Amino acid dipepetide frequency for Candidatus Dependentiae bacterium (ex Spumella elongata CCAP 955/1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.33AlaAla: 6.33 ± 0.217
1.271AlaCys: 1.271 ± 0.064
4.091AlaAsp: 4.091 ± 0.123
3.654AlaGlu: 3.654 ± 0.128
2.817AlaPhe: 2.817 ± 0.105
4.665AlaGly: 4.665 ± 0.142
1.906AlaHis: 1.906 ± 0.08
6.003AlaIle: 6.003 ± 0.146
4.219AlaLys: 4.219 ± 0.136
7.723AlaLeu: 7.723 ± 0.181
2.242AlaMet: 2.242 ± 0.087
2.86AlaAsn: 2.86 ± 0.151
2.19AlaPro: 2.19 ± 0.093
4.76AlaGln: 4.76 ± 0.138
2.585AlaArg: 2.585 ± 0.116
4.625AlaSer: 4.625 ± 0.148
4.598AlaThr: 4.598 ± 0.254
4.943AlaVal: 4.943 ± 0.149
0.66AlaTrp: 0.66 ± 0.048
2.52AlaTyr: 2.52 ± 0.093
0.0AlaXaa: 0.0 ± 0.0
Cys
0.975CysAla: 0.975 ± 0.051
0.397CysCys: 0.397 ± 0.054
0.666CysAsp: 0.666 ± 0.053
0.422CysGlu: 0.422 ± 0.033
0.733CysPhe: 0.733 ± 0.049
0.816CysGly: 0.816 ± 0.061
0.391CysHis: 0.391 ± 0.037
1.176CysIle: 1.176 ± 0.067
0.984CysLys: 0.984 ± 0.059
1.405CysLeu: 1.405 ± 0.07
0.522CysMet: 0.522 ± 0.041
0.779CysAsn: 0.779 ± 0.053
0.504CysPro: 0.504 ± 0.041
0.525CysGln: 0.525 ± 0.047
0.391CysArg: 0.391 ± 0.038
1.109CysSer: 1.109 ± 0.064
0.755CysThr: 0.755 ± 0.046
0.779CysVal: 0.779 ± 0.046
0.113CysTrp: 0.113 ± 0.019
0.489CysTyr: 0.489 ± 0.044
0.0CysXaa: 0.0 ± 0.0
Asp
4.424AspAla: 4.424 ± 0.144
0.831AspCys: 0.831 ± 0.051
2.838AspAsp: 2.838 ± 0.112
3.752AspGlu: 3.752 ± 0.137
3.113AspPhe: 3.113 ± 0.109
2.713AspGly: 2.713 ± 0.118
1.158AspHis: 1.158 ± 0.053
4.702AspIle: 4.702 ± 0.136
3.755AspLys: 3.755 ± 0.127
5.245AspLeu: 5.245 ± 0.126
1.265AspMet: 1.265 ± 0.065
2.881AspAsn: 2.881 ± 0.112
1.671AspPro: 1.671 ± 0.079
2.701AspGln: 2.701 ± 0.094
1.937AspArg: 1.937 ± 0.088
3.15AspSer: 3.15 ± 0.117
3.122AspThr: 3.122 ± 0.147
3.678AspVal: 3.678 ± 0.135
0.419AspTrp: 0.419 ± 0.035
2.01AspTyr: 2.01 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
3.0GluAla: 3.0 ± 0.134
0.501GluCys: 0.501 ± 0.04
2.728GluAsp: 2.728 ± 0.106
3.455GluGlu: 3.455 ± 0.136
2.472GluPhe: 2.472 ± 0.093
1.955GluGly: 1.955 ± 0.089
1.494GluHis: 1.494 ± 0.073
4.833GluIle: 4.833 ± 0.152
5.343GluLys: 5.343 ± 0.163
5.606GluLeu: 5.606 ± 0.159
1.537GluMet: 1.537 ± 0.063
3.55GluAsn: 3.55 ± 0.116
1.237GluPro: 1.237 ± 0.074
3.859GluGln: 3.859 ± 0.132
2.001GluArg: 2.001 ± 0.098
3.681GluSer: 3.681 ± 0.127
2.536GluThr: 2.536 ± 0.084
2.86GluVal: 2.86 ± 0.109
0.428GluTrp: 0.428 ± 0.034
2.12GluTyr: 2.12 ± 0.086
0.0GluXaa: 0.0 ± 0.0
Phe
3.272PheAla: 3.272 ± 0.12
0.791PheCys: 0.791 ± 0.05
3.302PheAsp: 3.302 ± 0.095
2.487PheGlu: 2.487 ± 0.1
3.037PhePhe: 3.037 ± 0.115
2.884PheGly: 2.884 ± 0.122
0.959PheHis: 0.959 ± 0.054
4.039PheIle: 4.039 ± 0.153
2.649PheLys: 2.649 ± 0.108
5.239PheLeu: 5.239 ± 0.158
1.442PheMet: 1.442 ± 0.077
2.487PheAsn: 2.487 ± 0.085
1.326PhePro: 1.326 ± 0.066
1.821PheGln: 1.821 ± 0.078
0.889PheArg: 0.889 ± 0.057
3.067PheSer: 3.067 ± 0.118
2.475PheThr: 2.475 ± 0.092
2.884PheVal: 2.884 ± 0.11
0.394PheTrp: 0.394 ± 0.037
2.12PheTyr: 2.12 ± 0.078
0.0PheXaa: 0.0 ± 0.0
Gly
4.146GlyAla: 4.146 ± 0.165
0.834GlyCys: 0.834 ± 0.056
2.172GlyAsp: 2.172 ± 0.104
1.744GlyGlu: 1.744 ± 0.074
2.682GlyPhe: 2.682 ± 0.1
3.064GlyGly: 3.064 ± 0.195
1.204GlyHis: 1.204 ± 0.069
4.375GlyIle: 4.375 ± 0.131
3.926GlyLys: 3.926 ± 0.127
4.888GlyLeu: 4.888 ± 0.158
1.476GlyMet: 1.476 ± 0.077
2.594GlyAsn: 2.594 ± 0.106
1.201GlyPro: 1.201 ± 0.063
2.316GlyGln: 2.316 ± 0.091
1.747GlyArg: 1.747 ± 0.088
3.785GlySer: 3.785 ± 0.162
3.29GlyThr: 3.29 ± 0.261
3.434GlyVal: 3.434 ± 0.127
0.538GlyTrp: 0.538 ± 0.042
2.291GlyTyr: 2.291 ± 0.108
0.0GlyXaa: 0.0 ± 0.0
His
1.983HisAla: 1.983 ± 0.081
0.376HisCys: 0.376 ± 0.034
1.699HisAsp: 1.699 ± 0.076
1.744HisGlu: 1.744 ± 0.074
0.926HisPhe: 0.926 ± 0.063
1.445HisGly: 1.445 ± 0.07
0.822HisHis: 0.822 ± 0.061
1.815HisIle: 1.815 ± 0.085
1.506HisLys: 1.506 ± 0.084
2.047HisLeu: 2.047 ± 0.08
0.458HisMet: 0.458 ± 0.043
1.43HisAsn: 1.43 ± 0.064
0.752HisPro: 0.752 ± 0.049
1.311HisGln: 1.311 ± 0.066
0.794HisArg: 0.794 ± 0.05
1.24HisSer: 1.24 ± 0.07
1.271HisThr: 1.271 ± 0.069
1.546HisVal: 1.546 ± 0.074
0.134HisTrp: 0.134 ± 0.025
1.02HisTyr: 1.02 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
7.109IleAla: 7.109 ± 0.147
0.981IleCys: 0.981 ± 0.054
5.438IleAsp: 5.438 ± 0.164
4.998IleGlu: 4.998 ± 0.131
3.862IlePhe: 3.862 ± 0.137
3.819IleGly: 3.819 ± 0.131
1.717IleHis: 1.717 ± 0.083
6.257IleIle: 6.257 ± 0.173
5.756IleLys: 5.756 ± 0.158
7.176IleLeu: 7.176 ± 0.173
2.059IleMet: 2.059 ± 0.082
4.213IleAsn: 4.213 ± 0.117
2.636IlePro: 2.636 ± 0.097
3.584IleGln: 3.584 ± 0.121
2.071IleArg: 2.071 ± 0.091
5.71IleSer: 5.71 ± 0.139
4.94IleThr: 4.94 ± 0.142
5.365IleVal: 5.365 ± 0.136
0.461IleTrp: 0.461 ± 0.041
2.423IleTyr: 2.423 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
4.396LysAla: 4.396 ± 0.15
0.443LysCys: 0.443 ± 0.036
4.265LysAsp: 4.265 ± 0.13
4.589LysGlu: 4.589 ± 0.161
2.655LysPhe: 2.655 ± 0.091
2.713LysGly: 2.713 ± 0.112
1.552LysHis: 1.552 ± 0.071
6.651LysIle: 6.651 ± 0.166
8.081LysLys: 8.081 ± 0.222
5.847LysLeu: 5.847 ± 0.147
1.998LysMet: 1.998 ± 0.084
6.003LysAsn: 6.003 ± 0.165
1.992LysPro: 1.992 ± 0.075
3.189LysGln: 3.189 ± 0.124
2.45LysArg: 2.45 ± 0.107
4.598LysSer: 4.598 ± 0.146
3.962LysThr: 3.962 ± 0.128
3.532LysVal: 3.532 ± 0.111
0.321LysTrp: 0.321 ± 0.031
2.239LysTyr: 2.239 ± 0.092
0.0LysXaa: 0.0 ± 0.0
Leu
7.063LeuAla: 7.063 ± 0.187
1.341LeuCys: 1.341 ± 0.071
5.209LeuAsp: 5.209 ± 0.151
5.45LeuGlu: 5.45 ± 0.163
5.065LeuPhe: 5.065 ± 0.16
4.665LeuGly: 4.665 ± 0.144
3.26LeuHis: 3.26 ± 0.143
6.727LeuIle: 6.727 ± 0.191
6.098LeuLys: 6.098 ± 0.174
10.949LeuLeu: 10.949 ± 0.277
2.401LeuMet: 2.401 ± 0.101
4.078LeuAsn: 4.078 ± 0.12
3.425LeuPro: 3.425 ± 0.117
6.513LeuGln: 6.513 ± 0.185
3.061LeuArg: 3.061 ± 0.11
7.143LeuSer: 7.143 ± 0.16
5.328LeuThr: 5.328 ± 0.129
5.563LeuVal: 5.563 ± 0.136
0.706LeuTrp: 0.706 ± 0.053
3.733LeuTyr: 3.733 ± 0.106
0.0LeuXaa: 0.0 ± 0.0
Met
1.411MetAla: 1.411 ± 0.075
0.251MetCys: 0.251 ± 0.031
0.917MetAsp: 0.917 ± 0.053
0.892MetGlu: 0.892 ± 0.058
1.051MetPhe: 1.051 ± 0.061
1.072MetGly: 1.072 ± 0.06
0.849MetHis: 0.849 ± 0.053
2.478MetIle: 2.478 ± 0.085
2.737MetLys: 2.737 ± 0.097
2.875MetLeu: 2.875 ± 0.096
0.8MetMet: 0.8 ± 0.047
1.546MetAsn: 1.546 ± 0.078
0.926MetPro: 0.926 ± 0.052
1.821MetGln: 1.821 ± 0.079
0.883MetArg: 0.883 ± 0.05
1.686MetSer: 1.686 ± 0.084
1.372MetThr: 1.372 ± 0.06
1.61MetVal: 1.61 ± 0.069
0.134MetTrp: 0.134 ± 0.02
1.042MetTyr: 1.042 ± 0.056
0.0MetXaa: 0.0 ± 0.0
Asn
3.302AsnAla: 3.302 ± 0.117
0.687AsnCys: 0.687 ± 0.047
2.368AsnAsp: 2.368 ± 0.092
2.734AsnGlu: 2.734 ± 0.096
2.85AsnPhe: 2.85 ± 0.105
2.423AsnGly: 2.423 ± 0.11
1.14AsnHis: 1.14 ± 0.065
5.047AsnIle: 5.047 ± 0.153
4.204AsnLys: 4.204 ± 0.128
5.297AsnLeu: 5.297 ± 0.137
1.335AsnMet: 1.335 ± 0.059
3.687AsnAsn: 3.687 ± 0.136
2.071AsnPro: 2.071 ± 0.089
2.685AsnGln: 2.685 ± 0.101
1.909AsnArg: 1.909 ± 0.069
3.831AsnSer: 3.831 ± 0.132
2.685AsnThr: 2.685 ± 0.131
2.798AsnVal: 2.798 ± 0.105
0.419AsnTrp: 0.419 ± 0.042
2.105AsnTyr: 2.105 ± 0.084
0.0AsnXaa: 0.0 ± 0.0
Pro
2.496ProAla: 2.496 ± 0.105
0.498ProCys: 0.498 ± 0.043
1.711ProAsp: 1.711 ± 0.075
2.261ProGlu: 2.261 ± 0.089
1.674ProPhe: 1.674 ± 0.077
1.738ProGly: 1.738 ± 0.082
0.816ProHis: 0.816 ± 0.053
2.374ProIle: 2.374 ± 0.086
1.573ProLys: 1.573 ± 0.082
3.648ProLeu: 3.648 ± 0.145
0.779ProMet: 0.779 ± 0.057
1.124ProAsn: 1.124 ± 0.065
0.69ProPro: 0.69 ± 0.103
1.402ProGln: 1.402 ± 0.073
0.764ProArg: 0.764 ± 0.045
2.279ProSer: 2.279 ± 0.086
1.928ProThr: 1.928 ± 0.079
2.502ProVal: 2.502 ± 0.085
0.299ProTrp: 0.299 ± 0.032
1.289ProTyr: 1.289 ± 0.074
0.0ProXaa: 0.0 ± 0.0
Gln
5.245GlnAla: 5.245 ± 0.155
0.507GlnCys: 0.507 ± 0.038
3.51GlnAsp: 3.51 ± 0.112
3.953GlnGlu: 3.953 ± 0.122
1.873GlnPhe: 1.873 ± 0.09
2.96GlnGly: 2.96 ± 0.127
1.14GlnHis: 1.14 ± 0.066
3.449GlnIle: 3.449 ± 0.11
3.773GlnLys: 3.773 ± 0.131
4.83GlnLeu: 4.83 ± 0.142
1.033GlnMet: 1.033 ± 0.051
3.098GlnAsn: 3.098 ± 0.105
1.601GlnPro: 1.601 ± 0.077
3.058GlnGln: 3.058 ± 0.109
1.683GlnArg: 1.683 ± 0.065
3.501GlnSer: 3.501 ± 0.12
2.853GlnThr: 2.853 ± 0.11
2.792GlnVal: 2.792 ± 0.1
0.449GlnTrp: 0.449 ± 0.04
1.647GlnTyr: 1.647 ± 0.072
0.0GlnXaa: 0.0 ± 0.0
Arg
2.343ArgAla: 2.343 ± 0.102
0.409ArgCys: 0.409 ± 0.034
1.622ArgAsp: 1.622 ± 0.08
1.717ArgGlu: 1.717 ± 0.096
1.586ArgPhe: 1.586 ± 0.074
1.509ArgGly: 1.509 ± 0.07
0.73ArgHis: 0.73 ± 0.05
2.368ArgIle: 2.368 ± 0.097
2.355ArgLys: 2.355 ± 0.08
3.165ArgLeu: 3.165 ± 0.118
0.904ArgMet: 0.904 ± 0.057
1.79ArgAsn: 1.79 ± 0.073
0.975ArgPro: 0.975 ± 0.057
1.485ArgGln: 1.485 ± 0.06
1.25ArgArg: 1.25 ± 0.073
2.187ArgSer: 2.187 ± 0.097
1.647ArgThr: 1.647 ± 0.07
1.809ArgVal: 1.809 ± 0.082
0.275ArgTrp: 0.275 ± 0.031
1.317ArgTyr: 1.317 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
4.326SerAla: 4.326 ± 0.152
1.274SerCys: 1.274 ± 0.073
3.354SerAsp: 3.354 ± 0.113
2.881SerGlu: 2.881 ± 0.094
4.1SerPhe: 4.1 ± 0.127
3.886SerGly: 3.886 ± 0.145
1.625SerHis: 1.625 ± 0.07
5.502SerIle: 5.502 ± 0.127
4.36SerLys: 4.36 ± 0.123
7.415SerLeu: 7.415 ± 0.186
2.203SerMet: 2.203 ± 0.088
3.11SerAsn: 3.11 ± 0.12
1.986SerPro: 1.986 ± 0.083
3.367SerGln: 3.367 ± 0.129
2.068SerArg: 2.068 ± 0.082
5.594SerSer: 5.594 ± 0.208
3.663SerThr: 3.663 ± 0.154
4.017SerVal: 4.017 ± 0.129
0.828SerTrp: 0.828 ± 0.052
2.89SerTyr: 2.89 ± 0.102
0.0SerXaa: 0.0 ± 0.0
Thr
4.457ThrAla: 4.457 ± 0.224
0.779ThrCys: 0.779 ± 0.052
2.918ThrAsp: 2.918 ± 0.137
2.578ThrGlu: 2.578 ± 0.106
2.45ThrPhe: 2.45 ± 0.09
3.278ThrGly: 3.278 ± 0.178
1.155ThrHis: 1.155 ± 0.058
4.903ThrIle: 4.903 ± 0.146
3.504ThrLys: 3.504 ± 0.121
5.157ThrLeu: 5.157 ± 0.13
1.243ThrMet: 1.243 ± 0.057
2.646ThrAsn: 2.646 ± 0.131
3.247ThrPro: 3.247 ± 0.115
2.86ThrGln: 2.86 ± 0.108
1.537ThrArg: 1.537 ± 0.066
4.103ThrSer: 4.103 ± 0.188
4.155ThrThr: 4.155 ± 0.238
3.504ThrVal: 3.504 ± 0.121
0.419ThrTrp: 0.419 ± 0.037
1.961ThrTyr: 1.961 ± 0.085
0.0ThrXaa: 0.0 ± 0.0
Val
4.98ValAla: 4.98 ± 0.186
0.959ValCys: 0.959 ± 0.056
3.981ValAsp: 3.981 ± 0.123
3.452ValGlu: 3.452 ± 0.127
2.303ValPhe: 2.303 ± 0.091
3.58ValGly: 3.58 ± 0.147
1.35ValHis: 1.35 ± 0.066
4.689ValIle: 4.689 ± 0.126
3.596ValLys: 3.596 ± 0.132
4.796ValLeu: 4.796 ± 0.139
1.665ValMet: 1.665 ± 0.079
2.963ValAsn: 2.963 ± 0.113
1.885ValPro: 1.885 ± 0.084
3.275ValGln: 3.275 ± 0.108
1.97ValArg: 1.97 ± 0.08
4.246ValSer: 4.246 ± 0.124
3.709ValThr: 3.709 ± 0.123
4.473ValVal: 4.473 ± 0.144
0.519ValTrp: 0.519 ± 0.038
2.249ValTyr: 2.249 ± 0.083
0.0ValXaa: 0.0 ± 0.0
Trp
0.47TrpAla: 0.47 ± 0.042
0.125TrpCys: 0.125 ± 0.022
0.428TrpAsp: 0.428 ± 0.035
0.275TrpGlu: 0.275 ± 0.033
0.428TrpPhe: 0.428 ± 0.035
0.486TrpGly: 0.486 ± 0.04
0.177TrpHis: 0.177 ± 0.025
0.605TrpIle: 0.605 ± 0.046
0.519TrpLys: 0.519 ± 0.044
0.752TrpLeu: 0.752 ± 0.052
0.235TrpMet: 0.235 ± 0.025
0.48TrpAsn: 0.48 ± 0.037
0.189TrpPro: 0.189 ± 0.023
0.483TrpGln: 0.483 ± 0.045
0.272TrpArg: 0.272 ± 0.03
0.684TrpSer: 0.684 ± 0.049
0.458TrpThr: 0.458 ± 0.041
0.431TrpVal: 0.431 ± 0.04
0.092TrpTrp: 0.092 ± 0.017
0.364TrpTyr: 0.364 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.933TyrAla: 2.933 ± 0.101
0.675TyrCys: 0.675 ± 0.048
2.148TyrAsp: 2.148 ± 0.082
2.157TyrGlu: 2.157 ± 0.092
1.888TyrPhe: 1.888 ± 0.086
2.035TyrGly: 2.035 ± 0.082
0.874TyrHis: 0.874 ± 0.055
2.582TyrIle: 2.582 ± 0.102
2.542TyrLys: 2.542 ± 0.093
3.718TyrLeu: 3.718 ± 0.124
0.752TyrMet: 0.752 ± 0.048
2.261TyrAsn: 2.261 ± 0.077
1.341TyrPro: 1.341 ± 0.062
1.943TyrGln: 1.943 ± 0.095
1.179TyrArg: 1.179 ± 0.058
2.227TyrSer: 2.227 ± 0.093
2.108TyrThr: 2.108 ± 0.105
2.123TyrVal: 2.123 ± 0.089
0.345TyrTrp: 0.345 ± 0.035
1.531TyrTyr: 1.531 ± 0.076
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1075 proteins (327330 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski