Amino acid dipepetide frequency for Aliidiomarina soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.99AlaAla: 9.99 ± 0.127
1.025AlaCys: 1.025 ± 0.036
6.122AlaAsp: 6.122 ± 0.087
7.085AlaGlu: 7.085 ± 0.094
3.479AlaPhe: 3.479 ± 0.065
7.27AlaGly: 7.27 ± 0.1
1.868AlaHis: 1.868 ± 0.044
5.433AlaIle: 5.433 ± 0.077
3.334AlaLys: 3.334 ± 0.072
11.31AlaLeu: 11.31 ± 0.127
2.737AlaMet: 2.737 ± 0.059
3.29AlaAsn: 3.29 ± 0.071
3.362AlaPro: 3.362 ± 0.06
4.692AlaGln: 4.692 ± 0.092
5.558AlaArg: 5.558 ± 0.082
5.972AlaSer: 5.972 ± 0.084
4.904AlaThr: 4.904 ± 0.086
6.908AlaVal: 6.908 ± 0.087
1.179AlaTrp: 1.179 ± 0.037
2.591AlaTyr: 2.591 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.81CysAla: 0.81 ± 0.03
0.1CysCys: 0.1 ± 0.011
0.507CysAsp: 0.507 ± 0.026
0.508CysGlu: 0.508 ± 0.023
0.321CysPhe: 0.321 ± 0.019
0.758CysGly: 0.758 ± 0.029
0.269CysHis: 0.269 ± 0.018
0.465CysIle: 0.465 ± 0.024
0.32CysLys: 0.32 ± 0.018
0.855CysLeu: 0.855 ± 0.031
0.198CysMet: 0.198 ± 0.015
0.279CysAsn: 0.279 ± 0.021
0.41CysPro: 0.41 ± 0.024
0.423CysGln: 0.423 ± 0.021
0.468CysArg: 0.468 ± 0.023
0.596CysSer: 0.596 ± 0.024
0.371CysThr: 0.371 ± 0.022
0.57CysVal: 0.57 ± 0.023
0.107CysTrp: 0.107 ± 0.01
0.263CysTyr: 0.263 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
5.61AspAla: 5.61 ± 0.088
0.444AspCys: 0.444 ± 0.022
4.01AspAsp: 4.01 ± 0.087
4.499AspGlu: 4.499 ± 0.076
2.533AspPhe: 2.533 ± 0.053
4.229AspGly: 4.229 ± 0.078
1.204AspHis: 1.204 ± 0.043
3.621AspIle: 3.621 ± 0.062
2.166AspLys: 2.166 ± 0.047
5.288AspLeu: 5.288 ± 0.074
1.576AspMet: 1.576 ± 0.043
2.298AspAsn: 2.298 ± 0.054
2.38AspPro: 2.38 ± 0.055
2.33AspGln: 2.33 ± 0.054
2.668AspArg: 2.668 ± 0.058
3.538AspSer: 3.538 ± 0.07
2.728AspThr: 2.728 ± 0.056
4.209AspVal: 4.209 ± 0.072
1.007AspTrp: 1.007 ± 0.032
2.334AspTyr: 2.334 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
5.881GluAla: 5.881 ± 0.107
0.4GluCys: 0.4 ± 0.022
3.107GluAsp: 3.107 ± 0.074
3.623GluGlu: 3.623 ± 0.074
2.439GluPhe: 2.439 ± 0.053
3.986GluGly: 3.986 ± 0.073
1.801GluHis: 1.801 ± 0.047
3.148GluIle: 3.148 ± 0.067
2.422GluLys: 2.422 ± 0.066
7.581GluLeu: 7.581 ± 0.104
1.541GluMet: 1.541 ± 0.041
2.206GluAsn: 2.206 ± 0.049
2.492GluPro: 2.492 ± 0.059
4.784GluGln: 4.784 ± 0.1
4.861GluArg: 4.861 ± 0.077
3.5GluSer: 3.5 ± 0.068
3.014GluThr: 3.014 ± 0.063
4.565GluVal: 4.565 ± 0.08
0.788GluTrp: 0.788 ± 0.026
1.663GluTyr: 1.663 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
4.104PheAla: 4.104 ± 0.074
0.392PheCys: 0.392 ± 0.02
2.594PheAsp: 2.594 ± 0.055
2.46PheGlu: 2.46 ± 0.047
1.615PhePhe: 1.615 ± 0.047
2.911PheGly: 2.911 ± 0.065
0.777PheHis: 0.777 ± 0.03
2.408PheIle: 2.408 ± 0.049
1.4PheLys: 1.4 ± 0.045
3.224PheLeu: 3.224 ± 0.069
0.955PheMet: 0.955 ± 0.032
1.69PheAsn: 1.69 ± 0.043
1.347PhePro: 1.347 ± 0.04
1.221PheGln: 1.221 ± 0.034
1.886PheArg: 1.886 ± 0.045
3.127PheSer: 3.127 ± 0.066
2.237PheThr: 2.237 ± 0.049
2.59PheVal: 2.59 ± 0.053
0.591PheTrp: 0.591 ± 0.031
1.321PheTyr: 1.321 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
5.998GlyAla: 5.998 ± 0.084
0.741GlyCys: 0.741 ± 0.033
4.192GlyAsp: 4.192 ± 0.077
4.721GlyGlu: 4.721 ± 0.075
3.244GlyPhe: 3.244 ± 0.06
5.113GlyGly: 5.113 ± 0.114
1.775GlyHis: 1.775 ± 0.047
4.068GlyIle: 4.068 ± 0.08
2.811GlyLys: 2.811 ± 0.065
7.248GlyLeu: 7.248 ± 0.093
2.014GlyMet: 2.014 ± 0.053
2.457GlyAsn: 2.457 ± 0.052
2.146GlyPro: 2.146 ± 0.045
3.332GlyGln: 3.332 ± 0.066
4.135GlyArg: 4.135 ± 0.068
4.425GlySer: 4.425 ± 0.074
3.372GlyThr: 3.372 ± 0.059
5.49GlyVal: 5.49 ± 0.08
1.062GlyTrp: 1.062 ± 0.033
2.545GlyTyr: 2.545 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.008HisAla: 2.008 ± 0.045
0.319HisCys: 0.319 ± 0.022
1.266HisAsp: 1.266 ± 0.044
1.265HisGlu: 1.265 ± 0.032
1.09HisPhe: 1.09 ± 0.035
1.878HisGly: 1.878 ± 0.049
0.634HisHis: 0.634 ± 0.032
1.231HisIle: 1.231 ± 0.035
0.781HisLys: 0.781 ± 0.035
2.312HisLeu: 2.312 ± 0.056
0.509HisMet: 0.509 ± 0.024
0.776HisAsn: 0.776 ± 0.031
1.274HisPro: 1.274 ± 0.038
1.329HisGln: 1.329 ± 0.04
1.311HisArg: 1.311 ± 0.037
1.516HisSer: 1.516 ± 0.042
1.029HisThr: 1.029 ± 0.033
1.37HisVal: 1.37 ± 0.042
0.436HisTrp: 0.436 ± 0.019
0.907HisTyr: 0.907 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.752IleAla: 5.752 ± 0.086
0.5IleCys: 0.5 ± 0.023
3.756IleAsp: 3.756 ± 0.064
4.439IleGlu: 4.439 ± 0.066
1.787IlePhe: 1.787 ± 0.048
4.193IleGly: 4.193 ± 0.07
1.152IleHis: 1.152 ± 0.041
2.675IleIle: 2.675 ± 0.062
1.917IleLys: 1.917 ± 0.051
4.478IleLeu: 4.478 ± 0.072
1.095IleMet: 1.095 ± 0.035
2.255IleAsn: 2.255 ± 0.057
2.225IlePro: 2.225 ± 0.05
2.022IleGln: 2.022 ± 0.051
3.038IleArg: 3.038 ± 0.058
3.503IleSer: 3.503 ± 0.06
2.868IleThr: 2.868 ± 0.053
3.49IleVal: 3.49 ± 0.074
0.545IleTrp: 0.545 ± 0.026
1.372IleTyr: 1.372 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
3.74LysAla: 3.74 ± 0.077
0.183LysCys: 0.183 ± 0.014
1.89LysAsp: 1.89 ± 0.047
2.111LysGlu: 2.111 ± 0.06
1.059LysPhe: 1.059 ± 0.039
2.309LysGly: 2.309 ± 0.058
0.853LysHis: 0.853 ± 0.033
1.607LysIle: 1.607 ± 0.043
1.736LysLys: 1.736 ± 0.061
3.708LysLeu: 3.708 ± 0.068
0.837LysMet: 0.837 ± 0.036
1.126LysAsn: 1.126 ± 0.041
1.848LysPro: 1.848 ± 0.046
1.817LysGln: 1.817 ± 0.05
2.466LysArg: 2.466 ± 0.061
2.007LysSer: 2.007 ± 0.055
1.857LysThr: 1.857 ± 0.046
2.762LysVal: 2.762 ± 0.057
0.395LysTrp: 0.395 ± 0.021
0.831LysTyr: 0.831 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
11.573LeuAla: 11.573 ± 0.126
0.946LeuCys: 0.946 ± 0.034
6.017LeuAsp: 6.017 ± 0.089
6.105LeuGlu: 6.105 ± 0.085
3.855LeuPhe: 3.855 ± 0.083
7.016LeuGly: 7.016 ± 0.093
2.472LeuHis: 2.472 ± 0.06
5.381LeuIle: 5.381 ± 0.084
3.817LeuLys: 3.817 ± 0.08
11.561LeuLeu: 11.561 ± 0.166
2.619LeuMet: 2.619 ± 0.055
4.154LeuAsn: 4.154 ± 0.071
5.104LeuPro: 5.104 ± 0.074
5.63LeuGln: 5.63 ± 0.099
6.32LeuArg: 6.32 ± 0.092
7.391LeuSer: 7.391 ± 0.105
6.253LeuThr: 6.253 ± 0.085
7.273LeuVal: 7.273 ± 0.091
1.264LeuTrp: 1.264 ± 0.04
2.607LeuTyr: 2.607 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.692MetAla: 2.692 ± 0.054
0.148MetCys: 0.148 ± 0.014
1.168MetAsp: 1.168 ± 0.035
1.217MetGlu: 1.217 ± 0.045
0.833MetPhe: 0.833 ± 0.027
1.587MetGly: 1.587 ± 0.047
0.584MetHis: 0.584 ± 0.025
1.143MetIle: 1.143 ± 0.041
1.089MetLys: 1.089 ± 0.039
2.789MetLeu: 2.789 ± 0.057
0.601MetMet: 0.601 ± 0.027
0.983MetAsn: 0.983 ± 0.035
1.257MetPro: 1.257 ± 0.038
1.535MetGln: 1.535 ± 0.04
1.547MetArg: 1.547 ± 0.039
1.69MetSer: 1.69 ± 0.04
1.597MetThr: 1.597 ± 0.042
1.866MetVal: 1.866 ± 0.046
0.221MetTrp: 0.221 ± 0.016
0.515MetTyr: 0.515 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.308AsnAla: 3.308 ± 0.063
0.313AsnCys: 0.313 ± 0.017
2.246AsnAsp: 2.246 ± 0.052
2.261AsnGlu: 2.261 ± 0.051
1.411AsnPhe: 1.411 ± 0.043
2.598AsnGly: 2.598 ± 0.055
0.791AsnHis: 0.791 ± 0.03
1.843AsnIle: 1.843 ± 0.046
1.224AsnLys: 1.224 ± 0.036
3.54AsnLeu: 3.54 ± 0.052
0.874AsnMet: 0.874 ± 0.031
1.31AsnAsn: 1.31 ± 0.038
2.047AsnPro: 2.047 ± 0.056
1.991AsnGln: 1.991 ± 0.051
2.023AsnArg: 2.023 ± 0.046
2.107AsnSer: 2.107 ± 0.05
1.808AsnThr: 1.808 ± 0.042
2.22AsnVal: 2.22 ± 0.059
0.591AsnTrp: 0.591 ± 0.022
1.186AsnTyr: 1.186 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
4.263ProAla: 4.263 ± 0.07
0.3ProCys: 0.3 ± 0.019
2.824ProAsp: 2.824 ± 0.056
3.187ProGlu: 3.187 ± 0.063
1.737ProPhe: 1.737 ± 0.044
3.307ProGly: 3.307 ± 0.061
0.893ProHis: 0.893 ± 0.03
1.875ProIle: 1.875 ± 0.05
1.277ProLys: 1.277 ± 0.039
4.452ProLeu: 4.452 ± 0.077
1.034ProMet: 1.034 ± 0.029
1.38ProAsn: 1.38 ± 0.037
1.417ProPro: 1.417 ± 0.044
2.072ProGln: 2.072 ± 0.054
1.999ProArg: 1.999 ± 0.055
2.299ProSer: 2.299 ± 0.051
2.073ProThr: 2.073 ± 0.052
3.489ProVal: 3.489 ± 0.069
0.584ProTrp: 0.584 ± 0.025
1.252ProTyr: 1.252 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
5.62GlnAla: 5.62 ± 0.103
0.37GlnCys: 0.37 ± 0.025
2.236GlnAsp: 2.236 ± 0.057
2.208GlnGlu: 2.208 ± 0.049
1.747GlnPhe: 1.747 ± 0.05
3.654GlnGly: 3.654 ± 0.07
1.456GlnHis: 1.456 ± 0.044
2.326GlnIle: 2.326 ± 0.051
1.351GlnLys: 1.351 ± 0.039
6.479GlnLeu: 6.479 ± 0.11
1.156GlnMet: 1.156 ± 0.039
1.417GlnAsn: 1.417 ± 0.042
2.382GlnPro: 2.382 ± 0.054
4.569GlnGln: 4.569 ± 0.101
4.084GlnArg: 4.084 ± 0.088
3.189GlnSer: 3.189 ± 0.063
2.399GlnThr: 2.399 ± 0.049
3.664GlnVal: 3.664 ± 0.066
0.8GlnTrp: 0.8 ± 0.033
1.215GlnTyr: 1.215 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
4.965ArgAla: 4.965 ± 0.075
0.466ArgCys: 0.466 ± 0.024
3.399ArgAsp: 3.399 ± 0.068
3.913ArgGlu: 3.913 ± 0.073
2.663ArgPhe: 2.663 ± 0.057
3.628ArgGly: 3.628 ± 0.061
1.555ArgHis: 1.555 ± 0.044
3.573ArgIle: 3.573 ± 0.067
2.041ArgLys: 2.041 ± 0.048
6.847ArgLeu: 6.847 ± 0.087
1.628ArgMet: 1.628 ± 0.049
2.144ArgAsn: 2.144 ± 0.049
2.245ArgPro: 2.245 ± 0.044
3.401ArgGln: 3.401 ± 0.07
3.76ArgArg: 3.76 ± 0.066
3.531ArgSer: 3.531 ± 0.072
2.614ArgThr: 2.614 ± 0.052
4.26ArgVal: 4.26 ± 0.062
0.986ArgTrp: 0.986 ± 0.034
2.122ArgTyr: 2.122 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
6.272SerAla: 6.272 ± 0.086
0.496SerCys: 0.496 ± 0.027
3.819SerAsp: 3.819 ± 0.068
4.06SerGlu: 4.06 ± 0.066
2.494SerPhe: 2.494 ± 0.058
5.108SerGly: 5.108 ± 0.079
1.366SerHis: 1.366 ± 0.039
3.343SerIle: 3.343 ± 0.067
2.233SerLys: 2.233 ± 0.056
6.697SerLeu: 6.697 ± 0.086
1.731SerMet: 1.731 ± 0.046
2.229SerAsn: 2.229 ± 0.046
2.485SerPro: 2.485 ± 0.052
2.884SerGln: 2.884 ± 0.055
3.54SerArg: 3.54 ± 0.066
4.152SerSer: 4.152 ± 0.073
2.984SerThr: 2.984 ± 0.064
4.387SerVal: 4.387 ± 0.069
0.894SerTrp: 0.894 ± 0.035
1.96SerTyr: 1.96 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
4.891ThrAla: 4.891 ± 0.075
0.39ThrCys: 0.39 ± 0.02
3.091ThrAsp: 3.091 ± 0.058
3.219ThrGlu: 3.219 ± 0.058
1.925ThrPhe: 1.925 ± 0.048
3.926ThrGly: 3.926 ± 0.069
1.192ThrHis: 1.192 ± 0.038
2.689ThrIle: 2.689 ± 0.052
1.463ThrLys: 1.463 ± 0.043
6.305ThrLeu: 6.305 ± 0.098
1.108ThrMet: 1.108 ± 0.032
1.583ThrAsn: 1.583 ± 0.042
2.545ThrPro: 2.545 ± 0.057
2.284ThrGln: 2.284 ± 0.05
2.911ThrArg: 2.911 ± 0.049
3.087ThrSer: 3.087 ± 0.056
2.684ThrThr: 2.684 ± 0.058
3.548ThrVal: 3.548 ± 0.062
0.595ThrTrp: 0.595 ± 0.026
1.339ThrTyr: 1.339 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
7.148ValAla: 7.148 ± 0.102
0.631ValCys: 0.631 ± 0.028
4.162ValAsp: 4.162 ± 0.068
4.808ValGlu: 4.808 ± 0.079
2.714ValPhe: 2.714 ± 0.059
4.601ValGly: 4.601 ± 0.079
1.428ValHis: 1.428 ± 0.04
4.146ValIle: 4.146 ± 0.082
2.575ValLys: 2.575 ± 0.063
7.364ValLeu: 7.364 ± 0.109
1.865ValMet: 1.865 ± 0.048
2.732ValAsn: 2.732 ± 0.054
2.822ValPro: 2.822 ± 0.051
2.733ValGln: 2.733 ± 0.048
4.176ValArg: 4.176 ± 0.066
4.797ValSer: 4.797 ± 0.071
4.057ValThr: 4.057 ± 0.073
5.592ValVal: 5.592 ± 0.097
0.822ValTrp: 0.822 ± 0.032
1.841ValTyr: 1.841 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.943TrpAla: 0.943 ± 0.034
0.125TrpCys: 0.125 ± 0.012
0.633TrpAsp: 0.633 ± 0.025
0.526TrpGlu: 0.526 ± 0.024
0.636TrpPhe: 0.636 ± 0.025
0.761TrpGly: 0.761 ± 0.032
0.427TrpHis: 0.427 ± 0.02
0.631TrpIle: 0.631 ± 0.024
0.304TrpLys: 0.304 ± 0.019
2.059TrpLeu: 2.059 ± 0.051
0.361TrpMet: 0.361 ± 0.021
0.402TrpAsn: 0.402 ± 0.022
0.595TrpPro: 0.595 ± 0.027
1.216TrpGln: 1.216 ± 0.04
0.997TrpArg: 0.997 ± 0.034
0.781TrpSer: 0.781 ± 0.032
0.515TrpThr: 0.515 ± 0.023
0.978TrpVal: 0.978 ± 0.037
0.275TrpTrp: 0.275 ± 0.019
0.417TrpTyr: 0.417 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.541TyrAla: 2.541 ± 0.053
0.308TyrCys: 0.308 ± 0.019
1.635TyrAsp: 1.635 ± 0.041
1.583TyrGlu: 1.583 ± 0.041
1.269TyrPhe: 1.269 ± 0.038
2.056TyrGly: 2.056 ± 0.047
0.744TyrHis: 0.744 ± 0.029
1.454TyrIle: 1.454 ± 0.045
0.881TyrLys: 0.881 ± 0.03
3.262TyrLeu: 3.262 ± 0.062
0.621TyrMet: 0.621 ± 0.023
0.981TyrAsn: 0.981 ± 0.036
1.33TyrPro: 1.33 ± 0.037
2.058TyrGln: 2.058 ± 0.052
1.994TyrArg: 1.994 ± 0.055
1.925TyrSer: 1.925 ± 0.046
1.414TyrThr: 1.414 ± 0.039
1.784TyrVal: 1.784 ± 0.047
0.44TyrTrp: 0.44 ± 0.021
0.973TyrTyr: 0.973 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2855 proteins (940704 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski