Amino acid dipepetide frequency for Denitratisoma sp. DHT3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.215AlaAla: 17.215 ± 0.202
1.265AlaCys: 1.265 ± 0.038
6.892AlaAsp: 6.892 ± 0.088
7.594AlaGlu: 7.594 ± 0.091
3.7AlaPhe: 3.7 ± 0.056
10.595AlaGly: 10.595 ± 0.141
2.419AlaHis: 2.419 ± 0.049
5.346AlaIle: 5.346 ± 0.078
3.759AlaLys: 3.759 ± 0.076
13.962AlaLeu: 13.962 ± 0.157
3.191AlaMet: 3.191 ± 0.063
2.959AlaAsn: 2.959 ± 0.065
5.525AlaPro: 5.525 ± 0.095
4.614AlaGln: 4.614 ± 0.067
9.096AlaArg: 9.096 ± 0.116
5.694AlaSer: 5.694 ± 0.085
5.708AlaThr: 5.708 ± 0.105
8.366AlaVal: 8.366 ± 0.105
1.66AlaTrp: 1.66 ± 0.042
2.525AlaTyr: 2.525 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.182CysAla: 1.182 ± 0.039
0.146CysCys: 0.146 ± 0.013
0.585CysAsp: 0.585 ± 0.024
0.525CysGlu: 0.525 ± 0.025
0.329CysPhe: 0.329 ± 0.017
1.078CysGly: 1.078 ± 0.04
0.368CysHis: 0.368 ± 0.021
0.395CysIle: 0.395 ± 0.023
0.257CysLys: 0.257 ± 0.016
0.98CysLeu: 0.98 ± 0.03
0.203CysMet: 0.203 ± 0.014
0.31CysAsn: 0.31 ± 0.019
0.639CysPro: 0.639 ± 0.026
0.318CysGln: 0.318 ± 0.019
0.793CysArg: 0.793 ± 0.028
0.487CysSer: 0.487 ± 0.022
0.491CysThr: 0.491 ± 0.031
0.676CysVal: 0.676 ± 0.019
0.147CysTrp: 0.147 ± 0.013
0.273CysTyr: 0.273 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
6.593AspAla: 6.593 ± 0.088
0.54AspCys: 0.54 ± 0.022
2.903AspAsp: 2.903 ± 0.068
3.404AspGlu: 3.404 ± 0.066
2.226AspPhe: 2.226 ± 0.05
4.787AspGly: 4.787 ± 0.08
1.196AspHis: 1.196 ± 0.03
2.805AspIle: 2.805 ± 0.054
1.887AspLys: 1.887 ± 0.049
5.746AspLeu: 5.746 ± 0.087
1.214AspMet: 1.214 ± 0.032
1.308AspAsn: 1.308 ± 0.034
2.992AspPro: 2.992 ± 0.053
1.838AspGln: 1.838 ± 0.044
3.587AspArg: 3.587 ± 0.06
2.422AspSer: 2.422 ± 0.059
2.494AspThr: 2.494 ± 0.066
3.732AspVal: 3.732 ± 0.061
0.992AspTrp: 0.992 ± 0.037
1.686AspTyr: 1.686 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
7.312GluAla: 7.312 ± 0.097
0.521GluCys: 0.521 ± 0.022
2.644GluAsp: 2.644 ± 0.055
3.267GluGlu: 3.267 ± 0.063
2.063GluPhe: 2.063 ± 0.045
4.052GluGly: 4.052 ± 0.065
1.309GluHis: 1.309 ± 0.037
3.319GluIle: 3.319 ± 0.07
2.343GluLys: 2.343 ± 0.064
6.226GluLeu: 6.226 ± 0.08
1.502GluMet: 1.502 ± 0.043
1.559GluAsn: 1.559 ± 0.038
2.363GluPro: 2.363 ± 0.052
2.641GluGln: 2.641 ± 0.051
5.026GluArg: 5.026 ± 0.073
2.865GluSer: 2.865 ± 0.054
3.065GluThr: 3.065 ± 0.06
4.193GluVal: 4.193 ± 0.075
0.755GluTrp: 0.755 ± 0.028
1.259GluTyr: 1.259 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.982PheAla: 3.982 ± 0.064
0.395PheCys: 0.395 ± 0.017
2.433PheAsp: 2.433 ± 0.048
2.115PheGlu: 2.115 ± 0.049
1.356PhePhe: 1.356 ± 0.038
3.307PheGly: 3.307 ± 0.059
0.872PheHis: 0.872 ± 0.031
1.596PheIle: 1.596 ± 0.037
1.177PheLys: 1.177 ± 0.041
3.252PheLeu: 3.252 ± 0.059
0.758PheMet: 0.758 ± 0.027
1.165PheAsn: 1.165 ± 0.035
1.624PhePro: 1.624 ± 0.039
1.113PheGln: 1.113 ± 0.031
2.119PheArg: 2.119 ± 0.044
2.241PheSer: 2.241 ± 0.045
1.721PheThr: 1.721 ± 0.049
2.555PheVal: 2.555 ± 0.049
0.513PheTrp: 0.513 ± 0.025
0.889PheTyr: 0.889 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
8.819GlyAla: 8.819 ± 0.12
1.063GlyCys: 1.063 ± 0.038
4.233GlyAsp: 4.233 ± 0.078
4.795GlyGlu: 4.795 ± 0.079
3.346GlyPhe: 3.346 ± 0.056
7.56GlyGly: 7.56 ± 0.122
2.052GlyHis: 2.052 ± 0.046
4.49GlyIle: 4.49 ± 0.071
3.579GlyLys: 3.579 ± 0.067
8.751GlyLeu: 8.751 ± 0.113
2.342GlyMet: 2.342 ± 0.049
2.492GlyAsn: 2.492 ± 0.074
2.814GlyPro: 2.814 ± 0.056
3.147GlyGln: 3.147 ± 0.06
6.287GlyArg: 6.287 ± 0.083
4.435GlySer: 4.435 ± 0.078
4.133GlyThr: 4.133 ± 0.08
6.034GlyVal: 6.034 ± 0.089
1.346GlyTrp: 1.346 ± 0.039
2.437GlyTyr: 2.437 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.472HisAla: 2.472 ± 0.05
0.327HisCys: 0.327 ± 0.018
1.193HisAsp: 1.193 ± 0.034
1.211HisGlu: 1.211 ± 0.032
0.978HisPhe: 0.978 ± 0.028
2.223HisGly: 2.223 ± 0.049
0.721HisHis: 0.721 ± 0.031
0.913HisIle: 0.913 ± 0.034
0.575HisLys: 0.575 ± 0.027
2.542HisLeu: 2.542 ± 0.049
0.469HisMet: 0.469 ± 0.021
0.508HisAsn: 0.508 ± 0.021
1.567HisPro: 1.567 ± 0.041
0.83HisGln: 0.83 ± 0.027
1.672HisArg: 1.672 ± 0.039
1.047HisSer: 1.047 ± 0.034
0.923HisThr: 0.923 ± 0.029
1.497HisVal: 1.497 ± 0.037
0.357HisTrp: 0.357 ± 0.018
0.692HisTyr: 0.692 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.971IleAla: 5.971 ± 0.086
0.528IleCys: 0.528 ± 0.023
3.198IleAsp: 3.198 ± 0.057
3.272IleGlu: 3.272 ± 0.062
1.448IlePhe: 1.448 ± 0.043
4.417IleGly: 4.417 ± 0.073
1.173IleHis: 1.173 ± 0.035
1.668IleIle: 1.668 ± 0.042
1.617IleLys: 1.617 ± 0.046
4.157IleLeu: 4.157 ± 0.068
0.824IleMet: 0.824 ± 0.028
1.589IleAsn: 1.589 ± 0.046
2.337IlePro: 2.337 ± 0.045
1.581IleGln: 1.581 ± 0.039
3.186IleArg: 3.186 ± 0.049
2.594IleSer: 2.594 ± 0.053
2.479IleThr: 2.479 ± 0.05
3.488IleVal: 3.488 ± 0.06
0.447IleTrp: 0.447 ± 0.021
1.089IleTyr: 1.089 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.996LysAla: 3.996 ± 0.07
0.212LysCys: 0.212 ± 0.016
1.727LysAsp: 1.727 ± 0.045
1.879LysGlu: 1.879 ± 0.05
1.016LysPhe: 1.016 ± 0.034
2.594LysGly: 2.594 ± 0.058
0.641LysHis: 0.641 ± 0.024
1.73LysIle: 1.73 ± 0.043
1.501LysLys: 1.501 ± 0.054
3.563LysLeu: 3.563 ± 0.063
0.865LysMet: 0.865 ± 0.032
1.079LysAsn: 1.079 ± 0.033
2.129LysPro: 2.129 ± 0.058
1.362LysGln: 1.362 ± 0.04
2.279LysArg: 2.279 ± 0.049
1.927LysSer: 1.927 ± 0.047
1.914LysThr: 1.914 ± 0.043
2.582LysVal: 2.582 ± 0.059
0.387LysTrp: 0.387 ± 0.021
0.806LysTyr: 0.806 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
15.156LeuAla: 15.156 ± 0.174
1.115LeuCys: 1.115 ± 0.031
6.28LeuAsp: 6.28 ± 0.079
6.112LeuGlu: 6.112 ± 0.091
3.559LeuPhe: 3.559 ± 0.073
8.704LeuGly: 8.704 ± 0.109
2.25LeuHis: 2.25 ± 0.05
4.638LeuIle: 4.638 ± 0.073
3.901LeuLys: 3.901 ± 0.073
11.674LeuLeu: 11.674 ± 0.159
2.342LeuMet: 2.342 ± 0.049
2.883LeuAsn: 2.883 ± 0.054
6.287LeuPro: 6.287 ± 0.096
3.447LeuGln: 3.447 ± 0.054
7.935LeuArg: 7.935 ± 0.098
6.132LeuSer: 6.132 ± 0.083
5.558LeuThr: 5.558 ± 0.094
7.188LeuVal: 7.188 ± 0.106
1.242LeuTrp: 1.242 ± 0.04
2.121LeuTyr: 2.121 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.05MetAla: 3.05 ± 0.063
0.155MetCys: 0.155 ± 0.012
1.257MetAsp: 1.257 ± 0.031
1.278MetGlu: 1.278 ± 0.037
0.687MetPhe: 0.687 ± 0.024
1.86MetGly: 1.86 ± 0.047
0.467MetHis: 0.467 ± 0.022
1.044MetIle: 1.044 ± 0.037
1.112MetLys: 1.112 ± 0.032
2.394MetLeu: 2.394 ± 0.05
0.619MetMet: 0.619 ± 0.029
0.864MetAsn: 0.864 ± 0.023
1.405MetPro: 1.405 ± 0.038
0.863MetGln: 0.863 ± 0.03
1.567MetArg: 1.567 ± 0.038
1.564MetSer: 1.564 ± 0.035
1.451MetThr: 1.451 ± 0.04
1.633MetVal: 1.633 ± 0.041
0.197MetTrp: 0.197 ± 0.014
0.399MetTyr: 0.399 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.223AsnAla: 3.223 ± 0.071
0.294AsnCys: 0.294 ± 0.017
1.46AsnAsp: 1.46 ± 0.049
1.301AsnGlu: 1.301 ± 0.04
1.018AsnPhe: 1.018 ± 0.036
2.313AsnGly: 2.313 ± 0.058
0.608AsnHis: 0.608 ± 0.023
1.377AsnIle: 1.377 ± 0.039
0.834AsnLys: 0.834 ± 0.033
3.083AsnLeu: 3.083 ± 0.057
0.622AsnMet: 0.622 ± 0.021
0.786AsnAsn: 0.786 ± 0.031
2.027AsnPro: 2.027 ± 0.045
1.024AsnGln: 1.024 ± 0.034
1.909AsnArg: 1.909 ± 0.044
1.251AsnSer: 1.251 ± 0.041
1.456AsnThr: 1.456 ± 0.05
1.953AsnVal: 1.953 ± 0.044
0.401AsnTrp: 0.401 ± 0.023
0.74AsnTyr: 0.74 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.482ProAla: 6.482 ± 0.099
0.443ProCys: 0.443 ± 0.021
3.137ProAsp: 3.137 ± 0.056
3.671ProGlu: 3.671 ± 0.059
1.76ProPhe: 1.76 ± 0.037
4.583ProGly: 4.583 ± 0.076
1.094ProHis: 1.094 ± 0.033
2.05ProIle: 2.05 ± 0.045
1.527ProLys: 1.527 ± 0.041
5.465ProLeu: 5.465 ± 0.085
1.235ProMet: 1.235 ± 0.033
1.265ProAsn: 1.265 ± 0.036
2.953ProPro: 2.953 ± 0.056
1.853ProGln: 1.853 ± 0.041
3.278ProArg: 3.278 ± 0.063
2.443ProSer: 2.443 ± 0.05
2.366ProThr: 2.366 ± 0.053
3.95ProVal: 3.95 ± 0.069
0.696ProTrp: 0.696 ± 0.033
1.206ProTyr: 1.206 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.985GlnAla: 4.985 ± 0.08
0.3GlnCys: 0.3 ± 0.017
1.624GlnAsp: 1.624 ± 0.039
1.981GlnGlu: 1.981 ± 0.047
1.185GlnPhe: 1.185 ± 0.033
3.062GlnGly: 3.062 ± 0.055
0.838GlnHis: 0.838 ± 0.026
1.754GlnIle: 1.754 ± 0.046
1.319GlnLys: 1.319 ± 0.042
3.846GlnLeu: 3.846 ± 0.069
0.967GlnMet: 0.967 ± 0.03
0.852GlnAsn: 0.852 ± 0.03
1.893GlnPro: 1.893 ± 0.048
1.626GlnGln: 1.626 ± 0.048
3.066GlnArg: 3.066 ± 0.058
1.856GlnSer: 1.856 ± 0.049
1.727GlnThr: 1.727 ± 0.041
2.822GlnVal: 2.822 ± 0.056
0.562GlnTrp: 0.562 ± 0.024
0.787GlnTyr: 0.787 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
7.27ArgAla: 7.27 ± 0.09
0.685ArgCys: 0.685 ± 0.027
3.753ArgAsp: 3.753 ± 0.065
4.658ArgGlu: 4.658 ± 0.08
2.925ArgPhe: 2.925 ± 0.058
4.726ArgGly: 4.726 ± 0.062
2.19ArgHis: 2.19 ± 0.049
4.132ArgIle: 4.132 ± 0.057
2.253ArgLys: 2.253 ± 0.049
8.938ArgLeu: 8.938 ± 0.104
1.898ArgMet: 1.898 ± 0.04
2.151ArgAsn: 2.151 ± 0.048
3.454ArgPro: 3.454 ± 0.064
3.452ArgGln: 3.452 ± 0.058
5.989ArgArg: 5.989 ± 0.096
3.208ArgSer: 3.208 ± 0.054
3.237ArgThr: 3.237 ± 0.054
4.831ArgVal: 4.831 ± 0.073
1.175ArgTrp: 1.175 ± 0.035
2.15ArgTyr: 2.15 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.851SerAla: 5.851 ± 0.091
0.53SerCys: 0.53 ± 0.026
2.464SerAsp: 2.464 ± 0.049
2.508SerGlu: 2.508 ± 0.059
1.903SerPhe: 1.903 ± 0.044
5.277SerGly: 5.277 ± 0.086
1.169SerHis: 1.169 ± 0.031
2.504SerIle: 2.504 ± 0.053
1.566SerLys: 1.566 ± 0.047
5.633SerLeu: 5.633 ± 0.081
1.257SerMet: 1.257 ± 0.035
1.448SerAsn: 1.448 ± 0.047
2.847SerPro: 2.847 ± 0.054
1.824SerGln: 1.824 ± 0.043
3.744SerArg: 3.744 ± 0.062
2.976SerSer: 2.976 ± 0.073
2.531SerThr: 2.531 ± 0.052
3.603SerVal: 3.603 ± 0.065
0.702SerTrp: 0.702 ± 0.026
1.301SerTyr: 1.301 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
5.663ThrAla: 5.663 ± 0.098
0.425ThrCys: 0.425 ± 0.021
2.485ThrAsp: 2.485 ± 0.054
2.471ThrGlu: 2.471 ± 0.054
1.639ThrPhe: 1.639 ± 0.043
4.652ThrGly: 4.652 ± 0.1
1.069ThrHis: 1.069 ± 0.034
2.246ThrIle: 2.246 ± 0.062
1.268ThrLys: 1.268 ± 0.04
6.344ThrLeu: 6.344 ± 0.088
1.054ThrMet: 1.054 ± 0.033
1.24ThrAsn: 1.24 ± 0.047
3.235ThrPro: 3.235 ± 0.059
1.707ThrGln: 1.707 ± 0.041
3.251ThrArg: 3.251 ± 0.055
2.473ThrSer: 2.473 ± 0.066
2.681ThrThr: 2.681 ± 0.09
3.909ThrVal: 3.909 ± 0.068
0.652ThrTrp: 0.652 ± 0.026
1.097ThrTyr: 1.097 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
9.077ValAla: 9.077 ± 0.107
0.757ValCys: 0.757 ± 0.025
4.115ValAsp: 4.115 ± 0.067
4.365ValGlu: 4.365 ± 0.075
2.585ValPhe: 2.585 ± 0.056
5.361ValGly: 5.361 ± 0.088
1.371ValHis: 1.371 ± 0.034
3.548ValIle: 3.548 ± 0.066
2.523ValLys: 2.523 ± 0.048
7.347ValLeu: 7.347 ± 0.111
1.753ValMet: 1.753 ± 0.043
2.172ValAsn: 2.172 ± 0.055
3.516ValPro: 3.516 ± 0.064
2.08ValGln: 2.08 ± 0.041
4.878ValArg: 4.878 ± 0.073
3.981ValSer: 3.981 ± 0.056
3.915ValThr: 3.915 ± 0.082
5.787ValVal: 5.787 ± 0.104
0.822ValTrp: 0.822 ± 0.03
1.416ValTyr: 1.416 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.191TrpAla: 1.191 ± 0.039
0.154TrpCys: 0.154 ± 0.012
0.629TrpAsp: 0.629 ± 0.025
0.671TrpGlu: 0.671 ± 0.025
0.486TrpPhe: 0.486 ± 0.022
0.903TrpGly: 0.903 ± 0.027
0.364TrpHis: 0.364 ± 0.018
0.647TrpIle: 0.647 ± 0.029
0.512TrpLys: 0.512 ± 0.023
1.906TrpLeu: 1.906 ± 0.05
0.317TrpMet: 0.317 ± 0.018
0.408TrpAsn: 0.408 ± 0.023
0.615TrpPro: 0.615 ± 0.023
0.722TrpGln: 0.722 ± 0.026
1.296TrpArg: 1.296 ± 0.044
0.783TrpSer: 0.783 ± 0.031
0.581TrpThr: 0.581 ± 0.025
0.915TrpVal: 0.915 ± 0.038
0.24TrpTrp: 0.24 ± 0.017
0.333TrpTyr: 0.333 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.592TyrAla: 2.592 ± 0.053
0.326TyrCys: 0.326 ± 0.019
1.339TyrAsp: 1.339 ± 0.035
1.203TyrGlu: 1.203 ± 0.036
0.976TyrPhe: 0.976 ± 0.027
2.101TyrGly: 2.101 ± 0.045
0.547TyrHis: 0.547 ± 0.021
0.861TyrIle: 0.861 ± 0.028
0.677TyrLys: 0.677 ± 0.027
2.717TyrLeu: 2.717 ± 0.055
0.437TyrMet: 0.437 ± 0.019
0.645TyrAsn: 0.645 ± 0.028
1.234TyrPro: 1.234 ± 0.035
1.011TyrGln: 1.011 ± 0.03
2.115TyrArg: 2.115 ± 0.048
1.261TyrSer: 1.261 ± 0.034
1.13TyrThr: 1.13 ± 0.036
1.656TyrVal: 1.656 ± 0.039
0.379TyrTrp: 0.379 ± 0.019
0.696TyrTyr: 0.696 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3216 proteins (1081138 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski