Amino acid dipepetide frequency for Faustovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.93AlaAla: 4.93 ± 0.298
1.035AlaCys: 1.035 ± 0.101
3.503AlaAsp: 3.503 ± 0.17
3.378AlaGlu: 3.378 ± 0.163
1.936AlaPhe: 1.936 ± 0.118
3.37AlaGly: 3.37 ± 0.269
1.219AlaHis: 1.219 ± 0.103
4.76AlaIle: 4.76 ± 0.162
4.641AlaLys: 4.641 ± 0.206
5.011AlaLeu: 5.011 ± 0.251
1.545AlaMet: 1.545 ± 0.109
3.976AlaAsn: 3.976 ± 0.231
2.276AlaPro: 2.276 ± 0.14
1.966AlaGln: 1.966 ± 0.158
3.015AlaArg: 3.015 ± 0.151
3.481AlaSer: 3.481 ± 0.196
4.205AlaThr: 4.205 ± 0.248
4.117AlaVal: 4.117 ± 0.26
0.591AlaTrp: 0.591 ± 0.069
2.284AlaTyr: 2.284 ± 0.144
0.0AlaXaa: 0.0 ± 0.0
Cys
1.094CysAla: 1.094 ± 0.092
0.554CysCys: 0.554 ± 0.07
1.537CysAsp: 1.537 ± 0.125
1.33CysGlu: 1.33 ± 0.106
0.503CysPhe: 0.503 ± 0.059
1.596CysGly: 1.596 ± 0.11
0.384CysHis: 0.384 ± 0.056
1.478CysIle: 1.478 ± 0.115
1.619CysLys: 1.619 ± 0.145
1.515CysLeu: 1.515 ± 0.108
0.488CysMet: 0.488 ± 0.063
1.271CysAsn: 1.271 ± 0.106
0.695CysPro: 0.695 ± 0.16
0.347CysGln: 0.347 ± 0.059
0.939CysArg: 0.939 ± 0.092
1.035CysSer: 1.035 ± 0.099
0.562CysThr: 0.562 ± 0.069
1.589CysVal: 1.589 ± 0.113
0.296CysTrp: 0.296 ± 0.044
0.902CysTyr: 0.902 ± 0.101
0.0CysXaa: 0.0 ± 0.0
Asp
4.006AspAla: 4.006 ± 0.19
1.005AspCys: 1.005 ± 0.103
3.917AspAsp: 3.917 ± 0.224
3.732AspGlu: 3.732 ± 0.208
2.166AspPhe: 2.166 ± 0.135
3.141AspGly: 3.141 ± 0.185
1.242AspHis: 1.242 ± 0.092
6.267AspIle: 6.267 ± 0.206
4.05AspLys: 4.05 ± 0.217
4.686AspLeu: 4.686 ± 0.187
1.589AspMet: 1.589 ± 0.108
4.301AspAsn: 4.301 ± 0.188
2.239AspPro: 2.239 ± 0.15
1.493AspGln: 1.493 ± 0.095
2.158AspArg: 2.158 ± 0.126
3.585AspSer: 3.585 ± 0.172
3.821AspThr: 3.821 ± 0.201
4.198AspVal: 4.198 ± 0.17
0.532AspTrp: 0.532 ± 0.067
3.208AspTyr: 3.208 ± 0.169
0.0AspXaa: 0.0 ± 0.0
Glu
2.838GluAla: 2.838 ± 0.166
1.168GluCys: 1.168 ± 0.117
2.498GluAsp: 2.498 ± 0.141
2.557GluGlu: 2.557 ± 0.176
3.089GluPhe: 3.089 ± 0.158
1.803GluGly: 1.803 ± 0.124
1.242GluHis: 1.242 ± 0.087
5.114GluIle: 5.114 ± 0.186
2.86GluLys: 2.86 ± 0.165
6.201GluLeu: 6.201 ± 0.268
1.626GluMet: 1.626 ± 0.115
2.964GluAsn: 2.964 ± 0.14
1.463GluPro: 1.463 ± 0.115
1.855GluGln: 1.855 ± 0.112
2.535GluArg: 2.535 ± 0.149
3.422GluSer: 3.422 ± 0.161
3.23GluThr: 3.23 ± 0.131
2.875GluVal: 2.875 ± 0.169
0.621GluTrp: 0.621 ± 0.07
3.821GluTyr: 3.821 ± 0.195
0.0GluXaa: 0.0 ± 0.0
Phe
2.616PheAla: 2.616 ± 0.141
0.421PheCys: 0.421 ± 0.067
2.949PheAsp: 2.949 ± 0.156
2.299PheGlu: 2.299 ± 0.129
0.576PhePhe: 0.576 ± 0.056
2.025PheGly: 2.025 ± 0.116
0.702PheHis: 0.702 ± 0.071
3.333PheIle: 3.333 ± 0.171
3.008PheLys: 3.008 ± 0.174
1.811PheLeu: 1.811 ± 0.112
1.153PheMet: 1.153 ± 0.098
3.282PheAsn: 3.282 ± 0.157
1.19PhePro: 1.19 ± 0.108
0.591PheGln: 0.591 ± 0.074
1.53PheArg: 1.53 ± 0.117
2.055PheSer: 2.055 ± 0.125
2.823PheThr: 2.823 ± 0.139
2.624PheVal: 2.624 ± 0.124
0.362PheTrp: 0.362 ± 0.053
1.559PheTyr: 1.559 ± 0.109
0.0PheXaa: 0.0 ± 0.0
Gly
3.259GlyAla: 3.259 ± 0.247
1.064GlyCys: 1.064 ± 0.09
3.607GlyAsp: 3.607 ± 0.174
3.562GlyGlu: 3.562 ± 0.17
2.328GlyPhe: 2.328 ± 0.149
3.629GlyGly: 3.629 ± 0.228
0.665GlyHis: 0.665 ± 0.068
3.843GlyIle: 3.843 ± 0.173
4.39GlyLys: 4.39 ± 0.236
3.821GlyLeu: 3.821 ± 0.192
1.456GlyMet: 1.456 ± 0.096
3.289GlyAsn: 3.289 ± 0.164
0.754GlyPro: 0.754 ± 0.079
1.301GlyGln: 1.301 ± 0.108
2.313GlyArg: 2.313 ± 0.125
3.525GlySer: 3.525 ± 0.26
2.04GlyThr: 2.04 ± 0.223
5.041GlyVal: 5.041 ± 0.179
0.695GlyTrp: 0.695 ± 0.071
2.882GlyTyr: 2.882 ± 0.231
0.0GlyXaa: 0.0 ± 0.0
His
1.197HisAla: 1.197 ± 0.1
0.458HisCys: 0.458 ± 0.066
1.256HisAsp: 1.256 ± 0.088
1.123HisGlu: 1.123 ± 0.086
0.739HisPhe: 0.739 ± 0.078
1.892HisGly: 1.892 ± 0.145
0.613HisHis: 0.613 ± 0.074
1.752HisIle: 1.752 ± 0.12
1.574HisLys: 1.574 ± 0.121
1.641HisLeu: 1.641 ± 0.103
0.466HisMet: 0.466 ± 0.057
1.478HisAsn: 1.478 ± 0.111
0.82HisPro: 0.82 ± 0.085
0.562HisGln: 0.562 ± 0.075
0.88HisArg: 0.88 ± 0.082
1.249HisSer: 1.249 ± 0.099
1.463HisThr: 1.463 ± 0.125
1.367HisVal: 1.367 ± 0.106
0.266HisTrp: 0.266 ± 0.041
1.249HisTyr: 1.249 ± 0.108
0.0HisXaa: 0.0 ± 0.0
Ile
5.284IleAla: 5.284 ± 0.204
1.759IleCys: 1.759 ± 0.133
5.469IleAsp: 5.469 ± 0.233
4.582IleGlu: 4.582 ± 0.176
2.417IlePhe: 2.417 ± 0.146
4.058IleGly: 4.058 ± 0.191
1.774IleHis: 1.774 ± 0.117
6.681IleIle: 6.681 ± 0.256
6.903IleLys: 6.903 ± 0.249
5.824IleLeu: 5.824 ± 0.195
2.151IleMet: 2.151 ± 0.12
6.43IleAsn: 6.43 ± 0.234
3.496IlePro: 3.496 ± 0.176
1.744IleGln: 1.744 ± 0.121
3.902IleArg: 3.902 ± 0.176
4.885IleSer: 4.885 ± 0.21
6.083IleThr: 6.083 ± 0.239
5.018IleVal: 5.018 ± 0.222
0.695IleTrp: 0.695 ± 0.07
3.784IleTyr: 3.784 ± 0.207
0.0IleXaa: 0.0 ± 0.0
Lys
3.518LysAla: 3.518 ± 0.203
1.626LysCys: 1.626 ± 0.142
3.082LysAsp: 3.082 ± 0.172
2.853LysGlu: 2.853 ± 0.169
3.378LysPhe: 3.378 ± 0.157
2.343LysGly: 2.343 ± 0.13
2.439LysHis: 2.439 ± 0.16
6.009LysIle: 6.009 ± 0.192
4.006LysLys: 4.006 ± 0.217
7.827LysLeu: 7.827 ± 0.272
1.766LysMet: 1.766 ± 0.129
3.311LysAsn: 3.311 ± 0.156
2.882LysPro: 2.882 ± 0.191
2.853LysGln: 2.853 ± 0.163
3.585LysArg: 3.585 ± 0.202
4.649LysSer: 4.649 ± 0.225
4.176LysThr: 4.176 ± 0.19
4.021LysVal: 4.021 ± 0.188
1.072LysTrp: 1.072 ± 0.092
4.649LysTyr: 4.649 ± 0.226
0.0LysXaa: 0.0 ± 0.0
Leu
5.181LeuAla: 5.181 ± 0.2
1.774LeuCys: 1.774 ± 0.128
4.479LeuAsp: 4.479 ± 0.203
4.139LeuGlu: 4.139 ± 0.198
3.2LeuPhe: 3.2 ± 0.177
4.028LeuGly: 4.028 ± 0.191
2.239LeuHis: 2.239 ± 0.128
6.216LeuIle: 6.216 ± 0.239
5.506LeuLys: 5.506 ± 0.215
6.977LeuLeu: 6.977 ± 0.258
2.121LeuMet: 2.121 ± 0.133
5.506LeuAsn: 5.506 ± 0.217
3.555LeuPro: 3.555 ± 0.141
2.476LeuGln: 2.476 ± 0.145
4.479LeuArg: 4.479 ± 0.19
5.077LeuSer: 5.077 ± 0.207
5.211LeuThr: 5.211 ± 0.222
5.1LeuVal: 5.1 ± 0.19
0.665LeuTrp: 0.665 ± 0.078
3.644LeuTyr: 3.644 ± 0.185
0.0LeuXaa: 0.0 ± 0.0
Met
1.471MetAla: 1.471 ± 0.117
0.547MetCys: 0.547 ± 0.056
1.789MetAsp: 1.789 ± 0.119
1.663MetGlu: 1.663 ± 0.12
1.256MetPhe: 1.256 ± 0.101
1.249MetGly: 1.249 ± 0.096
0.421MetHis: 0.421 ± 0.06
2.121MetIle: 2.121 ± 0.144
1.301MetLys: 1.301 ± 0.087
2.387MetLeu: 2.387 ± 0.133
0.835MetMet: 0.835 ± 0.078
1.404MetAsn: 1.404 ± 0.092
0.791MetPro: 0.791 ± 0.091
0.894MetGln: 0.894 ± 0.077
1.256MetArg: 1.256 ± 0.096
2.284MetSer: 2.284 ± 0.121
1.316MetThr: 1.316 ± 0.094
1.463MetVal: 1.463 ± 0.102
0.325MetTrp: 0.325 ± 0.057
1.227MetTyr: 1.227 ± 0.093
0.0MetXaa: 0.0 ± 0.0
Asn
4.013AsnAla: 4.013 ± 0.228
1.116AsnCys: 1.116 ± 0.11
4.272AsnAsp: 4.272 ± 0.192
3.422AsnGlu: 3.422 ± 0.172
2.151AsnPhe: 2.151 ± 0.138
4.412AsnGly: 4.412 ± 0.247
1.36AsnHis: 1.36 ± 0.103
6.282AsnIle: 6.282 ± 0.219
4.427AsnLys: 4.427 ± 0.175
4.56AsnLeu: 4.56 ± 0.199
1.552AsnMet: 1.552 ± 0.108
5.462AsnAsn: 5.462 ± 0.262
2.402AsnPro: 2.402 ± 0.136
1.833AsnGln: 1.833 ± 0.11
2.528AsnArg: 2.528 ± 0.152
3.888AsnSer: 3.888 ± 0.21
5.351AsnThr: 5.351 ± 0.335
4.383AsnVal: 4.383 ± 0.192
0.65AsnTrp: 0.65 ± 0.075
3.318AsnTyr: 3.318 ± 0.185
0.0AsnXaa: 0.0 ± 0.0
Pro
2.55ProAla: 2.55 ± 0.171
0.473ProCys: 0.473 ± 0.06
2.461ProAsp: 2.461 ± 0.134
1.973ProGlu: 1.973 ± 0.16
1.086ProPhe: 1.086 ± 0.094
1.685ProGly: 1.685 ± 0.128
0.739ProHis: 0.739 ± 0.067
2.964ProIle: 2.964 ± 0.181
2.38ProLys: 2.38 ± 0.152
2.705ProLeu: 2.705 ± 0.152
0.976ProMet: 0.976 ± 0.077
2.513ProAsn: 2.513 ± 0.165
1.619ProPro: 1.619 ± 0.157
1.079ProGln: 1.079 ± 0.108
1.685ProArg: 1.685 ± 0.127
2.306ProSer: 2.306 ± 0.148
2.823ProThr: 2.823 ± 0.19
2.602ProVal: 2.602 ± 0.18
0.333ProTrp: 0.333 ± 0.051
1.345ProTyr: 1.345 ± 0.105
0.0ProXaa: 0.0 ± 0.0
Gln
1.493GlnAla: 1.493 ± 0.099
0.392GlnCys: 0.392 ± 0.044
1.138GlnAsp: 1.138 ± 0.093
0.99GlnGlu: 0.99 ± 0.079
1.271GlnPhe: 1.271 ± 0.115
1.197GlnGly: 1.197 ± 0.097
0.902GlnHis: 0.902 ± 0.092
2.461GlnIle: 2.461 ± 0.129
1.582GlnLys: 1.582 ± 0.108
3.274GlnLeu: 3.274 ± 0.168
0.606GlnMet: 0.606 ± 0.07
1.545GlnAsn: 1.545 ± 0.118
1.508GlnPro: 1.508 ± 0.129
1.338GlnGln: 1.338 ± 0.103
1.611GlnArg: 1.611 ± 0.107
1.936GlnSer: 1.936 ± 0.131
1.641GlnThr: 1.641 ± 0.129
1.626GlnVal: 1.626 ± 0.108
0.333GlnTrp: 0.333 ± 0.05
1.471GlnTyr: 1.471 ± 0.108
0.0GlnXaa: 0.0 ± 0.0
Arg
2.624ArgAla: 2.624 ± 0.147
1.094ArgCys: 1.094 ± 0.107
2.786ArgAsp: 2.786 ± 0.175
3.259ArgGlu: 3.259 ± 0.161
1.899ArgPhe: 1.899 ± 0.106
2.779ArgGly: 2.779 ± 0.147
0.828ArgHis: 0.828 ± 0.086
3.4ArgIle: 3.4 ± 0.163
3.548ArgLys: 3.548 ± 0.162
3.961ArgLeu: 3.961 ± 0.161
1.249ArgMet: 1.249 ± 0.099
2.905ArgAsn: 2.905 ± 0.16
1.382ArgPro: 1.382 ± 0.094
1.064ArgGln: 1.064 ± 0.089
2.542ArgArg: 2.542 ± 0.162
2.594ArgSer: 2.594 ± 0.14
1.833ArgThr: 1.833 ± 0.128
3.355ArgVal: 3.355 ± 0.147
0.613ArgTrp: 0.613 ± 0.061
2.727ArgTyr: 2.727 ± 0.141
0.0ArgXaa: 0.0 ± 0.0
Ser
3.644SerAla: 3.644 ± 0.169
1.234SerCys: 1.234 ± 0.106
4.146SerAsp: 4.146 ± 0.195
3.045SerGlu: 3.045 ± 0.153
1.959SerPhe: 1.959 ± 0.114
4.124SerGly: 4.124 ± 0.239
1.205SerHis: 1.205 ± 0.092
4.752SerIle: 4.752 ± 0.198
4.353SerLys: 4.353 ± 0.205
4.442SerLeu: 4.442 ± 0.181
1.559SerMet: 1.559 ± 0.1
4.361SerAsn: 4.361 ± 0.217
2.446SerPro: 2.446 ± 0.139
1.914SerGln: 1.914 ± 0.148
3.06SerArg: 3.06 ± 0.166
4.183SerSer: 4.183 ± 0.253
3.895SerThr: 3.895 ± 0.219
4.072SerVal: 4.072 ± 0.197
0.658SerTrp: 0.658 ± 0.072
2.942SerTyr: 2.942 ± 0.145
0.0SerXaa: 0.0 ± 0.0
Thr
3.961ThrAla: 3.961 ± 0.381
1.242ThrCys: 1.242 ± 0.131
3.518ThrAsp: 3.518 ± 0.191
2.831ThrGlu: 2.831 ± 0.155
1.892ThrPhe: 1.892 ± 0.121
3.755ThrGly: 3.755 ± 0.304
1.604ThrHis: 1.604 ± 0.102
4.612ThrIle: 4.612 ± 0.198
3.902ThrLys: 3.902 ± 0.153
5.329ThrLeu: 5.329 ± 0.208
1.389ThrMet: 1.389 ± 0.112
4.205ThrAsn: 4.205 ± 0.219
3.474ThrPro: 3.474 ± 0.193
2.01ThrGln: 2.01 ± 0.144
3.148ThrArg: 3.148 ± 0.188
4.279ThrSer: 4.279 ± 0.179
5.432ThrThr: 5.432 ± 0.318
3.274ThrVal: 3.274 ± 0.182
0.636ThrTrp: 0.636 ± 0.073
2.912ThrTyr: 2.912 ± 0.15
0.0ThrXaa: 0.0 ± 0.0
Val
4.309ValAla: 4.309 ± 0.187
1.412ValCys: 1.412 ± 0.098
4.915ValAsp: 4.915 ± 0.199
3.888ValGlu: 3.888 ± 0.182
2.772ValPhe: 2.772 ± 0.145
3.304ValGly: 3.304 ± 0.243
0.894ValHis: 0.894 ± 0.075
5.942ValIle: 5.942 ± 0.196
5.233ValLys: 5.233 ± 0.228
4.701ValLeu: 4.701 ± 0.181
1.855ValMet: 1.855 ± 0.126
4.76ValAsn: 4.76 ± 0.226
1.434ValPro: 1.434 ± 0.114
1.249ValGln: 1.249 ± 0.093
2.262ValArg: 2.262 ± 0.123
3.828ValSer: 3.828 ± 0.18
3.422ValThr: 3.422 ± 0.175
5.077ValVal: 5.077 ± 0.194
0.584ValTrp: 0.584 ± 0.07
3.437ValTyr: 3.437 ± 0.166
0.0ValXaa: 0.0 ± 0.0
Trp
0.525TrpAla: 0.525 ± 0.063
0.362TrpCys: 0.362 ± 0.055
0.569TrpAsp: 0.569 ± 0.067
0.525TrpGlu: 0.525 ± 0.06
0.636TrpPhe: 0.636 ± 0.073
0.503TrpGly: 0.503 ± 0.058
0.259TrpHis: 0.259 ± 0.043
0.724TrpIle: 0.724 ± 0.089
0.576TrpLys: 0.576 ± 0.063
1.183TrpLeu: 1.183 ± 0.096
0.406TrpMet: 0.406 ± 0.05
0.576TrpAsn: 0.576 ± 0.062
0.229TrpPro: 0.229 ± 0.042
0.392TrpGln: 0.392 ± 0.052
0.791TrpArg: 0.791 ± 0.082
0.503TrpSer: 0.503 ± 0.053
0.451TrpThr: 0.451 ± 0.055
0.673TrpVal: 0.673 ± 0.069
0.185TrpTrp: 0.185 ± 0.041
0.547TrpTyr: 0.547 ± 0.059
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.727TyrAla: 2.727 ± 0.131
0.998TyrCys: 0.998 ± 0.095
3.452TyrAsp: 3.452 ± 0.166
2.631TyrGlu: 2.631 ± 0.12
1.656TyrPhe: 1.656 ± 0.095
2.572TyrGly: 2.572 ± 0.169
1.316TyrHis: 1.316 ± 0.099
4.228TyrIle: 4.228 ± 0.208
4.183TyrLys: 4.183 ± 0.199
3.718TyrLeu: 3.718 ± 0.197
1.205TyrMet: 1.205 ± 0.1
3.843TyrAsn: 3.843 ± 0.154
1.641TyrPro: 1.641 ± 0.118
1.353TyrGln: 1.353 ± 0.089
2.225TyrArg: 2.225 ± 0.129
3.23TyrSer: 3.23 ± 0.183
3.629TyrThr: 3.629 ± 0.166
2.801TyrVal: 2.801 ± 0.138
0.503TyrTrp: 0.503 ± 0.064
3.296TyrTyr: 3.296 ± 0.189
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 492 proteins (135304 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski