Amino acid dipepetide frequency for Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.565AlaAla: 18.565 ± 0.192	1.172AlaCys: 1.172 ± 0.029	6.902AlaAsp: 6.902 ± 0.084	9.225AlaGlu: 9.225 ± 0.105	4.572AlaPhe: 4.572 ± 0.062	10.913AlaGly: 10.913 ± 0.116	2.444AlaHis: 2.444 ± 0.039	5.692AlaIle: 5.692 ± 0.064	3.326AlaLys: 3.326 ± 0.058	15.094AlaLeu: 15.094 ± 0.156	3.732AlaMet: 3.732 ± 0.063	2.507AlaAsn: 2.507 ± 0.047	6.874AlaPro: 6.874 ± 0.109	4.797AlaGln: 4.797 ± 0.06	10.234AlaArg: 10.234 ± 0.117	5.523AlaSer: 5.523 ± 0.071	6.342AlaThr: 6.342 ± 0.068	8.684AlaVal: 8.684 ± 0.097	1.622AlaTrp: 1.622 ± 0.041	2.606AlaTyr: 2.606 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.228CysAla: 1.228 ± 0.037	0.105CysCys: 0.105 ± 0.009	0.585CysAsp: 0.585 ± 0.019	0.39CysGlu: 0.39 ± 0.019	0.308CysPhe: 0.308 ± 0.017	0.95CysGly: 0.95 ± 0.028	0.272CysHis: 0.272 ± 0.015	0.379CysIle: 0.379 ± 0.017	0.205CysLys: 0.205 ± 0.013	0.888CysLeu: 0.888 ± 0.031	0.153CysMet: 0.153 ± 0.011	0.211CysAsn: 0.211 ± 0.013	0.532CysPro: 0.532 ± 0.026	0.238CysGln: 0.238 ± 0.013	0.551CysArg: 0.551 ± 0.024	0.396CysSer: 0.396 ± 0.018	0.485CysThr: 0.485 ± 0.022	0.658CysVal: 0.658 ± 0.025	0.105CysTrp: 0.105 ± 0.009	0.203CysTyr: 0.203 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.701AspAla: 7.701 ± 0.085	0.468AspCys: 0.468 ± 0.017	3.096AspAsp: 3.096 ± 0.075	3.168AspGlu: 3.168 ± 0.057	2.145AspPhe: 2.145 ± 0.05	5.436AspGly: 5.436 ± 0.084	1.263AspHis: 1.263 ± 0.035	2.863AspIle: 2.863 ± 0.049	1.485AspLys: 1.485 ± 0.041	6.588AspLeu: 6.588 ± 0.077	1.583AspMet: 1.583 ± 0.033	1.165AspAsn: 1.165 ± 0.034	4.18AspPro: 4.18 ± 0.072	1.743AspGln: 1.743 ± 0.038	4.598AspArg: 4.598 ± 0.069	2.061AspSer: 2.061 ± 0.042	3.299AspThr: 3.299 ± 0.062	4.091AspVal: 4.091 ± 0.065	1.206AspTrp: 1.206 ± 0.032	1.446AspTyr: 1.446 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	8.675GluAla: 8.675 ± 0.092	0.338GluCys: 0.338 ± 0.018	3.553GluAsp: 3.553 ± 0.057	3.286GluGlu: 3.286 ± 0.065	1.785GluPhe: 1.785 ± 0.038	4.949GluGly: 4.949 ± 0.069	1.028GluHis: 1.028 ± 0.032	3.811GluIle: 3.811 ± 0.052	1.82GluLys: 1.82 ± 0.047	5.062GluLeu: 5.062 ± 0.073	1.881GluMet: 1.881 ± 0.042	1.612GluAsn: 1.612 ± 0.041	2.414GluPro: 2.414 ± 0.05	1.712GluGln: 1.712 ± 0.043	3.927GluArg: 3.927 ± 0.066	1.961GluSer: 1.961 ± 0.035	4.324GluThr: 4.324 ± 0.065	4.513GluVal: 4.513 ± 0.06	0.592GluTrp: 0.592 ± 0.021	0.972GluTyr: 0.972 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.732PheAla: 4.732 ± 0.067	0.434PheCys: 0.434 ± 0.02	2.829PheAsp: 2.829 ± 0.055	2.317PheGlu: 2.317 ± 0.045	1.524PhePhe: 1.524 ± 0.041	3.782PheGly: 3.782 ± 0.06	0.677PheHis: 0.677 ± 0.024	1.511PheIle: 1.511 ± 0.039	0.837PheLys: 0.837 ± 0.026	3.586PheLeu: 3.586 ± 0.063	0.833PheMet: 0.833 ± 0.029	0.956PheAsn: 0.956 ± 0.03	1.628PhePro: 1.628 ± 0.039	0.99PheGln: 0.99 ± 0.027	2.156PheArg: 2.156 ± 0.045	1.987PheSer: 1.987 ± 0.04	2.122PheThr: 2.122 ± 0.04	2.721PheVal: 2.721 ± 0.047	0.578PheTrp: 0.578 ± 0.023	0.896PheTyr: 0.896 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.928GlyAla: 10.928 ± 0.104	0.846GlyCys: 0.846 ± 0.026	4.594GlyAsp: 4.594 ± 0.075	4.317GlyGlu: 4.317 ± 0.069	3.794GlyPhe: 3.794 ± 0.057	7.38GlyGly: 7.38 ± 0.105	1.83GlyHis: 1.83 ± 0.036	4.45GlyIle: 4.45 ± 0.065	2.783GlyLys: 2.783 ± 0.053	9.798GlyLeu: 9.798 ± 0.112	2.49GlyMet: 2.49 ± 0.046	1.971GlyAsn: 1.971 ± 0.053	4.196GlyPro: 4.196 ± 0.059	3.046GlyGln: 3.046 ± 0.05	5.812GlyArg: 5.812 ± 0.077	4.022GlySer: 4.022 ± 0.066	5.029GlyThr: 5.029 ± 0.061	6.568GlyVal: 6.568 ± 0.076	1.526GlyTrp: 1.526 ± 0.033	2.212GlyTyr: 2.212 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.321HisAla: 2.321 ± 0.042	0.224HisCys: 0.224 ± 0.013	1.197HisAsp: 1.197 ± 0.036	0.956HisGlu: 0.956 ± 0.028	0.753HisPhe: 0.753 ± 0.021	1.978HisGly: 1.978 ± 0.045	0.537HisHis: 0.537 ± 0.024	0.856HisIle: 0.856 ± 0.025	0.477HisLys: 0.477 ± 0.021	2.051HisLeu: 2.051 ± 0.043	0.516HisMet: 0.516 ± 0.018	0.422HisAsn: 0.422 ± 0.021	1.353HisPro: 1.353 ± 0.033	0.497HisGln: 0.497 ± 0.019	1.333HisArg: 1.333 ± 0.034	0.789HisSer: 0.789 ± 0.026	0.846HisThr: 0.846 ± 0.027	1.55HisVal: 1.55 ± 0.038	0.338HisTrp: 0.338 ± 0.016	0.506HisTyr: 0.506 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.028IleAla: 7.028 ± 0.075	0.537IleCys: 0.537 ± 0.023	3.291IleAsp: 3.291 ± 0.053	3.33IleGlu: 3.33 ± 0.06	1.652IlePhe: 1.652 ± 0.04	4.655IleGly: 4.655 ± 0.063	0.849IleHis: 0.849 ± 0.027	2.0IleIle: 2.0 ± 0.052	1.223IleLys: 1.223 ± 0.033	4.81IleLeu: 4.81 ± 0.081	0.99IleMet: 0.99 ± 0.029	1.233IleAsn: 1.233 ± 0.033	2.486IlePro: 2.486 ± 0.046	1.068IleGln: 1.068 ± 0.034	2.942IleArg: 2.942 ± 0.047	2.711IleSer: 2.711 ± 0.045	2.931IleThr: 2.931 ± 0.049	3.595IleVal: 3.595 ± 0.053	0.7IleTrp: 0.7 ± 0.023	1.055IleTyr: 1.055 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.525LysAla: 3.525 ± 0.064	0.182LysCys: 0.182 ± 0.014	1.539LysAsp: 1.539 ± 0.038	1.236LysGlu: 1.236 ± 0.034	0.805LysPhe: 0.805 ± 0.026	2.364LysGly: 2.364 ± 0.045	0.52LysHis: 0.52 ± 0.017	1.456LysIle: 1.456 ± 0.033	0.956LysLys: 0.956 ± 0.033	2.688LysLeu: 2.688 ± 0.05	0.723LysMet: 0.723 ± 0.025	0.611LysAsn: 0.611 ± 0.025	1.649LysPro: 1.649 ± 0.04	0.753LysGln: 0.753 ± 0.025	1.978LysArg: 1.978 ± 0.037	1.559LysSer: 1.559 ± 0.039	1.859LysThr: 1.859 ± 0.037	2.061LysVal: 2.061 ± 0.045	0.341LysTrp: 0.341 ± 0.017	0.554LysTyr: 0.554 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.036LeuAla: 14.036 ± 0.138	1.016LeuCys: 1.016 ± 0.03	6.253LeuAsp: 6.253 ± 0.083	5.545LeuGlu: 5.545 ± 0.077	3.543LeuPhe: 3.543 ± 0.069	9.002LeuGly: 9.002 ± 0.091	1.862LeuHis: 1.862 ± 0.041	5.052LeuIle: 5.052 ± 0.068	2.812LeuLys: 2.812 ± 0.053	9.41LeuLeu: 9.41 ± 0.131	2.521LeuMet: 2.521 ± 0.05	2.434LeuAsn: 2.434 ± 0.044	5.815LeuPro: 5.815 ± 0.081	2.736LeuGln: 2.736 ± 0.047	7.706LeuArg: 7.706 ± 0.09	6.664LeuSer: 6.664 ± 0.076	6.061LeuThr: 6.061 ± 0.063	7.344LeuVal: 7.344 ± 0.091	1.408LeuTrp: 1.408 ± 0.036	1.981LeuTyr: 1.981 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.442MetAla: 3.442 ± 0.054	0.178MetCys: 0.178 ± 0.011	1.344MetAsp: 1.344 ± 0.033	1.288MetGlu: 1.288 ± 0.031	0.777MetPhe: 0.777 ± 0.025	2.127MetGly: 2.127 ± 0.044	0.432MetHis: 0.432 ± 0.02	1.424MetIle: 1.424 ± 0.033	0.882MetLys: 0.882 ± 0.029	2.575MetLeu: 2.575 ± 0.047	0.724MetMet: 0.724 ± 0.026	0.729MetAsn: 0.729 ± 0.024	1.573MetPro: 1.573 ± 0.037	0.929MetGln: 0.929 ± 0.029	1.889MetArg: 1.889 ± 0.04	1.713MetSer: 1.713 ± 0.038	2.053MetThr: 2.053 ± 0.042	1.898MetVal: 1.898 ± 0.044	0.225MetTrp: 0.225 ± 0.014	0.327MetTyr: 0.327 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.931AsnAla: 2.931 ± 0.047	0.239AsnCys: 0.239 ± 0.013	1.218AsnAsp: 1.218 ± 0.04	1.062AsnGlu: 1.062 ± 0.031	0.92AsnPhe: 0.92 ± 0.033	2.103AsnGly: 2.103 ± 0.048	0.469AsnHis: 0.469 ± 0.021	1.258AsnIle: 1.258 ± 0.033	0.563AsnLys: 0.563 ± 0.024	2.314AsnLeu: 2.314 ± 0.042	0.643AsnMet: 0.643 ± 0.024	0.582AsnAsn: 0.582 ± 0.021	1.769AsnPro: 1.769 ± 0.037	0.639AsnGln: 0.639 ± 0.022	1.645AsnArg: 1.645 ± 0.036	1.017AsnSer: 1.017 ± 0.035	1.305AsnThr: 1.305 ± 0.033	1.601AsnVal: 1.601 ± 0.036	0.383AsnTrp: 0.383 ± 0.016	0.561AsnTyr: 0.561 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.457ProAla: 6.457 ± 0.088	0.404ProCys: 0.404 ± 0.019	4.242ProAsp: 4.242 ± 0.064	4.731ProGlu: 4.731 ± 0.072	2.033ProPhe: 2.033 ± 0.035	5.062ProGly: 5.062 ± 0.072	1.046ProHis: 1.046 ± 0.028	2.335ProIle: 2.335 ± 0.041	1.58ProLys: 1.58 ± 0.037	4.935ProLeu: 4.935 ± 0.069	1.403ProMet: 1.403 ± 0.033	1.322ProAsn: 1.322 ± 0.033	2.829ProPro: 2.829 ± 0.059	1.659ProGln: 1.659 ± 0.038	3.246ProArg: 3.246 ± 0.055	2.518ProSer: 2.518 ± 0.05	2.585ProThr: 2.585 ± 0.042	4.568ProVal: 4.568 ± 0.06	0.694ProTrp: 0.694 ± 0.025	1.061ProTyr: 1.061 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.124GlnAla: 4.124 ± 0.061	0.184GlnCys: 0.184 ± 0.013	1.659GlnAsp: 1.659 ± 0.034	1.476GlnGlu: 1.476 ± 0.036	1.014GlnPhe: 1.014 ± 0.027	2.588GlnGly: 2.588 ± 0.049	0.524GlnHis: 0.524 ± 0.022	1.877GlnIle: 1.877 ± 0.039	0.886GlnLys: 0.886 ± 0.028	2.671GlnLeu: 2.671 ± 0.052	0.965GlnMet: 0.965 ± 0.027	0.828GlnAsn: 0.828 ± 0.027	1.637GlnPro: 1.637 ± 0.038	0.97GlnGln: 0.97 ± 0.038	2.105GlnArg: 2.105 ± 0.05	1.686GlnSer: 1.686 ± 0.035	1.919GlnThr: 1.919 ± 0.045	2.472GlnVal: 2.472 ± 0.042	0.364GlnTrp: 0.364 ± 0.017	0.546GlnTyr: 0.546 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.228ArgAla: 9.228 ± 0.112	0.519ArgCys: 0.519 ± 0.022	4.584ArgAsp: 4.584 ± 0.066	3.679ArgGlu: 3.679 ± 0.055	2.795ArgPhe: 2.795 ± 0.053	4.853ArgGly: 4.853 ± 0.059	1.487ArgHis: 1.487 ± 0.039	3.771ArgIle: 3.771 ± 0.055	2.255ArgLys: 2.255 ± 0.046	7.458ArgLeu: 7.458 ± 0.081	1.976ArgMet: 1.976 ± 0.046	1.678ArgAsn: 1.678 ± 0.039	3.656ArgPro: 3.656 ± 0.057	2.239ArgGln: 2.239 ± 0.046	5.152ArgArg: 5.152 ± 0.084	3.296ArgSer: 3.296 ± 0.06	3.302ArgThr: 3.302 ± 0.059	5.014ArgVal: 5.014 ± 0.077	0.951ArgTrp: 0.951 ± 0.03	1.495ArgTyr: 1.495 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.734SerAla: 5.734 ± 0.083	0.45SerCys: 0.45 ± 0.019	3.077SerAsp: 3.077 ± 0.044	2.856SerGlu: 2.856 ± 0.053	2.266SerPhe: 2.266 ± 0.046	5.101SerGly: 5.101 ± 0.07	0.999SerHis: 0.999 ± 0.029	2.185SerIle: 2.185 ± 0.045	1.257SerLys: 1.257 ± 0.033	4.929SerLeu: 4.929 ± 0.064	1.244SerMet: 1.244 ± 0.033	1.173SerAsn: 1.173 ± 0.036	2.528SerPro: 2.528 ± 0.045	1.474SerGln: 1.474 ± 0.037	3.206SerArg: 3.206 ± 0.055	2.316SerSer: 2.316 ± 0.049	2.422SerThr: 2.422 ± 0.047	3.683SerVal: 3.683 ± 0.057	0.702SerTrp: 0.702 ± 0.029	1.182SerTyr: 1.182 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.688ThrAla: 6.688 ± 0.085	0.487ThrCys: 0.487 ± 0.022	3.311ThrAsp: 3.311 ± 0.056	3.24ThrGlu: 3.24 ± 0.058	1.936ThrPhe: 1.936 ± 0.036	5.746ThrGly: 5.746 ± 0.09	1.124ThrHis: 1.124 ± 0.028	2.523ThrIle: 2.523 ± 0.05	1.296ThrLys: 1.296 ± 0.034	6.499ThrLeu: 6.499 ± 0.086	1.28ThrMet: 1.28 ± 0.034	1.165ThrAsn: 1.165 ± 0.029	3.951ThrPro: 3.951 ± 0.055	1.614ThrGln: 1.614 ± 0.037	3.782ThrArg: 3.782 ± 0.06	2.625ThrSer: 2.625 ± 0.047	2.894ThrThr: 2.894 ± 0.049	4.534ThrVal: 4.534 ± 0.068	0.694ThrTrp: 0.694 ± 0.023	1.247ThrTyr: 1.247 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.512ValAla: 9.512 ± 0.095	0.678ValCys: 0.678 ± 0.023	4.066ValAsp: 4.066 ± 0.06	4.269ValGlu: 4.269 ± 0.06	3.035ValPhe: 3.035 ± 0.047	5.471ValGly: 5.471 ± 0.067	1.308ValHis: 1.308 ± 0.033	4.036ValIle: 4.036 ± 0.06	1.847ValLys: 1.847 ± 0.038	8.012ValLeu: 8.012 ± 0.086	2.001ValMet: 2.001 ± 0.047	1.697ValAsn: 1.697 ± 0.037	3.872ValPro: 3.872 ± 0.065	2.176ValGln: 2.176 ± 0.039	4.462ValArg: 4.462 ± 0.068	4.181ValSer: 4.181 ± 0.061	4.859ValThr: 4.859 ± 0.064	5.738ValVal: 5.738 ± 0.077	0.976ValTrp: 0.976 ± 0.027	1.54ValTyr: 1.54 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.406TrpAla: 1.406 ± 0.035	0.156TrpCys: 0.156 ± 0.011	0.79TrpAsp: 0.79 ± 0.028	0.694TrpGlu: 0.694 ± 0.024	0.539TrpPhe: 0.539 ± 0.021	1.006TrpGly: 1.006 ± 0.028	0.338TrpHis: 0.338 ± 0.016	0.709TrpIle: 0.709 ± 0.024	0.346TrpLys: 0.346 ± 0.017	1.659TrpLeu: 1.659 ± 0.043	0.427TrpMet: 0.427 ± 0.019	0.396TrpAsn: 0.396 ± 0.018	0.726TrpPro: 0.726 ± 0.027	0.581TrpGln: 0.581 ± 0.023	1.138TrpArg: 1.138 ± 0.033	0.751TrpSer: 0.751 ± 0.023	0.84TrpThr: 0.84 ± 0.028	0.964TrpVal: 0.964 ± 0.031	0.25TrpTrp: 0.25 ± 0.015	0.281TrpTyr: 0.281 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.563TyrAla: 2.563 ± 0.048	0.227TyrCys: 0.227 ± 0.012	1.454TyrAsp: 1.454 ± 0.036	1.15TyrGlu: 1.15 ± 0.035	0.897TyrPhe: 0.897 ± 0.028	2.128TyrGly: 2.128 ± 0.04	0.492TyrHis: 0.492 ± 0.02	0.897TyrIle: 0.897 ± 0.025	0.524TyrLys: 0.524 ± 0.022	2.177TyrLeu: 2.177 ± 0.042	0.442TyrMet: 0.442 ± 0.018	0.531TyrAsn: 0.531 ± 0.021	1.044TyrPro: 1.044 ± 0.029	0.633TyrGln: 0.633 ± 0.025	1.527TyrArg: 1.527 ± 0.037	1.009TyrSer: 1.009 ± 0.031	1.159TyrThr: 1.159 ± 0.031	1.476TyrVal: 1.476 ± 0.033	0.34TyrTrp: 0.34 ± 0.015	0.534TyrTyr: 0.534 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4086 proteins (1291468 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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