Amino acid dipepetide frequency for Streptomyces malaysiense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.088AlaAla: 22.088 ± 0.175	1.124AlaCys: 1.124 ± 0.025	8.361AlaAsp: 8.361 ± 0.066	9.118AlaGlu: 9.118 ± 0.105	3.516AlaPhe: 3.516 ± 0.037	13.779AlaGly: 13.779 ± 0.102	3.023AlaHis: 3.023 ± 0.046	3.161AlaIle: 3.161 ± 0.045	2.673AlaLys: 2.673 ± 0.049	14.902AlaLeu: 14.902 ± 0.106	2.374AlaMet: 2.374 ± 0.032	1.87AlaAsn: 1.87 ± 0.034	7.445AlaPro: 7.445 ± 0.093	3.64AlaGln: 3.64 ± 0.044	11.29AlaArg: 11.29 ± 0.108	5.539AlaSer: 5.539 ± 0.055	6.91AlaThr: 6.91 ± 0.065	12.414AlaVal: 12.414 ± 0.088	1.808AlaTrp: 1.808 ± 0.03	2.787AlaTyr: 2.787 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.206CysAla: 1.206 ± 0.029	0.103CysCys: 0.103 ± 0.008	0.473CysAsp: 0.473 ± 0.017	0.411CysGlu: 0.411 ± 0.015	0.24CysPhe: 0.24 ± 0.012	1.033CysGly: 1.033 ± 0.026	0.21CysHis: 0.21 ± 0.011	0.145CysIle: 0.145 ± 0.008	0.103CysLys: 0.103 ± 0.007	0.809CysLeu: 0.809 ± 0.019	0.121CysMet: 0.121 ± 0.008	0.134CysAsn: 0.134 ± 0.008	0.526CysPro: 0.526 ± 0.018	0.172CysGln: 0.172 ± 0.009	0.641CysArg: 0.641 ± 0.02	0.409CysSer: 0.409 ± 0.015	0.504CysThr: 0.504 ± 0.017	0.718CysVal: 0.718 ± 0.02	0.139CysTrp: 0.139 ± 0.009	0.156CysTyr: 0.156 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.614AspAla: 7.614 ± 0.074	0.417AspCys: 0.417 ± 0.014	3.403AspAsp: 3.403 ± 0.044	3.727AspGlu: 3.727 ± 0.048	1.636AspPhe: 1.636 ± 0.029	6.334AspGly: 6.334 ± 0.061	1.428AspHis: 1.428 ± 0.023	1.808AspIle: 1.808 ± 0.027	1.16AspLys: 1.16 ± 0.032	6.245AspLeu: 6.245 ± 0.062	0.824AspMet: 0.824 ± 0.021	0.888AspAsn: 0.888 ± 0.023	4.542AspPro: 4.542 ± 0.052	1.49AspGln: 1.49 ± 0.029	4.995AspArg: 4.995 ± 0.053	2.436AspSer: 2.436 ± 0.042	3.268AspThr: 3.268 ± 0.047	4.633AspVal: 4.633 ± 0.049	1.039AspTrp: 1.039 ± 0.025	1.101AspTyr: 1.101 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.327GluAla: 7.327 ± 0.082	0.385GluCys: 0.385 ± 0.014	2.83GluAsp: 2.83 ± 0.04	3.684GluGlu: 3.684 ± 0.06	1.479GluPhe: 1.479 ± 0.027	4.324GluGly: 4.324 ± 0.05	1.585GluHis: 1.585 ± 0.028	2.244GluIle: 2.244 ± 0.039	1.32GluLys: 1.32 ± 0.032	6.911GluLeu: 6.911 ± 0.067	0.886GluMet: 0.886 ± 0.021	0.989GluAsn: 0.989 ± 0.025	3.416GluPro: 3.416 ± 0.048	2.099GluGln: 2.099 ± 0.03	5.876GluArg: 5.876 ± 0.063	2.42GluSer: 2.42 ± 0.033	2.852GluThr: 2.852 ± 0.034	4.424GluVal: 4.424 ± 0.05	0.731GluTrp: 0.731 ± 0.02	1.093GluTyr: 1.093 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.761PheAla: 3.761 ± 0.046	0.279PheCys: 0.279 ± 0.01	1.882PheAsp: 1.882 ± 0.028	1.498PheGlu: 1.498 ± 0.026	0.885PhePhe: 0.885 ± 0.022	3.058PheGly: 3.058 ± 0.044	0.65PheHis: 0.65 ± 0.018	0.654PheIle: 0.654 ± 0.019	0.496PheLys: 0.496 ± 0.019	2.678PheLeu: 2.678 ± 0.041	0.39PheMet: 0.39 ± 0.014	0.51PheAsn: 0.51 ± 0.017	1.41PhePro: 1.41 ± 0.024	0.647PheGln: 0.647 ± 0.017	1.871PheArg: 1.871 ± 0.028	1.408PheSer: 1.408 ± 0.026	2.008PheThr: 2.008 ± 0.033	2.102PheVal: 2.102 ± 0.036	0.409PheTrp: 0.409 ± 0.015	0.567PheTyr: 0.567 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.582GlyAla: 11.582 ± 0.094	0.878GlyCys: 0.878 ± 0.021	5.242GlyAsp: 5.242 ± 0.053	5.175GlyGlu: 5.175 ± 0.058	2.921GlyPhe: 2.921 ± 0.037	9.092GlyGly: 9.092 ± 0.09	2.569GlyHis: 2.569 ± 0.038	3.336GlyIle: 3.336 ± 0.044	2.328GlyLys: 2.328 ± 0.045	9.618GlyLeu: 9.618 ± 0.077	1.986GlyMet: 1.986 ± 0.032	1.704GlyAsn: 1.704 ± 0.036	5.405GlyPro: 5.405 ± 0.059	2.626GlyGln: 2.626 ± 0.046	8.33GlyArg: 8.33 ± 0.066	5.297GlySer: 5.297 ± 0.063	6.721GlyThr: 6.721 ± 0.063	7.677GlyVal: 7.677 ± 0.066	1.695GlyTrp: 1.695 ± 0.032	2.39GlyTyr: 2.39 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.751HisAla: 2.751 ± 0.04	0.224HisCys: 0.224 ± 0.011	1.313HisAsp: 1.313 ± 0.024	1.273HisGlu: 1.273 ± 0.025	0.656HisPhe: 0.656 ± 0.018	2.622HisGly: 2.622 ± 0.036	0.744HisHis: 0.744 ± 0.023	0.7HisIle: 0.7 ± 0.02	0.352HisLys: 0.352 ± 0.013	2.506HisLeu: 2.506 ± 0.035	0.332HisMet: 0.332 ± 0.011	0.35HisAsn: 0.35 ± 0.014	1.911HisPro: 1.911 ± 0.031	0.649HisGln: 0.649 ± 0.017	2.228HisArg: 2.228 ± 0.038	1.017HisSer: 1.017 ± 0.024	1.441HisThr: 1.441 ± 0.028	1.695HisVal: 1.695 ± 0.032	0.404HisTrp: 0.404 ± 0.013	0.494HisTyr: 0.494 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.567IleAla: 4.567 ± 0.053	0.289IleCys: 0.289 ± 0.011	2.065IleAsp: 2.065 ± 0.034	1.882IleGlu: 1.882 ± 0.033	0.623IlePhe: 0.623 ± 0.019	3.462IleGly: 3.462 ± 0.037	0.57IleHis: 0.57 ± 0.016	0.792IleIle: 0.792 ± 0.021	0.709IleLys: 0.709 ± 0.022	2.243IleLeu: 2.243 ± 0.037	0.41IleMet: 0.41 ± 0.013	0.623IleAsn: 0.623 ± 0.019	1.649IlePro: 1.649 ± 0.027	0.683IleGln: 0.683 ± 0.019	2.168IleArg: 2.168 ± 0.036	1.573IleSer: 1.573 ± 0.029	2.079IleThr: 2.079 ± 0.033	2.612IleVal: 2.612 ± 0.037	0.339IleTrp: 0.339 ± 0.013	0.485IleTyr: 0.485 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.77LysAla: 2.77 ± 0.049	0.113LysCys: 0.113 ± 0.008	1.288LysAsp: 1.288 ± 0.031	1.105LysGlu: 1.105 ± 0.027	0.42LysPhe: 0.42 ± 0.016	1.785LysGly: 1.785 ± 0.037	0.402LysHis: 0.402 ± 0.014	0.798LysIle: 0.798 ± 0.023	0.78LysLys: 0.78 ± 0.031	1.897LysLeu: 1.897 ± 0.036	0.362LysMet: 0.362 ± 0.014	0.48LysAsn: 0.48 ± 0.017	1.225LysPro: 1.225 ± 0.028	0.661LysGln: 0.661 ± 0.022	1.351LysArg: 1.351 ± 0.03	1.084LysSer: 1.084 ± 0.028	1.207LysThr: 1.207 ± 0.033	1.831LysVal: 1.831 ± 0.036	0.25LysTrp: 0.25 ± 0.011	0.445LysTyr: 0.445 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.621LeuAla: 15.621 ± 0.112	0.915LeuCys: 0.915 ± 0.021	6.868LeuAsp: 6.868 ± 0.067	4.716LeuGlu: 4.716 ± 0.049	2.633LeuPhe: 2.633 ± 0.046	9.594LeuGly: 9.594 ± 0.08	2.357LeuHis: 2.357 ± 0.036	3.112LeuIle: 3.112 ± 0.039	1.968LeuLys: 1.968 ± 0.037	11.687LeuLeu: 11.687 ± 0.106	1.622LeuMet: 1.622 ± 0.03	1.603LeuAsn: 1.603 ± 0.028	6.712LeuPro: 6.712 ± 0.068	2.094LeuGln: 2.094 ± 0.031	9.17LeuArg: 9.17 ± 0.087	5.171LeuSer: 5.171 ± 0.053	6.976LeuThr: 6.976 ± 0.065	9.019LeuVal: 9.019 ± 0.073	1.301LeuTrp: 1.301 ± 0.028	1.87LeuTyr: 1.87 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.2MetAla: 2.2 ± 0.034	0.143MetCys: 0.143 ± 0.008	0.872MetAsp: 0.872 ± 0.022	0.745MetGlu: 0.745 ± 0.018	0.462MetPhe: 0.462 ± 0.014	1.277MetGly: 1.277 ± 0.025	0.354MetHis: 0.354 ± 0.014	0.634MetIle: 0.634 ± 0.02	0.386MetLys: 0.386 ± 0.014	1.655MetLeu: 1.655 ± 0.029	0.281MetMet: 0.281 ± 0.011	0.392MetAsn: 0.392 ± 0.014	1.097MetPro: 1.097 ± 0.02	0.406MetGln: 0.406 ± 0.012	1.415MetArg: 1.415 ± 0.03	1.295MetSer: 1.295 ± 0.024	1.539MetThr: 1.539 ± 0.027	1.239MetVal: 1.239 ± 0.025	0.216MetTrp: 0.216 ± 0.011	0.312MetTyr: 0.312 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.066AsnAla: 2.066 ± 0.035	0.155AsnCys: 0.155 ± 0.009	0.875AsnAsp: 0.875 ± 0.022	0.703AsnGlu: 0.703 ± 0.021	0.469AsnPhe: 0.469 ± 0.015	1.749AsnGly: 1.749 ± 0.033	0.374AsnHis: 0.374 ± 0.013	0.594AsnIle: 0.594 ± 0.018	0.375AsnLys: 0.375 ± 0.013	1.608AsnLeu: 1.608 ± 0.032	0.305AsnMet: 0.305 ± 0.013	0.368AsnAsn: 0.368 ± 0.014	1.304AsnPro: 1.304 ± 0.024	0.493AsnGln: 0.493 ± 0.018	1.203AsnArg: 1.203 ± 0.026	0.873AsnSer: 0.873 ± 0.023	1.031AsnThr: 1.031 ± 0.031	1.293AsnVal: 1.293 ± 0.027	0.261AsnTrp: 0.261 ± 0.012	0.389AsnTyr: 0.389 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	9.266ProAla: 9.266 ± 0.106	0.378ProCys: 0.378 ± 0.014	4.486ProAsp: 4.486 ± 0.052	4.383ProGlu: 4.383 ± 0.055	1.502ProPhe: 1.502 ± 0.026	7.193ProGly: 7.193 ± 0.075	1.432ProHis: 1.432 ± 0.03	1.135ProIle: 1.135 ± 0.023	1.118ProLys: 1.118 ± 0.027	5.606ProLeu: 5.606 ± 0.057	0.955ProMet: 0.955 ± 0.022	0.824ProAsn: 0.824 ± 0.02	3.514ProPro: 3.514 ± 0.062	1.59ProGln: 1.59 ± 0.036	4.349ProArg: 4.349 ± 0.049	3.013ProSer: 3.013 ± 0.041	2.943ProThr: 2.943 ± 0.046	5.738ProVal: 5.738 ± 0.06	0.866ProTrp: 0.866 ± 0.02	1.457ProTyr: 1.457 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.536GlnAla: 3.536 ± 0.046	0.172GlnCys: 0.172 ± 0.008	1.361GlnAsp: 1.361 ± 0.027	1.412GlnGlu: 1.412 ± 0.031	0.644GlnPhe: 0.644 ± 0.018	2.248GlnGly: 2.248 ± 0.037	0.636GlnHis: 0.636 ± 0.017	0.998GlnIle: 0.998 ± 0.021	0.606GlnLys: 0.606 ± 0.02	2.902GlnLeu: 2.902 ± 0.041	0.474GlnMet: 0.474 ± 0.013	0.463GlnAsn: 0.463 ± 0.016	1.532GlnPro: 1.532 ± 0.037	1.108GlnGln: 1.108 ± 0.036	2.273GlnArg: 2.273 ± 0.032	1.225GlnSer: 1.225 ± 0.025	1.26GlnThr: 1.26 ± 0.025	2.317GlnVal: 2.317 ± 0.034	0.422GlnTrp: 0.422 ± 0.013	0.574GlnTyr: 0.574 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.655ArgAla: 10.655 ± 0.094	0.629ArgCys: 0.629 ± 0.02	4.347ArgAsp: 4.347 ± 0.045	5.011ArgGlu: 5.011 ± 0.058	2.416ArgPhe: 2.416 ± 0.034	6.298ArgGly: 6.298 ± 0.06	2.231ArgHis: 2.231 ± 0.036	3.099ArgIle: 3.099 ± 0.042	1.54ArgLys: 1.54 ± 0.031	9.688ArgLeu: 9.688 ± 0.09	1.763ArgMet: 1.763 ± 0.028	1.252ArgAsn: 1.252 ± 0.024	5.447ArgPro: 5.447 ± 0.065	2.29ArgGln: 2.29 ± 0.031	8.285ArgArg: 8.285 ± 0.081	3.974ArgSer: 3.974 ± 0.045	5.588ArgThr: 5.588 ± 0.062	6.215ArgVal: 6.215 ± 0.066	1.41ArgTrp: 1.41 ± 0.027	1.875ArgTyr: 1.875 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.623SerAla: 6.623 ± 0.062	0.437SerCys: 0.437 ± 0.015	2.487SerAsp: 2.487 ± 0.039	2.241SerGlu: 2.241 ± 0.038	1.518SerPhe: 1.518 ± 0.029	5.863SerGly: 5.863 ± 0.06	0.981SerHis: 0.981 ± 0.023	1.263SerIle: 1.263 ± 0.028	0.928SerLys: 0.928 ± 0.029	4.743SerLeu: 4.743 ± 0.05	1.022SerMet: 1.022 ± 0.02	0.78SerAsn: 0.78 ± 0.019	3.068SerPro: 3.068 ± 0.044	1.114SerGln: 1.114 ± 0.024	3.611SerArg: 3.611 ± 0.044	2.581SerSer: 2.581 ± 0.047	2.974SerThr: 2.974 ± 0.051	4.177SerVal: 4.177 ± 0.049	0.87SerTrp: 0.87 ± 0.02	1.287SerTyr: 1.287 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	9.114ThrAla: 9.114 ± 0.08	0.446ThrCys: 0.446 ± 0.016	3.527ThrAsp: 3.527 ± 0.046	3.288ThrGlu: 3.288 ± 0.039	1.568ThrPhe: 1.568 ± 0.025	7.075ThrGly: 7.075 ± 0.07	1.236ThrHis: 1.236 ± 0.026	1.568ThrIle: 1.568 ± 0.031	1.049ThrLys: 1.049 ± 0.028	5.726ThrLeu: 5.726 ± 0.051	0.885ThrMet: 0.885 ± 0.022	0.95ThrAsn: 0.95 ± 0.026	4.083ThrPro: 4.083 ± 0.055	1.247ThrGln: 1.247 ± 0.03	4.081ThrArg: 4.081 ± 0.045	3.101ThrSer: 3.101 ± 0.054	3.818ThrThr: 3.818 ± 0.075	6.037ThrVal: 6.037 ± 0.062	0.901ThrTrp: 0.901 ± 0.021	1.345ThrTyr: 1.345 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	10.617ValAla: 10.617 ± 0.094	0.832ValCys: 0.832 ± 0.023	4.803ValAsp: 4.803 ± 0.042	4.564ValGlu: 4.564 ± 0.051	2.432ValPhe: 2.432 ± 0.042	6.436ValGly: 6.436 ± 0.066	2.066ValHis: 2.066 ± 0.03	2.796ValIle: 2.796 ± 0.037	1.625ValLys: 1.625 ± 0.035	9.703ValLeu: 9.703 ± 0.079	1.381ValMet: 1.381 ± 0.024	1.557ValAsn: 1.557 ± 0.031	5.582ValPro: 5.582 ± 0.062	1.979ValGln: 1.979 ± 0.034	7.709ValArg: 7.709 ± 0.066	4.277ValSer: 4.277 ± 0.047	5.664ValThr: 5.664 ± 0.064	7.947ValVal: 7.947 ± 0.073	1.123ValTrp: 1.123 ± 0.022	1.616ValTyr: 1.616 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.693TrpAla: 1.693 ± 0.029	0.162TrpCys: 0.162 ± 0.009	0.813TrpAsp: 0.813 ± 0.019	0.693TrpGlu: 0.693 ± 0.016	0.486TrpPhe: 0.486 ± 0.016	1.04TrpGly: 1.04 ± 0.02	0.399TrpHis: 0.399 ± 0.014	0.513TrpIle: 0.513 ± 0.018	0.368TrpLys: 0.368 ± 0.015	1.767TrpLeu: 1.767 ± 0.029	0.273TrpMet: 0.273 ± 0.01	0.372TrpAsn: 0.372 ± 0.014	0.782TrpPro: 0.782 ± 0.019	0.57TrpGln: 0.57 ± 0.018	1.347TrpArg: 1.347 ± 0.028	0.924TrpSer: 0.924 ± 0.021	1.029TrpThr: 1.029 ± 0.022	0.95TrpVal: 0.95 ± 0.023	0.332TrpTrp: 0.332 ± 0.014	0.354TrpTyr: 0.354 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.767TyrAla: 2.767 ± 0.035	0.175TyrCys: 0.175 ± 0.01	1.69TyrAsp: 1.69 ± 0.048	1.245TyrGlu: 1.245 ± 0.027	0.656TyrPhe: 0.656 ± 0.021	2.31TyrGly: 2.31 ± 0.036	0.416TyrHis: 0.416 ± 0.014	0.479TyrIle: 0.479 ± 0.016	0.373TyrLys: 0.373 ± 0.016	2.112TyrLeu: 2.112 ± 0.033	0.272TyrMet: 0.272 ± 0.011	0.378TyrAsn: 0.378 ± 0.017	1.098TyrPro: 1.098 ± 0.025	0.607TyrGln: 0.607 ± 0.017	1.818TyrArg: 1.818 ± 0.031	0.949TyrSer: 0.949 ± 0.024	1.233TyrThr: 1.233 ± 0.033	1.67TyrVal: 1.67 ± 0.032	0.349TyrTrp: 0.349 ± 0.013	0.451TyrTyr: 0.451 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6612 proteins (2174823 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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