Amino acid dipepetide frequency for Ignavigranum ruoffiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.967AlaAla: 4.967 ± 0.119
0.54AlaCys: 0.54 ± 0.028
4.572AlaAsp: 4.572 ± 0.097
5.31AlaGlu: 5.31 ± 0.113
3.141AlaPhe: 3.141 ± 0.079
5.055AlaGly: 5.055 ± 0.096
1.32AlaHis: 1.32 ± 0.049
6.072AlaIle: 6.072 ± 0.124
4.804AlaLys: 4.804 ± 0.098
7.662AlaLeu: 7.662 ± 0.142
2.25AlaMet: 2.25 ± 0.068
3.259AlaAsn: 3.259 ± 0.073
1.836AlaPro: 1.836 ± 0.057
3.664AlaGln: 3.664 ± 0.096
2.81AlaArg: 2.81 ± 0.072
4.641AlaSer: 4.641 ± 0.096
3.414AlaThr: 3.414 ± 0.085
4.39AlaVal: 4.39 ± 0.095
0.66AlaTrp: 0.66 ± 0.03
3.033AlaTyr: 3.033 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.355CysAla: 0.355 ± 0.033
0.064CysCys: 0.064 ± 0.013
0.307CysAsp: 0.307 ± 0.024
0.256CysGlu: 0.256 ± 0.02
0.284CysPhe: 0.284 ± 0.019
0.497CysGly: 0.497 ± 0.032
0.177CysHis: 0.177 ± 0.02
0.435CysIle: 0.435 ± 0.032
0.22CysLys: 0.22 ± 0.021
0.802CysLeu: 0.802 ± 0.038
0.133CysMet: 0.133 ± 0.017
0.196CysAsn: 0.196 ± 0.02
0.281CysPro: 0.281 ± 0.023
0.456CysGln: 0.456 ± 0.029
0.303CysArg: 0.303 ± 0.024
0.343CysSer: 0.343 ± 0.027
0.234CysThr: 0.234 ± 0.018
0.34CysVal: 0.34 ± 0.025
0.045CysTrp: 0.045 ± 0.008
0.239CysTyr: 0.239 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.241AspAla: 3.241 ± 0.078
0.369AspCys: 0.369 ± 0.028
2.633AspAsp: 2.633 ± 0.086
3.799AspGlu: 3.799 ± 0.093
2.812AspPhe: 2.812 ± 0.069
3.151AspGly: 3.151 ± 0.082
1.597AspHis: 1.597 ± 0.058
4.359AspIle: 4.359 ± 0.096
3.279AspLys: 3.279 ± 0.078
6.486AspLeu: 6.486 ± 0.107
1.311AspMet: 1.311 ± 0.045
2.252AspAsn: 2.252 ± 0.063
2.249AspPro: 2.249 ± 0.067
4.767AspGln: 4.767 ± 0.112
2.595AspArg: 2.595 ± 0.077
3.073AspSer: 3.073 ± 0.101
2.361AspThr: 2.361 ± 0.078
3.134AspVal: 3.134 ± 0.094
0.721AspTrp: 0.721 ± 0.041
3.007AspTyr: 3.007 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
5.668GluAla: 5.668 ± 0.114
0.265GluCys: 0.265 ± 0.02
4.118GluAsp: 4.118 ± 0.085
6.082GluGlu: 6.082 ± 0.161
2.56GluPhe: 2.56 ± 0.067
3.64GluGly: 3.64 ± 0.084
1.303GluHis: 1.303 ± 0.056
6.051GluIle: 6.051 ± 0.115
4.211GluLys: 4.211 ± 0.091
6.509GluLeu: 6.509 ± 0.117
1.989GluMet: 1.989 ± 0.053
3.266GluAsn: 3.266 ± 0.08
1.796GluPro: 1.796 ± 0.062
3.439GluGln: 3.439 ± 0.093
3.021GluArg: 3.021 ± 0.085
3.938GluSer: 3.938 ± 0.128
3.525GluThr: 3.525 ± 0.082
4.61GluVal: 4.61 ± 0.108
0.617GluTrp: 0.617 ± 0.037
2.233GluTyr: 2.233 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.194PheAla: 3.194 ± 0.085
0.274PheCys: 0.274 ± 0.023
2.845PheAsp: 2.845 ± 0.072
2.772PheGlu: 2.772 ± 0.072
1.93PhePhe: 1.93 ± 0.078
2.77PheGly: 2.77 ± 0.088
0.738PheHis: 0.738 ± 0.034
3.756PheIle: 3.756 ± 0.11
2.463PheLys: 2.463 ± 0.062
4.081PheLeu: 4.081 ± 0.118
1.173PheMet: 1.173 ± 0.049
2.278PheAsn: 2.278 ± 0.068
1.514PhePro: 1.514 ± 0.053
1.751PheGln: 1.751 ± 0.059
1.426PheArg: 1.426 ± 0.051
2.836PheSer: 2.836 ± 0.076
2.264PheThr: 2.264 ± 0.062
2.917PheVal: 2.917 ± 0.079
0.43PheTrp: 0.43 ± 0.03
1.732PheTyr: 1.732 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
4.156GlyAla: 4.156 ± 0.111
0.421GlyCys: 0.421 ± 0.026
3.059GlyAsp: 3.059 ± 0.085
3.557GlyGlu: 3.557 ± 0.093
2.879GlyPhe: 2.879 ± 0.076
4.028GlyGly: 4.028 ± 0.123
1.426GlyHis: 1.426 ± 0.056
5.298GlyIle: 5.298 ± 0.111
3.768GlyLys: 3.768 ± 0.089
6.782GlyLeu: 6.782 ± 0.122
1.831GlyMet: 1.831 ± 0.06
2.406GlyAsn: 2.406 ± 0.058
1.739GlyPro: 1.739 ± 0.055
4.033GlyGln: 4.033 ± 0.101
2.763GlyArg: 2.763 ± 0.069
3.747GlySer: 3.747 ± 0.079
3.085GlyThr: 3.085 ± 0.08
4.199GlyVal: 4.199 ± 0.106
0.589GlyTrp: 0.589 ± 0.036
2.562GlyTyr: 2.562 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.175HisAla: 1.175 ± 0.042
0.166HisCys: 0.166 ± 0.018
1.079HisAsp: 1.079 ± 0.049
1.104HisGlu: 1.104 ± 0.042
1.067HisPhe: 1.067 ± 0.042
1.332HisGly: 1.332 ± 0.046
0.728HisHis: 0.728 ± 0.044
1.334HisIle: 1.334 ± 0.051
0.979HisLys: 0.979 ± 0.044
2.359HisLeu: 2.359 ± 0.073
0.423HisMet: 0.423 ± 0.026
0.776HisAsn: 0.776 ± 0.037
1.223HisPro: 1.223 ± 0.051
1.547HisGln: 1.547 ± 0.063
1.067HisArg: 1.067 ± 0.044
1.209HisSer: 1.209 ± 0.041
0.889HisThr: 0.889 ± 0.046
0.972HisVal: 0.972 ± 0.043
0.258HisTrp: 0.258 ± 0.019
1.084HisTyr: 1.084 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
5.971IleAla: 5.971 ± 0.119
0.563IleCys: 0.563 ± 0.036
5.192IleAsp: 5.192 ± 0.106
5.985IleGlu: 5.985 ± 0.102
3.586IlePhe: 3.586 ± 0.101
5.14IleGly: 5.14 ± 0.108
1.722IleHis: 1.722 ± 0.057
6.339IleIle: 6.339 ± 0.145
4.547IleLys: 4.547 ± 0.101
7.991IleLeu: 7.991 ± 0.158
1.843IleMet: 1.843 ± 0.06
3.929IleAsn: 3.929 ± 0.095
3.3IlePro: 3.3 ± 0.074
4.04IleGln: 4.04 ± 0.092
3.143IleArg: 3.143 ± 0.072
4.929IleSer: 4.929 ± 0.106
3.465IleThr: 3.465 ± 0.069
5.038IleVal: 5.038 ± 0.108
0.61IleTrp: 0.61 ± 0.031
3.132IleTyr: 3.132 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.192LysAla: 4.192 ± 0.092
0.161LysCys: 0.161 ± 0.018
3.879LysAsp: 3.879 ± 0.093
5.14LysGlu: 5.14 ± 0.104
2.169LysPhe: 2.169 ± 0.062
3.118LysGly: 3.118 ± 0.07
1.166LysHis: 1.166 ± 0.045
4.534LysIle: 4.534 ± 0.089
3.766LysLys: 3.766 ± 0.102
5.32LysLeu: 5.32 ± 0.101
1.693LysMet: 1.693 ± 0.052
2.76LysAsn: 2.76 ± 0.076
1.703LysPro: 1.703 ± 0.06
2.907LysGln: 2.907 ± 0.077
2.38LysArg: 2.38 ± 0.067
3.125LysSer: 3.125 ± 0.071
2.961LysThr: 2.961 ± 0.077
4.016LysVal: 4.016 ± 0.075
0.466LysTrp: 0.466 ± 0.031
2.385LysTyr: 2.385 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
9.551LeuAla: 9.551 ± 0.141
0.66LeuCys: 0.66 ± 0.036
5.854LeuAsp: 5.854 ± 0.099
6.363LeuGlu: 6.363 ± 0.111
4.256LeuPhe: 4.256 ± 0.087
6.54LeuGly: 6.54 ± 0.108
1.57LeuHis: 1.57 ± 0.052
8.279LeuIle: 8.279 ± 0.142
6.484LeuLys: 6.484 ± 0.119
10.458LeuLeu: 10.458 ± 0.201
2.886LeuMet: 2.886 ± 0.076
5.36LeuAsn: 5.36 ± 0.113
3.938LeuPro: 3.938 ± 0.087
3.86LeuGln: 3.86 ± 0.093
3.697LeuArg: 3.697 ± 0.09
7.451LeuSer: 7.451 ± 0.119
5.868LeuThr: 5.868 ± 0.105
6.503LeuVal: 6.503 ± 0.116
0.932LeuTrp: 0.932 ± 0.045
3.295LeuTyr: 3.295 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.309MetAla: 2.309 ± 0.07
0.102MetCys: 0.102 ± 0.013
1.545MetAsp: 1.545 ± 0.062
1.639MetGlu: 1.639 ± 0.054
0.833MetPhe: 0.833 ± 0.05
1.783MetGly: 1.783 ± 0.068
0.404MetHis: 0.404 ± 0.026
2.453MetIle: 2.453 ± 0.074
1.824MetLys: 1.824 ± 0.052
2.141MetLeu: 2.141 ± 0.062
0.795MetMet: 0.795 ± 0.038
1.62MetAsn: 1.62 ± 0.053
0.937MetPro: 0.937 ± 0.042
1.008MetGln: 1.008 ± 0.038
0.972MetArg: 0.972 ± 0.048
1.656MetSer: 1.656 ± 0.06
1.84MetThr: 1.84 ± 0.053
1.835MetVal: 1.835 ± 0.066
0.152MetTrp: 0.152 ± 0.017
0.681MetTyr: 0.681 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.451AsnAla: 2.451 ± 0.065
0.281AsnCys: 0.281 ± 0.025
2.226AsnAsp: 2.226 ± 0.081
2.808AsnGlu: 2.808 ± 0.085
2.103AsnPhe: 2.103 ± 0.056
2.536AsnGly: 2.536 ± 0.076
1.263AsnHis: 1.263 ± 0.048
3.589AsnIle: 3.589 ± 0.092
2.758AsnLys: 2.758 ± 0.073
5.135AsnLeu: 5.135 ± 0.105
1.048AsnMet: 1.048 ± 0.044
2.174AsnAsn: 2.174 ± 0.065
2.221AsnPro: 2.221 ± 0.065
3.584AsnGln: 3.584 ± 0.088
2.027AsnArg: 2.027 ± 0.057
2.205AsnSer: 2.205 ± 0.061
1.848AsnThr: 1.848 ± 0.068
2.512AsnVal: 2.512 ± 0.071
0.416AsnTrp: 0.416 ± 0.026
2.039AsnTyr: 2.039 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
2.576ProAla: 2.576 ± 0.074
0.192ProCys: 0.192 ± 0.019
2.037ProAsp: 2.037 ± 0.071
3.039ProGlu: 3.039 ± 0.082
1.599ProPhe: 1.599 ± 0.053
2.24ProGly: 2.24 ± 0.064
0.717ProHis: 0.717 ± 0.038
2.825ProIle: 2.825 ± 0.074
1.84ProLys: 1.84 ± 0.056
3.657ProLeu: 3.657 ± 0.082
0.899ProMet: 0.899 ± 0.04
1.632ProAsn: 1.632 ± 0.057
0.681ProPro: 0.681 ± 0.036
1.845ProGln: 1.845 ± 0.058
1.162ProArg: 1.162 ± 0.039
2.178ProSer: 2.178 ± 0.065
1.848ProThr: 1.848 ± 0.06
2.555ProVal: 2.555 ± 0.064
0.326ProTrp: 0.326 ± 0.024
1.46ProTyr: 1.46 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
6.037GlnAla: 6.037 ± 0.15
0.192GlnCys: 0.192 ± 0.019
3.186GlnAsp: 3.186 ± 0.085
4.388GlnGlu: 4.388 ± 0.115
1.907GlnPhe: 1.907 ± 0.063
3.48GlnGly: 3.48 ± 0.076
1.105GlnHis: 1.105 ± 0.048
4.206GlnIle: 4.206 ± 0.096
2.836GlnLys: 2.836 ± 0.078
5.554GlnLeu: 5.554 ± 0.116
1.476GlnMet: 1.476 ± 0.05
2.044GlnAsn: 2.044 ± 0.061
1.743GlnPro: 1.743 ± 0.073
3.04GlnGln: 3.04 ± 0.109
2.493GlnArg: 2.493 ± 0.079
3.158GlnSer: 3.158 ± 0.071
3.046GlnThr: 3.046 ± 0.077
4.055GlnVal: 4.055 ± 0.106
0.618GlnTrp: 0.618 ± 0.038
1.66GlnTyr: 1.66 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
2.515ArgAla: 2.515 ± 0.072
0.244ArgCys: 0.244 ± 0.019
2.1ArgAsp: 2.1 ± 0.062
2.543ArgGlu: 2.543 ± 0.075
1.822ArgPhe: 1.822 ± 0.054
2.098ArgGly: 2.098 ± 0.071
0.87ArgHis: 0.87 ± 0.039
3.257ArgIle: 3.257 ± 0.082
2.63ArgLys: 2.63 ± 0.063
4.464ArgLeu: 4.464 ± 0.105
1.155ArgMet: 1.155 ± 0.045
1.767ArgAsn: 1.767 ± 0.055
1.613ArgPro: 1.613 ± 0.05
2.971ArgGln: 2.971 ± 0.073
2.11ArgArg: 2.11 ± 0.059
2.108ArgSer: 2.108 ± 0.061
1.874ArgThr: 1.874 ± 0.063
2.524ArgVal: 2.524 ± 0.074
0.398ArgTrp: 0.398 ± 0.027
1.67ArgTyr: 1.67 ± 0.054
0.002ArgXaa: 0.002 ± 0.002
Ser
4.029SerAla: 4.029 ± 0.087
0.281SerCys: 0.281 ± 0.024
2.898SerAsp: 2.898 ± 0.082
3.825SerGlu: 3.825 ± 0.145
2.923SerPhe: 2.923 ± 0.07
4.139SerGly: 4.139 ± 0.093
1.237SerHis: 1.237 ± 0.047
4.601SerIle: 4.601 ± 0.092
3.338SerLys: 3.338 ± 0.09
7.04SerLeu: 7.04 ± 0.128
1.535SerMet: 1.535 ± 0.052
2.477SerAsn: 2.477 ± 0.066
1.987SerPro: 1.987 ± 0.058
4.291SerGln: 4.291 ± 0.114
2.38SerArg: 2.38 ± 0.067
3.648SerSer: 3.648 ± 0.093
2.929SerThr: 2.929 ± 0.086
3.648SerVal: 3.648 ± 0.085
0.653SerTrp: 0.653 ± 0.034
2.34SerTyr: 2.34 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
3.413ThrAla: 3.413 ± 0.082
0.338ThrCys: 0.338 ± 0.025
2.931ThrAsp: 2.931 ± 0.07
3.162ThrGlu: 3.162 ± 0.1
2.122ThrPhe: 2.122 ± 0.063
3.55ThrGly: 3.55 ± 0.08
1.024ThrHis: 1.024 ± 0.043
4.213ThrIle: 4.213 ± 0.084
2.301ThrLys: 2.301 ± 0.065
5.067ThrLeu: 5.067 ± 0.109
1.336ThrMet: 1.336 ± 0.05
2.023ThrAsn: 2.023 ± 0.07
2.113ThrPro: 2.113 ± 0.061
2.077ThrGln: 2.077 ± 0.055
1.791ThrArg: 1.791 ± 0.06
3.065ThrSer: 3.065 ± 0.087
2.715ThrThr: 2.715 ± 0.105
3.525ThrVal: 3.525 ± 0.082
0.473ThrTrp: 0.473 ± 0.031
2.243ThrTyr: 2.243 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
4.811ValAla: 4.811 ± 0.097
0.492ValCys: 0.492 ± 0.028
4.106ValAsp: 4.106 ± 0.095
4.556ValGlu: 4.556 ± 0.115
2.692ValPhe: 2.692 ± 0.077
4.295ValGly: 4.295 ± 0.106
1.123ValHis: 1.123 ± 0.042
5.464ValIle: 5.464 ± 0.106
3.641ValLys: 3.641 ± 0.094
6.164ValLeu: 6.164 ± 0.119
1.686ValMet: 1.686 ± 0.059
3.03ValAsn: 3.03 ± 0.072
2.339ValPro: 2.339 ± 0.069
2.451ValGln: 2.451 ± 0.075
2.297ValArg: 2.297 ± 0.064
4.13ValSer: 4.13 ± 0.094
3.177ValThr: 3.177 ± 0.082
4.39ValVal: 4.39 ± 0.097
0.542ValTrp: 0.542 ± 0.028
2.353ValTyr: 2.353 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.539TrpAla: 0.539 ± 0.034
0.045TrpCys: 0.045 ± 0.009
0.471TrpAsp: 0.471 ± 0.029
0.469TrpGlu: 0.469 ± 0.026
0.416TrpPhe: 0.416 ± 0.027
0.546TrpGly: 0.546 ± 0.037
0.227TrpHis: 0.227 ± 0.021
0.761TrpIle: 0.761 ± 0.041
0.379TrpLys: 0.379 ± 0.024
1.339TrpLeu: 1.339 ± 0.061
0.293TrpMet: 0.293 ± 0.023
0.397TrpAsn: 0.397 ± 0.027
0.353TrpPro: 0.353 ± 0.025
0.819TrpGln: 0.819 ± 0.035
0.419TrpArg: 0.419 ± 0.029
0.502TrpSer: 0.502 ± 0.032
0.426TrpThr: 0.426 ± 0.028
0.56TrpVal: 0.56 ± 0.035
0.12TrpTrp: 0.12 ± 0.014
0.314TrpTyr: 0.314 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.249TyrAla: 2.249 ± 0.069
0.315TyrCys: 0.315 ± 0.03
2.16TyrAsp: 2.16 ± 0.071
2.044TyrGlu: 2.044 ± 0.056
2.042TyrPhe: 2.042 ± 0.067
2.392TyrGly: 2.392 ± 0.068
1.057TyrHis: 1.057 ± 0.044
2.64TyrIle: 2.64 ± 0.08
1.77TyrLys: 1.77 ± 0.062
4.792TyrLeu: 4.792 ± 0.108
0.773TyrMet: 0.773 ± 0.037
1.578TyrAsn: 1.578 ± 0.061
1.743TyrPro: 1.743 ± 0.056
3.674TyrGln: 3.674 ± 0.105
1.88TyrArg: 1.88 ± 0.061
2.259TyrSer: 2.259 ± 0.06
1.712TyrThr: 1.712 ± 0.071
2.015TyrVal: 2.015 ± 0.055
0.369TyrTrp: 0.369 ± 0.026
1.93TyrTyr: 1.93 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.002XaaAsn: 0.002 ± 0.002
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.005XaaXaa: 0.005 ± 0.006
Statistics based on 1874 proteins (577246 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski