Amino acid dipepetide frequency for Osedax symbiont Rs2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.516AlaAla: 9.516 ± 0.137
1.075AlaCys: 1.075 ± 0.031
5.343AlaAsp: 5.343 ± 0.092
5.101AlaGlu: 5.101 ± 0.076
3.349AlaPhe: 3.349 ± 0.063
6.351AlaGly: 6.351 ± 0.087
1.571AlaHis: 1.571 ± 0.04
6.513AlaIle: 6.513 ± 0.081
5.15AlaLys: 5.15 ± 0.072
10.306AlaLeu: 10.306 ± 0.103
2.626AlaMet: 2.626 ± 0.05
3.762AlaAsn: 3.762 ± 0.077
2.696AlaPro: 2.696 ± 0.05
4.795AlaGln: 4.795 ± 0.067
3.652AlaArg: 3.652 ± 0.065
5.871AlaSer: 5.871 ± 0.075
4.705AlaThr: 4.705 ± 0.076
6.406AlaVal: 6.406 ± 0.081
0.866AlaTrp: 0.866 ± 0.028
2.156AlaTyr: 2.156 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.134CysAla: 1.134 ± 0.034
0.221CysCys: 0.221 ± 0.013
0.7CysAsp: 0.7 ± 0.024
0.603CysGlu: 0.603 ± 0.022
0.544CysPhe: 0.544 ± 0.021
0.897CysGly: 0.897 ± 0.03
0.328CysHis: 0.328 ± 0.015
0.789CysIle: 0.789 ± 0.027
0.524CysLys: 0.524 ± 0.021
1.156CysLeu: 1.156 ± 0.034
0.242CysMet: 0.242 ± 0.015
0.478CysAsn: 0.478 ± 0.019
0.47CysPro: 0.47 ± 0.022
0.571CysGln: 0.571 ± 0.022
0.536CysArg: 0.536 ± 0.022
0.926CysSer: 0.926 ± 0.03
0.539CysThr: 0.539 ± 0.022
0.686CysVal: 0.686 ± 0.021
0.175CysTrp: 0.175 ± 0.012
0.417CysTyr: 0.417 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.16AspAla: 4.16 ± 0.081
0.664AspCys: 0.664 ± 0.023
2.655AspAsp: 2.655 ± 0.054
2.947AspGlu: 2.947 ± 0.058
2.398AspPhe: 2.398 ± 0.049
3.111AspGly: 3.111 ± 0.06
0.992AspHis: 0.992 ± 0.028
4.054AspIle: 4.054 ± 0.062
3.08AspLys: 3.08 ± 0.057
5.512AspLeu: 5.512 ± 0.078
1.328AspMet: 1.328 ± 0.033
2.524AspAsn: 2.524 ± 0.047
2.221AspPro: 2.221 ± 0.041
2.559AspGln: 2.559 ± 0.043
2.222AspArg: 2.222 ± 0.041
3.786AspSer: 3.786 ± 0.062
2.55AspThr: 2.55 ± 0.06
3.233AspVal: 3.233 ± 0.059
0.723AspTrp: 0.723 ± 0.023
2.022AspTyr: 2.022 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
4.261GluAla: 4.261 ± 0.078
0.431GluCys: 0.431 ± 0.017
2.386GluAsp: 2.386 ± 0.051
2.654GluGlu: 2.654 ± 0.055
2.166GluPhe: 2.166 ± 0.049
2.895GluGly: 2.895 ± 0.047
1.409GluHis: 1.409 ± 0.035
4.058GluIle: 4.058 ± 0.065
3.197GluLys: 3.197 ± 0.063
6.345GluLeu: 6.345 ± 0.078
1.43GluMet: 1.43 ± 0.031
2.417GluAsn: 2.417 ± 0.04
1.674GluPro: 1.674 ± 0.037
4.149GluGln: 4.149 ± 0.071
2.71GluArg: 2.71 ± 0.056
3.186GluSer: 3.186 ± 0.053
2.608GluThr: 2.608 ± 0.048
3.542GluVal: 3.542 ± 0.057
0.424GluTrp: 0.424 ± 0.02
1.542GluTyr: 1.542 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.707PheAla: 3.707 ± 0.051
0.666PheCys: 0.666 ± 0.024
2.471PheAsp: 2.471 ± 0.043
2.129PheGlu: 2.129 ± 0.036
1.849PhePhe: 1.849 ± 0.043
2.714PheGly: 2.714 ± 0.055
0.725PheHis: 0.725 ± 0.026
2.928PheIle: 2.928 ± 0.056
2.132PheLys: 2.132 ± 0.038
3.544PheLeu: 3.544 ± 0.071
0.941PheMet: 0.941 ± 0.026
2.059PheAsn: 2.059 ± 0.043
1.352PhePro: 1.352 ± 0.034
1.327PheGln: 1.327 ± 0.029
1.41PheArg: 1.41 ± 0.035
4.029PheSer: 4.029 ± 0.073
1.968PheThr: 1.968 ± 0.048
2.764PheVal: 2.764 ± 0.047
0.483PheTrp: 0.483 ± 0.023
1.359PheTyr: 1.359 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.565GlyAla: 5.565 ± 0.079
0.936GlyCys: 0.936 ± 0.028
3.38GlyAsp: 3.38 ± 0.054
3.746GlyGlu: 3.746 ± 0.065
3.165GlyPhe: 3.165 ± 0.05
4.636GlyGly: 4.636 ± 0.074
1.376GlyHis: 1.376 ± 0.032
4.755GlyIle: 4.755 ± 0.064
3.602GlyLys: 3.602 ± 0.057
7.015GlyLeu: 7.015 ± 0.09
1.931GlyMet: 1.931 ± 0.037
2.399GlyAsn: 2.399 ± 0.052
1.777GlyPro: 1.777 ± 0.045
2.786GlyGln: 2.786 ± 0.047
2.982GlyArg: 2.982 ± 0.056
4.34GlySer: 4.34 ± 0.071
3.16GlyThr: 3.16 ± 0.063
4.851GlyVal: 4.851 ± 0.073
0.893GlyTrp: 0.893 ± 0.033
2.393GlyTyr: 2.393 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.451HisAla: 1.451 ± 0.037
0.433HisCys: 0.433 ± 0.022
0.878HisAsp: 0.878 ± 0.028
0.789HisGlu: 0.789 ± 0.027
1.075HisPhe: 1.075 ± 0.029
1.261HisGly: 1.261 ± 0.032
0.521HisHis: 0.521 ± 0.023
1.295HisIle: 1.295 ± 0.031
1.067HisLys: 1.067 ± 0.027
2.338HisLeu: 2.338 ± 0.044
0.515HisMet: 0.515 ± 0.018
0.902HisAsn: 0.902 ± 0.027
1.094HisPro: 1.094 ± 0.029
1.177HisGln: 1.177 ± 0.033
1.087HisArg: 1.087 ± 0.033
1.747HisSer: 1.747 ± 0.041
0.854HisThr: 0.854 ± 0.026
0.964HisVal: 0.964 ± 0.03
0.374HisTrp: 0.374 ± 0.018
0.784HisTyr: 0.784 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.214IleAla: 7.214 ± 0.081
0.969IleCys: 0.969 ± 0.028
4.645IleAsp: 4.645 ± 0.075
4.761IleGlu: 4.761 ± 0.065
2.593IlePhe: 2.593 ± 0.057
4.864IleGly: 4.864 ± 0.069
1.194IleHis: 1.194 ± 0.03
4.485IleIle: 4.485 ± 0.074
3.549IleLys: 3.549 ± 0.051
6.024IleLeu: 6.024 ± 0.087
1.369IleMet: 1.369 ± 0.038
3.331IleAsn: 3.331 ± 0.056
2.565IlePro: 2.565 ± 0.053
2.434IleGln: 2.434 ± 0.047
2.837IleArg: 2.837 ± 0.045
5.695IleSer: 5.695 ± 0.068
3.691IleThr: 3.691 ± 0.066
4.342IleVal: 4.342 ± 0.066
0.643IleTrp: 0.643 ± 0.024
1.957IleTyr: 1.957 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
4.4LysAla: 4.4 ± 0.077
0.354LysCys: 0.354 ± 0.015
2.318LysAsp: 2.318 ± 0.048
2.509LysGlu: 2.509 ± 0.046
1.776LysPhe: 1.776 ± 0.038
2.998LysGly: 2.998 ± 0.051
1.099LysHis: 1.099 ± 0.03
3.951LysIle: 3.951 ± 0.067
3.079LysLys: 3.079 ± 0.065
6.066LysLeu: 6.066 ± 0.08
1.512LysMet: 1.512 ± 0.033
2.374LysAsn: 2.374 ± 0.048
1.909LysPro: 1.909 ± 0.045
2.778LysGln: 2.778 ± 0.053
2.483LysArg: 2.483 ± 0.045
3.471LysSer: 3.471 ± 0.058
2.752LysThr: 2.752 ± 0.046
3.881LysVal: 3.881 ± 0.055
0.499LysTrp: 0.499 ± 0.022
1.504LysTyr: 1.504 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
10.899LeuAla: 10.899 ± 0.108
1.303LeuCys: 1.303 ± 0.033
5.699LeuAsp: 5.699 ± 0.076
5.879LeuGlu: 5.879 ± 0.075
4.272LeuPhe: 4.272 ± 0.077
7.0LeuGly: 7.0 ± 0.08
2.115LeuHis: 2.115 ± 0.05
7.266LeuIle: 7.266 ± 0.099
5.766LeuLys: 5.766 ± 0.078
12.808LeuLeu: 12.808 ± 0.15
2.767LeuMet: 2.767 ± 0.052
4.596LeuAsn: 4.596 ± 0.067
4.508LeuPro: 4.508 ± 0.063
6.071LeuGln: 6.071 ± 0.085
4.548LeuArg: 4.548 ± 0.065
8.912LeuSer: 8.912 ± 0.09
5.308LeuThr: 5.308 ± 0.069
6.955LeuVal: 6.955 ± 0.078
1.105LeuTrp: 1.105 ± 0.028
2.765LeuTyr: 2.765 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.439MetAla: 2.439 ± 0.045
0.222MetCys: 0.222 ± 0.014
1.164MetAsp: 1.164 ± 0.028
1.003MetGlu: 1.003 ± 0.028
0.969MetPhe: 0.969 ± 0.03
1.735MetGly: 1.735 ± 0.042
0.61MetHis: 0.61 ± 0.024
1.649MetIle: 1.649 ± 0.038
1.231MetLys: 1.231 ± 0.031
3.145MetLeu: 3.145 ± 0.053
0.707MetMet: 0.707 ± 0.025
1.003MetAsn: 1.003 ± 0.027
1.21MetPro: 1.21 ± 0.034
1.698MetGln: 1.698 ± 0.036
1.248MetArg: 1.248 ± 0.034
2.087MetSer: 2.087 ± 0.043
1.358MetThr: 1.358 ± 0.033
1.505MetVal: 1.505 ± 0.036
0.177MetTrp: 0.177 ± 0.012
0.5MetTyr: 0.5 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.451AsnAla: 3.451 ± 0.073
0.583AsnCys: 0.583 ± 0.02
1.929AsnAsp: 1.929 ± 0.041
1.649AsnGlu: 1.649 ± 0.038
1.705AsnPhe: 1.705 ± 0.041
2.541AsnGly: 2.541 ± 0.061
0.856AsnHis: 0.856 ± 0.026
3.238AsnIle: 3.238 ± 0.062
2.266AsnLys: 2.266 ± 0.046
4.394AsnLeu: 4.394 ± 0.065
1.029AsnMet: 1.029 ± 0.028
2.117AsnAsn: 2.117 ± 0.051
1.989AsnPro: 1.989 ± 0.042
2.042AsnGln: 2.042 ± 0.038
2.054AsnArg: 2.054 ± 0.048
3.32AsnSer: 3.32 ± 0.065
2.287AsnThr: 2.287 ± 0.054
2.253AsnVal: 2.253 ± 0.05
0.644AsnTrp: 0.644 ± 0.024
1.425AsnTyr: 1.425 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
3.271ProAla: 3.271 ± 0.06
0.392ProCys: 0.392 ± 0.02
2.02ProAsp: 2.02 ± 0.039
2.426ProGlu: 2.426 ± 0.053
1.579ProPhe: 1.579 ± 0.035
2.602ProGly: 2.602 ± 0.052
0.753ProHis: 0.753 ± 0.025
2.354ProIle: 2.354 ± 0.048
1.912ProLys: 1.912 ± 0.036
4.255ProLeu: 4.255 ± 0.064
0.949ProMet: 0.949 ± 0.031
1.388ProAsn: 1.388 ± 0.032
1.112ProPro: 1.112 ± 0.037
1.911ProGln: 1.911 ± 0.042
1.298ProArg: 1.298 ± 0.036
2.501ProSer: 2.501 ± 0.041
1.743ProThr: 1.743 ± 0.038
2.852ProVal: 2.852 ± 0.047
0.515ProTrp: 0.515 ± 0.021
1.05ProTyr: 1.05 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
4.606GlnAla: 4.606 ± 0.064
0.517GlnCys: 0.517 ± 0.022
1.906GlnAsp: 1.906 ± 0.046
2.052GlnGlu: 2.052 ± 0.046
1.739GlnPhe: 1.739 ± 0.046
3.465GlnGly: 3.465 ± 0.055
1.385GlnHis: 1.385 ± 0.033
3.346GlnIle: 3.346 ± 0.052
2.318GlnLys: 2.318 ± 0.044
7.426GlnLeu: 7.426 ± 0.1
1.477GlnMet: 1.477 ± 0.032
1.636GlnAsn: 1.636 ± 0.03
1.921GlnPro: 1.921 ± 0.038
5.43GlnGln: 5.43 ± 0.11
2.988GlnArg: 2.988 ± 0.055
3.587GlnSer: 3.587 ± 0.062
2.087GlnThr: 2.087 ± 0.044
3.399GlnVal: 3.399 ± 0.062
0.847GlnTrp: 0.847 ± 0.026
1.578GlnTyr: 1.578 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
3.871ArgAla: 3.871 ± 0.058
0.528ArgCys: 0.528 ± 0.02
2.395ArgAsp: 2.395 ± 0.043
2.768ArgGlu: 2.768 ± 0.05
1.87ArgPhe: 1.87 ± 0.045
2.743ArgGly: 2.743 ± 0.047
1.046ArgHis: 1.046 ± 0.032
3.099ArgIle: 3.099 ± 0.047
2.211ArgLys: 2.211 ± 0.041
4.762ArgLeu: 4.762 ± 0.071
1.14ArgMet: 1.14 ± 0.032
1.772ArgAsn: 1.772 ± 0.034
1.525ArgPro: 1.525 ± 0.037
2.577ArgGln: 2.577 ± 0.051
2.26ArgArg: 2.26 ± 0.045
3.01ArgSer: 3.01 ± 0.056
1.956ArgThr: 1.956 ± 0.045
2.736ArgVal: 2.736 ± 0.051
0.556ArgTrp: 0.556 ± 0.024
1.551ArgTyr: 1.551 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.995SerAla: 6.995 ± 0.084
0.872SerCys: 0.872 ± 0.03
3.89SerAsp: 3.89 ± 0.052
3.947SerGlu: 3.947 ± 0.059
3.189SerPhe: 3.189 ± 0.05
5.497SerGly: 5.497 ± 0.066
1.492SerHis: 1.492 ± 0.033
5.05SerIle: 5.05 ± 0.067
3.44SerLys: 3.44 ± 0.054
7.785SerLeu: 7.785 ± 0.09
1.87SerMet: 1.87 ± 0.042
2.892SerAsn: 2.892 ± 0.057
2.397SerPro: 2.397 ± 0.042
3.358SerGln: 3.358 ± 0.062
3.218SerArg: 3.218 ± 0.047
5.534SerSer: 5.534 ± 0.09
3.53SerThr: 3.53 ± 0.053
5.006SerVal: 5.006 ± 0.067
0.872SerTrp: 0.872 ± 0.025
2.349SerTyr: 2.349 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
5.102ThrAla: 5.102 ± 0.079
0.418ThrCys: 0.418 ± 0.02
3.011ThrAsp: 3.011 ± 0.065
2.99ThrGlu: 2.99 ± 0.051
1.768ThrPhe: 1.768 ± 0.045
3.766ThrGly: 3.766 ± 0.072
0.966ThrHis: 0.966 ± 0.028
3.001ThrIle: 3.001 ± 0.06
2.232ThrLys: 2.232 ± 0.044
5.539ThrLeu: 5.539 ± 0.073
1.1ThrMet: 1.1 ± 0.03
1.828ThrAsn: 1.828 ± 0.044
2.294ThrPro: 2.294 ± 0.044
2.364ThrGln: 2.364 ± 0.048
1.829ThrArg: 1.829 ± 0.042
3.219ThrSer: 3.219 ± 0.06
2.59ThrThr: 2.59 ± 0.05
3.611ThrVal: 3.611 ± 0.068
0.47ThrTrp: 0.47 ± 0.02
1.152ThrTyr: 1.152 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
6.642ValAla: 6.642 ± 0.084
0.794ValCys: 0.794 ± 0.024
3.921ValAsp: 3.921 ± 0.071
3.929ValGlu: 3.929 ± 0.057
2.652ValPhe: 2.652 ± 0.053
4.066ValGly: 4.066 ± 0.068
1.202ValHis: 1.202 ± 0.034
4.926ValIle: 4.926 ± 0.066
3.144ValLys: 3.144 ± 0.056
6.883ValLeu: 6.883 ± 0.071
1.773ValMet: 1.773 ± 0.04
2.769ValAsn: 2.769 ± 0.053
2.307ValPro: 2.307 ± 0.045
2.684ValGln: 2.684 ± 0.051
2.662ValArg: 2.662 ± 0.051
4.834ValSer: 4.834 ± 0.054
3.749ValThr: 3.749 ± 0.072
4.631ValVal: 4.631 ± 0.067
0.627ValTrp: 0.627 ± 0.023
1.701ValTyr: 1.701 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.774TrpAla: 0.774 ± 0.026
0.122TrpCys: 0.122 ± 0.01
0.572TrpAsp: 0.572 ± 0.021
0.443TrpGlu: 0.443 ± 0.02
0.504TrpPhe: 0.504 ± 0.021
0.75TrpGly: 0.75 ± 0.023
0.286TrpHis: 0.286 ± 0.014
0.682TrpIle: 0.682 ± 0.024
0.445TrpLys: 0.445 ± 0.019
1.736TrpLeu: 1.736 ± 0.04
0.33TrpMet: 0.33 ± 0.017
0.398TrpAsn: 0.398 ± 0.018
0.498TrpPro: 0.498 ± 0.022
0.963TrpGln: 0.963 ± 0.03
0.658TrpArg: 0.658 ± 0.024
0.766TrpSer: 0.766 ± 0.023
0.397TrpThr: 0.397 ± 0.018
0.71TrpVal: 0.71 ± 0.026
0.158TrpTrp: 0.158 ± 0.011
0.31TrpTyr: 0.31 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.351TyrAla: 2.351 ± 0.047
0.438TyrCys: 0.438 ± 0.019
1.458TyrAsp: 1.458 ± 0.043
1.16TyrGlu: 1.16 ± 0.03
1.395TyrPhe: 1.395 ± 0.035
1.797TyrGly: 1.797 ± 0.04
0.681TyrHis: 0.681 ± 0.023
1.723TyrIle: 1.723 ± 0.036
1.368TyrLys: 1.368 ± 0.034
3.501TyrLeu: 3.501 ± 0.055
0.622TyrMet: 0.622 ± 0.021
1.128TyrAsn: 1.128 ± 0.034
1.366TyrPro: 1.366 ± 0.036
2.035TyrGln: 2.035 ± 0.044
1.694TyrArg: 1.694 ± 0.039
2.362TyrSer: 2.362 ± 0.041
1.416TyrThr: 1.416 ± 0.033
1.571TyrVal: 1.571 ± 0.041
0.45TyrTrp: 0.45 ± 0.02
1.011TyrTyr: 1.011 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4523 proteins (1267671 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski