Amino acid dipepetide frequency for Microlunatus sagamiharensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.389AlaAla: 20.389 ± 0.181	0.948AlaCys: 0.948 ± 0.03	8.53AlaAsp: 8.53 ± 0.1	7.942AlaGlu: 7.942 ± 0.113	3.509AlaPhe: 3.509 ± 0.067	13.298AlaGly: 13.298 ± 0.132	2.343AlaHis: 2.343 ± 0.049	3.363AlaIle: 3.363 ± 0.065	2.331AlaLys: 2.331 ± 0.059	14.627AlaLeu: 14.627 ± 0.136	2.455AlaMet: 2.455 ± 0.05	1.999AlaAsn: 1.999 ± 0.052	7.092AlaPro: 7.092 ± 0.125	3.74AlaGln: 3.74 ± 0.048	10.104AlaArg: 10.104 ± 0.124	7.196AlaSer: 7.196 ± 0.114	7.799AlaThr: 7.799 ± 0.205	13.029AlaVal: 13.029 ± 0.138	2.01AlaTrp: 2.01 ± 0.04	3.027AlaTyr: 3.027 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.79CysAla: 0.79 ± 0.023	0.081CysCys: 0.081 ± 0.008	0.39CysAsp: 0.39 ± 0.018	0.314CysGlu: 0.314 ± 0.014	0.209CysPhe: 0.209 ± 0.013	0.777CysGly: 0.777 ± 0.023	0.143CysHis: 0.143 ± 0.011	0.151CysIle: 0.151 ± 0.011	0.07CysLys: 0.07 ± 0.007	0.639CysLeu: 0.639 ± 0.022	0.084CysMet: 0.084 ± 0.008	0.105CysAsn: 0.105 ± 0.011	0.454CysPro: 0.454 ± 0.041	0.139CysGln: 0.139 ± 0.009	0.483CysArg: 0.483 ± 0.02	0.389CysSer: 0.389 ± 0.018	0.462CysThr: 0.462 ± 0.047	0.57CysVal: 0.57 ± 0.021	0.112CysTrp: 0.112 ± 0.009	0.126CysTyr: 0.126 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.726AspAla: 8.726 ± 0.098	0.305AspCys: 0.305 ± 0.016	4.456AspAsp: 4.456 ± 0.077	4.123AspGlu: 4.123 ± 0.058	1.482AspPhe: 1.482 ± 0.035	6.326AspGly: 6.326 ± 0.089	1.412AspHis: 1.412 ± 0.04	1.363AspIle: 1.363 ± 0.035	0.932AspLys: 0.932 ± 0.033	7.392AspLeu: 7.392 ± 0.073	0.622AspMet: 0.622 ± 0.023	0.86AspAsn: 0.86 ± 0.026	4.645AspPro: 4.645 ± 0.069	1.797AspGln: 1.797 ± 0.044	4.855AspArg: 4.855 ± 0.076	2.247AspSer: 2.247 ± 0.037	2.727AspThr: 2.727 ± 0.045	6.32AspVal: 6.32 ± 0.069	0.879AspTrp: 0.879 ± 0.028	1.12AspTyr: 1.12 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.087GluAla: 7.087 ± 0.1	0.226GluCys: 0.226 ± 0.013	2.85GluAsp: 2.85 ± 0.057	2.902GluGlu: 2.902 ± 0.056	1.097GluPhe: 1.097 ± 0.03	4.289GluGly: 4.289 ± 0.065	1.533GluHis: 1.533 ± 0.032	1.698GluIle: 1.698 ± 0.038	0.875GluLys: 0.875 ± 0.03	5.985GluLeu: 5.985 ± 0.081	0.688GluMet: 0.688 ± 0.025	0.757GluAsn: 0.757 ± 0.026	3.416GluPro: 3.416 ± 0.065	2.314GluGln: 2.314 ± 0.049	5.292GluArg: 5.292 ± 0.078	2.233GluSer: 2.233 ± 0.041	2.763GluThr: 2.763 ± 0.049	5.693GluVal: 5.693 ± 0.089	0.593GluTrp: 0.593 ± 0.022	0.74GluTyr: 0.74 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.791PheAla: 3.791 ± 0.061	0.24PheCys: 0.24 ± 0.014	2.064PheAsp: 2.064 ± 0.047	1.26PheGlu: 1.26 ± 0.034	0.951PhePhe: 0.951 ± 0.035	3.076PheGly: 3.076 ± 0.064	0.52PheHis: 0.52 ± 0.023	0.626PheIle: 0.626 ± 0.024	0.427PheLys: 0.427 ± 0.022	2.531PheLeu: 2.531 ± 0.057	0.335PheMet: 0.335 ± 0.017	0.538PheAsn: 0.538 ± 0.023	1.216PhePro: 1.216 ± 0.031	0.58PheGln: 0.58 ± 0.023	1.698PheArg: 1.698 ± 0.036	1.597PheSer: 1.597 ± 0.036	1.88PheThr: 1.88 ± 0.048	2.797PheVal: 2.797 ± 0.053	0.394PheTrp: 0.394 ± 0.02	0.596PheTyr: 0.596 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.102GlyAla: 11.102 ± 0.115	0.703GlyCys: 0.703 ± 0.024	5.123GlyAsp: 5.123 ± 0.07	4.686GlyGlu: 4.686 ± 0.068	2.988GlyPhe: 2.988 ± 0.051	8.496GlyGly: 8.496 ± 0.119	1.965GlyHis: 1.965 ± 0.039	3.091GlyIle: 3.091 ± 0.054	1.872GlyLys: 1.872 ± 0.05	10.502GlyLeu: 10.502 ± 0.116	1.736GlyMet: 1.736 ± 0.043	1.562GlyAsn: 1.562 ± 0.06	5.251GlyPro: 5.251 ± 0.069	2.785GlyGln: 2.785 ± 0.057	7.935GlyArg: 7.935 ± 0.095	6.166GlySer: 6.166 ± 0.092	6.445GlyThr: 6.445 ± 0.111	8.652GlyVal: 8.652 ± 0.085	1.92GlyTrp: 1.92 ± 0.041	2.167GlyTyr: 2.167 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.431HisAla: 2.431 ± 0.045	0.135HisCys: 0.135 ± 0.01	1.402HisAsp: 1.402 ± 0.035	1.07HisGlu: 1.07 ± 0.025	0.511HisPhe: 0.511 ± 0.02	2.013HisGly: 2.013 ± 0.043	0.591HisHis: 0.591 ± 0.022	0.372HisIle: 0.372 ± 0.018	0.233HisLys: 0.233 ± 0.014	2.326HisLeu: 2.326 ± 0.052	0.224HisMet: 0.224 ± 0.012	0.305HisAsn: 0.305 ± 0.017	1.58HisPro: 1.58 ± 0.043	0.551HisGln: 0.551 ± 0.021	1.705HisArg: 1.705 ± 0.036	0.771HisSer: 0.771 ± 0.023	0.882HisThr: 0.882 ± 0.027	1.941HisVal: 1.941 ± 0.042	0.297HisTrp: 0.297 ± 0.014	0.368HisTyr: 0.368 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.953IleAla: 3.953 ± 0.06	0.207IleCys: 0.207 ± 0.013	2.012IleAsp: 2.012 ± 0.04	1.579IleGlu: 1.579 ± 0.039	0.754IlePhe: 0.754 ± 0.03	3.064IleGly: 3.064 ± 0.067	0.417IleHis: 0.417 ± 0.017	0.884IleIle: 0.884 ± 0.032	0.637IleLys: 0.637 ± 0.021	2.042IleLeu: 2.042 ± 0.051	0.41IleMet: 0.41 ± 0.02	0.659IleAsn: 0.659 ± 0.024	1.421IlePro: 1.421 ± 0.037	0.555IleGln: 0.555 ± 0.02	1.622IleArg: 1.622 ± 0.033	1.673IleSer: 1.673 ± 0.037	1.959IleThr: 1.959 ± 0.043	2.487IleVal: 2.487 ± 0.053	0.297IleTrp: 0.297 ± 0.015	0.559IleTyr: 0.559 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.322LysAla: 2.322 ± 0.055	0.061LysCys: 0.061 ± 0.007	0.984LysAsp: 0.984 ± 0.032	0.721LysGlu: 0.721 ± 0.024	0.411LysPhe: 0.411 ± 0.019	1.489LysGly: 1.489 ± 0.041	0.348LysHis: 0.348 ± 0.017	0.735LysIle: 0.735 ± 0.026	0.634LysLys: 0.634 ± 0.034	1.407LysLeu: 1.407 ± 0.042	0.303LysMet: 0.303 ± 0.015	0.446LysAsn: 0.446 ± 0.023	1.099LysPro: 1.099 ± 0.031	0.601LysGln: 0.601 ± 0.021	1.147LysArg: 1.147 ± 0.032	0.973LysSer: 0.973 ± 0.026	1.205LysThr: 1.205 ± 0.041	1.834LysVal: 1.834 ± 0.043	0.163LysTrp: 0.163 ± 0.011	0.338LysTyr: 0.338 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.749LeuAla: 15.749 ± 0.152	0.634LeuCys: 0.634 ± 0.023	7.414LeuAsp: 7.414 ± 0.08	5.203LeuGlu: 5.203 ± 0.073	2.455LeuPhe: 2.455 ± 0.06	10.176LeuGly: 10.176 ± 0.115	2.008LeuHis: 2.008 ± 0.041	2.416LeuIle: 2.416 ± 0.06	1.475LeuLys: 1.475 ± 0.036	11.55LeuLeu: 11.55 ± 0.181	1.369LeuMet: 1.369 ± 0.039	1.605LeuAsn: 1.605 ± 0.038	5.944LeuPro: 5.944 ± 0.076	2.458LeuGln: 2.458 ± 0.046	8.134LeuArg: 8.134 ± 0.107	5.339LeuSer: 5.339 ± 0.069	6.484LeuThr: 6.484 ± 0.081	12.13LeuVal: 12.13 ± 0.143	1.223LeuTrp: 1.223 ± 0.035	1.632LeuTyr: 1.632 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	1.993MetAla: 1.993 ± 0.044	0.09MetCys: 0.09 ± 0.009	0.736MetAsp: 0.736 ± 0.024	0.549MetGlu: 0.549 ± 0.021	0.4MetPhe: 0.4 ± 0.017	1.141MetGly: 1.141 ± 0.033	0.278MetHis: 0.278 ± 0.015	0.583MetIle: 0.583 ± 0.025	0.303MetLys: 0.303 ± 0.015	1.51MetLeu: 1.51 ± 0.036	0.234MetMet: 0.234 ± 0.014	0.338MetAsn: 0.338 ± 0.017	1.056MetPro: 1.056 ± 0.033	0.395MetGln: 0.395 ± 0.018	1.169MetArg: 1.169 ± 0.03	1.387MetSer: 1.387 ± 0.033	1.526MetThr: 1.526 ± 0.035	1.353MetVal: 1.353 ± 0.037	0.162MetTrp: 0.162 ± 0.011	0.222MetTyr: 0.222 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.159AsnAla: 2.159 ± 0.045	0.104AsnCys: 0.104 ± 0.008	0.912AsnAsp: 0.912 ± 0.029	0.707AsnGlu: 0.707 ± 0.023	0.511AsnPhe: 0.511 ± 0.018	1.647AsnGly: 1.647 ± 0.038	0.338AsnHis: 0.338 ± 0.015	0.53AsnIle: 0.53 ± 0.019	0.354AsnLys: 0.354 ± 0.02	1.773AsnLeu: 1.773 ± 0.038	0.216AsnMet: 0.216 ± 0.014	0.418AsnAsn: 0.418 ± 0.021	1.354AsnPro: 1.354 ± 0.034	0.474AsnGln: 0.474 ± 0.022	1.21AsnArg: 1.21 ± 0.029	0.732AsnSer: 0.732 ± 0.026	1.005AsnThr: 1.005 ± 0.072	1.533AsnVal: 1.533 ± 0.043	0.221AsnTrp: 0.221 ± 0.013	0.392AsnTyr: 0.392 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	8.232ProAla: 8.232 ± 0.113	0.259ProCys: 0.259 ± 0.017	4.587ProAsp: 4.587 ± 0.065	3.856ProGlu: 3.856 ± 0.063	1.514ProPhe: 1.514 ± 0.04	6.539ProGly: 6.539 ± 0.091	1.082ProHis: 1.082 ± 0.031	1.159ProIle: 1.159 ± 0.032	0.939ProLys: 0.939 ± 0.029	5.143ProLeu: 5.143 ± 0.08	0.867ProMet: 0.867 ± 0.027	0.871ProAsn: 0.871 ± 0.028	2.945ProPro: 2.945 ± 0.054	1.609ProGln: 1.609 ± 0.04	3.828ProArg: 3.828 ± 0.058	3.449ProSer: 3.449 ± 0.055	3.916ProThr: 3.916 ± 0.071	5.775ProVal: 5.775 ± 0.069	0.902ProTrp: 0.902 ± 0.031	1.293ProTyr: 1.293 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.891GlnAla: 3.891 ± 0.074	0.123GlnCys: 0.123 ± 0.009	1.307GlnAsp: 1.307 ± 0.034	1.174GlnGlu: 1.174 ± 0.028	0.644GlnPhe: 0.644 ± 0.025	2.369GlnGly: 2.369 ± 0.05	0.637GlnHis: 0.637 ± 0.022	0.933GlnIle: 0.933 ± 0.027	0.51GlnLys: 0.51 ± 0.022	2.985GlnLeu: 2.985 ± 0.052	0.406GlnMet: 0.406 ± 0.019	0.453GlnAsn: 0.453 ± 0.018	1.743GlnPro: 1.743 ± 0.046	1.197GlnGln: 1.197 ± 0.041	2.409GlnArg: 2.409 ± 0.045	1.254GlnSer: 1.254 ± 0.033	1.673GlnThr: 1.673 ± 0.045	3.089GlnVal: 3.089 ± 0.055	0.361GlnTrp: 0.361 ± 0.017	0.493GlnTyr: 0.493 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.48ArgAla: 9.48 ± 0.095	0.52ArgCys: 0.52 ± 0.022	4.265ArgAsp: 4.265 ± 0.067	4.106ArgGlu: 4.106 ± 0.064	2.317ArgPhe: 2.317 ± 0.048	5.99ArgGly: 5.99 ± 0.085	1.64ArgHis: 1.64 ± 0.035	2.291ArgIle: 2.291 ± 0.046	1.183ArgLys: 1.183 ± 0.03	8.686ArgLeu: 8.686 ± 0.112	1.556ArgMet: 1.556 ± 0.034	1.14ArgAsn: 1.14 ± 0.033	4.817ArgPro: 4.817 ± 0.074	2.205ArgGln: 2.205 ± 0.042	7.936ArgArg: 7.936 ± 0.115	4.547ArgSer: 4.547 ± 0.071	5.232ArgThr: 5.232 ± 0.076	6.905ArgVal: 6.905 ± 0.088	1.514ArgTrp: 1.514 ± 0.037	1.578ArgTyr: 1.578 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	7.09SerAla: 7.09 ± 0.109	0.351SerCys: 0.351 ± 0.018	3.024SerAsp: 3.024 ± 0.045	2.563SerGlu: 2.563 ± 0.04	1.682SerPhe: 1.682 ± 0.04	6.084SerGly: 6.084 ± 0.087	0.907SerHis: 0.907 ± 0.026	1.708SerIle: 1.708 ± 0.04	1.037SerLys: 1.037 ± 0.031	5.066SerLeu: 5.066 ± 0.076	1.182SerMet: 1.182 ± 0.037	0.945SerAsn: 0.945 ± 0.031	3.25SerPro: 3.25 ± 0.057	1.326SerGln: 1.326 ± 0.035	3.888SerArg: 3.888 ± 0.056	3.758SerSer: 3.758 ± 0.078	4.065SerThr: 4.065 ± 0.079	4.948SerVal: 4.948 ± 0.087	0.926SerTrp: 0.926 ± 0.025	1.203SerTyr: 1.203 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	8.142ThrAla: 8.142 ± 0.225	0.456ThrCys: 0.456 ± 0.072	3.689ThrAsp: 3.689 ± 0.056	2.819ThrGlu: 2.819 ± 0.046	1.93ThrPhe: 1.93 ± 0.037	6.437ThrGly: 6.437 ± 0.119	1.05ThrHis: 1.05 ± 0.028	1.966ThrIle: 1.966 ± 0.047	1.219ThrLys: 1.219 ± 0.037	6.118ThrLeu: 6.118 ± 0.065	0.948ThrMet: 0.948 ± 0.027	1.149ThrAsn: 1.149 ± 0.052	4.097ThrPro: 4.097 ± 0.063	1.597ThrGln: 1.597 ± 0.053	4.115ThrArg: 4.115 ± 0.06	4.063ThrSer: 4.063 ± 0.095	4.885ThrThr: 4.885 ± 0.167	6.187ThrVal: 6.187 ± 0.146	1.065ThrTrp: 1.065 ± 0.029	1.558ThrTyr: 1.558 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	13.731ValAla: 13.731 ± 0.129	0.745ValCys: 0.745 ± 0.03	6.592ValAsp: 6.592 ± 0.077	5.835ValGlu: 5.835 ± 0.083	2.62ValPhe: 2.62 ± 0.054	8.731ValGly: 8.731 ± 0.094	1.839ValHis: 1.839 ± 0.038	2.551ValIle: 2.551 ± 0.055	1.605ValLys: 1.605 ± 0.036	11.392ValLeu: 11.392 ± 0.141	1.357ValMet: 1.357 ± 0.037	1.686ValAsn: 1.686 ± 0.036	5.546ValPro: 5.546 ± 0.073	2.343ValGln: 2.343 ± 0.047	7.508ValArg: 7.508 ± 0.085	5.167ValSer: 5.167 ± 0.086	6.388ValThr: 6.388 ± 0.214	12.284ValVal: 12.284 ± 0.14	1.263ValTrp: 1.263 ± 0.032	1.602ValTyr: 1.602 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.702TrpAla: 1.702 ± 0.04	0.137TrpCys: 0.137 ± 0.009	0.843TrpAsp: 0.843 ± 0.028	0.627TrpGlu: 0.627 ± 0.022	0.535TrpPhe: 0.535 ± 0.022	1.056TrpGly: 1.056 ± 0.028	0.323TrpHis: 0.323 ± 0.014	0.409TrpIle: 0.409 ± 0.017	0.265TrpLys: 0.265 ± 0.016	1.668TrpLeu: 1.668 ± 0.046	0.238TrpMet: 0.238 ± 0.015	0.353TrpAsn: 0.353 ± 0.016	0.803TrpPro: 0.803 ± 0.025	0.513TrpGln: 0.513 ± 0.023	1.353TrpArg: 1.353 ± 0.036	1.063TrpSer: 1.063 ± 0.026	1.096TrpThr: 1.096 ± 0.028	1.355TrpVal: 1.355 ± 0.034	0.389TrpTrp: 0.389 ± 0.019	0.291TrpTyr: 0.291 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.969TyrAla: 2.969 ± 0.044	0.165TyrCys: 0.165 ± 0.011	1.411TyrAsp: 1.411 ± 0.042	0.996TyrGlu: 0.996 ± 0.03	0.595TyrPhe: 0.595 ± 0.023	2.149TyrGly: 2.149 ± 0.047	0.331TyrHis: 0.331 ± 0.015	0.364TyrIle: 0.364 ± 0.016	0.319TyrLys: 0.319 ± 0.018	2.054TyrLeu: 2.054 ± 0.042	0.195TyrMet: 0.195 ± 0.013	0.401TyrAsn: 0.401 ± 0.021	1.038TyrPro: 1.038 ± 0.032	0.475TyrGln: 0.475 ± 0.02	1.514TyrArg: 1.514 ± 0.036	1.0TyrSer: 1.0 ± 0.033	1.099TyrThr: 1.099 ± 0.05	1.903TyrVal: 1.903 ± 0.042	0.327TyrTrp: 0.327 ± 0.018	0.434TyrTyr: 0.434 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3981 proteins (1314726 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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