Amino acid dipepetide frequency for Arthrobacter livingstonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.147AlaAla: 21.147 ± 0.192	0.802AlaCys: 0.802 ± 0.024	6.985AlaAsp: 6.985 ± 0.085	7.16AlaGlu: 7.16 ± 0.086	3.781AlaPhe: 3.781 ± 0.051	13.914AlaGly: 13.914 ± 0.136	2.421AlaHis: 2.421 ± 0.046	5.199AlaIle: 5.199 ± 0.065	3.945AlaLys: 3.945 ± 0.074	13.53AlaLeu: 13.53 ± 0.128	3.101AlaMet: 3.101 ± 0.044	3.068AlaAsn: 3.068 ± 0.049	6.182AlaPro: 6.182 ± 0.097	4.072AlaGln: 4.072 ± 0.062	7.897AlaArg: 7.897 ± 0.101	6.928AlaSer: 6.928 ± 0.071	7.447AlaThr: 7.447 ± 0.09	11.666AlaVal: 11.666 ± 0.116	1.691AlaTrp: 1.691 ± 0.042	2.294AlaTyr: 2.294 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.771CysAla: 0.771 ± 0.024	0.071CysCys: 0.071 ± 0.007	0.345CysAsp: 0.345 ± 0.017	0.307CysGlu: 0.307 ± 0.015	0.229CysPhe: 0.229 ± 0.01	0.73CysGly: 0.73 ± 0.026	0.164CysHis: 0.164 ± 0.012	0.272CysIle: 0.272 ± 0.015	0.132CysLys: 0.132 ± 0.01	0.557CysLeu: 0.557 ± 0.022	0.114CysMet: 0.114 ± 0.01	0.149CysAsn: 0.149 ± 0.011	0.362CysPro: 0.362 ± 0.016	0.193CysGln: 0.193 ± 0.012	0.407CysArg: 0.407 ± 0.017	0.435CysSer: 0.435 ± 0.019	0.429CysThr: 0.429 ± 0.018	0.466CysVal: 0.466 ± 0.02	0.099CysTrp: 0.099 ± 0.009	0.144CysTyr: 0.144 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.521AspAla: 7.521 ± 0.088	0.313AspCys: 0.313 ± 0.017	2.979AspAsp: 2.979 ± 0.053	2.897AspGlu: 2.897 ± 0.059	1.886AspPhe: 1.886 ± 0.035	5.763AspGly: 5.763 ± 0.07	1.23AspHis: 1.23 ± 0.03	2.318AspIle: 2.318 ± 0.039	1.387AspLys: 1.387 ± 0.039	5.09AspLeu: 5.09 ± 0.067	1.008AspMet: 1.008 ± 0.027	1.155AspAsn: 1.155 ± 0.027	3.664AspPro: 3.664 ± 0.052	1.509AspGln: 1.509 ± 0.034	3.17AspArg: 3.17 ± 0.056	2.922AspSer: 2.922 ± 0.045	2.794AspThr: 2.794 ± 0.048	4.78AspVal: 4.78 ± 0.052	0.882AspTrp: 0.882 ± 0.026	1.249AspTyr: 1.249 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.114GluAla: 6.114 ± 0.083	0.287GluCys: 0.287 ± 0.014	2.506GluAsp: 2.506 ± 0.046	2.739GluGlu: 2.739 ± 0.049	1.76GluPhe: 1.76 ± 0.043	3.526GluGly: 3.526 ± 0.061	1.344GluHis: 1.344 ± 0.032	2.544GluIle: 2.544 ± 0.046	1.609GluLys: 1.609 ± 0.04	6.78GluLeu: 6.78 ± 0.084	0.996GluMet: 0.996 ± 0.029	1.456GluAsn: 1.456 ± 0.03	2.647GluPro: 2.647 ± 0.047	2.066GluGln: 2.066 ± 0.042	3.725GluArg: 3.725 ± 0.063	2.933GluSer: 2.933 ± 0.049	2.801GluThr: 2.801 ± 0.047	3.942GluVal: 3.942 ± 0.053	0.688GluTrp: 0.688 ± 0.023	0.977GluTyr: 0.977 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.099PheAla: 4.099 ± 0.058	0.257PheCys: 0.257 ± 0.014	2.083PheAsp: 2.083 ± 0.048	1.574PheGlu: 1.574 ± 0.034	1.171PhePhe: 1.171 ± 0.032	3.408PheGly: 3.408 ± 0.048	0.705PheHis: 0.705 ± 0.023	1.432PheIle: 1.432 ± 0.036	0.813PheLys: 0.813 ± 0.023	3.107PheLeu: 3.107 ± 0.049	0.678PheMet: 0.678 ± 0.023	0.991PheAsn: 0.991 ± 0.025	1.55PhePro: 1.55 ± 0.033	0.824PheGln: 0.824 ± 0.021	1.732PheArg: 1.732 ± 0.04	2.194PheSer: 2.194 ± 0.04	2.278PheThr: 2.278 ± 0.047	2.558PheVal: 2.558 ± 0.044	0.483PheTrp: 0.483 ± 0.018	0.716PheTyr: 0.716 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.686GlyAla: 10.686 ± 0.093	0.639GlyCys: 0.639 ± 0.022	4.134GlyAsp: 4.134 ± 0.062	4.33GlyGlu: 4.33 ± 0.055	3.328GlyPhe: 3.328 ± 0.054	7.945GlyGly: 7.945 ± 0.096	2.236GlyHis: 2.236 ± 0.042	4.741GlyIle: 4.741 ± 0.053	2.886GlyLys: 2.886 ± 0.057	9.432GlyLeu: 9.432 ± 0.092	2.204GlyMet: 2.204 ± 0.045	2.414GlyAsn: 2.414 ± 0.043	4.451GlyPro: 4.451 ± 0.067	3.129GlyGln: 3.129 ± 0.051	6.185GlyArg: 6.185 ± 0.075	5.829GlySer: 5.829 ± 0.077	6.431GlyThr: 6.431 ± 0.087	7.22GlyVal: 7.22 ± 0.079	1.667GlyTrp: 1.667 ± 0.037	2.335GlyTyr: 2.335 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.445HisAla: 2.445 ± 0.045	0.175HisCys: 0.175 ± 0.011	1.206HisAsp: 1.206 ± 0.03	1.16HisGlu: 1.16 ± 0.029	0.75HisPhe: 0.75 ± 0.023	2.223HisGly: 2.223 ± 0.044	0.651HisHis: 0.651 ± 0.021	0.863HisIle: 0.863 ± 0.024	0.469HisLys: 0.469 ± 0.017	2.153HisLeu: 2.153 ± 0.04	0.413HisMet: 0.413 ± 0.02	0.509HisAsn: 0.509 ± 0.02	1.537HisPro: 1.537 ± 0.038	0.707HisGln: 0.707 ± 0.024	1.543HisArg: 1.543 ± 0.032	1.239HisSer: 1.239 ± 0.03	1.149HisThr: 1.149 ± 0.032	1.687HisVal: 1.687 ± 0.035	0.335HisTrp: 0.335 ± 0.015	0.518HisTyr: 0.518 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.864IleAla: 5.864 ± 0.077	0.353IleCys: 0.353 ± 0.014	2.699IleAsp: 2.699 ± 0.047	2.254IleGlu: 2.254 ± 0.047	1.486IlePhe: 1.486 ± 0.038	4.217IleGly: 4.217 ± 0.068	0.976IleHis: 0.976 ± 0.03	2.023IleIle: 2.023 ± 0.05	1.239IleLys: 1.239 ± 0.034	3.874IleLeu: 3.874 ± 0.065	0.88IleMet: 0.88 ± 0.027	1.346IleAsn: 1.346 ± 0.03	2.484IlePro: 2.484 ± 0.044	1.106IleGln: 1.106 ± 0.026	2.437IleArg: 2.437 ± 0.048	2.764IleSer: 2.764 ± 0.049	2.754IleThr: 2.754 ± 0.049	3.79IleVal: 3.79 ± 0.059	0.507IleTrp: 0.507 ± 0.02	0.888IleTyr: 0.888 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.583LysAla: 3.583 ± 0.06	0.149LysCys: 0.149 ± 0.012	1.676LysAsp: 1.676 ± 0.043	1.315LysGlu: 1.315 ± 0.034	0.882LysPhe: 0.882 ± 0.027	2.032LysGly: 2.032 ± 0.039	0.578LysHis: 0.578 ± 0.019	1.343LysIle: 1.343 ± 0.034	1.016LysLys: 1.016 ± 0.034	2.74LysLeu: 2.74 ± 0.049	0.705LysMet: 0.705 ± 0.022	0.844LysAsn: 0.844 ± 0.027	1.575LysPro: 1.575 ± 0.043	0.81LysGln: 0.81 ± 0.027	1.636LysArg: 1.636 ± 0.038	1.712LysSer: 1.712 ± 0.045	1.737LysThr: 1.737 ± 0.043	2.46LysVal: 2.46 ± 0.049	0.348LysTrp: 0.348 ± 0.017	0.672LysTyr: 0.672 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.358LeuAla: 15.358 ± 0.136	0.693LeuCys: 0.693 ± 0.025	6.089LeuAsp: 6.089 ± 0.059	5.239LeuGlu: 5.239 ± 0.071	3.039LeuPhe: 3.039 ± 0.049	9.375LeuGly: 9.375 ± 0.097	2.086LeuHis: 2.086 ± 0.044	4.163LeuIle: 4.163 ± 0.073	2.591LeuLys: 2.591 ± 0.046	10.446LeuLeu: 10.446 ± 0.128	2.007LeuMet: 2.007 ± 0.037	2.601LeuAsn: 2.601 ± 0.04	5.743LeuPro: 5.743 ± 0.066	2.742LeuGln: 2.742 ± 0.041	6.737LeuArg: 6.737 ± 0.081	6.012LeuSer: 6.012 ± 0.074	6.037LeuThr: 6.037 ± 0.073	8.551LeuVal: 8.551 ± 0.098	1.32LeuTrp: 1.32 ± 0.035	1.744LeuTyr: 1.744 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.057MetAla: 3.057 ± 0.051	0.138MetCys: 0.138 ± 0.011	1.156MetAsp: 1.156 ± 0.028	0.968MetGlu: 0.968 ± 0.029	0.652MetPhe: 0.652 ± 0.023	1.782MetGly: 1.782 ± 0.036	0.397MetHis: 0.397 ± 0.017	0.899MetIle: 0.899 ± 0.027	0.645MetLys: 0.645 ± 0.021	2.048MetLeu: 2.048 ± 0.04	0.468MetMet: 0.468 ± 0.019	0.67MetAsn: 0.67 ± 0.022	1.195MetPro: 1.195 ± 0.026	0.549MetGln: 0.549 ± 0.025	1.204MetArg: 1.204 ± 0.029	1.55MetSer: 1.55 ± 0.037	1.607MetThr: 1.607 ± 0.034	1.895MetVal: 1.895 ± 0.038	0.237MetTrp: 0.237 ± 0.014	0.369MetTyr: 0.369 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.203AsnAla: 3.203 ± 0.052	0.189AsnCys: 0.189 ± 0.012	1.411AsnAsp: 1.411 ± 0.033	1.209AsnGlu: 1.209 ± 0.029	0.888AsnPhe: 0.888 ± 0.025	2.482AsnGly: 2.482 ± 0.045	0.535AsnHis: 0.535 ± 0.019	1.157AsnIle: 1.157 ± 0.031	0.751AsnLys: 0.751 ± 0.022	2.381AsnLeu: 2.381 ± 0.042	0.51AsnMet: 0.51 ± 0.017	0.806AsnAsn: 0.806 ± 0.029	1.963AsnPro: 1.963 ± 0.04	0.833AsnGln: 0.833 ± 0.026	1.571AsnArg: 1.571 ± 0.032	1.482AsnSer: 1.482 ± 0.035	1.527AsnThr: 1.527 ± 0.032	2.085AsnVal: 2.085 ± 0.041	0.416AsnTrp: 0.416 ± 0.017	0.656AsnTyr: 0.656 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	8.035ProAla: 8.035 ± 0.098	0.233ProCys: 0.233 ± 0.014	3.509ProAsp: 3.509 ± 0.062	3.584ProGlu: 3.584 ± 0.062	1.683ProPhe: 1.683 ± 0.034	5.652ProGly: 5.652 ± 0.075	1.106ProHis: 1.106 ± 0.034	1.812ProIle: 1.812 ± 0.035	1.363ProLys: 1.363 ± 0.037	5.023ProLeu: 5.023 ± 0.067	1.124ProMet: 1.124 ± 0.026	1.321ProAsn: 1.321 ± 0.032	2.271ProPro: 2.271 ± 0.048	1.651ProGln: 1.651 ± 0.034	2.903ProArg: 2.903 ± 0.05	3.15ProSer: 3.15 ± 0.052	3.001ProThr: 3.001 ± 0.054	4.84ProVal: 4.84 ± 0.068	0.82ProTrp: 0.82 ± 0.028	1.042ProTyr: 1.042 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.007GlnAla: 4.007 ± 0.059	0.182GlnCys: 0.182 ± 0.011	1.516GlnAsp: 1.516 ± 0.036	1.466GlnGlu: 1.466 ± 0.032	0.923GlnPhe: 0.923 ± 0.022	2.41GlnGly: 2.41 ± 0.042	0.733GlnHis: 0.733 ± 0.027	1.439GlnIle: 1.439 ± 0.03	0.875GlnLys: 0.875 ± 0.025	3.679GlnLeu: 3.679 ± 0.052	0.68GlnMet: 0.68 ± 0.021	0.723GlnAsn: 0.723 ± 0.024	1.647GlnPro: 1.647 ± 0.034	1.296GlnGln: 1.296 ± 0.033	2.27GlnArg: 2.27 ± 0.044	1.672GlnSer: 1.672 ± 0.038	1.515GlnThr: 1.515 ± 0.035	2.474GlnVal: 2.474 ± 0.043	0.583GlnTrp: 0.583 ± 0.021	0.635GlnTyr: 0.635 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.081ArgAla: 7.081 ± 0.081	0.362ArgCys: 0.362 ± 0.016	3.408ArgAsp: 3.408 ± 0.053	3.623ArgGlu: 3.623 ± 0.056	2.063ArgPhe: 2.063 ± 0.042	4.871ArgGly: 4.871 ± 0.067	1.632ArgHis: 1.632 ± 0.037	3.15ArgIle: 3.15 ± 0.052	1.823ArgLys: 1.823 ± 0.035	6.543ArgLeu: 6.543 ± 0.08	1.491ArgMet: 1.491 ± 0.034	1.775ArgAsn: 1.775 ± 0.041	3.34ArgPro: 3.34 ± 0.049	2.253ArgGln: 2.253 ± 0.043	5.249ArgArg: 5.249 ± 0.081	3.751ArgSer: 3.751 ± 0.058	3.864ArgThr: 3.864 ± 0.061	4.598ArgVal: 4.598 ± 0.064	1.031ArgTrp: 1.031 ± 0.028	1.42ArgTyr: 1.42 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.361SerAla: 7.361 ± 0.08	0.362SerCys: 0.362 ± 0.017	2.781SerAsp: 2.781 ± 0.048	2.641SerGlu: 2.641 ± 0.048	1.973SerPhe: 1.973 ± 0.041	6.092SerGly: 6.092 ± 0.07	1.239SerHis: 1.239 ± 0.027	2.581SerIle: 2.581 ± 0.041	1.537SerLys: 1.537 ± 0.039	5.835SerLeu: 5.835 ± 0.067	1.448SerMet: 1.448 ± 0.035	1.541SerAsn: 1.541 ± 0.039	3.304SerPro: 3.304 ± 0.048	1.701SerGln: 1.701 ± 0.037	3.766SerArg: 3.766 ± 0.053	3.618SerSer: 3.618 ± 0.055	3.688SerThr: 3.688 ± 0.056	4.801SerVal: 4.801 ± 0.066	0.951SerTrp: 0.951 ± 0.023	1.443SerTyr: 1.443 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.249ThrAla: 8.249 ± 0.092	0.292ThrCys: 0.292 ± 0.014	3.171ThrAsp: 3.171 ± 0.049	2.854ThrGlu: 2.854 ± 0.041	2.032ThrPhe: 2.032 ± 0.045	6.09ThrGly: 6.09 ± 0.077	1.212ThrHis: 1.212 ± 0.031	2.711ThrIle: 2.711 ± 0.046	1.59ThrLys: 1.59 ± 0.036	5.94ThrLeu: 5.94 ± 0.076	1.202ThrMet: 1.202 ± 0.033	1.456ThrAsn: 1.456 ± 0.039	3.604ThrPro: 3.604 ± 0.064	1.587ThrGln: 1.587 ± 0.037	3.228ThrArg: 3.228 ± 0.042	3.396ThrSer: 3.396 ± 0.054	3.703ThrThr: 3.703 ± 0.067	5.645ThrVal: 5.645 ± 0.077	0.815ThrTrp: 0.815 ± 0.023	1.113ThrTyr: 1.113 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.792ValAla: 10.792 ± 0.097	0.607ValCys: 0.607 ± 0.021	4.902ValAsp: 4.902 ± 0.06	4.496ValGlu: 4.496 ± 0.061	2.746ValPhe: 2.746 ± 0.049	6.695ValGly: 6.695 ± 0.084	1.791ValHis: 1.791 ± 0.036	3.913ValIle: 3.913 ± 0.064	2.197ValLys: 2.197 ± 0.043	9.258ValLeu: 9.258 ± 0.108	1.753ValMet: 1.753 ± 0.038	2.188ValAsn: 2.188 ± 0.04	4.788ValPro: 4.788 ± 0.06	2.418ValGln: 2.418 ± 0.042	5.151ValArg: 5.151 ± 0.068	4.911ValSer: 4.911 ± 0.069	5.101ValThr: 5.101 ± 0.066	8.117ValVal: 8.117 ± 0.091	1.004ValTrp: 1.004 ± 0.028	1.442ValTyr: 1.442 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.537TrpAla: 1.537 ± 0.032	0.123TrpCys: 0.123 ± 0.011	0.804TrpAsp: 0.804 ± 0.021	0.648TrpGlu: 0.648 ± 0.022	0.57TrpPhe: 0.57 ± 0.022	1.022TrpGly: 1.022 ± 0.029	0.354TrpHis: 0.354 ± 0.016	0.675TrpIle: 0.675 ± 0.026	0.406TrpLys: 0.406 ± 0.016	1.867TrpLeu: 1.867 ± 0.037	0.342TrpMet: 0.342 ± 0.016	0.471TrpAsn: 0.471 ± 0.02	0.713TrpPro: 0.713 ± 0.024	0.601TrpGln: 0.601 ± 0.02	1.028TrpArg: 1.028 ± 0.025	0.822TrpSer: 0.822 ± 0.024	0.868TrpThr: 0.868 ± 0.023	1.078TrpVal: 1.078 ± 0.03	0.314TrpTrp: 0.314 ± 0.019	0.299TrpTyr: 0.299 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.322TyrAla: 2.322 ± 0.042	0.149TyrCys: 0.149 ± 0.01	1.156TyrAsp: 1.156 ± 0.029	0.976TyrGlu: 0.976 ± 0.024	0.813TyrPhe: 0.813 ± 0.025	1.99TyrGly: 1.99 ± 0.034	0.342TyrHis: 0.342 ± 0.013	0.708TyrIle: 0.708 ± 0.021	0.538TyrLys: 0.538 ± 0.023	2.288TyrLeu: 2.288 ± 0.039	0.362TyrMet: 0.362 ± 0.015	0.571TyrAsn: 0.571 ± 0.022	1.104TyrPro: 1.104 ± 0.027	0.678TyrGln: 0.678 ± 0.023	1.492TyrArg: 1.492 ± 0.034	1.339TyrSer: 1.339 ± 0.033	1.158TyrThr: 1.158 ± 0.029	1.62TyrVal: 1.62 ± 0.037	0.351TyrTrp: 0.351 ± 0.016	0.467TyrTyr: 0.467 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4378 proteins (1399206 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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