: 1.001 ± 0.248
0.167TrpHis: 0.167 ± 0.105
0.417TrpIle: 0.417 ± 0.205
0.834TrpLys: 0.834 ± 0.236
1.335TrpLeu: 1.335 ± 0.361
0.501TrpMet: 0.501 ± 0.266
0.667TrpAsn: 0.667 ± 0.226
0.417TrpPro: 0.417 ± 0.165
0.417TrpGln: 0.417 ± 0.194
0.834TrpArg: 0.834 ± 0.268
1.251TrpSer: 1.251 ± 0.363
1.085TrpThr: 1.085 ± 0.294
1.502TrpVal: 1.502 ± 0.43
0.25TrpTrp: 0.25 ± 0.13
0.417TrpTyr: 0.417 ± 0.191
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.754TyrAla: 3.754 ± 0.521
0.501TyrCys: 0.501 ± 0.184
2.002TyrAsp: 2.002 ± 0.381
2.753TyrGlu: 2.753 ± 0.373
0.751TyrPhe: 0.751 ± 0.257
2.92TyrGly: 2.92 ± 0.48
0.417TyrHis: 0.417 ± 0.178
1.502TyrIle: 1.502 ± 0.429
2.169TyrLys: 2.169 ± 0.313
3.671TyrLeu: 3.671 ± 0.568
1.251TyrMet: 1.251 ± 0.317
1.585TyrAsn: 1.585 ± 0.339
1.085TyrPro: 1.085 ± 0.262
1.168TyrGln: 1.168 ± 0.288
2.753TyrArg: 2.753 ± 0.536
3.087TyrSer: 3.087 ± 0.498
2.086TyrThr: 2.086 ± 0.481
2.92TyrVal: 2.92 ± 0.491
0.417TyrTrp: 0.417 ± 0.185
1.001TyrTyr: 1.001 ± 0.295
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (11987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski