Amino acid dipepetide frequency for Coleofasciculus chthonoplastes PCC 7420

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.584AlaAla: 6.584 ± 0.064	0.777AlaCys: 0.777 ± 0.018	4.17AlaAsp: 4.17 ± 0.049	5.118AlaGlu: 5.118 ± 0.064	2.776AlaPhe: 2.776 ± 0.041	5.443AlaGly: 5.443 ± 0.068	1.223AlaHis: 1.223 ± 0.027	6.393AlaIle: 6.393 ± 0.064	3.788AlaLys: 3.788 ± 0.05	8.303AlaLeu: 8.303 ± 0.084	1.615AlaMet: 1.615 ± 0.028	3.546AlaAsn: 3.546 ± 0.072	2.76AlaPro: 2.76 ± 0.049	4.532AlaGln: 4.532 ± 0.056	3.4AlaArg: 3.4 ± 0.046	4.698AlaSer: 4.698 ± 0.061	4.573AlaThr: 4.573 ± 0.057	4.998AlaVal: 4.998 ± 0.06	1.016AlaTrp: 1.016 ± 0.025	2.255AlaTyr: 2.255 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.603CysAla: 0.603 ± 0.017	0.207CysCys: 0.207 ± 0.011	0.596CysAsp: 0.596 ± 0.018	0.484CysGlu: 0.484 ± 0.015	0.394CysPhe: 0.394 ± 0.014	0.728CysGly: 0.728 ± 0.02	0.373CysHis: 0.373 ± 0.013	0.543CysIle: 0.543 ± 0.017	0.326CysLys: 0.326 ± 0.012	1.249CysLeu: 1.249 ± 0.023	0.162CysMet: 0.162 ± 0.009	0.355CysAsn: 0.355 ± 0.012	0.579CysPro: 0.579 ± 0.015	0.788CysGln: 0.788 ± 0.019	0.633CysArg: 0.633 ± 0.017	0.712CysSer: 0.712 ± 0.017	0.475CysThr: 0.475 ± 0.015	0.532CysVal: 0.532 ± 0.016	0.164CysTrp: 0.164 ± 0.009	0.388CysTyr: 0.388 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.935AspAla: 3.935 ± 0.046	0.608AspCys: 0.608 ± 0.017	2.547AspAsp: 2.547 ± 0.058	3.196AspGlu: 3.196 ± 0.043	2.342AspPhe: 2.342 ± 0.036	3.578AspGly: 3.578 ± 0.071	0.871AspHis: 0.871 ± 0.02	3.721AspIle: 3.721 ± 0.05	2.242AspLys: 2.242 ± 0.034	5.662AspLeu: 5.662 ± 0.066	0.869AspMet: 0.869 ± 0.018	2.254AspAsn: 2.254 ± 0.038	2.395AspPro: 2.395 ± 0.037	2.54AspGln: 2.54 ± 0.042	3.2AspArg: 3.2 ± 0.04	3.209AspSer: 3.209 ± 0.048	2.82AspThr: 2.82 ± 0.047	3.21AspVal: 3.21 ± 0.046	1.043AspTrp: 1.043 ± 0.028	2.163AspTyr: 2.163 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.631GluAla: 5.631 ± 0.063	0.481GluCys: 0.481 ± 0.016	2.996GluAsp: 2.996 ± 0.045	3.968GluGlu: 3.968 ± 0.058	2.402GluPhe: 2.402 ± 0.041	3.497GluGly: 3.497 ± 0.046	0.936GluHis: 0.936 ± 0.022	4.357GluIle: 4.357 ± 0.051	2.996GluLys: 2.996 ± 0.041	6.964GluLeu: 6.964 ± 0.065	1.308GluMet: 1.308 ± 0.025	2.515GluAsn: 2.515 ± 0.04	2.746GluPro: 2.746 ± 0.047	3.98GluGln: 3.98 ± 0.057	3.737GluArg: 3.737 ± 0.051	3.825GluSer: 3.825 ± 0.055	3.845GluThr: 3.845 ± 0.046	3.885GluVal: 3.885 ± 0.042	0.81GluTrp: 0.81 ± 0.019	1.681GluTyr: 1.681 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	2.754PheAla: 2.754 ± 0.036	0.555PheCys: 0.555 ± 0.016	2.239PheAsp: 2.239 ± 0.037	2.217PheGlu: 2.217 ± 0.032	1.59PhePhe: 1.59 ± 0.031	2.686PheGly: 2.686 ± 0.041	0.726PheHis: 0.726 ± 0.018	2.368PheIle: 2.368 ± 0.039	1.541PheLys: 1.541 ± 0.032	3.88PheLeu: 3.88 ± 0.046	0.712PheMet: 0.712 ± 0.017	1.809PheAsn: 1.809 ± 0.032	1.991PhePro: 1.991 ± 0.027	1.811PheGln: 1.811 ± 0.028	1.813PheArg: 1.813 ± 0.029	2.96PheSer: 2.96 ± 0.047	2.283PheThr: 2.283 ± 0.041	2.267PheVal: 2.267 ± 0.039	0.694PheTrp: 0.694 ± 0.02	1.308PheTyr: 1.308 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	4.731GlyAla: 4.731 ± 0.074	0.761GlyCys: 0.761 ± 0.022	3.802GlyAsp: 3.802 ± 0.082	4.606GlyGlu: 4.606 ± 0.058	2.991GlyPhe: 2.991 ± 0.038	5.08GlyGly: 5.08 ± 0.104	1.224GlyHis: 1.224 ± 0.03	5.009GlyIle: 5.009 ± 0.06	3.76GlyLys: 3.76 ± 0.047	6.936GlyLeu: 6.936 ± 0.07	1.515GlyMet: 1.515 ± 0.032	3.368GlyAsn: 3.368 ± 0.092	0.914GlyPro: 0.914 ± 0.023	3.199GlyGln: 3.199 ± 0.04	3.326GlyArg: 3.326 ± 0.043	4.192GlySer: 4.192 ± 0.058	4.153GlyThr: 4.153 ± 0.075	4.744GlyVal: 4.744 ± 0.057	1.13GlyTrp: 1.13 ± 0.025	2.242GlyTyr: 2.242 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	1.037HisAla: 1.037 ± 0.024	0.289HisCys: 0.289 ± 0.011	0.833HisAsp: 0.833 ± 0.021	0.898HisGlu: 0.898 ± 0.021	0.798HisPhe: 0.798 ± 0.018	1.12HisGly: 1.12 ± 0.023	0.675HisHis: 0.675 ± 0.02	1.038HisIle: 1.038 ± 0.021	0.732HisLys: 0.732 ± 0.019	2.396HisLeu: 2.396 ± 0.034	0.144HisMet: 0.144 ± 0.008	0.743HisAsn: 0.743 ± 0.021	1.616HisPro: 1.616 ± 0.029	1.412HisGln: 1.412 ± 0.033	1.209HisArg: 1.209 ± 0.027	1.288HisSer: 1.288 ± 0.025	0.917HisThr: 0.917 ± 0.023	0.784HisVal: 0.784 ± 0.017	0.375HisTrp: 0.375 ± 0.014	0.754HisTyr: 0.754 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.391IleAla: 6.391 ± 0.057	0.713IleCys: 0.713 ± 0.017	3.574IleAsp: 3.574 ± 0.049	4.354IleGlu: 4.354 ± 0.046	2.263IlePhe: 2.263 ± 0.035	4.321IleGly: 4.321 ± 0.051	1.26IleHis: 1.26 ± 0.025	3.565IleIle: 3.565 ± 0.046	2.691IleLys: 2.691 ± 0.033	6.419IleLeu: 6.419 ± 0.066	0.807IleMet: 0.807 ± 0.019	2.933IleAsn: 2.933 ± 0.054	3.614IlePro: 3.614 ± 0.052	3.355IleGln: 3.355 ± 0.042	3.34IleArg: 3.34 ± 0.035	4.2IleSer: 4.2 ± 0.049	3.79IleThr: 3.79 ± 0.069	3.913IleVal: 3.913 ± 0.046	0.826IleTrp: 0.826 ± 0.02	1.804IleTyr: 1.804 ± 0.032	0.001IleXaa: 0.001 ± 0.001
Lys	3.729LysAla: 3.729 ± 0.049	0.321LysCys: 0.321 ± 0.012	1.976LysAsp: 1.976 ± 0.032	2.38LysGlu: 2.38 ± 0.039	1.487LysPhe: 1.487 ± 0.029	2.712LysGly: 2.712 ± 0.04	0.808LysHis: 0.808 ± 0.022	2.818LysIle: 2.818 ± 0.046	2.108LysLys: 2.108 ± 0.042	4.795LysLeu: 4.795 ± 0.057	0.854LysMet: 0.854 ± 0.021	1.631LysAsn: 1.631 ± 0.031	2.568LysPro: 2.568 ± 0.043	2.654LysGln: 2.654 ± 0.042	2.677LysArg: 2.677 ± 0.041	2.725LysSer: 2.725 ± 0.039	2.897LysThr: 2.897 ± 0.037	2.588LysVal: 2.588 ± 0.039	0.481LysTrp: 0.481 ± 0.016	1.17LysTyr: 1.17 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	9.282LeuAla: 9.282 ± 0.079	1.075LeuCys: 1.075 ± 0.022	5.705LeuAsp: 5.705 ± 0.057	7.129LeuGlu: 7.129 ± 0.073	3.817LeuPhe: 3.817 ± 0.051	7.485LeuGly: 7.485 ± 0.067	1.974LeuHis: 1.974 ± 0.037	6.661LeuIle: 6.661 ± 0.056	5.21LeuLys: 5.21 ± 0.057	10.692LeuLeu: 10.692 ± 0.102	2.109LeuMet: 2.109 ± 0.031	5.138LeuAsn: 5.138 ± 0.062	5.715LeuPro: 5.715 ± 0.064	5.541LeuGln: 5.541 ± 0.066	5.701LeuArg: 5.701 ± 0.062	8.067LeuSer: 8.067 ± 0.081	6.869LeuThr: 6.869 ± 0.077	6.921LeuVal: 6.921 ± 0.059	1.548LeuTrp: 1.548 ± 0.035	2.782LeuTyr: 2.782 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.685MetAla: 1.685 ± 0.026	0.117MetCys: 0.117 ± 0.007	0.815MetAsp: 0.815 ± 0.019	1.036MetGlu: 1.036 ± 0.022	0.553MetPhe: 0.553 ± 0.016	1.415MetGly: 1.415 ± 0.026	0.308MetHis: 0.308 ± 0.011	1.144MetIle: 1.144 ± 0.023	0.841MetLys: 0.841 ± 0.021	1.744MetLeu: 1.744 ± 0.033	0.415MetMet: 0.415 ± 0.012	0.847MetAsn: 0.847 ± 0.015	0.956MetPro: 0.956 ± 0.022	0.871MetGln: 0.871 ± 0.023	0.983MetArg: 0.983 ± 0.022	1.3MetSer: 1.3 ± 0.027	1.34MetThr: 1.34 ± 0.024	1.326MetVal: 1.326 ± 0.027	0.156MetTrp: 0.156 ± 0.008	0.363MetTyr: 0.363 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.854AsnAla: 2.854 ± 0.045	0.496AsnCys: 0.496 ± 0.016	1.881AsnAsp: 1.881 ± 0.063	1.692AsnGlu: 1.692 ± 0.032	1.7AsnPhe: 1.7 ± 0.031	2.735AsnGly: 2.735 ± 0.069	0.957AsnHis: 0.957 ± 0.022	2.21AsnIle: 2.21 ± 0.044	1.404AsnLys: 1.404 ± 0.026	5.654AsnLeu: 5.654 ± 0.099	0.567AsnMet: 0.567 ± 0.016	1.809AsnAsn: 1.809 ± 0.049	3.464AsnPro: 3.464 ± 0.051	3.203AsnGln: 3.203 ± 0.046	2.672AsnArg: 2.672 ± 0.038	2.856AsnSer: 2.856 ± 0.051	2.184AsnThr: 2.184 ± 0.044	2.205AsnVal: 2.205 ± 0.038	0.777AsnTrp: 0.777 ± 0.02	1.442AsnTyr: 1.442 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	3.128ProAla: 3.128 ± 0.051	0.402ProCys: 0.402 ± 0.014	3.69ProAsp: 3.69 ± 0.048	4.145ProGlu: 4.145 ± 0.056	1.776ProPhe: 1.776 ± 0.028	3.008ProGly: 3.008 ± 0.042	0.935ProHis: 0.935 ± 0.024	3.204ProIle: 3.204 ± 0.041	2.116ProLys: 2.116 ± 0.037	5.117ProLeu: 5.117 ± 0.057	0.868ProMet: 0.868 ± 0.02	2.294ProAsn: 2.294 ± 0.037	2.965ProPro: 2.965 ± 0.051	2.745ProGln: 2.745 ± 0.033	1.87ProArg: 1.87 ± 0.031	3.349ProSer: 3.349 ± 0.049	3.129ProThr: 3.129 ± 0.05	3.219ProVal: 3.219 ± 0.043	0.643ProTrp: 0.643 ± 0.019	1.311ProTyr: 1.311 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	5.262GlnAla: 5.262 ± 0.058	0.41GlnCys: 0.41 ± 0.013	2.621GlnAsp: 2.621 ± 0.035	3.747GlnGlu: 3.747 ± 0.05	2.069GlnPhe: 2.069 ± 0.036	3.926GlnGly: 3.926 ± 0.056	0.971GlnHis: 0.971 ± 0.021	3.587GlnIle: 3.587 ± 0.043	2.418GlnLys: 2.418 ± 0.037	6.887GlnLeu: 6.887 ± 0.077	1.15GlnMet: 1.15 ± 0.022	2.029GlnAsn: 2.029 ± 0.036	3.011GlnPro: 3.011 ± 0.043	4.092GlnGln: 4.092 ± 0.064	3.487GlnArg: 3.487 ± 0.046	3.279GlnSer: 3.279 ± 0.044	3.34GlnThr: 3.34 ± 0.045	4.186GlnVal: 4.186 ± 0.047	0.802GlnTrp: 0.802 ± 0.021	1.255GlnTyr: 1.255 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.239ArgAla: 3.239 ± 0.047	0.612ArgCys: 0.612 ± 0.017	2.926ArgAsp: 2.926 ± 0.038	3.416ArgGlu: 3.416 ± 0.053	2.351ArgPhe: 2.351 ± 0.033	3.273ArgGly: 3.273 ± 0.043	1.196ArgHis: 1.196 ± 0.023	3.322ArgIle: 3.322 ± 0.04	2.228ArgLys: 2.228 ± 0.038	6.594ArgLeu: 6.594 ± 0.065	1.08ArgMet: 1.08 ± 0.022	1.918ArgAsn: 1.918 ± 0.03	1.966ArgPro: 1.966 ± 0.034	3.846ArgGln: 3.846 ± 0.05	3.493ArgArg: 3.493 ± 0.04	3.348ArgSer: 3.348 ± 0.045	2.587ArgThr: 2.587 ± 0.039	3.512ArgVal: 3.512 ± 0.04	0.948ArgTrp: 0.948 ± 0.023	2.009ArgTyr: 2.009 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.528SerAla: 4.528 ± 0.05	0.67SerCys: 0.67 ± 0.02	3.501SerAsp: 3.501 ± 0.043	3.851SerGlu: 3.851 ± 0.046	2.542SerPhe: 2.542 ± 0.038	4.903SerGly: 4.903 ± 0.069	1.417SerHis: 1.417 ± 0.026	3.596SerIle: 3.596 ± 0.04	2.317SerLys: 2.317 ± 0.031	7.492SerLeu: 7.492 ± 0.066	1.166SerMet: 1.166 ± 0.027	2.532SerAsn: 2.532 ± 0.041	4.195SerPro: 4.195 ± 0.059	4.068SerGln: 4.068 ± 0.053	3.468SerArg: 3.468 ± 0.039	4.452SerSer: 4.452 ± 0.06	3.557SerThr: 3.557 ± 0.053	4.074SerVal: 4.074 ± 0.056	0.929SerTrp: 0.929 ± 0.022	1.802SerTyr: 1.802 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	4.561ThrAla: 4.561 ± 0.068	0.524ThrCys: 0.524 ± 0.015	3.022ThrAsp: 3.022 ± 0.043	3.399ThrGlu: 3.399 ± 0.049	2.088ThrPhe: 2.088 ± 0.033	4.296ThrGly: 4.296 ± 0.066	1.132ThrHis: 1.132 ± 0.022	3.98ThrIle: 3.98 ± 0.064	2.008ThrLys: 2.008 ± 0.033	6.906ThrLeu: 6.906 ± 0.07	0.808ThrMet: 0.808 ± 0.02	2.298ThrAsn: 2.298 ± 0.042	3.888ThrPro: 3.888 ± 0.051	3.304ThrGln: 3.304 ± 0.047	2.528ThrArg: 2.528 ± 0.036	3.547ThrSer: 3.547 ± 0.053	3.395ThrThr: 3.395 ± 0.062	4.247ThrVal: 4.247 ± 0.053	0.74ThrTrp: 0.74 ± 0.022	1.594ThrTyr: 1.594 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	5.246ValAla: 5.246 ± 0.059	0.644ValCys: 0.644 ± 0.016	3.342ValAsp: 3.342 ± 0.043	4.472ValGlu: 4.472 ± 0.047	2.387ValPhe: 2.387 ± 0.032	4.543ValGly: 4.543 ± 0.05	0.957ValHis: 0.957 ± 0.021	4.139ValIle: 4.139 ± 0.046	2.973ValLys: 2.973 ± 0.038	6.283ValLeu: 6.283 ± 0.057	1.339ValMet: 1.339 ± 0.027	2.908ValAsn: 2.908 ± 0.044	2.769ValPro: 2.769 ± 0.037	3.013ValGln: 3.013 ± 0.041	3.333ValArg: 3.333 ± 0.043	4.244ValSer: 4.244 ± 0.052	3.964ValThr: 3.964 ± 0.057	4.516ValVal: 4.516 ± 0.061	0.87ValTrp: 0.87 ± 0.023	1.773ValTyr: 1.773 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	0.893TrpAla: 0.893 ± 0.022	0.163TrpCys: 0.163 ± 0.008	0.736TrpAsp: 0.736 ± 0.025	0.848TrpGlu: 0.848 ± 0.02	0.641TrpPhe: 0.641 ± 0.018	0.993TrpGly: 0.993 ± 0.023	0.392TrpHis: 0.392 ± 0.014	0.876TrpIle: 0.876 ± 0.023	0.574TrpLys: 0.574 ± 0.017	1.965TrpLeu: 1.965 ± 0.035	0.327TrpMet: 0.327 ± 0.013	0.606TrpAsn: 0.606 ± 0.017	0.153TrpPro: 0.153 ± 0.01	1.358TrpGln: 1.358 ± 0.024	0.921TrpArg: 0.921 ± 0.02	0.873TrpSer: 0.873 ± 0.023	0.682TrpThr: 0.682 ± 0.019	1.051TrpVal: 1.051 ± 0.022	0.265TrpTrp: 0.265 ± 0.012	0.469TrpTyr: 0.469 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.894TyrAla: 1.894 ± 0.032	0.465TyrCys: 0.465 ± 0.014	1.433TyrAsp: 1.433 ± 0.029	1.603TyrGlu: 1.603 ± 0.029	1.238TyrPhe: 1.238 ± 0.026	1.94TyrGly: 1.94 ± 0.038	0.723TyrHis: 0.723 ± 0.018	1.602TyrIle: 1.602 ± 0.028	1.106TyrLys: 1.106 ± 0.021	3.484TyrLeu: 3.484 ± 0.044	0.401TyrMet: 0.401 ± 0.014	1.227TyrAsn: 1.227 ± 0.028	1.65TyrPro: 1.65 ± 0.028	2.219TyrGln: 2.219 ± 0.035	2.072TyrArg: 2.072 ± 0.032	1.939TyrSer: 1.939 ± 0.029	1.466TyrThr: 1.466 ± 0.029	1.534TyrVal: 1.534 ± 0.028	0.568TyrTrp: 0.568 ± 0.017	1.094TyrTyr: 1.094 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.127XaaXaa: 0.127 ± 0.05

Statistics based on 8193 proteins (2324273 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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