Amino acid dipepetide frequency for Corynebacterium phage Troy

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.751AlaAla: 19.751 ± 2.493
0.505AlaCys: 0.505 ± 0.187
9.371AlaAsp: 9.371 ± 0.988
9.587AlaGlu: 9.587 ± 0.991
2.739AlaPhe: 2.739 ± 0.593
11.101AlaGly: 11.101 ± 1.207
2.09AlaHis: 2.09 ± 0.419
6.487AlaIle: 6.487 ± 0.791
3.748AlaLys: 3.748 ± 0.707
10.236AlaLeu: 10.236 ± 0.833
3.604AlaMet: 3.604 ± 0.554
2.739AlaAsn: 2.739 ± 0.639
7.208AlaPro: 7.208 ± 0.728
4.83AlaGln: 4.83 ± 0.894
8.073AlaArg: 8.073 ± 0.751
4.974AlaSer: 4.974 ± 0.652
7.064AlaThr: 7.064 ± 0.534
8.866AlaVal: 8.866 ± 0.914
2.379AlaTrp: 2.379 ± 0.529
2.883AlaTyr: 2.883 ± 0.526
0.0AlaXaa: 0.0 ± 0.0
Cys
0.505CysAla: 0.505 ± 0.252
0.072CysCys: 0.072 ± 0.084
0.216CysAsp: 0.216 ± 0.118
0.36CysGlu: 0.36 ± 0.155
0.144CysPhe: 0.144 ± 0.106
0.577CysGly: 0.577 ± 0.163
0.072CysHis: 0.072 ± 0.077
0.216CysIle: 0.216 ± 0.116
0.288CysLys: 0.288 ± 0.149
0.577CysLeu: 0.577 ± 0.214
0.0CysMet: 0.0 ± 0.0
0.36CysAsn: 0.36 ± 0.172
0.216CysPro: 0.216 ± 0.13
0.288CysGln: 0.288 ± 0.152
0.505CysArg: 0.505 ± 0.171
0.432CysSer: 0.432 ± 0.174
0.505CysThr: 0.505 ± 0.209
0.288CysVal: 0.288 ± 0.163
0.216CysTrp: 0.216 ± 0.137
0.144CysTyr: 0.144 ± 0.113
0.0CysXaa: 0.0 ± 0.0
Asp
10.164AspAla: 10.164 ± 0.905
0.432AspCys: 0.432 ± 0.218
5.406AspAsp: 5.406 ± 0.894
4.902AspGlu: 4.902 ± 0.544
1.586AspPhe: 1.586 ± 0.38
7.929AspGly: 7.929 ± 0.871
1.586AspHis: 1.586 ± 0.416
2.379AspIle: 2.379 ± 0.511
1.586AspLys: 1.586 ± 0.564
5.622AspLeu: 5.622 ± 0.6
1.37AspMet: 1.37 ± 0.263
1.297AspAsn: 1.297 ± 0.285
3.965AspPro: 3.965 ± 0.63
3.1AspGln: 3.1 ± 0.525
3.82AspArg: 3.82 ± 0.513
2.883AspSer: 2.883 ± 0.497
3.82AspThr: 3.82 ± 0.757
4.757AspVal: 4.757 ± 0.596
1.946AspTrp: 1.946 ± 0.316
1.442AspTyr: 1.442 ± 0.36
0.0AspXaa: 0.0 ± 0.0
Glu
6.415GluAla: 6.415 ± 0.572
0.36GluCys: 0.36 ± 0.143
2.883GluAsp: 2.883 ± 0.394
3.676GluGlu: 3.676 ± 0.729
1.802GluPhe: 1.802 ± 0.343
3.532GluGly: 3.532 ± 0.47
1.73GluHis: 1.73 ± 0.401
3.388GluIle: 3.388 ± 0.488
2.451GluLys: 2.451 ± 0.478
5.767GluLeu: 5.767 ± 0.709
1.297GluMet: 1.297 ± 0.3
1.514GluAsn: 1.514 ± 0.312
4.325GluPro: 4.325 ± 0.708
3.46GluGln: 3.46 ± 0.426
4.397GluArg: 4.397 ± 0.666
3.244GluSer: 3.244 ± 0.392
3.532GluThr: 3.532 ± 0.476
4.325GluVal: 4.325 ± 0.457
1.37GluTrp: 1.37 ± 0.297
2.235GluTyr: 2.235 ± 0.466
0.0GluXaa: 0.0 ± 0.0
Phe
2.09PheAla: 2.09 ± 0.443
0.288PheCys: 0.288 ± 0.145
2.307PheAsp: 2.307 ± 0.37
1.658PheGlu: 1.658 ± 0.392
1.009PhePhe: 1.009 ± 0.357
3.244PheGly: 3.244 ± 0.47
0.649PheHis: 0.649 ± 0.27
1.37PheIle: 1.37 ± 0.3
0.865PheLys: 0.865 ± 0.251
2.018PheLeu: 2.018 ± 0.387
0.577PheMet: 0.577 ± 0.153
0.36PheAsn: 0.36 ± 0.151
0.937PhePro: 0.937 ± 0.283
0.721PheGln: 0.721 ± 0.219
1.442PheArg: 1.442 ± 0.356
1.297PheSer: 1.297 ± 0.395
1.658PheThr: 1.658 ± 0.313
1.37PheVal: 1.37 ± 0.254
0.649PheTrp: 0.649 ± 0.205
0.432PheTyr: 0.432 ± 0.174
0.0PheXaa: 0.0 ± 0.0
Gly
8.722GlyAla: 8.722 ± 1.212
0.36GlyCys: 0.36 ± 0.185
5.478GlyAsp: 5.478 ± 0.603
5.334GlyGlu: 5.334 ± 0.562
2.883GlyPhe: 2.883 ± 0.413
7.929GlyGly: 7.929 ± 0.908
2.811GlyHis: 2.811 ± 0.539
3.892GlyIle: 3.892 ± 0.749
4.253GlyLys: 4.253 ± 0.605
6.127GlyLeu: 6.127 ± 0.654
3.1GlyMet: 3.1 ± 0.445
2.523GlyAsn: 2.523 ± 0.475
4.253GlyPro: 4.253 ± 0.596
2.739GlyGln: 2.739 ± 0.448
6.343GlyArg: 6.343 ± 0.692
4.757GlySer: 4.757 ± 0.658
5.55GlyThr: 5.55 ± 0.556
6.487GlyVal: 6.487 ± 0.737
2.235GlyTrp: 2.235 ± 0.364
1.73GlyTyr: 1.73 ± 0.267
0.0GlyXaa: 0.0 ± 0.0
His
2.379HisAla: 2.379 ± 0.45
0.288HisCys: 0.288 ± 0.169
1.442HisAsp: 1.442 ± 0.404
1.081HisGlu: 1.081 ± 0.258
0.577HisPhe: 0.577 ± 0.204
1.874HisGly: 1.874 ± 0.447
0.937HisHis: 0.937 ± 0.311
1.658HisIle: 1.658 ± 0.43
0.505HisLys: 0.505 ± 0.182
2.235HisLeu: 2.235 ± 0.581
0.288HisMet: 0.288 ± 0.146
0.36HisAsn: 0.36 ± 0.151
1.442HisPro: 1.442 ± 0.318
1.081HisGln: 1.081 ± 0.283
1.153HisArg: 1.153 ± 0.299
0.937HisSer: 0.937 ± 0.294
1.37HisThr: 1.37 ± 0.308
2.379HisVal: 2.379 ± 0.462
0.505HisTrp: 0.505 ± 0.248
0.649HisTyr: 0.649 ± 0.204
0.0HisXaa: 0.0 ± 0.0
Ile
6.92IleAla: 6.92 ± 0.692
0.216IleCys: 0.216 ± 0.138
4.685IleAsp: 4.685 ± 0.694
2.379IleGlu: 2.379 ± 0.399
1.009IlePhe: 1.009 ± 0.247
4.83IleGly: 4.83 ± 0.916
1.225IleHis: 1.225 ± 0.287
2.739IleIle: 2.739 ± 0.415
1.009IleLys: 1.009 ± 0.278
2.811IleLeu: 2.811 ± 0.422
0.649IleMet: 0.649 ± 0.178
1.225IleAsn: 1.225 ± 0.28
2.955IlePro: 2.955 ± 0.565
1.442IleGln: 1.442 ± 0.3
2.955IleArg: 2.955 ± 0.466
2.595IleSer: 2.595 ± 0.467
3.748IleThr: 3.748 ± 0.63
3.172IleVal: 3.172 ± 0.388
0.288IleTrp: 0.288 ± 0.147
1.081IleTyr: 1.081 ± 0.378
0.0IleXaa: 0.0 ± 0.0
Lys
4.325LysAla: 4.325 ± 0.875
0.0LysCys: 0.0 ± 0.0
1.802LysAsp: 1.802 ± 0.384
1.297LysGlu: 1.297 ± 0.267
0.865LysPhe: 0.865 ± 0.257
2.235LysGly: 2.235 ± 0.493
0.721LysHis: 0.721 ± 0.249
1.586LysIle: 1.586 ± 0.36
1.225LysLys: 1.225 ± 0.336
3.676LysLeu: 3.676 ± 0.504
0.721LysMet: 0.721 ± 0.286
0.505LysAsn: 0.505 ± 0.2
1.946LysPro: 1.946 ± 0.366
1.874LysGln: 1.874 ± 0.449
1.874LysArg: 1.874 ± 0.352
2.09LysSer: 2.09 ± 0.416
2.379LysThr: 2.379 ± 0.424
1.802LysVal: 1.802 ± 0.403
0.865LysTrp: 0.865 ± 0.251
0.937LysTyr: 0.937 ± 0.195
0.0LysXaa: 0.0 ± 0.0
Leu
10.019LeuAla: 10.019 ± 0.888
0.505LeuCys: 0.505 ± 0.215
6.56LeuAsp: 6.56 ± 0.816
3.965LeuGlu: 3.965 ± 0.576
1.442LeuPhe: 1.442 ± 0.382
6.92LeuGly: 6.92 ± 0.714
1.946LeuHis: 1.946 ± 0.407
3.676LeuIle: 3.676 ± 0.47
2.523LeuLys: 2.523 ± 0.412
4.974LeuLeu: 4.974 ± 0.694
1.658LeuMet: 1.658 ± 0.313
2.018LeuAsn: 2.018 ± 0.348
5.622LeuPro: 5.622 ± 0.707
2.162LeuGln: 2.162 ± 0.336
6.56LeuArg: 6.56 ± 0.727
4.397LeuSer: 4.397 ± 0.537
5.19LeuThr: 5.19 ± 0.642
4.613LeuVal: 4.613 ± 0.551
1.658LeuTrp: 1.658 ± 0.324
1.802LeuTyr: 1.802 ± 0.481
0.0LeuXaa: 0.0 ± 0.0
Met
2.811MetAla: 2.811 ± 0.493
0.072MetCys: 0.072 ± 0.078
1.658MetAsp: 1.658 ± 0.31
1.802MetGlu: 1.802 ± 0.406
0.36MetPhe: 0.36 ± 0.164
2.235MetGly: 2.235 ± 0.605
0.288MetHis: 0.288 ± 0.145
0.721MetIle: 0.721 ± 0.247
1.153MetLys: 1.153 ± 0.255
1.009MetLeu: 1.009 ± 0.291
0.36MetMet: 0.36 ± 0.169
0.721MetAsn: 0.721 ± 0.234
1.73MetPro: 1.73 ± 0.293
0.649MetGln: 0.649 ± 0.18
1.802MetArg: 1.802 ± 0.499
1.73MetSer: 1.73 ± 0.309
3.676MetThr: 3.676 ± 0.648
1.153MetVal: 1.153 ± 0.291
0.288MetTrp: 0.288 ± 0.176
0.288MetTyr: 0.288 ± 0.129
0.0MetXaa: 0.0 ± 0.0
Asn
3.604AsnAla: 3.604 ± 0.448
0.072AsnCys: 0.072 ± 0.083
1.081AsnAsp: 1.081 ± 0.268
1.009AsnGlu: 1.009 ± 0.276
0.505AsnPhe: 0.505 ± 0.187
2.883AsnGly: 2.883 ± 0.554
0.649AsnHis: 0.649 ± 0.248
1.081AsnIle: 1.081 ± 0.225
0.649AsnLys: 0.649 ± 0.233
2.667AsnLeu: 2.667 ± 0.42
0.36AsnMet: 0.36 ± 0.13
0.505AsnAsn: 0.505 ± 0.204
2.235AsnPro: 2.235 ± 0.367
0.432AsnGln: 0.432 ± 0.177
2.09AsnArg: 2.09 ± 0.368
0.865AsnSer: 0.865 ± 0.222
1.297AsnThr: 1.297 ± 0.28
1.514AsnVal: 1.514 ± 0.366
0.072AsnTrp: 0.072 ± 0.075
0.577AsnTyr: 0.577 ± 0.247
0.0AsnXaa: 0.0 ± 0.0
Pro
6.992ProAla: 6.992 ± 0.717
0.216ProCys: 0.216 ± 0.129
5.19ProAsp: 5.19 ± 0.653
4.469ProGlu: 4.469 ± 0.586
1.658ProPhe: 1.658 ± 0.293
5.478ProGly: 5.478 ± 0.94
0.865ProHis: 0.865 ± 0.283
2.451ProIle: 2.451 ± 0.389
2.09ProLys: 2.09 ± 0.547
3.604ProLeu: 3.604 ± 0.474
1.874ProMet: 1.874 ± 0.443
1.225ProAsn: 1.225 ± 0.303
3.388ProPro: 3.388 ± 0.69
1.442ProGln: 1.442 ± 0.328
3.46ProArg: 3.46 ± 0.572
2.667ProSer: 2.667 ± 0.507
3.82ProThr: 3.82 ± 0.55
4.541ProVal: 4.541 ± 0.527
1.442ProTrp: 1.442 ± 0.39
0.793ProTyr: 0.793 ± 0.244
0.0ProXaa: 0.0 ± 0.0
Gln
5.118GlnAla: 5.118 ± 0.701
0.216GlnCys: 0.216 ± 0.114
1.081GlnAsp: 1.081 ± 0.231
1.802GlnGlu: 1.802 ± 0.371
0.793GlnPhe: 0.793 ± 0.32
2.667GlnGly: 2.667 ± 0.429
0.577GlnHis: 0.577 ± 0.209
1.37GlnIle: 1.37 ± 0.252
1.442GlnLys: 1.442 ± 0.257
3.46GlnLeu: 3.46 ± 0.412
1.081GlnMet: 1.081 ± 0.281
0.721GlnAsn: 0.721 ± 0.27
1.37GlnPro: 1.37 ± 0.323
1.514GlnGln: 1.514 ± 0.313
2.523GlnArg: 2.523 ± 0.39
1.081GlnSer: 1.081 ± 0.28
1.802GlnThr: 1.802 ± 0.315
3.82GlnVal: 3.82 ± 0.426
1.297GlnTrp: 1.297 ± 0.269
0.721GlnTyr: 0.721 ± 0.234
0.0GlnXaa: 0.0 ± 0.0
Arg
7.785ArgAla: 7.785 ± 0.751
0.721ArgCys: 0.721 ± 0.255
6.127ArgAsp: 6.127 ± 0.829
4.109ArgGlu: 4.109 ± 0.486
2.09ArgPhe: 2.09 ± 0.254
4.685ArgGly: 4.685 ± 0.638
1.586ArgHis: 1.586 ± 0.366
3.965ArgIle: 3.965 ± 0.544
2.739ArgLys: 2.739 ± 0.357
5.55ArgLeu: 5.55 ± 0.796
2.595ArgMet: 2.595 ± 0.436
1.73ArgAsn: 1.73 ± 0.354
3.316ArgPro: 3.316 ± 0.602
2.162ArgGln: 2.162 ± 0.456
6.704ArgArg: 6.704 ± 1.019
3.027ArgSer: 3.027 ± 0.494
4.037ArgThr: 4.037 ± 0.405
4.397ArgVal: 4.397 ± 0.547
2.018ArgTrp: 2.018 ± 0.463
1.153ArgTyr: 1.153 ± 0.32
0.0ArgXaa: 0.0 ± 0.0
Ser
5.622SerAla: 5.622 ± 0.734
0.432SerCys: 0.432 ± 0.223
2.595SerAsp: 2.595 ± 0.518
2.523SerGlu: 2.523 ± 0.521
1.586SerPhe: 1.586 ± 0.322
5.19SerGly: 5.19 ± 1.022
1.225SerHis: 1.225 ± 0.437
1.874SerIle: 1.874 ± 0.355
1.081SerLys: 1.081 ± 0.246
3.676SerLeu: 3.676 ± 0.641
1.153SerMet: 1.153 ± 0.272
1.081SerAsn: 1.081 ± 0.311
2.235SerPro: 2.235 ± 0.413
1.658SerGln: 1.658 ± 0.344
3.965SerArg: 3.965 ± 0.532
2.595SerSer: 2.595 ± 0.523
3.965SerThr: 3.965 ± 0.674
3.965SerVal: 3.965 ± 0.553
1.153SerTrp: 1.153 ± 0.209
1.153SerTyr: 1.153 ± 0.271
0.0SerXaa: 0.0 ± 0.0
Thr
8.362ThrAla: 8.362 ± 0.666
0.216ThrCys: 0.216 ± 0.168
4.037ThrAsp: 4.037 ± 0.644
3.604ThrGlu: 3.604 ± 0.429
1.297ThrPhe: 1.297 ± 0.331
5.767ThrGly: 5.767 ± 0.583
1.442ThrHis: 1.442 ± 0.279
3.965ThrIle: 3.965 ± 0.885
2.379ThrLys: 2.379 ± 0.347
5.695ThrLeu: 5.695 ± 0.597
1.946ThrMet: 1.946 ± 0.357
2.09ThrAsn: 2.09 ± 0.404
4.469ThrPro: 4.469 ± 0.686
1.586ThrGln: 1.586 ± 0.339
3.748ThrArg: 3.748 ± 0.666
2.451ThrSer: 2.451 ± 0.699
5.478ThrThr: 5.478 ± 0.863
5.118ThrVal: 5.118 ± 0.808
1.225ThrTrp: 1.225 ± 0.31
1.514ThrTyr: 1.514 ± 0.39
0.0ThrXaa: 0.0 ± 0.0
Val
10.884ValAla: 10.884 ± 1.043
0.432ValCys: 0.432 ± 0.175
5.046ValAsp: 5.046 ± 0.729
5.334ValGlu: 5.334 ± 0.541
1.442ValPhe: 1.442 ± 0.362
5.478ValGly: 5.478 ± 0.691
1.514ValHis: 1.514 ± 0.33
2.955ValIle: 2.955 ± 0.426
2.018ValLys: 2.018 ± 0.468
5.118ValLeu: 5.118 ± 0.74
0.865ValMet: 0.865 ± 0.294
1.946ValAsn: 1.946 ± 0.437
3.532ValPro: 3.532 ± 0.431
1.73ValGln: 1.73 ± 0.314
4.902ValArg: 4.902 ± 0.642
4.037ValSer: 4.037 ± 0.555
4.902ValThr: 4.902 ± 0.614
4.685ValVal: 4.685 ± 0.71
1.802ValTrp: 1.802 ± 0.307
1.297ValTyr: 1.297 ± 0.256
0.0ValXaa: 0.0 ± 0.0
Trp
3.388TrpAla: 3.388 ± 0.504
0.36TrpCys: 0.36 ± 0.173
1.514TrpAsp: 1.514 ± 0.334
1.297TrpGlu: 1.297 ± 0.295
0.721TrpPhe: 0.721 ± 0.226
1.297TrpGly: 1.297 ± 0.336
0.505TrpHis: 0.505 ± 0.192
1.081TrpIle: 1.081 ± 0.29
0.288TrpLys: 0.288 ± 0.117
2.018TrpLeu: 2.018 ± 0.434
0.649TrpMet: 0.649 ± 0.247
0.721TrpAsn: 0.721 ± 0.228
1.442TrpPro: 1.442 ± 0.36
0.793TrpGln: 0.793 ± 0.181
2.018TrpArg: 2.018 ± 0.284
1.225TrpSer: 1.225 ± 0.327
1.009TrpThr: 1.009 ± 0.345
1.225TrpVal: 1.225 ± 0.296
0.505TrpTrp: 0.505 ± 0.167
0.144TrpTyr: 0.144 ± 0.13
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.379TyrAla: 2.379 ± 0.366
0.216TyrCys: 0.216 ± 0.153
1.514TyrAsp: 1.514 ± 0.322
1.514TyrGlu: 1.514 ± 0.281
0.432TyrPhe: 0.432 ± 0.178
1.658TyrGly: 1.658 ± 0.356
0.721TyrHis: 0.721 ± 0.259
1.081TyrIle: 1.081 ± 0.316
0.432TyrLys: 0.432 ± 0.228
1.37TyrLeu: 1.37 ± 0.354
0.288TyrMet: 0.288 ± 0.165
0.505TyrAsn: 0.505 ± 0.189
1.081TyrPro: 1.081 ± 0.265
0.865TyrGln: 0.865 ± 0.251
2.162TyrArg: 2.162 ± 0.428
1.442TyrSer: 1.442 ± 0.404
1.586TyrThr: 1.586 ± 0.345
1.442TyrVal: 1.442 ± 0.252
0.288TyrTrp: 0.288 ± 0.159
0.144TyrTyr: 0.144 ± 0.105
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 60 proteins (13874 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski