Amino acid dipepetide frequency for Methylacidiphilum fumariolicum (strain SolV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.434AlaAla: 5.434 ± 0.094	0.92AlaCys: 0.92 ± 0.037	2.829AlaAsp: 2.829 ± 0.069	4.113AlaGlu: 4.113 ± 0.086	3.699AlaPhe: 3.699 ± 0.086	4.329AlaGly: 4.329 ± 0.088	1.367AlaHis: 1.367 ± 0.051	5.714AlaIle: 5.714 ± 0.096	4.684AlaLys: 4.684 ± 0.085	8.071AlaLeu: 8.071 ± 0.109	1.661AlaMet: 1.661 ± 0.046	2.382AlaAsn: 2.382 ± 0.06	2.426AlaPro: 2.426 ± 0.064	2.582AlaGln: 2.582 ± 0.079	3.311AlaArg: 3.311 ± 0.069	4.737AlaSer: 4.737 ± 0.083	3.179AlaThr: 3.179 ± 0.067	4.335AlaVal: 4.335 ± 0.087	0.811AlaTrp: 0.811 ± 0.04	2.282AlaTyr: 2.282 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	0.756CysAla: 0.756 ± 0.035	0.22CysCys: 0.22 ± 0.019	0.467CysAsp: 0.467 ± 0.027	0.618CysGlu: 0.618 ± 0.027	0.703CysPhe: 0.703 ± 0.035	1.099CysGly: 1.099 ± 0.048	0.382CysHis: 0.382 ± 0.029	0.759CysIle: 0.759 ± 0.034	0.597CysLys: 0.597 ± 0.034	1.387CysLeu: 1.387 ± 0.051	0.267CysMet: 0.267 ± 0.02	0.364CysAsn: 0.364 ± 0.024	0.756CysPro: 0.756 ± 0.04	0.533CysGln: 0.533 ± 0.03	0.673CysArg: 0.673 ± 0.029	0.962CysSer: 0.962 ± 0.043	0.427CysThr: 0.427 ± 0.027	0.626CysVal: 0.626 ± 0.034	0.242CysTrp: 0.242 ± 0.02	0.439CysTyr: 0.439 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	2.446AspAla: 2.446 ± 0.072	0.736AspCys: 0.736 ± 0.031	1.273AspAsp: 1.273 ± 0.049	2.42AspGlu: 2.42 ± 0.065	2.544AspPhe: 2.544 ± 0.059	2.731AspGly: 2.731 ± 0.069	0.926AspHis: 0.926 ± 0.039	3.202AspIle: 3.202 ± 0.06	2.535AspLys: 2.535 ± 0.069	4.964AspLeu: 4.964 ± 0.087	0.821AspMet: 0.821 ± 0.037	1.358AspAsn: 1.358 ± 0.046	3.019AspPro: 3.019 ± 0.068	1.67AspGln: 1.67 ± 0.052	2.264AspArg: 2.264 ± 0.064	2.653AspSer: 2.653 ± 0.056	1.637AspThr: 1.637 ± 0.052	2.364AspVal: 2.364 ± 0.065	0.843AspTrp: 0.843 ± 0.039	1.715AspTyr: 1.715 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.811GluAla: 5.811 ± 0.104	0.562GluCys: 0.562 ± 0.03	2.799GluAsp: 2.799 ± 0.063	6.774GluGlu: 6.774 ± 0.137	2.422GluPhe: 2.422 ± 0.061	4.458GluGly: 4.458 ± 0.089	1.115GluHis: 1.115 ± 0.039	5.846GluIle: 5.846 ± 0.097	7.516GluLys: 7.516 ± 0.15	6.993GluLeu: 6.993 ± 0.121	1.541GluMet: 1.541 ± 0.049	3.125GluAsn: 3.125 ± 0.07	2.455GluPro: 2.455 ± 0.055	2.411GluGln: 2.411 ± 0.062	3.579GluArg: 3.579 ± 0.09	3.963GluSer: 3.963 ± 0.078	2.861GluThr: 2.861 ± 0.07	3.907GluVal: 3.907 ± 0.098	0.9GluTrp: 0.9 ± 0.033	1.815GluTyr: 1.815 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.919PheAla: 2.919 ± 0.071	0.877PheCys: 0.877 ± 0.039	2.455PheAsp: 2.455 ± 0.068	3.009PheGlu: 3.009 ± 0.074	3.967PhePhe: 3.967 ± 0.118	3.563PheGly: 3.563 ± 0.082	1.267PheHis: 1.267 ± 0.042	3.206PheIle: 3.206 ± 0.079	2.258PheLys: 2.258 ± 0.061	7.028PheLeu: 7.028 ± 0.127	0.853PheMet: 0.853 ± 0.037	1.627PheAsn: 1.627 ± 0.051	2.876PhePro: 2.876 ± 0.07	1.814PheGln: 1.814 ± 0.051	2.211PheArg: 2.211 ± 0.059	4.79PheSer: 4.79 ± 0.104	1.861PheThr: 1.861 ± 0.052	3.053PheVal: 3.053 ± 0.077	1.002PheTrp: 1.002 ± 0.044	2.193PheTyr: 2.193 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	4.341GlyAla: 4.341 ± 0.087	1.009GlyCys: 1.009 ± 0.044	2.402GlyAsp: 2.402 ± 0.064	4.081GlyGlu: 4.081 ± 0.07	3.652GlyPhe: 3.652 ± 0.086	4.945GlyGly: 4.945 ± 0.112	1.406GlyHis: 1.406 ± 0.051	6.122GlyIle: 6.122 ± 0.106	5.572GlyLys: 5.572 ± 0.097	6.833GlyLeu: 6.833 ± 0.109	1.809GlyMet: 1.809 ± 0.051	2.332GlyAsn: 2.332 ± 0.062	2.406GlyPro: 2.406 ± 0.071	2.228GlyGln: 2.228 ± 0.062	3.182GlyArg: 3.182 ± 0.078	4.534GlySer: 4.534 ± 0.091	3.25GlyThr: 3.25 ± 0.073	4.12GlyVal: 4.12 ± 0.086	1.265GlyTrp: 1.265 ± 0.046	2.529GlyTyr: 2.529 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.276HisAla: 1.276 ± 0.048	0.338HisCys: 0.338 ± 0.023	0.712HisAsp: 0.712 ± 0.033	1.017HisGlu: 1.017 ± 0.04	1.223HisPhe: 1.223 ± 0.045	1.571HisGly: 1.571 ± 0.047	0.585HisHis: 0.585 ± 0.034	1.227HisIle: 1.227 ± 0.044	1.077HisLys: 1.077 ± 0.044	2.44HisLeu: 2.44 ± 0.052	0.365HisMet: 0.365 ± 0.023	0.674HisAsn: 0.674 ± 0.033	1.494HisPro: 1.494 ± 0.047	0.776HisGln: 0.776 ± 0.035	1.087HisArg: 1.087 ± 0.043	1.49HisSer: 1.49 ± 0.045	0.812HisThr: 0.812 ± 0.038	1.117HisVal: 1.117 ± 0.044	0.468HisTrp: 0.468 ± 0.026	0.873HisTyr: 0.873 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.736IleAla: 5.736 ± 0.104	0.99IleCys: 0.99 ± 0.043	4.166IleAsp: 4.166 ± 0.075	6.001IleGlu: 6.001 ± 0.124	3.588IlePhe: 3.588 ± 0.085	5.767IleGly: 5.767 ± 0.099	1.781IleHis: 1.781 ± 0.055	4.546IleIle: 4.546 ± 0.087	4.207IleLys: 4.207 ± 0.09	7.987IleLeu: 7.987 ± 0.133	1.059IleMet: 1.059 ± 0.042	2.509IleAsn: 2.509 ± 0.063	4.378IlePro: 4.378 ± 0.084	2.853IleGln: 2.853 ± 0.066	3.858IleArg: 3.858 ± 0.069	4.882IleSer: 4.882 ± 0.079	2.914IleThr: 2.914 ± 0.069	4.696IleVal: 4.696 ± 0.071	0.799IleTrp: 0.799 ± 0.039	2.159IleTyr: 2.159 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.049LysAla: 5.049 ± 0.099	0.461LysCys: 0.461 ± 0.026	3.172LysAsp: 3.172 ± 0.075	7.801LysGlu: 7.801 ± 0.141	2.062LysPhe: 2.062 ± 0.057	4.204LysGly: 4.204 ± 0.084	0.997LysHis: 0.997 ± 0.038	6.066LysIle: 6.066 ± 0.09	6.863LysLys: 6.863 ± 0.139	5.939LysLeu: 5.939 ± 0.099	1.52LysMet: 1.52 ± 0.05	3.622LysAsn: 3.622 ± 0.074	2.726LysPro: 2.726 ± 0.065	2.025LysGln: 2.025 ± 0.059	3.64LysArg: 3.64 ± 0.085	3.567LysSer: 3.567 ± 0.073	3.661LysThr: 3.661 ± 0.073	3.791LysVal: 3.791 ± 0.083	0.864LysTrp: 0.864 ± 0.039	1.599LysTyr: 1.599 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	7.754LeuAla: 7.754 ± 0.111	1.543LeuCys: 1.543 ± 0.048	4.635LeuAsp: 4.635 ± 0.082	7.904LeuGlu: 7.904 ± 0.126	6.815LeuPhe: 6.815 ± 0.136	7.201LeuGly: 7.201 ± 0.137	2.211LeuHis: 2.211 ± 0.062	7.199LeuIle: 7.199 ± 0.1	7.143LeuLys: 7.143 ± 0.123	12.733LeuLeu: 12.733 ± 0.194	1.862LeuMet: 1.862 ± 0.061	3.791LeuAsn: 3.791 ± 0.07	5.569LeuPro: 5.569 ± 0.103	3.723LeuGln: 3.723 ± 0.066	5.299LeuArg: 5.299 ± 0.091	9.148LeuSer: 9.148 ± 0.139	4.658LeuThr: 4.658 ± 0.083	6.266LeuVal: 6.266 ± 0.102	1.574LeuTrp: 1.574 ± 0.058	3.25LeuTyr: 3.25 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	1.856MetAla: 1.856 ± 0.054	0.127MetCys: 0.127 ± 0.014	1.188MetAsp: 1.188 ± 0.038	1.746MetGlu: 1.746 ± 0.046	0.652MetPhe: 0.652 ± 0.032	1.691MetGly: 1.691 ± 0.047	0.423MetHis: 0.423 ± 0.031	1.55MetIle: 1.55 ± 0.046	1.54MetLys: 1.54 ± 0.04	1.779MetLeu: 1.779 ± 0.048	0.441MetMet: 0.441 ± 0.026	0.99MetAsn: 0.99 ± 0.044	1.023MetPro: 1.023 ± 0.039	0.65MetGln: 0.65 ± 0.033	0.944MetArg: 0.944 ± 0.042	1.094MetSer: 1.094 ± 0.043	1.055MetThr: 1.055 ± 0.04	1.302MetVal: 1.302 ± 0.046	0.186MetTrp: 0.186 ± 0.018	0.364MetTyr: 0.364 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.426AsnAla: 2.426 ± 0.063	0.436AsnCys: 0.436 ± 0.029	1.297AsnAsp: 1.297 ± 0.052	2.22AsnGlu: 2.22 ± 0.067	1.953AsnPhe: 1.953 ± 0.063	2.629AsnGly: 2.629 ± 0.076	0.761AsnHis: 0.761 ± 0.036	2.603AsnIle: 2.603 ± 0.061	2.152AsnLys: 2.152 ± 0.059	4.199AsnLeu: 4.199 ± 0.084	0.733AsnMet: 0.733 ± 0.034	1.385AsnAsn: 1.385 ± 0.052	2.756AsnPro: 2.756 ± 0.073	1.517AsnGln: 1.517 ± 0.054	2.144AsnArg: 2.144 ± 0.057	2.384AsnSer: 2.384 ± 0.055	1.529AsnThr: 1.529 ± 0.052	2.009AsnVal: 2.009 ± 0.056	0.638AsnTrp: 0.638 ± 0.03	1.359AsnTyr: 1.359 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.796ProAla: 2.796 ± 0.065	0.458ProCys: 0.458 ± 0.029	2.009ProAsp: 2.009 ± 0.057	3.432ProGlu: 3.432 ± 0.072	3.026ProPhe: 3.026 ± 0.071	3.176ProGly: 3.176 ± 0.07	1.053ProHis: 1.053 ± 0.037	3.65ProIle: 3.65 ± 0.074	3.21ProLys: 3.21 ± 0.069	5.634ProLeu: 5.634 ± 0.098	1.097ProMet: 1.097 ± 0.041	1.699ProAsn: 1.699 ± 0.055	2.559ProPro: 2.559 ± 0.075	1.965ProGln: 1.965 ± 0.055	1.961ProArg: 1.961 ± 0.054	3.793ProSer: 3.793 ± 0.083	2.338ProThr: 2.338 ± 0.061	2.932ProVal: 2.932 ± 0.075	0.771ProTrp: 0.771 ± 0.034	1.694ProTyr: 1.694 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	2.767GlnAla: 2.767 ± 0.074	0.323GlnCys: 0.323 ± 0.023	1.335GlnAsp: 1.335 ± 0.046	2.6GlnGlu: 2.6 ± 0.065	1.479GlnPhe: 1.479 ± 0.047	2.228GlnGly: 2.228 ± 0.063	0.603GlnHis: 0.603 ± 0.03	2.706GlnIle: 2.706 ± 0.068	3.306GlnLys: 3.306 ± 0.077	3.681GlnLeu: 3.681 ± 0.068	0.811GlnMet: 0.811 ± 0.034	1.559GlnAsn: 1.559 ± 0.048	1.562GlnPro: 1.562 ± 0.055	1.434GlnGln: 1.434 ± 0.053	1.953GlnArg: 1.953 ± 0.062	2.49GlnSer: 2.49 ± 0.069	1.758GlnThr: 1.758 ± 0.058	1.846GlnVal: 1.846 ± 0.061	0.676GlnTrp: 0.676 ± 0.032	0.99GlnTyr: 0.99 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.017ArgAla: 3.017 ± 0.075	0.553ArgCys: 0.553 ± 0.029	1.779ArgAsp: 1.779 ± 0.062	3.314ArgGlu: 3.314 ± 0.082	2.665ArgPhe: 2.665 ± 0.066	2.823ArgGly: 2.823 ± 0.07	0.941ArgHis: 0.941 ± 0.042	4.364ArgIle: 4.364 ± 0.094	4.011ArgLys: 4.011 ± 0.081	5.576ArgLeu: 5.576 ± 0.095	1.258ArgMet: 1.258 ± 0.038	2.003ArgAsn: 2.003 ± 0.055	1.868ArgPro: 1.868 ± 0.047	1.693ArgGln: 1.693 ± 0.052	2.529ArgArg: 2.529 ± 0.08	2.952ArgSer: 2.952 ± 0.059	2.052ArgThr: 2.052 ± 0.053	2.838ArgVal: 2.838 ± 0.071	0.799ArgTrp: 0.799 ± 0.033	1.684ArgTyr: 1.684 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.047SerAla: 4.047 ± 0.09	0.899SerCys: 0.899 ± 0.039	2.396SerAsp: 2.396 ± 0.06	3.719SerGlu: 3.719 ± 0.078	4.46SerPhe: 4.46 ± 0.095	4.626SerGly: 4.626 ± 0.091	1.468SerHis: 1.468 ± 0.05	4.96SerIle: 4.96 ± 0.088	4.238SerLys: 4.238 ± 0.086	8.76SerLeu: 8.76 ± 0.128	1.549SerMet: 1.549 ± 0.048	2.312SerAsn: 2.312 ± 0.062	3.681SerPro: 3.681 ± 0.075	2.761SerGln: 2.761 ± 0.062	3.147SerArg: 3.147 ± 0.067	5.314SerSer: 5.314 ± 0.1	2.988SerThr: 2.988 ± 0.07	3.611SerVal: 3.611 ± 0.077	1.08SerTrp: 1.08 ± 0.043	2.349SerTyr: 2.349 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	3.234ThrAla: 3.234 ± 0.066	0.356ThrCys: 0.356 ± 0.023	2.073ThrAsp: 2.073 ± 0.057	2.923ThrGlu: 2.923 ± 0.065	2.158ThrPhe: 2.158 ± 0.074	3.203ThrGly: 3.203 ± 0.076	0.918ThrHis: 0.918 ± 0.04	3.47ThrIle: 3.47 ± 0.073	2.752ThrLys: 2.752 ± 0.063	4.667ThrLeu: 4.667 ± 0.077	0.871ThrMet: 0.871 ± 0.037	1.565ThrAsn: 1.565 ± 0.053	2.42ThrPro: 2.42 ± 0.068	1.534ThrGln: 1.534 ± 0.052	1.774ThrArg: 1.774 ± 0.053	2.544ThrSer: 2.544 ± 0.069	2.367ThrThr: 2.367 ± 0.067	3.009ThrVal: 3.009 ± 0.072	0.4ThrTrp: 0.4 ± 0.031	1.358ThrTyr: 1.358 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.22ValAla: 4.22 ± 0.084	0.791ValCys: 0.791 ± 0.038	3.037ValAsp: 3.037 ± 0.073	4.272ValGlu: 4.272 ± 0.086	3.102ValPhe: 3.102 ± 0.075	4.385ValGly: 4.385 ± 0.092	1.33ValHis: 1.33 ± 0.042	4.399ValIle: 4.399 ± 0.094	3.079ValLys: 3.079 ± 0.066	6.461ValLeu: 6.461 ± 0.114	1.106ValMet: 1.106 ± 0.041	2.003ValAsn: 2.003 ± 0.063	2.781ValPro: 2.781 ± 0.067	1.973ValGln: 1.973 ± 0.059	2.658ValArg: 2.658 ± 0.069	4.035ValSer: 4.035 ± 0.08	2.32ValThr: 2.32 ± 0.066	4.298ValVal: 4.298 ± 0.101	0.758ValTrp: 0.758 ± 0.038	1.838ValTyr: 1.838 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.894TrpAla: 0.894 ± 0.038	0.159TrpCys: 0.159 ± 0.018	0.671TrpAsp: 0.671 ± 0.033	1.073TrpGlu: 1.073 ± 0.042	0.665TrpPhe: 0.665 ± 0.037	0.915TrpGly: 0.915 ± 0.044	0.291TrpHis: 0.291 ± 0.02	1.526TrpIle: 1.526 ± 0.056	1.258TrpLys: 1.258 ± 0.049	1.587TrpLeu: 1.587 ± 0.053	0.43TrpMet: 0.43 ± 0.029	0.7TrpAsn: 0.7 ± 0.033	0.597TrpPro: 0.597 ± 0.033	0.611TrpGln: 0.611 ± 0.029	0.639TrpArg: 0.639 ± 0.03	0.811TrpSer: 0.811 ± 0.039	0.679TrpThr: 0.679 ± 0.03	0.786TrpVal: 0.786 ± 0.038	0.277TrpTrp: 0.277 ± 0.025	0.374TrpTyr: 0.374 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.087TyrAla: 2.087 ± 0.057	0.52TyrCys: 0.52 ± 0.035	1.426TyrAsp: 1.426 ± 0.049	1.817TyrGlu: 1.817 ± 0.054	1.994TyrPhe: 1.994 ± 0.059	2.476TyrGly: 2.476 ± 0.055	0.797TyrHis: 0.797 ± 0.038	1.758TyrIle: 1.758 ± 0.057	1.629TyrLys: 1.629 ± 0.055	3.561TyrLeu: 3.561 ± 0.085	0.542TyrMet: 0.542 ± 0.029	1.13TyrAsn: 1.13 ± 0.041	1.902TyrPro: 1.902 ± 0.06	1.355TyrGln: 1.355 ± 0.045	1.865TyrArg: 1.865 ± 0.056	2.223TyrSer: 2.223 ± 0.058	1.252TyrThr: 1.252 ± 0.046	1.94TyrVal: 1.94 ± 0.052	0.591TyrTrp: 0.591 ± 0.031	1.194TyrTyr: 1.194 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2208 proteins (659916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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