Amino acid dipepetide frequency for Salmonella phage vB_SenS_PHB07

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.078AlaAla: 7.078 ± 0.841
0.829AlaCys: 0.829 ± 0.262
4.655AlaAsp: 4.655 ± 0.525
5.739AlaGlu: 5.739 ± 0.618
3.061AlaPhe: 3.061 ± 0.471
5.994AlaGly: 5.994 ± 0.69
0.638AlaHis: 0.638 ± 0.21
4.846AlaIle: 4.846 ± 0.571
7.078AlaLys: 7.078 ± 1.092
7.716AlaLeu: 7.716 ± 0.657
2.551AlaMet: 2.551 ± 0.352
3.762AlaAsn: 3.762 ± 0.631
2.168AlaPro: 2.168 ± 0.352
4.846AlaGln: 4.846 ± 0.634
4.336AlaArg: 4.336 ± 0.589
3.954AlaSer: 3.954 ± 0.497
3.507AlaThr: 3.507 ± 0.515
5.612AlaVal: 5.612 ± 0.78
0.893AlaTrp: 0.893 ± 0.199
3.125AlaTyr: 3.125 ± 0.423
0.0AlaXaa: 0.0 ± 0.0
Cys
1.339CysAla: 1.339 ± 0.286
0.383CysCys: 0.383 ± 0.262
1.275CysAsp: 1.275 ± 0.221
1.275CysGlu: 1.275 ± 0.353
0.383CysPhe: 0.383 ± 0.143
1.275CysGly: 1.275 ± 0.286
0.319CysHis: 0.319 ± 0.167
0.319CysIle: 0.319 ± 0.139
0.765CysLys: 0.765 ± 0.241
0.957CysLeu: 0.957 ± 0.277
0.701CysMet: 0.701 ± 0.201
0.51CysAsn: 0.51 ± 0.161
0.446CysPro: 0.446 ± 0.184
0.255CysGln: 0.255 ± 0.189
0.765CysArg: 0.765 ± 0.259
0.51CysSer: 0.51 ± 0.163
0.829CysThr: 0.829 ± 0.265
1.148CysVal: 1.148 ± 0.304
0.383CysTrp: 0.383 ± 0.138
0.446CysTyr: 0.446 ± 0.137
0.0CysXaa: 0.0 ± 0.0
Asp
4.655AspAla: 4.655 ± 0.644
0.638AspCys: 0.638 ± 0.213
3.125AspAsp: 3.125 ± 0.531
4.655AspGlu: 4.655 ± 0.43
2.232AspPhe: 2.232 ± 0.408
6.058AspGly: 6.058 ± 0.886
1.275AspHis: 1.275 ± 0.232
3.762AspIle: 3.762 ± 0.361
4.4AspLys: 4.4 ± 0.442
4.783AspLeu: 4.783 ± 0.416
1.403AspMet: 1.403 ± 0.332
3.061AspAsn: 3.061 ± 0.357
2.359AspPro: 2.359 ± 0.355
1.913AspGln: 1.913 ± 0.284
2.678AspArg: 2.678 ± 0.402
3.252AspSer: 3.252 ± 0.445
3.443AspThr: 3.443 ± 0.439
3.507AspVal: 3.507 ± 0.435
0.957AspTrp: 0.957 ± 0.182
3.443AspTyr: 3.443 ± 0.415
0.0AspXaa: 0.0 ± 0.0
Glu
5.165GluAla: 5.165 ± 0.561
1.339GluCys: 1.339 ± 0.314
2.806GluAsp: 2.806 ± 0.477
4.081GluGlu: 4.081 ± 0.64
3.954GluPhe: 3.954 ± 0.557
3.571GluGly: 3.571 ± 0.347
1.53GluHis: 1.53 ± 0.34
4.974GluIle: 4.974 ± 0.565
5.356GluLys: 5.356 ± 0.612
4.91GluLeu: 4.91 ± 0.67
2.423GluMet: 2.423 ± 0.311
3.635GluAsn: 3.635 ± 0.43
2.296GluPro: 2.296 ± 0.494
3.954GluGln: 3.954 ± 0.653
3.699GluArg: 3.699 ± 0.5
4.145GluSer: 4.145 ± 0.504
4.272GluThr: 4.272 ± 0.504
4.591GluVal: 4.591 ± 0.604
0.957GluTrp: 0.957 ± 0.283
2.806GluTyr: 2.806 ± 0.395
0.0GluXaa: 0.0 ± 0.0
Phe
2.742PheAla: 2.742 ± 0.493
0.51PheCys: 0.51 ± 0.192
3.125PheAsp: 3.125 ± 0.527
2.423PheGlu: 2.423 ± 0.426
0.957PhePhe: 0.957 ± 0.254
3.443PheGly: 3.443 ± 0.556
0.829PheHis: 0.829 ± 0.274
2.423PheIle: 2.423 ± 0.447
3.061PheLys: 3.061 ± 0.444
2.041PheLeu: 2.041 ± 0.295
1.275PheMet: 1.275 ± 0.333
3.252PheAsn: 3.252 ± 0.39
1.594PhePro: 1.594 ± 0.288
1.275PheGln: 1.275 ± 0.254
1.403PheArg: 1.403 ± 0.286
2.296PheSer: 2.296 ± 0.448
2.551PheThr: 2.551 ± 0.512
2.551PheVal: 2.551 ± 0.33
0.51PheTrp: 0.51 ± 0.185
1.084PheTyr: 1.084 ± 0.34
0.0PheXaa: 0.0 ± 0.0
Gly
5.42GlyAla: 5.42 ± 0.799
1.275GlyCys: 1.275 ± 0.271
4.4GlyAsp: 4.4 ± 0.625
5.612GlyGlu: 5.612 ± 0.57
3.507GlyPhe: 3.507 ± 0.517
7.206GlyGly: 7.206 ± 0.836
1.403GlyHis: 1.403 ± 0.262
4.017GlyIle: 4.017 ± 0.442
5.42GlyLys: 5.42 ± 0.573
4.846GlyLeu: 4.846 ± 0.486
2.742GlyMet: 2.742 ± 0.329
3.252GlyAsn: 3.252 ± 0.411
0.128GlyPro: 0.128 ± 0.092
1.913GlyGln: 1.913 ± 0.42
2.742GlyArg: 2.742 ± 0.385
5.038GlySer: 5.038 ± 0.614
3.507GlyThr: 3.507 ± 0.535
5.93GlyVal: 5.93 ± 0.583
1.594GlyTrp: 1.594 ± 0.258
3.252GlyTyr: 3.252 ± 0.435
0.0GlyXaa: 0.0 ± 0.0
His
1.148HisAla: 1.148 ± 0.266
0.191HisCys: 0.191 ± 0.102
1.53HisAsp: 1.53 ± 0.34
1.084HisGlu: 1.084 ± 0.296
0.957HisPhe: 0.957 ± 0.261
1.594HisGly: 1.594 ± 0.352
0.51HisHis: 0.51 ± 0.209
0.957HisIle: 0.957 ± 0.221
1.275HisLys: 1.275 ± 0.307
1.53HisLeu: 1.53 ± 0.388
0.383HisMet: 0.383 ± 0.157
0.446HisAsn: 0.446 ± 0.161
0.574HisPro: 0.574 ± 0.217
1.084HisGln: 1.084 ± 0.292
1.084HisArg: 1.084 ± 0.315
1.212HisSer: 1.212 ± 0.284
1.084HisThr: 1.084 ± 0.256
1.594HisVal: 1.594 ± 0.326
0.128HisTrp: 0.128 ± 0.084
0.765HisTyr: 0.765 ± 0.203
0.0HisXaa: 0.0 ± 0.0
Ile
6.632IleAla: 6.632 ± 0.655
0.957IleCys: 0.957 ± 0.269
4.655IleAsp: 4.655 ± 0.499
5.101IleGlu: 5.101 ± 0.574
2.041IlePhe: 2.041 ± 0.374
3.252IleGly: 3.252 ± 0.429
1.339IleHis: 1.339 ± 0.324
3.507IleIle: 3.507 ± 0.514
5.038IleLys: 5.038 ± 0.631
3.252IleLeu: 3.252 ± 0.485
2.168IleMet: 2.168 ± 0.399
3.571IleAsn: 3.571 ± 0.506
2.678IlePro: 2.678 ± 0.37
2.104IleGln: 2.104 ± 0.364
3.061IleArg: 3.061 ± 0.482
3.699IleSer: 3.699 ± 0.44
4.91IleThr: 4.91 ± 0.557
3.826IleVal: 3.826 ± 0.406
0.701IleTrp: 0.701 ± 0.209
1.722IleTyr: 1.722 ± 0.34
0.0IleXaa: 0.0 ± 0.0
Lys
7.206LysAla: 7.206 ± 0.91
0.701LysCys: 0.701 ± 0.203
4.017LysAsp: 4.017 ± 0.415
6.441LysGlu: 6.441 ± 0.765
2.168LysPhe: 2.168 ± 0.361
3.954LysGly: 3.954 ± 0.566
1.53LysHis: 1.53 ± 0.311
4.655LysIle: 4.655 ± 0.478
4.017LysLys: 4.017 ± 0.591
5.038LysLeu: 5.038 ± 0.625
3.316LysMet: 3.316 ± 0.469
3.443LysAsn: 3.443 ± 0.422
3.188LysPro: 3.188 ± 0.442
2.041LysGln: 2.041 ± 0.443
4.145LysArg: 4.145 ± 0.564
3.635LysSer: 3.635 ± 0.482
4.4LysThr: 4.4 ± 0.658
5.165LysVal: 5.165 ± 0.542
1.02LysTrp: 1.02 ± 0.317
2.359LysTyr: 2.359 ± 0.351
0.0LysXaa: 0.0 ± 0.0
Leu
6.696LeuAla: 6.696 ± 0.997
0.957LeuCys: 0.957 ± 0.313
3.507LeuAsp: 3.507 ± 0.346
4.336LeuGlu: 4.336 ± 0.693
2.551LeuPhe: 2.551 ± 0.432
3.762LeuGly: 3.762 ± 0.469
1.467LeuHis: 1.467 ± 0.352
4.655LeuIle: 4.655 ± 0.495
5.038LeuLys: 5.038 ± 0.613
4.464LeuLeu: 4.464 ± 0.568
2.296LeuMet: 2.296 ± 0.38
4.017LeuAsn: 4.017 ± 0.459
3.061LeuPro: 3.061 ± 0.496
2.041LeuGln: 2.041 ± 0.429
3.571LeuArg: 3.571 ± 0.492
4.591LeuSer: 4.591 ± 0.466
5.038LeuThr: 5.038 ± 0.602
4.464LeuVal: 4.464 ± 0.524
1.084LeuTrp: 1.084 ± 0.234
1.785LeuTyr: 1.785 ± 0.334
0.0LeuXaa: 0.0 ± 0.0
Met
2.614MetAla: 2.614 ± 0.374
0.51MetCys: 0.51 ± 0.207
1.594MetAsp: 1.594 ± 0.305
1.275MetGlu: 1.275 ± 0.321
1.339MetPhe: 1.339 ± 0.299
1.467MetGly: 1.467 ± 0.299
0.638MetHis: 0.638 ± 0.181
2.742MetIle: 2.742 ± 0.424
2.933MetLys: 2.933 ± 0.417
2.487MetLeu: 2.487 ± 0.334
1.148MetMet: 1.148 ± 0.301
1.403MetAsn: 1.403 ± 0.288
1.084MetPro: 1.084 ± 0.249
1.785MetGln: 1.785 ± 0.355
1.849MetArg: 1.849 ± 0.322
2.104MetSer: 2.104 ± 0.41
1.658MetThr: 1.658 ± 0.316
1.913MetVal: 1.913 ± 0.296
0.255MetTrp: 0.255 ± 0.112
0.765MetTyr: 0.765 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
4.719AsnAla: 4.719 ± 0.667
0.638AsnCys: 0.638 ± 0.19
3.699AsnAsp: 3.699 ± 0.423
3.443AsnGlu: 3.443 ± 0.529
1.849AsnPhe: 1.849 ± 0.329
5.038AsnGly: 5.038 ± 0.562
0.701AsnHis: 0.701 ± 0.263
3.061AsnIle: 3.061 ± 0.397
3.635AsnLys: 3.635 ± 0.511
2.678AsnLeu: 2.678 ± 0.42
0.957AsnMet: 0.957 ± 0.298
3.125AsnAsn: 3.125 ± 0.698
1.658AsnPro: 1.658 ± 0.35
2.232AsnGln: 2.232 ± 0.418
1.913AsnArg: 1.913 ± 0.381
2.742AsnSer: 2.742 ± 0.465
1.722AsnThr: 1.722 ± 0.322
3.635AsnVal: 3.635 ± 0.421
0.638AsnTrp: 0.638 ± 0.183
1.339AsnTyr: 1.339 ± 0.294
0.0AsnXaa: 0.0 ± 0.0
Pro
2.104ProAla: 2.104 ± 0.38
0.383ProCys: 0.383 ± 0.196
2.232ProAsp: 2.232 ± 0.45
3.252ProGlu: 3.252 ± 0.63
1.148ProPhe: 1.148 ± 0.218
2.742ProGly: 2.742 ± 0.395
0.765ProHis: 0.765 ± 0.238
2.232ProIle: 2.232 ± 0.441
1.594ProLys: 1.594 ± 0.281
1.785ProLeu: 1.785 ± 0.358
0.957ProMet: 0.957 ± 0.254
1.913ProAsn: 1.913 ± 0.387
1.403ProPro: 1.403 ± 0.313
1.403ProGln: 1.403 ± 0.236
1.594ProArg: 1.594 ± 0.325
1.275ProSer: 1.275 ± 0.265
1.53ProThr: 1.53 ± 0.33
2.87ProVal: 2.87 ± 0.344
0.383ProTrp: 0.383 ± 0.152
1.467ProTyr: 1.467 ± 0.243
0.0ProXaa: 0.0 ± 0.0
Gln
3.252GlnAla: 3.252 ± 0.495
0.638GlnCys: 0.638 ± 0.219
2.359GlnAsp: 2.359 ± 0.436
2.742GlnGlu: 2.742 ± 0.387
1.594GlnPhe: 1.594 ± 0.272
1.913GlnGly: 1.913 ± 0.383
0.383GlnHis: 0.383 ± 0.17
2.933GlnIle: 2.933 ± 0.448
2.678GlnLys: 2.678 ± 0.476
3.826GlnLeu: 3.826 ± 0.681
1.148GlnMet: 1.148 ± 0.251
1.722GlnAsn: 1.722 ± 0.401
1.275GlnPro: 1.275 ± 0.244
2.933GlnGln: 2.933 ± 0.714
2.168GlnArg: 2.168 ± 0.434
2.87GlnSer: 2.87 ± 0.448
2.104GlnThr: 2.104 ± 0.439
2.614GlnVal: 2.614 ± 0.374
0.51GlnTrp: 0.51 ± 0.162
1.339GlnTyr: 1.339 ± 0.235
0.0GlnXaa: 0.0 ± 0.0
Arg
4.017ArgAla: 4.017 ± 0.538
0.957ArgCys: 0.957 ± 0.316
2.551ArgAsp: 2.551 ± 0.383
3.826ArgGlu: 3.826 ± 0.525
2.614ArgPhe: 2.614 ± 0.433
3.061ArgGly: 3.061 ± 0.422
0.829ArgHis: 0.829 ± 0.225
3.699ArgIle: 3.699 ± 0.434
4.017ArgLys: 4.017 ± 0.612
2.997ArgLeu: 2.997 ± 0.558
1.913ArgMet: 1.913 ± 0.318
1.977ArgAsn: 1.977 ± 0.34
1.467ArgPro: 1.467 ± 0.342
1.849ArgGln: 1.849 ± 0.389
3.316ArgArg: 3.316 ± 0.57
2.232ArgSer: 2.232 ± 0.378
1.594ArgThr: 1.594 ± 0.346
3.89ArgVal: 3.89 ± 0.502
0.638ArgTrp: 0.638 ± 0.167
1.913ArgTyr: 1.913 ± 0.377
0.0ArgXaa: 0.0 ± 0.0
Ser
4.91SerAla: 4.91 ± 0.584
0.446SerCys: 0.446 ± 0.157
4.527SerAsp: 4.527 ± 0.47
4.272SerGlu: 4.272 ± 0.555
1.785SerPhe: 1.785 ± 0.323
5.484SerGly: 5.484 ± 0.583
0.893SerHis: 0.893 ± 0.271
3.699SerIle: 3.699 ± 0.564
3.252SerLys: 3.252 ± 0.431
3.699SerLeu: 3.699 ± 0.465
1.722SerMet: 1.722 ± 0.334
2.041SerAsn: 2.041 ± 0.319
2.041SerPro: 2.041 ± 0.505
2.742SerGln: 2.742 ± 0.499
2.423SerArg: 2.423 ± 0.446
2.232SerSer: 2.232 ± 0.371
2.551SerThr: 2.551 ± 0.484
4.209SerVal: 4.209 ± 0.404
0.893SerTrp: 0.893 ± 0.252
2.232SerTyr: 2.232 ± 0.343
0.0SerXaa: 0.0 ± 0.0
Thr
4.464ThrAla: 4.464 ± 0.656
0.51ThrCys: 0.51 ± 0.166
3.635ThrAsp: 3.635 ± 0.489
2.359ThrGlu: 2.359 ± 0.429
3.125ThrPhe: 3.125 ± 0.357
5.293ThrGly: 5.293 ± 0.611
1.02ThrHis: 1.02 ± 0.22
3.507ThrIle: 3.507 ± 0.397
3.699ThrLys: 3.699 ± 0.731
3.699ThrLeu: 3.699 ± 0.415
1.467ThrMet: 1.467 ± 0.246
2.614ThrAsn: 2.614 ± 0.468
2.551ThrPro: 2.551 ± 0.338
2.551ThrGln: 2.551 ± 0.448
1.977ThrArg: 1.977 ± 0.33
2.551ThrSer: 2.551 ± 0.445
2.104ThrThr: 2.104 ± 0.402
4.272ThrVal: 4.272 ± 0.606
0.957ThrTrp: 0.957 ± 0.208
1.849ThrTyr: 1.849 ± 0.34
0.0ThrXaa: 0.0 ± 0.0
Val
4.464ValAla: 4.464 ± 0.548
1.212ValCys: 1.212 ± 0.327
4.655ValAsp: 4.655 ± 0.541
5.484ValGlu: 5.484 ± 0.553
2.041ValPhe: 2.041 ± 0.371
4.209ValGly: 4.209 ± 0.457
1.275ValHis: 1.275 ± 0.214
5.165ValIle: 5.165 ± 0.593
5.739ValLys: 5.739 ± 0.709
4.974ValLeu: 4.974 ± 0.466
2.296ValMet: 2.296 ± 0.391
3.252ValAsn: 3.252 ± 0.408
1.849ValPro: 1.849 ± 0.332
1.977ValGln: 1.977 ± 0.332
3.443ValArg: 3.443 ± 0.523
4.527ValSer: 4.527 ± 0.511
4.4ValThr: 4.4 ± 0.458
4.209ValVal: 4.209 ± 0.584
1.275ValTrp: 1.275 ± 0.232
2.487ValTyr: 2.487 ± 0.398
0.0ValXaa: 0.0 ± 0.0
Trp
0.957TrpAla: 0.957 ± 0.253
0.383TrpCys: 0.383 ± 0.165
0.701TrpAsp: 0.701 ± 0.186
0.893TrpGlu: 0.893 ± 0.272
0.765TrpPhe: 0.765 ± 0.227
1.084TrpGly: 1.084 ± 0.237
0.574TrpHis: 0.574 ± 0.207
0.829TrpIle: 0.829 ± 0.215
0.893TrpLys: 0.893 ± 0.202
1.467TrpLeu: 1.467 ± 0.295
0.064TrpMet: 0.064 ± 0.073
0.829TrpAsn: 0.829 ± 0.2
0.255TrpPro: 0.255 ± 0.122
0.446TrpGln: 0.446 ± 0.152
1.084TrpArg: 1.084 ± 0.306
0.701TrpSer: 0.701 ± 0.229
1.084TrpThr: 1.084 ± 0.25
0.829TrpVal: 0.829 ± 0.234
0.128TrpTrp: 0.128 ± 0.093
0.319TrpTyr: 0.319 ± 0.127
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.806TyrAla: 2.806 ± 0.512
0.829TyrCys: 0.829 ± 0.242
2.551TyrAsp: 2.551 ± 0.329
2.168TyrGlu: 2.168 ± 0.41
1.275TyrPhe: 1.275 ± 0.341
2.806TyrGly: 2.806 ± 0.416
1.212TyrHis: 1.212 ± 0.254
2.232TyrIle: 2.232 ± 0.381
2.551TyrLys: 2.551 ± 0.465
2.296TyrLeu: 2.296 ± 0.38
0.574TyrMet: 0.574 ± 0.196
1.594TyrAsn: 1.594 ± 0.326
0.957TyrPro: 0.957 ± 0.217
1.658TyrGln: 1.658 ± 0.303
2.104TyrArg: 2.104 ± 0.45
2.487TyrSer: 2.487 ± 0.439
1.913TyrThr: 1.913 ± 0.313
2.104TyrVal: 2.104 ± 0.369
0.383TyrTrp: 0.383 ± 0.152
1.212TyrTyr: 1.212 ± 0.252
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 87 proteins (15683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski