Amino acid dipepetide frequency for Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.865AlaAla: 4.865 ± 0.087	0.543AlaCys: 0.543 ± 0.022	3.148AlaAsp: 3.148 ± 0.059	4.223AlaGlu: 4.223 ± 0.074	3.059AlaPhe: 3.059 ± 0.063	4.826AlaGly: 4.826 ± 0.069	1.165AlaHis: 1.165 ± 0.035	6.225AlaIle: 6.225 ± 0.08	4.126AlaLys: 4.126 ± 0.072	6.485AlaLeu: 6.485 ± 0.078	1.929AlaMet: 1.929 ± 0.046	2.981AlaAsn: 2.981 ± 0.066	1.895AlaPro: 1.895 ± 0.037	1.904AlaGln: 1.904 ± 0.047	2.193AlaArg: 2.193 ± 0.047	4.119AlaSer: 4.119 ± 0.064	3.584AlaThr: 3.584 ± 0.06	4.846AlaVal: 4.846 ± 0.067	0.58AlaTrp: 0.58 ± 0.028	2.299AlaTyr: 2.299 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.315CysAla: 0.315 ± 0.017	0.072CysCys: 0.072 ± 0.009	0.34CysAsp: 0.34 ± 0.018	0.348CysGlu: 0.348 ± 0.019	0.276CysPhe: 0.276 ± 0.018	0.556CysGly: 0.556 ± 0.025	0.171CysHis: 0.171 ± 0.013	0.506CysIle: 0.506 ± 0.022	0.314CysLys: 0.314 ± 0.019	0.543CysLeu: 0.543 ± 0.02	0.179CysMet: 0.179 ± 0.015	0.295CysAsn: 0.295 ± 0.015	0.289CysPro: 0.289 ± 0.021	0.194CysGln: 0.194 ± 0.015	0.224CysArg: 0.224 ± 0.015	0.422CysSer: 0.422 ± 0.021	0.368CysThr: 0.368 ± 0.019	0.366CysVal: 0.366 ± 0.019	0.05CysTrp: 0.05 ± 0.007	0.221CysTyr: 0.221 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.357AspAla: 3.357 ± 0.064	0.304AspCys: 0.304 ± 0.018	2.841AspAsp: 2.841 ± 0.063	4.763AspGlu: 4.763 ± 0.077	2.373AspPhe: 2.373 ± 0.043	3.433AspGly: 3.433 ± 0.07	1.229AspHis: 1.229 ± 0.036	4.766AspIle: 4.766 ± 0.067	3.494AspLys: 3.494 ± 0.054	4.913AspLeu: 4.913 ± 0.08	1.484AspMet: 1.484 ± 0.04	2.468AspAsn: 2.468 ± 0.053	2.131AspPro: 2.131 ± 0.048	2.298AspGln: 2.298 ± 0.051	2.261AspArg: 2.261 ± 0.051	2.962AspSer: 2.962 ± 0.054	2.749AspThr: 2.749 ± 0.053	3.864AspVal: 3.864 ± 0.066	0.623AspTrp: 0.623 ± 0.024	2.433AspTyr: 2.433 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.083GluAla: 5.083 ± 0.082	0.285GluCys: 0.285 ± 0.015	4.533GluAsp: 4.533 ± 0.07	7.604GluGlu: 7.604 ± 0.107	2.52GluPhe: 2.52 ± 0.051	4.377GluGly: 4.377 ± 0.074	1.466GluHis: 1.466 ± 0.037	6.05GluIle: 6.05 ± 0.071	6.104GluLys: 6.104 ± 0.086	6.988GluLeu: 6.988 ± 0.092	2.333GluMet: 2.333 ± 0.052	4.08GluAsn: 4.08 ± 0.072	1.985GluPro: 1.985 ± 0.044	3.785GluGln: 3.785 ± 0.071	3.202GluArg: 3.202 ± 0.062	4.007GluSer: 4.007 ± 0.063	3.695GluThr: 3.695 ± 0.067	5.343GluVal: 5.343 ± 0.083	0.832GluTrp: 0.832 ± 0.028	2.323GluTyr: 2.323 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.853PheAla: 2.853 ± 0.068	0.268PheCys: 0.268 ± 0.018	2.428PheAsp: 2.428 ± 0.046	2.792PheGlu: 2.792 ± 0.054	2.186PhePhe: 2.186 ± 0.061	3.156PheGly: 3.156 ± 0.069	1.054PheHis: 1.054 ± 0.033	4.301PheIle: 4.301 ± 0.082	2.123PheLys: 2.123 ± 0.044	4.419PheLeu: 4.419 ± 0.086	1.175PheMet: 1.175 ± 0.037	1.948PheAsn: 1.948 ± 0.049	1.645PhePro: 1.645 ± 0.039	1.795PheGln: 1.795 ± 0.046	1.47PheArg: 1.47 ± 0.036	3.056PheSer: 3.056 ± 0.059	2.618PheThr: 2.618 ± 0.057	3.067PheVal: 3.067 ± 0.062	0.506PheTrp: 0.506 ± 0.021	1.676PheTyr: 1.676 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.408GlyAla: 4.408 ± 0.078	0.539GlyCys: 0.539 ± 0.023	3.311GlyAsp: 3.311 ± 0.062	4.603GlyGlu: 4.603 ± 0.079	3.358GlyPhe: 3.358 ± 0.068	4.685GlyGly: 4.685 ± 0.087	1.302GlyHis: 1.302 ± 0.041	6.278GlyIle: 6.278 ± 0.087	4.572GlyLys: 4.572 ± 0.072	6.362GlyLeu: 6.362 ± 0.098	2.147GlyMet: 2.147 ± 0.051	2.962GlyAsn: 2.962 ± 0.057	1.758GlyPro: 1.758 ± 0.047	1.936GlyGln: 1.936 ± 0.048	2.258GlyArg: 2.258 ± 0.051	4.01GlySer: 4.01 ± 0.064	3.963GlyThr: 3.963 ± 0.07	4.876GlyVal: 4.876 ± 0.067	0.779GlyTrp: 0.779 ± 0.03	2.854GlyTyr: 2.854 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.397HisAla: 1.397 ± 0.036	0.174HisCys: 0.174 ± 0.013	1.074HisAsp: 1.074 ± 0.035	1.368HisGlu: 1.368 ± 0.034	1.029HisPhe: 1.029 ± 0.03	1.447HisGly: 1.447 ± 0.039	0.677HisHis: 0.677 ± 0.029	1.681HisIle: 1.681 ± 0.042	1.003HisLys: 1.003 ± 0.033	2.075HisLeu: 2.075 ± 0.043	0.528HisMet: 0.528 ± 0.019	0.801HisAsn: 0.801 ± 0.029	1.216HisPro: 1.216 ± 0.034	1.084HisGln: 1.084 ± 0.033	0.954HisArg: 0.954 ± 0.03	1.235HisSer: 1.235 ± 0.039	1.115HisThr: 1.115 ± 0.034	1.45HisVal: 1.45 ± 0.037	0.218HisTrp: 0.218 ± 0.015	0.873HisTyr: 0.873 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.297IleAla: 6.297 ± 0.077	0.604IleCys: 0.604 ± 0.025	5.033IleAsp: 5.033 ± 0.068	5.974IleGlu: 5.974 ± 0.085	3.592IlePhe: 3.592 ± 0.073	6.499IleGly: 6.499 ± 0.096	1.88IleHis: 1.88 ± 0.042	7.331IleIle: 7.331 ± 0.12	4.515IleLys: 4.515 ± 0.071	7.559IleLeu: 7.559 ± 0.105	1.966IleMet: 1.966 ± 0.048	3.809IleAsn: 3.809 ± 0.064	3.71IlePro: 3.71 ± 0.063	3.419IleGln: 3.419 ± 0.056	3.234IleArg: 3.234 ± 0.057	5.645IleSer: 5.645 ± 0.089	4.877IleThr: 4.877 ± 0.065	5.835IleVal: 5.835 ± 0.083	0.744IleTrp: 0.744 ± 0.027	2.81IleTyr: 2.81 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	3.922LysAla: 3.922 ± 0.074	0.283LysCys: 0.283 ± 0.017	3.895LysAsp: 3.895 ± 0.068	6.593LysGlu: 6.593 ± 0.089	1.758LysPhe: 1.758 ± 0.04	3.855LysGly: 3.855 ± 0.065	1.384LysHis: 1.384 ± 0.04	4.28LysIle: 4.28 ± 0.071	5.35LysLys: 5.35 ± 0.082	5.466LysLeu: 5.466 ± 0.077	1.977LysMet: 1.977 ± 0.042	3.335LysAsn: 3.335 ± 0.055	1.915LysPro: 1.915 ± 0.043	3.615LysGln: 3.615 ± 0.067	2.961LysArg: 2.961 ± 0.053	3.476LysSer: 3.476 ± 0.06	3.163LysThr: 3.163 ± 0.058	4.188LysVal: 4.188 ± 0.06	0.689LysTrp: 0.689 ± 0.024	2.059LysTyr: 2.059 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.484LeuAla: 6.484 ± 0.085	0.555LeuCys: 0.555 ± 0.024	5.063LeuAsp: 5.063 ± 0.066	6.799LeuGlu: 6.799 ± 0.087	4.774LeuPhe: 4.774 ± 0.103	6.233LeuGly: 6.233 ± 0.095	2.072LeuHis: 2.072 ± 0.043	7.757LeuIle: 7.757 ± 0.114	5.491LeuLys: 5.491 ± 0.082	9.62LeuLeu: 9.62 ± 0.138	2.469LeuMet: 2.469 ± 0.048	4.09LeuAsn: 4.09 ± 0.063	3.81LeuPro: 3.81 ± 0.059	3.946LeuGln: 3.946 ± 0.073	3.336LeuArg: 3.336 ± 0.06	6.553LeuSer: 6.553 ± 0.09	5.503LeuThr: 5.503 ± 0.069	5.757LeuVal: 5.757 ± 0.076	0.795LeuTrp: 0.795 ± 0.034	3.069LeuTyr: 3.069 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.833MetAla: 1.833 ± 0.043	0.112MetCys: 0.112 ± 0.011	1.695MetAsp: 1.695 ± 0.038	2.276MetGlu: 2.276 ± 0.047	1.064MetPhe: 1.064 ± 0.034	1.725MetGly: 1.725 ± 0.041	0.516MetHis: 0.516 ± 0.025	2.269MetIle: 2.269 ± 0.052	2.439MetLys: 2.439 ± 0.043	2.528MetLeu: 2.528 ± 0.051	0.853MetMet: 0.853 ± 0.031	1.741MetAsn: 1.741 ± 0.039	0.871MetPro: 0.871 ± 0.033	1.062MetGln: 1.062 ± 0.03	1.05MetArg: 1.05 ± 0.028	1.681MetSer: 1.681 ± 0.04	1.587MetThr: 1.587 ± 0.041	1.818MetVal: 1.818 ± 0.044	0.175MetTrp: 0.175 ± 0.014	0.827MetTyr: 0.827 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.759AsnAla: 2.759 ± 0.055	0.292AsnCys: 0.292 ± 0.014	2.643AsnAsp: 2.643 ± 0.053	3.829AsnGlu: 3.829 ± 0.066	1.764AsnPhe: 1.764 ± 0.039	3.321AsnGly: 3.321 ± 0.059	1.199AsnHis: 1.199 ± 0.033	3.896AsnIle: 3.896 ± 0.066	3.147AsnLys: 3.147 ± 0.059	3.89AsnLeu: 3.89 ± 0.062	1.317AsnMet: 1.317 ± 0.037	2.668AsnAsn: 2.668 ± 0.057	2.016AsnPro: 2.016 ± 0.05	2.487AsnGln: 2.487 ± 0.055	2.093AsnArg: 2.093 ± 0.044	2.616AsnSer: 2.616 ± 0.066	2.412AsnThr: 2.412 ± 0.049	3.192AsnVal: 3.192 ± 0.05	0.618AsnTrp: 0.618 ± 0.025	1.93AsnTyr: 1.93 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.071ProAla: 2.071 ± 0.046	0.157ProCys: 0.157 ± 0.015	2.084ProAsp: 2.084 ± 0.043	2.99ProGlu: 2.99 ± 0.056	1.957ProPhe: 1.957 ± 0.046	2.299ProGly: 2.299 ± 0.054	0.745ProHis: 0.745 ± 0.029	3.144ProIle: 3.144 ± 0.066	1.987ProLys: 1.987 ± 0.044	3.305ProLeu: 3.305 ± 0.055	0.858ProMet: 0.858 ± 0.029	1.741ProAsn: 1.741 ± 0.043	0.912ProPro: 0.912 ± 0.031	0.98ProGln: 0.98 ± 0.031	1.012ProArg: 1.012 ± 0.027	2.43ProSer: 2.43 ± 0.048	2.05ProThr: 2.05 ± 0.052	2.635ProVal: 2.635 ± 0.051	0.353ProTrp: 0.353 ± 0.018	1.386ProTyr: 1.386 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.765GlnAla: 2.765 ± 0.055	0.175GlnCys: 0.175 ± 0.014	2.02GlnAsp: 2.02 ± 0.043	3.22GlnGlu: 3.22 ± 0.062	1.691GlnPhe: 1.691 ± 0.039	2.327GlnGly: 2.327 ± 0.042	0.904GlnHis: 0.904 ± 0.031	2.91GlnIle: 2.91 ± 0.056	2.6GlnLys: 2.6 ± 0.05	4.562GlnLeu: 4.562 ± 0.071	1.195GlnMet: 1.195 ± 0.034	1.658GlnAsn: 1.658 ± 0.051	1.282GlnPro: 1.282 ± 0.038	2.254GlnGln: 2.254 ± 0.055	1.607GlnArg: 1.607 ± 0.039	2.604GlnSer: 2.604 ± 0.043	2.212GlnThr: 2.212 ± 0.049	2.615GlnVal: 2.615 ± 0.051	0.481GlnTrp: 0.481 ± 0.022	1.336GlnTyr: 1.336 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.091ArgAla: 2.091 ± 0.047	0.238ArgCys: 0.238 ± 0.017	1.991ArgAsp: 1.991 ± 0.046	2.919ArgGlu: 2.919 ± 0.058	1.816ArgPhe: 1.816 ± 0.045	2.119ArgGly: 2.119 ± 0.043	0.759ArgHis: 0.759 ± 0.028	3.115ArgIle: 3.115 ± 0.055	2.922ArgLys: 2.922 ± 0.054	3.618ArgLeu: 3.618 ± 0.07	1.308ArgMet: 1.308 ± 0.036	2.03ArgAsn: 2.03 ± 0.042	1.131ArgPro: 1.131 ± 0.034	1.496ArgGln: 1.496 ± 0.037	1.577ArgArg: 1.577 ± 0.051	2.223ArgSer: 2.223 ± 0.046	1.991ArgThr: 1.991 ± 0.047	2.423ArgVal: 2.423 ± 0.055	0.372ArgTrp: 0.372 ± 0.021	1.466ArgTyr: 1.466 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	3.478SerAla: 3.478 ± 0.065	0.305SerCys: 0.305 ± 0.02	3.206SerAsp: 3.206 ± 0.056	4.233SerGlu: 4.233 ± 0.059	3.238SerPhe: 3.238 ± 0.066	4.389SerGly: 4.389 ± 0.076	1.286SerHis: 1.286 ± 0.037	5.848SerIle: 5.848 ± 0.087	3.921SerLys: 3.921 ± 0.058	5.927SerLeu: 5.927 ± 0.088	1.812SerMet: 1.812 ± 0.042	3.222SerAsn: 3.222 ± 0.061	2.131SerPro: 2.131 ± 0.041	2.009SerGln: 2.009 ± 0.048	2.102SerArg: 2.102 ± 0.042	4.204SerSer: 4.204 ± 0.075	3.381SerThr: 3.381 ± 0.058	4.275SerVal: 4.275 ± 0.071	0.661SerTrp: 0.661 ± 0.025	2.457SerTyr: 2.457 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.67ThrAla: 3.67 ± 0.056	0.314ThrCys: 0.314 ± 0.02	2.957ThrAsp: 2.957 ± 0.062	3.71ThrGlu: 3.71 ± 0.062	2.616ThrPhe: 2.616 ± 0.052	3.96ThrGly: 3.96 ± 0.063	1.082ThrHis: 1.082 ± 0.035	5.096ThrIle: 5.096 ± 0.068	3.381ThrLys: 3.381 ± 0.057	5.041ThrLeu: 5.041 ± 0.081	1.41ThrMet: 1.41 ± 0.04	2.799ThrAsn: 2.799 ± 0.049	2.212ThrPro: 2.212 ± 0.045	1.478ThrGln: 1.478 ± 0.036	1.715ThrArg: 1.715 ± 0.041	3.62ThrSer: 3.62 ± 0.063	3.197ThrThr: 3.197 ± 0.062	4.015ThrVal: 4.015 ± 0.069	0.521ThrTrp: 0.521 ± 0.023	2.146ThrTyr: 2.146 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.691ValAla: 4.691 ± 0.08	0.501ValCys: 0.501 ± 0.022	3.94ValAsp: 3.94 ± 0.07	5.046ValGlu: 5.046 ± 0.077	3.094ValPhe: 3.094 ± 0.058	4.627ValGly: 4.627 ± 0.08	1.389ValHis: 1.389 ± 0.035	6.133ValIle: 6.133 ± 0.082	3.913ValLys: 3.913 ± 0.071	6.325ValLeu: 6.325 ± 0.092	1.875ValMet: 1.875 ± 0.046	3.287ValAsn: 3.287 ± 0.064	2.539ValPro: 2.539 ± 0.051	2.431ValGln: 2.431 ± 0.05	2.442ValArg: 2.442 ± 0.052	4.496ValSer: 4.496 ± 0.073	4.052ValThr: 4.052 ± 0.066	4.819ValVal: 4.819 ± 0.081	0.574ValTrp: 0.574 ± 0.024	2.142ValTyr: 2.142 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.568TrpAla: 0.568 ± 0.024	0.075TrpCys: 0.075 ± 0.009	0.519TrpAsp: 0.519 ± 0.022	0.715TrpGlu: 0.715 ± 0.027	0.523TrpPhe: 0.523 ± 0.024	0.654TrpGly: 0.654 ± 0.029	0.188TrpHis: 0.188 ± 0.015	0.922TrpIle: 0.922 ± 0.033	0.751TrpLys: 0.751 ± 0.031	1.043TrpLeu: 1.043 ± 0.036	0.379TrpMet: 0.379 ± 0.019	0.594TrpAsn: 0.594 ± 0.028	0.234TrpPro: 0.234 ± 0.016	0.377TrpGln: 0.377 ± 0.019	0.346TrpArg: 0.346 ± 0.015	0.6TrpSer: 0.6 ± 0.024	0.509TrpThr: 0.509 ± 0.022	0.628TrpVal: 0.628 ± 0.027	0.151TrpTrp: 0.151 ± 0.014	0.369TrpTyr: 0.369 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.086TyrAla: 2.086 ± 0.045	0.253TyrCys: 0.253 ± 0.016	2.021TyrAsp: 2.021 ± 0.044	2.59TyrGlu: 2.59 ± 0.056	1.851TyrPhe: 1.851 ± 0.039	2.474TyrGly: 2.474 ± 0.053	0.934TyrHis: 0.934 ± 0.032	2.823TyrIle: 2.823 ± 0.055	2.014TyrLys: 2.014 ± 0.046	3.507TyrLeu: 3.507 ± 0.063	0.928TyrMet: 0.928 ± 0.032	1.579TyrAsn: 1.579 ± 0.043	1.414TyrPro: 1.414 ± 0.041	1.869TyrGln: 1.869 ± 0.049	1.567TyrArg: 1.567 ± 0.037	2.124TyrSer: 2.124 ± 0.047	1.915TyrThr: 1.915 ± 0.044	2.303TyrVal: 2.303 ± 0.042	0.422TyrTrp: 0.422 ± 0.022	1.556TyrTyr: 1.556 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3490 proteins (1017601 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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