Amino acid dipepetide frequency for Mycolicibacterium diernhoferi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.467AlaAla: 20.467 ± 0.163	0.948AlaCys: 0.948 ± 0.024	8.809AlaAsp: 8.809 ± 0.083	8.181AlaGlu: 8.181 ± 0.081	3.597AlaPhe: 3.597 ± 0.044	12.322AlaGly: 12.322 ± 0.102	2.575AlaHis: 2.575 ± 0.043	5.226AlaIle: 5.226 ± 0.054	2.909AlaLys: 2.909 ± 0.047	13.215AlaLeu: 13.215 ± 0.1	2.865AlaMet: 2.865 ± 0.044	2.5AlaAsn: 2.5 ± 0.042	6.515AlaPro: 6.515 ± 0.096	4.064AlaGln: 4.064 ± 0.052	8.336AlaArg: 8.336 ± 0.081	5.438AlaSer: 5.438 ± 0.057	7.228AlaThr: 7.228 ± 0.072	12.022AlaVal: 12.022 ± 0.096	1.54AlaTrp: 1.54 ± 0.029	2.329AlaTyr: 2.329 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.047CysAla: 1.047 ± 0.026	0.078CysCys: 0.078 ± 0.007	0.479CysAsp: 0.479 ± 0.018	0.419CysGlu: 0.419 ± 0.016	0.209CysPhe: 0.209 ± 0.011	0.922CysGly: 0.922 ± 0.025	0.175CysHis: 0.175 ± 0.009	0.265CysIle: 0.265 ± 0.014	0.112CysLys: 0.112 ± 0.008	0.649CysLeu: 0.649 ± 0.021	0.129CysMet: 0.129 ± 0.009	0.184CysAsn: 0.184 ± 0.01	0.487CysPro: 0.487 ± 0.019	0.211CysGln: 0.211 ± 0.009	0.58CysArg: 0.58 ± 0.017	0.452CysSer: 0.452 ± 0.018	0.506CysThr: 0.506 ± 0.018	0.612CysVal: 0.612 ± 0.018	0.111CysTrp: 0.111 ± 0.008	0.17CysTyr: 0.17 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.726AspAla: 7.726 ± 0.068	0.444AspCys: 0.444 ± 0.016	3.944AspAsp: 3.944 ± 0.061	4.11AspGlu: 4.11 ± 0.059	1.84AspPhe: 1.84 ± 0.035	6.172AspGly: 6.172 ± 0.061	1.327AspHis: 1.327 ± 0.029	2.828AspIle: 2.828 ± 0.04	1.33AspLys: 1.33 ± 0.029	6.296AspLeu: 6.296 ± 0.07	0.996AspMet: 0.996 ± 0.026	1.261AspAsn: 1.261 ± 0.029	4.574AspPro: 4.574 ± 0.056	1.646AspGln: 1.646 ± 0.033	4.659AspArg: 4.659 ± 0.05	2.837AspSer: 2.837 ± 0.045	3.512AspThr: 3.512 ± 0.044	5.128AspVal: 5.128 ± 0.057	0.996AspTrp: 0.996 ± 0.025	1.421AspTyr: 1.421 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.211GluAla: 6.211 ± 0.073	0.338GluCys: 0.338 ± 0.013	2.753GluAsp: 2.753 ± 0.043	2.591GluGlu: 2.591 ± 0.04	1.969GluPhe: 1.969 ± 0.034	3.322GluGly: 3.322 ± 0.047	1.545GluHis: 1.545 ± 0.03	2.683GluIle: 2.683 ± 0.042	1.362GluLys: 1.362 ± 0.03	6.512GluLeu: 6.512 ± 0.078	1.08GluMet: 1.08 ± 0.026	1.204GluAsn: 1.204 ± 0.028	3.152GluPro: 3.152 ± 0.053	2.322GluGln: 2.322 ± 0.035	4.213GluArg: 4.213 ± 0.051	2.823GluSer: 2.823 ± 0.036	2.751GluThr: 2.751 ± 0.044	4.616GluVal: 4.616 ± 0.054	0.72GluTrp: 0.72 ± 0.021	1.178GluTyr: 1.178 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.007PheAla: 4.007 ± 0.057	0.323PheCys: 0.323 ± 0.013	2.466PheAsp: 2.466 ± 0.039	1.65PheGlu: 1.65 ± 0.03	0.995PhePhe: 0.995 ± 0.029	3.584PheGly: 3.584 ± 0.056	0.625PheHis: 0.625 ± 0.018	1.225PheIle: 1.225 ± 0.033	0.554PheLys: 0.554 ± 0.019	2.669PheLeu: 2.669 ± 0.041	0.53PheMet: 0.53 ± 0.019	0.775PheAsn: 0.775 ± 0.024	1.465PhePro: 1.465 ± 0.027	0.709PheGln: 0.709 ± 0.022	1.704PheArg: 1.704 ± 0.032	1.71PheSer: 1.71 ± 0.032	2.207PheThr: 2.207 ± 0.038	2.591PheVal: 2.591 ± 0.041	0.446PheTrp: 0.446 ± 0.016	0.732PheTyr: 0.732 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.69GlyAla: 10.69 ± 0.092	0.77GlyCys: 0.77 ± 0.024	5.059GlyAsp: 5.059 ± 0.053	4.526GlyGlu: 4.526 ± 0.048	3.12GlyPhe: 3.12 ± 0.039	7.892GlyGly: 7.892 ± 0.121	2.018GlyHis: 2.018 ± 0.035	4.245GlyIle: 4.245 ± 0.05	2.267GlyLys: 2.267 ± 0.037	8.869GlyLeu: 8.869 ± 0.078	2.149GlyMet: 2.149 ± 0.038	1.992GlyAsn: 1.992 ± 0.042	4.756GlyPro: 4.756 ± 0.053	2.778GlyGln: 2.778 ± 0.047	6.2GlyArg: 6.2 ± 0.068	5.227GlySer: 5.227 ± 0.067	5.546GlyThr: 5.546 ± 0.062	7.734GlyVal: 7.734 ± 0.056	1.648GlyTrp: 1.648 ± 0.03	2.44GlyTyr: 2.44 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.383HisAla: 2.383 ± 0.04	0.204HisCys: 0.204 ± 0.01	1.317HisAsp: 1.317 ± 0.026	1.032HisGlu: 1.032 ± 0.024	0.686HisPhe: 0.686 ± 0.02	2.152HisGly: 2.152 ± 0.039	0.633HisHis: 0.633 ± 0.021	0.869HisIle: 0.869 ± 0.02	0.367HisLys: 0.367 ± 0.013	2.098HisLeu: 2.098 ± 0.031	0.35HisMet: 0.35 ± 0.014	0.459HisAsn: 0.459 ± 0.016	1.626HisPro: 1.626 ± 0.031	0.597HisGln: 0.597 ± 0.019	1.821HisArg: 1.821 ± 0.032	1.037HisSer: 1.037 ± 0.031	1.253HisThr: 1.253 ± 0.025	1.616HisVal: 1.616 ± 0.033	0.4HisTrp: 0.4 ± 0.015	0.543HisTyr: 0.543 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.63IleAla: 6.63 ± 0.066	0.418IleCys: 0.418 ± 0.013	3.45IleAsp: 3.45 ± 0.046	2.726IleGlu: 2.726 ± 0.043	1.108IlePhe: 1.108 ± 0.03	4.832IleGly: 4.832 ± 0.052	0.775IleHis: 0.775 ± 0.017	1.612IleIle: 1.612 ± 0.032	0.923IleLys: 0.923 ± 0.023	3.171IleLeu: 3.171 ± 0.043	0.624IleMet: 0.624 ± 0.018	1.13IleAsn: 1.13 ± 0.03	2.444IlePro: 2.444 ± 0.04	0.921IleGln: 0.921 ± 0.022	2.625IleArg: 2.625 ± 0.044	2.401IleSer: 2.401 ± 0.04	2.889IleThr: 2.889 ± 0.043	3.711IleVal: 3.711 ± 0.053	0.487IleTrp: 0.487 ± 0.019	0.848IleTyr: 0.848 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.727LysAla: 2.727 ± 0.047	0.108LysCys: 0.108 ± 0.009	1.087LysAsp: 1.087 ± 0.027	0.942LysGlu: 0.942 ± 0.026	0.643LysPhe: 0.643 ± 0.021	1.536LysGly: 1.536 ± 0.036	0.483LysHis: 0.483 ± 0.016	1.005LysIle: 1.005 ± 0.029	0.681LysLys: 0.681 ± 0.026	2.238LysLeu: 2.238 ± 0.039	0.492LysMet: 0.492 ± 0.016	0.531LysAsn: 0.531 ± 0.019	1.458LysPro: 1.458 ± 0.031	0.728LysGln: 0.728 ± 0.021	1.522LysArg: 1.522 ± 0.029	1.232LysSer: 1.232 ± 0.029	1.319LysThr: 1.319 ± 0.03	2.002LysVal: 2.002 ± 0.037	0.319LysTrp: 0.319 ± 0.015	0.473LysTyr: 0.473 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.893LeuAla: 13.893 ± 0.11	0.816LeuCys: 0.816 ± 0.021	6.585LeuAsp: 6.585 ± 0.075	4.376LeuGlu: 4.376 ± 0.054	2.717LeuPhe: 2.717 ± 0.044	8.98LeuGly: 8.98 ± 0.081	2.084LeuHis: 2.084 ± 0.037	4.33LeuIle: 4.33 ± 0.059	1.869LeuLys: 1.869 ± 0.036	9.729LeuLeu: 9.729 ± 0.108	1.766LeuMet: 1.766 ± 0.034	2.228LeuAsn: 2.228 ± 0.042	5.802LeuPro: 5.802 ± 0.06	2.696LeuGln: 2.696 ± 0.042	7.364LeuArg: 7.364 ± 0.076	5.72LeuSer: 5.72 ± 0.061	6.564LeuThr: 6.564 ± 0.061	8.321LeuVal: 8.321 ± 0.067	1.171LeuTrp: 1.171 ± 0.023	1.683LeuTyr: 1.683 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.586MetAla: 2.586 ± 0.04	0.19MetCys: 0.19 ± 0.01	0.903MetAsp: 0.903 ± 0.022	0.718MetGlu: 0.718 ± 0.022	0.644MetPhe: 0.644 ± 0.024	1.476MetGly: 1.476 ± 0.03	0.397MetHis: 0.397 ± 0.015	0.908MetIle: 0.908 ± 0.028	0.476MetLys: 0.476 ± 0.016	2.03MetLeu: 2.03 ± 0.034	0.445MetMet: 0.445 ± 0.016	0.523MetAsn: 0.523 ± 0.017	1.194MetPro: 1.194 ± 0.026	0.565MetGln: 0.565 ± 0.018	1.525MetArg: 1.525 ± 0.026	1.62MetSer: 1.62 ± 0.03	1.815MetThr: 1.815 ± 0.034	1.647MetVal: 1.647 ± 0.031	0.248MetTrp: 0.248 ± 0.012	0.347MetTyr: 0.347 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.71AsnAla: 2.71 ± 0.038	0.187AsnCys: 0.187 ± 0.01	1.179AsnAsp: 1.179 ± 0.029	1.007AsnGlu: 1.007 ± 0.027	0.71AsnPhe: 0.71 ± 0.022	2.107AsnGly: 2.107 ± 0.04	0.459AsnHis: 0.459 ± 0.018	0.948AsnIle: 0.948 ± 0.025	0.474AsnLys: 0.474 ± 0.015	2.154AsnLeu: 2.154 ± 0.036	0.431AsnMet: 0.431 ± 0.018	0.58AsnAsn: 0.58 ± 0.019	1.815AsnPro: 1.815 ± 0.033	0.639AsnGln: 0.639 ± 0.02	1.515AsnArg: 1.515 ± 0.028	1.205AsnSer: 1.205 ± 0.025	1.353AsnThr: 1.353 ± 0.035	1.837AsnVal: 1.837 ± 0.033	0.422AsnTrp: 0.422 ± 0.015	0.558AsnTyr: 0.558 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.791ProAla: 7.791 ± 0.096	0.279ProCys: 0.279 ± 0.013	4.541ProAsp: 4.541 ± 0.048	3.897ProGlu: 3.897 ± 0.048	1.698ProPhe: 1.698 ± 0.028	5.736ProGly: 5.736 ± 0.066	1.189ProHis: 1.189 ± 0.027	2.184ProIle: 2.184 ± 0.032	1.275ProLys: 1.275 ± 0.031	4.846ProLeu: 4.846 ± 0.049	1.18ProMet: 1.18 ± 0.026	1.269ProAsn: 1.269 ± 0.031	3.491ProPro: 3.491 ± 0.086	1.731ProGln: 1.731 ± 0.031	3.327ProArg: 3.327 ± 0.043	2.93ProSer: 2.93 ± 0.038	3.455ProThr: 3.455 ± 0.049	5.285ProVal: 5.285 ± 0.068	0.848ProTrp: 0.848 ± 0.023	1.196ProTyr: 1.196 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.547GlnAla: 3.547 ± 0.048	0.194GlnCys: 0.194 ± 0.012	1.327GlnAsp: 1.327 ± 0.027	1.195GlnGlu: 1.195 ± 0.026	1.009GlnPhe: 1.009 ± 0.024	2.04GlnGly: 2.04 ± 0.039	0.7GlnHis: 0.7 ± 0.021	1.606GlnIle: 1.606 ± 0.033	0.653GlnLys: 0.653 ± 0.021	3.31GlnLeu: 3.31 ± 0.036	0.688GlnMet: 0.688 ± 0.021	0.639GlnAsn: 0.639 ± 0.019	1.721GlnPro: 1.721 ± 0.036	1.252GlnGln: 1.252 ± 0.031	2.613GlnArg: 2.613 ± 0.037	1.48GlnSer: 1.48 ± 0.029	1.693GlnThr: 1.693 ± 0.031	2.561GlnVal: 2.561 ± 0.039	0.579GlnTrp: 0.579 ± 0.018	0.68GlnTyr: 0.68 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.121ArgAla: 8.121 ± 0.072	0.555ArgCys: 0.555 ± 0.021	4.134ArgAsp: 4.134 ± 0.051	3.739ArgGlu: 3.739 ± 0.05	2.361ArgPhe: 2.361 ± 0.035	5.075ArgGly: 5.075 ± 0.058	1.709ArgHis: 1.709 ± 0.032	3.491ArgIle: 3.491 ± 0.048	1.506ArgLys: 1.506 ± 0.028	7.128ArgLeu: 7.128 ± 0.076	1.744ArgMet: 1.744 ± 0.032	1.652ArgAsn: 1.652 ± 0.033	3.872ArgPro: 3.872 ± 0.047	2.12ArgGln: 2.12 ± 0.036	6.121ArgArg: 6.121 ± 0.07	3.894ArgSer: 3.894 ± 0.053	4.268ArgThr: 4.268 ± 0.053	5.466ArgVal: 5.466 ± 0.055	1.251ArgTrp: 1.251 ± 0.025	1.889ArgTyr: 1.889 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.01SerAla: 7.01 ± 0.07	0.404SerCys: 0.404 ± 0.016	3.172SerAsp: 3.172 ± 0.041	2.606SerGlu: 2.606 ± 0.037	1.717SerPhe: 1.717 ± 0.034	5.572SerGly: 5.572 ± 0.057	1.007SerHis: 1.007 ± 0.027	2.216SerIle: 2.216 ± 0.039	1.097SerLys: 1.097 ± 0.025	4.666SerLeu: 4.666 ± 0.048	1.37SerMet: 1.37 ± 0.027	1.111SerAsn: 1.111 ± 0.028	3.046SerPro: 3.046 ± 0.046	1.363SerGln: 1.363 ± 0.033	3.456SerArg: 3.456 ± 0.042	3.076SerSer: 3.076 ± 0.049	3.502SerThr: 3.502 ± 0.053	4.63SerVal: 4.63 ± 0.055	0.934SerTrp: 0.934 ± 0.024	1.229SerTyr: 1.229 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	8.193ThrAla: 8.193 ± 0.073	0.428ThrCys: 0.428 ± 0.015	4.022ThrAsp: 4.022 ± 0.048	3.482ThrGlu: 3.482 ± 0.048	1.964ThrPhe: 1.964 ± 0.037	6.181ThrGly: 6.181 ± 0.056	1.119ThrHis: 1.119 ± 0.026	2.467ThrIle: 2.467 ± 0.04	1.194ThrLys: 1.194 ± 0.03	5.787ThrLeu: 5.787 ± 0.075	1.171ThrMet: 1.171 ± 0.027	1.226ThrAsn: 1.226 ± 0.029	3.858ThrPro: 3.858 ± 0.05	1.453ThrGln: 1.453 ± 0.028	3.67ThrArg: 3.67 ± 0.047	3.172ThrSer: 3.172 ± 0.047	3.792ThrThr: 3.792 ± 0.072	6.35ThrVal: 6.35 ± 0.072	0.819ThrTrp: 0.819 ± 0.021	1.344ThrTyr: 1.344 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	11.396ValAla: 11.396 ± 0.096	0.734ValCys: 0.734 ± 0.02	5.643ValAsp: 5.643 ± 0.058	4.404ValGlu: 4.404 ± 0.059	2.685ValPhe: 2.685 ± 0.042	6.99ValGly: 6.99 ± 0.068	1.839ValHis: 1.839 ± 0.032	4.22ValIle: 4.22 ± 0.055	1.734ValLys: 1.734 ± 0.037	9.256ValLeu: 9.256 ± 0.083	1.592ValMet: 1.592 ± 0.03	2.104ValAsn: 2.104 ± 0.038	4.813ValPro: 4.813 ± 0.053	2.355ValGln: 2.355 ± 0.035	5.84ValArg: 5.84 ± 0.063	4.839ValSer: 4.839 ± 0.051	5.794ValThr: 5.794 ± 0.067	8.234ValVal: 8.234 ± 0.079	1.022ValTrp: 1.022 ± 0.026	1.636ValTyr: 1.636 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.523TrpAla: 1.523 ± 0.029	0.15TrpCys: 0.15 ± 0.01	0.819TrpAsp: 0.819 ± 0.021	0.675TrpGlu: 0.675 ± 0.021	0.529TrpPhe: 0.529 ± 0.019	0.996TrpGly: 0.996 ± 0.024	0.341TrpHis: 0.341 ± 0.013	0.657TrpIle: 0.657 ± 0.02	0.323TrpLys: 0.323 ± 0.014	1.632TrpLeu: 1.632 ± 0.03	0.35TrpMet: 0.35 ± 0.013	0.42TrpAsn: 0.42 ± 0.017	0.799TrpPro: 0.799 ± 0.022	0.636TrpGln: 0.636 ± 0.02	1.157TrpArg: 1.157 ± 0.025	0.913TrpSer: 0.913 ± 0.019	0.925TrpThr: 0.925 ± 0.022	1.147TrpVal: 1.147 ± 0.026	0.316TrpTrp: 0.316 ± 0.015	0.325TrpTyr: 0.325 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.429TyrAla: 2.429 ± 0.038	0.228TyrCys: 0.228 ± 0.011	1.359TyrAsp: 1.359 ± 0.031	1.067TyrGlu: 1.067 ± 0.024	0.77TyrPhe: 0.77 ± 0.023	2.036TyrGly: 2.036 ± 0.035	0.444TyrHis: 0.444 ± 0.017	0.741TyrIle: 0.741 ± 0.02	0.417TyrLys: 0.417 ± 0.015	2.443TyrLeu: 2.443 ± 0.04	0.306TyrMet: 0.306 ± 0.012	0.501TyrAsn: 0.501 ± 0.016	1.26TyrPro: 1.26 ± 0.029	0.698TyrGln: 0.698 ± 0.019	1.849TyrArg: 1.849 ± 0.03	1.175TyrSer: 1.175 ± 0.026	1.322TyrThr: 1.322 ± 0.027	1.619TyrVal: 1.619 ± 0.032	0.356TyrTrp: 0.356 ± 0.013	0.509TyrTyr: 0.509 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5529 proteins (1805390 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---