Amino acid dipepetide frequency for Vanrija humicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.908AlaAla: 14.908 ± 0.174	1.017AlaCys: 1.017 ± 0.022	5.605AlaAsp: 5.605 ± 0.054	6.483AlaGlu: 6.483 ± 0.065	3.673AlaPhe: 3.673 ± 0.055	8.012AlaGly: 8.012 ± 0.085	2.249AlaHis: 2.249 ± 0.032	4.568AlaIle: 4.568 ± 0.056	4.883AlaLys: 4.883 ± 0.054	9.977AlaLeu: 9.977 ± 0.091	2.048AlaMet: 2.048 ± 0.033	3.111AlaAsn: 3.111 ± 0.044	7.09AlaPro: 7.09 ± 0.09	3.701AlaGln: 3.701 ± 0.059	6.434AlaArg: 6.434 ± 0.064	7.928AlaSer: 7.928 ± 0.085	6.028AlaThr: 6.028 ± 0.06	7.133AlaVal: 7.133 ± 0.063	1.453AlaTrp: 1.453 ± 0.028	2.489AlaTyr: 2.489 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.94CysAla: 0.94 ± 0.025	0.189CysCys: 0.189 ± 0.009	0.479CysAsp: 0.479 ± 0.016	0.486CysGlu: 0.486 ± 0.017	0.427CysPhe: 0.427 ± 0.014	0.888CysGly: 0.888 ± 0.025	0.243CysHis: 0.243 ± 0.012	0.57CysIle: 0.57 ± 0.016	0.365CysLys: 0.365 ± 0.014	0.978CysLeu: 0.978 ± 0.027	0.248CysMet: 0.248 ± 0.012	0.31CysAsn: 0.31 ± 0.014	0.549CysPro: 0.549 ± 0.019	0.301CysGln: 0.301 ± 0.013	0.578CysArg: 0.578 ± 0.02	0.683CysSer: 0.683 ± 0.019	0.576CysThr: 0.576 ± 0.017	0.766CysVal: 0.766 ± 0.02	0.154CysTrp: 0.154 ± 0.008	0.296CysTyr: 0.296 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	5.965AspAla: 5.965 ± 0.056	0.443AspCys: 0.443 ± 0.016	4.658AspAsp: 4.658 ± 0.084	4.812AspGlu: 4.812 ± 0.07	1.914AspPhe: 1.914 ± 0.032	4.36AspGly: 4.36 ± 0.057	1.101AspHis: 1.101 ± 0.027	2.609AspIle: 2.609 ± 0.037	2.646AspLys: 2.646 ± 0.042	4.982AspLeu: 4.982 ± 0.046	1.112AspMet: 1.112 ± 0.026	1.609AspAsn: 1.609 ± 0.029	3.183AspPro: 3.183 ± 0.049	1.473AspGln: 1.473 ± 0.027	3.093AspArg: 3.093 ± 0.056	3.304AspSer: 3.304 ± 0.055	2.65AspThr: 2.65 ± 0.042	4.164AspVal: 4.164 ± 0.048	0.9AspTrp: 0.9 ± 0.023	1.454AspTyr: 1.454 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.326GluAla: 6.326 ± 0.078	0.506GluCys: 0.506 ± 0.017	3.898GluAsp: 3.898 ± 0.063	4.896GluGlu: 4.896 ± 0.077	1.811GluPhe: 1.811 ± 0.03	4.12GluGly: 4.12 ± 0.049	1.369GluHis: 1.369 ± 0.025	2.635GluIle: 2.635 ± 0.04	3.009GluLys: 3.009 ± 0.045	5.375GluLeu: 5.375 ± 0.066	1.263GluMet: 1.263 ± 0.024	1.561GluAsn: 1.561 ± 0.028	2.696GluPro: 2.696 ± 0.044	2.05GluGln: 2.05 ± 0.033	4.292GluArg: 4.292 ± 0.065	3.413GluSer: 3.413 ± 0.047	2.996GluThr: 2.996 ± 0.043	4.012GluVal: 4.012 ± 0.053	0.937GluTrp: 0.937 ± 0.02	1.518GluTyr: 1.518 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.501PheAla: 3.501 ± 0.05	0.498PheCys: 0.498 ± 0.017	2.16PheAsp: 2.16 ± 0.034	1.988PheGlu: 1.988 ± 0.029	1.574PhePhe: 1.574 ± 0.038	3.19PheGly: 3.19 ± 0.052	0.805PheHis: 0.805 ± 0.023	1.797PheIle: 1.797 ± 0.038	1.532PheLys: 1.532 ± 0.03	3.342PheLeu: 3.342 ± 0.049	0.693PheMet: 0.693 ± 0.02	1.309PheAsn: 1.309 ± 0.026	1.855PhePro: 1.855 ± 0.031	1.071PheGln: 1.071 ± 0.024	1.788PheArg: 1.788 ± 0.027	2.493PheSer: 2.493 ± 0.042	2.124PheThr: 2.124 ± 0.036	2.735PheVal: 2.735 ± 0.041	0.595PheTrp: 0.595 ± 0.021	1.007PheTyr: 1.007 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	7.509GlyAla: 7.509 ± 0.076	0.787GlyCys: 0.787 ± 0.022	3.973GlyAsp: 3.973 ± 0.053	4.171GlyGlu: 4.171 ± 0.048	2.9GlyPhe: 2.9 ± 0.049	7.432GlyGly: 7.432 ± 0.097	1.752GlyHis: 1.752 ± 0.034	3.531GlyIle: 3.531 ± 0.054	3.876GlyLys: 3.876 ± 0.051	6.774GlyLeu: 6.774 ± 0.072	1.563GlyMet: 1.563 ± 0.034	2.209GlyAsn: 2.209 ± 0.037	3.724GlyPro: 3.724 ± 0.048	2.522GlyGln: 2.522 ± 0.047	4.612GlyArg: 4.612 ± 0.046	5.551GlySer: 5.551 ± 0.071	4.18GlyThr: 4.18 ± 0.049	5.459GlyVal: 5.459 ± 0.065	1.455GlyTrp: 1.455 ± 0.028	2.153GlyTyr: 2.153 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.232HisAla: 2.232 ± 0.033	0.238HisCys: 0.238 ± 0.01	1.224HisAsp: 1.224 ± 0.022	1.206HisGlu: 1.206 ± 0.027	0.818HisPhe: 0.818 ± 0.019	1.707HisGly: 1.707 ± 0.033	0.745HisHis: 0.745 ± 0.024	1.058HisIle: 1.058 ± 0.022	0.834HisLys: 0.834 ± 0.024	2.275HisLeu: 2.275 ± 0.033	0.419HisMet: 0.419 ± 0.014	0.679HisAsn: 0.679 ± 0.021	1.724HisPro: 1.724 ± 0.034	0.802HisGln: 0.802 ± 0.02	1.418HisArg: 1.418 ± 0.028	1.535HisSer: 1.535 ± 0.03	1.243HisThr: 1.243 ± 0.029	1.513HisVal: 1.513 ± 0.027	0.347HisTrp: 0.347 ± 0.014	0.635HisTyr: 0.635 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.768IleAla: 4.768 ± 0.058	0.543IleCys: 0.543 ± 0.019	2.726IleAsp: 2.726 ± 0.04	2.548IleGlu: 2.548 ± 0.04	1.747IlePhe: 1.747 ± 0.032	3.347IleGly: 3.347 ± 0.05	1.002IleHis: 1.002 ± 0.023	2.216IleIle: 2.216 ± 0.036	2.086IleLys: 2.086 ± 0.034	4.076IleLeu: 4.076 ± 0.059	0.875IleMet: 0.875 ± 0.024	1.567IleAsn: 1.567 ± 0.03	2.712IlePro: 2.712 ± 0.037	1.453IleGln: 1.453 ± 0.026	2.45IleArg: 2.45 ± 0.035	2.868IleSer: 2.868 ± 0.046	2.54IleThr: 2.54 ± 0.037	3.49IleVal: 3.49 ± 0.053	0.629IleTrp: 0.629 ± 0.02	1.177IleTyr: 1.177 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	5.073LysAla: 5.073 ± 0.06	0.354LysCys: 0.354 ± 0.012	2.634LysAsp: 2.634 ± 0.043	3.039LysGlu: 3.039 ± 0.053	1.319LysPhe: 1.319 ± 0.027	3.262LysGly: 3.262 ± 0.044	1.001LysHis: 1.001 ± 0.02	1.957LysIle: 1.957 ± 0.038	2.943LysLys: 2.943 ± 0.062	3.914LysLeu: 3.914 ± 0.045	0.876LysMet: 0.876 ± 0.023	1.406LysAsn: 1.406 ± 0.029	2.625LysPro: 2.625 ± 0.044	1.551LysGln: 1.551 ± 0.028	3.236LysArg: 3.236 ± 0.045	2.661LysSer: 2.661 ± 0.038	2.568LysThr: 2.568 ± 0.04	3.132LysVal: 3.132 ± 0.044	0.684LysTrp: 0.684 ± 0.018	1.24LysTyr: 1.24 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.085LeuAla: 10.085 ± 0.086	1.031LeuCys: 1.031 ± 0.025	5.293LeuAsp: 5.293 ± 0.056	5.035LeuGlu: 5.035 ± 0.063	3.418LeuPhe: 3.418 ± 0.056	6.818LeuGly: 6.818 ± 0.073	2.174LeuHis: 2.174 ± 0.031	3.975LeuIle: 3.975 ± 0.046	3.913LeuLys: 3.913 ± 0.046	8.944LeuLeu: 8.944 ± 0.095	1.662LeuMet: 1.662 ± 0.034	2.849LeuAsn: 2.849 ± 0.037	6.041LeuPro: 6.041 ± 0.071	3.221LeuGln: 3.221 ± 0.05	5.763LeuArg: 5.763 ± 0.053	6.921LeuSer: 6.921 ± 0.073	5.22LeuThr: 5.22 ± 0.052	6.432LeuVal: 6.432 ± 0.059	1.162LeuTrp: 1.162 ± 0.024	2.234LeuTyr: 2.234 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.075MetAla: 2.075 ± 0.033	0.24MetCys: 0.24 ± 0.013	1.009MetAsp: 1.009 ± 0.024	0.953MetGlu: 0.953 ± 0.023	0.745MetPhe: 0.745 ± 0.02	1.455MetGly: 1.455 ± 0.029	0.349MetHis: 0.349 ± 0.014	0.874MetIle: 0.874 ± 0.02	0.744MetLys: 0.744 ± 0.02	1.774MetLeu: 1.774 ± 0.034	0.466MetMet: 0.466 ± 0.017	0.566MetAsn: 0.566 ± 0.017	1.133MetPro: 1.133 ± 0.024	0.603MetGln: 0.603 ± 0.018	1.192MetArg: 1.192 ± 0.025	1.649MetSer: 1.649 ± 0.028	1.211MetThr: 1.211 ± 0.025	1.307MetVal: 1.307 ± 0.032	0.27MetTrp: 0.27 ± 0.01	0.508MetTyr: 0.508 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.162AsnAla: 3.162 ± 0.038	0.28AsnCys: 0.28 ± 0.013	1.613AsnAsp: 1.613 ± 0.031	1.577AsnGlu: 1.577 ± 0.029	1.177AsnPhe: 1.177 ± 0.025	2.684AsnGly: 2.684 ± 0.044	0.659AsnHis: 0.659 ± 0.017	1.545AsnIle: 1.545 ± 0.028	1.394AsnLys: 1.394 ± 0.028	2.824AsnLeu: 2.824 ± 0.037	0.601AsnMet: 0.601 ± 0.017	1.095AsnAsn: 1.095 ± 0.033	2.142AsnPro: 2.142 ± 0.036	0.91AsnGln: 0.91 ± 0.021	1.545AsnArg: 1.545 ± 0.025	1.941AsnSer: 1.941 ± 0.031	1.699AsnThr: 1.699 ± 0.03	2.254AsnVal: 2.254 ± 0.035	0.481AsnTrp: 0.481 ± 0.015	0.885AsnTyr: 0.885 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.421ProAla: 7.421 ± 0.101	0.409ProCys: 0.409 ± 0.017	3.152ProAsp: 3.152 ± 0.04	3.758ProGlu: 3.758 ± 0.045	1.994ProPhe: 1.994 ± 0.034	4.401ProGly: 4.401 ± 0.061	1.385ProHis: 1.385 ± 0.028	2.342ProIle: 2.342 ± 0.034	2.634ProLys: 2.634 ± 0.039	5.235ProLeu: 5.235 ± 0.056	0.905ProMet: 0.905 ± 0.023	1.847ProAsn: 1.847 ± 0.032	6.055ProPro: 6.055 ± 0.119	2.146ProGln: 2.146 ± 0.043	3.703ProArg: 3.703 ± 0.054	5.614ProSer: 5.614 ± 0.076	4.204ProThr: 4.204 ± 0.056	4.16ProVal: 4.16 ± 0.053	0.764ProTrp: 0.764 ± 0.022	1.453ProTyr: 1.453 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.709GlnAla: 3.709 ± 0.066	0.308GlnCys: 0.308 ± 0.013	1.473GlnAsp: 1.473 ± 0.026	1.666GlnGlu: 1.666 ± 0.032	1.163GlnPhe: 1.163 ± 0.026	2.119GlnGly: 2.119 ± 0.034	0.877GlnHis: 0.877 ± 0.023	1.5GlnIle: 1.5 ± 0.028	1.382GlnLys: 1.382 ± 0.027	3.335GlnLeu: 3.335 ± 0.046	0.761GlnMet: 0.761 ± 0.02	0.986GlnAsn: 0.986 ± 0.025	2.258GlnPro: 2.258 ± 0.034	2.098GlnGln: 2.098 ± 0.085	2.398GlnArg: 2.398 ± 0.04	2.123GlnSer: 2.123 ± 0.033	1.917GlnThr: 1.917 ± 0.035	2.131GlnVal: 2.131 ± 0.034	0.572GlnTrp: 0.572 ± 0.019	0.97GlnTyr: 0.97 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	6.48ArgAla: 6.48 ± 0.064	0.601ArgCys: 0.601 ± 0.015	3.481ArgAsp: 3.481 ± 0.063	3.82ArgGlu: 3.82 ± 0.064	2.048ArgPhe: 2.048 ± 0.032	4.392ArgGly: 4.392 ± 0.057	1.479ArgHis: 1.479 ± 0.029	2.639ArgIle: 2.639 ± 0.033	3.111ArgLys: 3.111 ± 0.045	5.642ArgLeu: 5.642 ± 0.058	1.191ArgMet: 1.191 ± 0.026	1.804ArgAsn: 1.804 ± 0.03	3.684ArgPro: 3.684 ± 0.053	2.27ArgGln: 2.27 ± 0.037	5.519ArgArg: 5.519 ± 0.075	4.18ArgSer: 4.18 ± 0.057	3.405ArgThr: 3.405 ± 0.038	4.052ArgVal: 4.052 ± 0.046	0.97ArgTrp: 0.97 ± 0.022	1.55ArgTyr: 1.55 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	7.507SerAla: 7.507 ± 0.078	0.674SerCys: 0.674 ± 0.02	3.603SerAsp: 3.603 ± 0.054	3.279SerGlu: 3.279 ± 0.047	2.613SerPhe: 2.613 ± 0.04	5.399SerGly: 5.399 ± 0.059	1.569SerHis: 1.569 ± 0.028	3.073SerIle: 3.073 ± 0.045	3.072SerLys: 3.072 ± 0.041	6.624SerLeu: 6.624 ± 0.068	1.344SerMet: 1.344 ± 0.027	2.116SerAsn: 2.116 ± 0.038	5.005SerPro: 5.005 ± 0.073	2.237SerGln: 2.237 ± 0.034	4.343SerArg: 4.343 ± 0.061	6.944SerSer: 6.944 ± 0.113	4.85SerThr: 4.85 ± 0.068	4.595SerVal: 4.595 ± 0.05	0.987SerTrp: 0.987 ± 0.025	1.749SerTyr: 1.749 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.109ThrAla: 6.109 ± 0.057	0.572ThrCys: 0.572 ± 0.019	2.692ThrAsp: 2.692 ± 0.037	2.699ThrGlu: 2.699 ± 0.041	2.257ThrPhe: 2.257 ± 0.034	4.325ThrGly: 4.325 ± 0.049	1.346ThrHis: 1.346 ± 0.027	2.738ThrIle: 2.738 ± 0.039	2.307ThrLys: 2.307 ± 0.041	5.542ThrLeu: 5.542 ± 0.057	0.96ThrMet: 0.96 ± 0.02	1.722ThrAsn: 1.722 ± 0.029	4.814ThrPro: 4.814 ± 0.061	1.725ThrGln: 1.725 ± 0.034	3.227ThrArg: 3.227 ± 0.041	4.415ThrSer: 4.415 ± 0.057	3.931ThrThr: 3.931 ± 0.06	3.885ThrVal: 3.885 ± 0.047	0.812ThrTrp: 0.812 ± 0.025	1.479ThrTyr: 1.479 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	7.13ValAla: 7.13 ± 0.071	0.81ValCys: 0.81 ± 0.022	4.169ValAsp: 4.169 ± 0.051	4.047ValGlu: 4.047 ± 0.065	2.776ValPhe: 2.776 ± 0.035	5.009ValGly: 5.009 ± 0.061	1.554ValHis: 1.554 ± 0.032	3.194ValIle: 3.194 ± 0.042	3.04ValLys: 3.04 ± 0.046	6.67ValLeu: 6.67 ± 0.068	1.307ValMet: 1.307 ± 0.027	2.202ValAsn: 2.202 ± 0.034	4.28ValPro: 4.28 ± 0.052	2.275ValGln: 2.275 ± 0.038	4.159ValArg: 4.159 ± 0.054	4.66ValSer: 4.66 ± 0.051	3.775ValThr: 3.775 ± 0.047	5.478ValVal: 5.478 ± 0.061	1.072ValTrp: 1.072 ± 0.025	1.878ValTyr: 1.878 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.4TrpAla: 1.4 ± 0.027	0.192TrpCys: 0.192 ± 0.009	0.958TrpAsp: 0.958 ± 0.025	0.842TrpGlu: 0.842 ± 0.02	0.571TrpPhe: 0.571 ± 0.016	1.129TrpGly: 1.129 ± 0.027	0.337TrpHis: 0.337 ± 0.013	0.728TrpIle: 0.728 ± 0.02	0.656TrpLys: 0.656 ± 0.019	1.369TrpLeu: 1.369 ± 0.027	0.335TrpMet: 0.335 ± 0.012	0.559TrpAsn: 0.559 ± 0.016	0.618TrpPro: 0.618 ± 0.019	0.492TrpGln: 0.492 ± 0.016	1.056TrpArg: 1.056 ± 0.024	1.047TrpSer: 1.047 ± 0.024	0.897TrpThr: 0.897 ± 0.021	1.047TrpVal: 1.047 ± 0.026	0.322TrpTrp: 0.322 ± 0.015	0.419TrpTyr: 0.419 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.488TyrAla: 2.488 ± 0.039	0.331TyrCys: 0.331 ± 0.012	1.634TyrAsp: 1.634 ± 0.03	1.378TyrGlu: 1.378 ± 0.025	1.113TyrPhe: 1.113 ± 0.024	2.084TyrGly: 2.084 ± 0.037	0.654TyrHis: 0.654 ± 0.018	1.271TyrIle: 1.271 ± 0.027	1.046TyrLys: 1.046 ± 0.024	2.541TyrLeu: 2.541 ± 0.037	0.495TyrMet: 0.495 ± 0.016	0.959TyrAsn: 0.959 ± 0.022	1.394TyrPro: 1.394 ± 0.026	0.847TyrGln: 0.847 ± 0.02	1.511TyrArg: 1.511 ± 0.028	1.655TyrSer: 1.655 ± 0.031	1.541TyrThr: 1.541 ± 0.025	1.743TyrVal: 1.743 ± 0.028	0.409TyrTrp: 0.409 ± 0.015	0.825TyrTyr: 0.825 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4373 proteins (2036452 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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