Amino acid dipepetide frequency for Sinorhizobium phage ort11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.519AlaAla: 7.519 ± 0.909
0.344AlaCys: 0.344 ± 0.124
5.156AlaAsp: 5.156 ± 0.47
5.414AlaGlu: 5.414 ± 0.517
2.363AlaPhe: 2.363 ± 0.329
5.715AlaGly: 5.715 ± 0.873
1.031AlaHis: 1.031 ± 0.21
5.414AlaIle: 5.414 ± 0.496
4.426AlaLys: 4.426 ± 0.58
6.875AlaLeu: 6.875 ± 0.636
1.719AlaMet: 1.719 ± 0.287
3.695AlaAsn: 3.695 ± 0.419
3.008AlaPro: 3.008 ± 0.405
3.781AlaGln: 3.781 ± 0.546
3.437AlaArg: 3.437 ± 0.565
4.898AlaSer: 4.898 ± 0.741
4.64AlaThr: 4.64 ± 0.546
4.941AlaVal: 4.941 ± 0.899
1.418AlaTrp: 1.418 ± 0.266
3.265AlaTyr: 3.265 ± 0.373
0.0AlaXaa: 0.0 ± 0.0
Cys
0.516CysAla: 0.516 ± 0.19
0.129CysCys: 0.129 ± 0.069
0.387CysAsp: 0.387 ± 0.141
0.473CysGlu: 0.473 ± 0.148
0.644CysPhe: 0.644 ± 0.178
0.559CysGly: 0.559 ± 0.159
0.258CysHis: 0.258 ± 0.117
0.559CysIle: 0.559 ± 0.167
0.387CysLys: 0.387 ± 0.153
0.559CysLeu: 0.559 ± 0.177
0.258CysMet: 0.258 ± 0.107
0.516CysAsn: 0.516 ± 0.159
0.258CysPro: 0.258 ± 0.106
0.215CysGln: 0.215 ± 0.09
0.387CysArg: 0.387 ± 0.153
0.516CysSer: 0.516 ± 0.178
0.687CysThr: 0.687 ± 0.184
0.258CysVal: 0.258 ± 0.107
0.258CysTrp: 0.258 ± 0.124
0.344CysTyr: 0.344 ± 0.122
0.0CysXaa: 0.0 ± 0.0
Asp
4.554AspAla: 4.554 ± 0.533
0.73AspCys: 0.73 ± 0.184
3.265AspAsp: 3.265 ± 0.462
4.511AspGlu: 4.511 ± 0.408
2.535AspPhe: 2.535 ± 0.346
3.91AspGly: 3.91 ± 0.42
1.676AspHis: 1.676 ± 0.226
4.039AspIle: 4.039 ± 0.538
3.609AspLys: 3.609 ± 0.464
5.929AspLeu: 5.929 ± 0.585
1.933AspMet: 1.933 ± 0.233
2.922AspAsn: 2.922 ± 0.349
3.351AspPro: 3.351 ± 0.316
2.449AspGln: 2.449 ± 0.326
2.922AspArg: 2.922 ± 0.361
2.922AspSer: 2.922 ± 0.38
3.523AspThr: 3.523 ± 0.365
3.781AspVal: 3.781 ± 0.43
0.687AspTrp: 0.687 ± 0.189
2.32AspTyr: 2.32 ± 0.211
0.0AspXaa: 0.0 ± 0.0
Glu
5.843GluAla: 5.843 ± 1.006
0.602GluCys: 0.602 ± 0.181
3.781GluAsp: 3.781 ± 0.396
5.972GluGlu: 5.972 ± 0.64
3.094GluPhe: 3.094 ± 0.372
3.91GluGly: 3.91 ± 0.338
0.945GluHis: 0.945 ± 0.254
4.469GluIle: 4.469 ± 0.413
4.039GluLys: 4.039 ± 0.455
6.531GluLeu: 6.531 ± 0.645
2.922GluMet: 2.922 ± 0.347
3.523GluAsn: 3.523 ± 0.378
2.707GluPro: 2.707 ± 0.405
3.652GluGln: 3.652 ± 0.509
3.18GluArg: 3.18 ± 0.363
3.867GluSer: 3.867 ± 0.366
4.082GluThr: 4.082 ± 0.343
4.597GluVal: 4.597 ± 0.371
1.031GluTrp: 1.031 ± 0.2
2.019GluTyr: 2.019 ± 0.396
0.0GluXaa: 0.0 ± 0.0
Phe
1.976PheAla: 1.976 ± 0.276
0.387PheCys: 0.387 ± 0.146
2.449PheAsp: 2.449 ± 0.304
2.492PheGlu: 2.492 ± 0.358
1.332PhePhe: 1.332 ± 0.217
2.75PheGly: 2.75 ± 0.339
0.773PheHis: 0.773 ± 0.176
2.793PheIle: 2.793 ± 0.372
2.836PheLys: 2.836 ± 0.354
3.437PheLeu: 3.437 ± 0.421
1.203PheMet: 1.203 ± 0.245
2.449PheAsn: 2.449 ± 0.358
1.203PhePro: 1.203 ± 0.217
2.019PheGln: 2.019 ± 0.29
1.805PheArg: 1.805 ± 0.348
2.191PheSer: 2.191 ± 0.27
3.051PheThr: 3.051 ± 0.349
2.578PheVal: 2.578 ± 0.37
0.387PheTrp: 0.387 ± 0.124
1.246PheTyr: 1.246 ± 0.201
0.0PheXaa: 0.0 ± 0.0
Gly
4.726GlyAla: 4.726 ± 0.607
0.644GlyCys: 0.644 ± 0.21
3.308GlyAsp: 3.308 ± 0.425
3.824GlyGlu: 3.824 ± 0.364
3.523GlyPhe: 3.523 ± 0.483
3.91GlyGly: 3.91 ± 0.525
0.902GlyHis: 0.902 ± 0.254
4.426GlyIle: 4.426 ± 0.377
4.511GlyLys: 4.511 ± 0.391
4.426GlyLeu: 4.426 ± 0.644
1.633GlyMet: 1.633 ± 0.246
3.437GlyAsn: 3.437 ± 0.313
1.805GlyPro: 1.805 ± 0.232
2.922GlyGln: 2.922 ± 0.471
3.008GlyArg: 3.008 ± 0.405
5.457GlySer: 5.457 ± 0.579
4.855GlyThr: 4.855 ± 0.42
4.211GlyVal: 4.211 ± 0.626
0.816GlyTrp: 0.816 ± 0.174
3.094GlyTyr: 3.094 ± 0.383
0.0GlyXaa: 0.0 ± 0.0
His
1.074HisAla: 1.074 ± 0.204
0.387HisCys: 0.387 ± 0.147
0.945HisAsp: 0.945 ± 0.193
1.031HisGlu: 1.031 ± 0.196
1.031HisPhe: 1.031 ± 0.189
0.816HisGly: 0.816 ± 0.233
0.644HisHis: 0.644 ± 0.179
1.16HisIle: 1.16 ± 0.256
1.246HisLys: 1.246 ± 0.267
1.891HisLeu: 1.891 ± 0.301
0.687HisMet: 0.687 ± 0.138
0.559HisAsn: 0.559 ± 0.201
0.687HisPro: 0.687 ± 0.177
0.773HisGln: 0.773 ± 0.191
0.687HisArg: 0.687 ± 0.153
1.074HisSer: 1.074 ± 0.245
0.859HisThr: 0.859 ± 0.202
1.719HisVal: 1.719 ± 0.298
0.473HisTrp: 0.473 ± 0.129
0.902HisTyr: 0.902 ± 0.185
0.0HisXaa: 0.0 ± 0.0
Ile
5.371IleAla: 5.371 ± 0.728
0.387IleCys: 0.387 ± 0.145
4.039IleAsp: 4.039 ± 0.452
5.07IleGlu: 5.07 ± 0.342
2.277IlePhe: 2.277 ± 0.371
3.996IleGly: 3.996 ± 0.369
1.461IleHis: 1.461 ± 0.251
3.91IleIle: 3.91 ± 0.6
4.297IleLys: 4.297 ± 0.479
4.769IleLeu: 4.769 ± 0.631
1.203IleMet: 1.203 ± 0.245
3.48IleAsn: 3.48 ± 0.5
3.094IlePro: 3.094 ± 0.405
2.793IleGln: 2.793 ± 0.38
2.836IleArg: 2.836 ± 0.4
3.91IleSer: 3.91 ± 0.446
4.726IleThr: 4.726 ± 0.376
3.953IleVal: 3.953 ± 0.415
0.473IleTrp: 0.473 ± 0.133
1.891IleTyr: 1.891 ± 0.297
0.0IleXaa: 0.0 ± 0.0
Lys
5.586LysAla: 5.586 ± 0.498
0.215LysCys: 0.215 ± 0.105
4.34LysAsp: 4.34 ± 0.53
4.683LysGlu: 4.683 ± 0.558
2.234LysPhe: 2.234 ± 0.288
3.996LysGly: 3.996 ± 0.351
1.074LysHis: 1.074 ± 0.252
4.168LysIle: 4.168 ± 0.39
4.168LysLys: 4.168 ± 0.476
6.402LysLeu: 6.402 ± 0.52
1.676LysMet: 1.676 ± 0.299
2.922LysAsn: 2.922 ± 0.325
2.191LysPro: 2.191 ± 0.376
3.094LysGln: 3.094 ± 0.364
3.308LysArg: 3.308 ± 0.389
3.394LysSer: 3.394 ± 0.396
4.168LysThr: 4.168 ± 0.448
3.824LysVal: 3.824 ± 0.454
0.516LysTrp: 0.516 ± 0.169
1.933LysTyr: 1.933 ± 0.371
0.0LysXaa: 0.0 ± 0.0
Leu
5.886LeuAla: 5.886 ± 0.587
0.559LeuCys: 0.559 ± 0.191
5.843LeuAsp: 5.843 ± 0.657
5.113LeuGlu: 5.113 ± 0.535
2.793LeuPhe: 2.793 ± 0.342
5.929LeuGly: 5.929 ± 0.44
1.805LeuHis: 1.805 ± 0.287
4.898LeuIle: 4.898 ± 0.545
6.316LeuLys: 6.316 ± 0.744
6.015LeuLeu: 6.015 ± 0.622
2.449LeuMet: 2.449 ± 0.303
4.34LeuAsn: 4.34 ± 0.532
3.953LeuPro: 3.953 ± 0.321
3.48LeuGln: 3.48 ± 0.371
3.437LeuArg: 3.437 ± 0.32
5.629LeuSer: 5.629 ± 0.511
5.586LeuThr: 5.586 ± 0.458
5.414LeuVal: 5.414 ± 0.398
0.859LeuTrp: 0.859 ± 0.252
2.449LeuTyr: 2.449 ± 0.353
0.0LeuXaa: 0.0 ± 0.0
Met
2.32MetAla: 2.32 ± 0.368
0.129MetCys: 0.129 ± 0.075
1.547MetAsp: 1.547 ± 0.247
2.062MetGlu: 2.062 ± 0.274
1.031MetPhe: 1.031 ± 0.244
1.332MetGly: 1.332 ± 0.191
0.387MetHis: 0.387 ± 0.122
1.848MetIle: 1.848 ± 0.259
2.019MetLys: 2.019 ± 0.303
2.277MetLeu: 2.277 ± 0.329
0.644MetMet: 0.644 ± 0.167
1.976MetAsn: 1.976 ± 0.228
0.945MetPro: 0.945 ± 0.195
1.031MetGln: 1.031 ± 0.223
1.031MetArg: 1.031 ± 0.176
1.676MetSer: 1.676 ± 0.277
1.805MetThr: 1.805 ± 0.297
1.805MetVal: 1.805 ± 0.252
0.086MetTrp: 0.086 ± 0.07
0.773MetTyr: 0.773 ± 0.202
0.0MetXaa: 0.0 ± 0.0
Asn
4.898AsnAla: 4.898 ± 0.484
0.516AsnCys: 0.516 ± 0.233
2.32AsnAsp: 2.32 ± 0.286
3.523AsnGlu: 3.523 ± 0.434
1.848AsnPhe: 1.848 ± 0.306
4.211AsnGly: 4.211 ± 0.571
1.117AsnHis: 1.117 ± 0.264
3.308AsnIle: 3.308 ± 0.335
2.492AsnLys: 2.492 ± 0.332
4.34AsnLeu: 4.34 ± 0.368
1.375AsnMet: 1.375 ± 0.253
2.492AsnAsn: 2.492 ± 0.321
3.351AsnPro: 3.351 ± 0.456
2.879AsnGln: 2.879 ± 0.41
2.793AsnArg: 2.793 ± 0.344
3.008AsnSer: 3.008 ± 0.479
2.793AsnThr: 2.793 ± 0.329
2.621AsnVal: 2.621 ± 0.303
0.602AsnTrp: 0.602 ± 0.188
2.277AsnTyr: 2.277 ± 0.384
0.0AsnXaa: 0.0 ± 0.0
Pro
3.051ProAla: 3.051 ± 0.454
0.258ProCys: 0.258 ± 0.107
3.308ProAsp: 3.308 ± 0.427
3.738ProGlu: 3.738 ± 0.408
1.719ProPhe: 1.719 ± 0.231
1.762ProGly: 1.762 ± 0.211
0.387ProHis: 0.387 ± 0.141
2.105ProIle: 2.105 ± 0.228
2.836ProLys: 2.836 ± 0.355
2.922ProLeu: 2.922 ± 0.283
0.945ProMet: 0.945 ± 0.2
2.191ProAsn: 2.191 ± 0.326
1.16ProPro: 1.16 ± 0.331
1.719ProGln: 1.719 ± 0.308
1.633ProArg: 1.633 ± 0.306
2.922ProSer: 2.922 ± 0.43
3.008ProThr: 3.008 ± 0.266
3.781ProVal: 3.781 ± 0.353
0.516ProTrp: 0.516 ± 0.131
0.859ProTyr: 0.859 ± 0.183
0.0ProXaa: 0.0 ± 0.0
Gln
4.812GlnAla: 4.812 ± 0.579
0.086GlnCys: 0.086 ± 0.062
2.707GlnAsp: 2.707 ± 0.328
3.781GlnGlu: 3.781 ± 0.469
2.191GlnPhe: 2.191 ± 0.318
2.707GlnGly: 2.707 ± 0.397
0.773GlnHis: 0.773 ± 0.208
3.137GlnIle: 3.137 ± 0.292
2.535GlnLys: 2.535 ± 0.295
3.523GlnLeu: 3.523 ± 0.418
1.031GlnMet: 1.031 ± 0.203
2.234GlnAsn: 2.234 ± 0.322
1.117GlnPro: 1.117 ± 0.237
2.363GlnGln: 2.363 ± 0.411
2.664GlnArg: 2.664 ± 0.365
2.148GlnSer: 2.148 ± 0.405
3.265GlnThr: 3.265 ± 0.377
2.535GlnVal: 2.535 ± 0.383
0.473GlnTrp: 0.473 ± 0.157
1.289GlnTyr: 1.289 ± 0.188
0.0GlnXaa: 0.0 ± 0.0
Arg
3.308ArgAla: 3.308 ± 0.43
0.43ArgCys: 0.43 ± 0.143
2.148ArgAsp: 2.148 ± 0.272
3.094ArgGlu: 3.094 ± 0.464
1.891ArgPhe: 1.891 ± 0.248
3.008ArgGly: 3.008 ± 0.366
0.73ArgHis: 0.73 ± 0.177
3.008ArgIle: 3.008 ± 0.299
2.793ArgLys: 2.793 ± 0.348
3.867ArgLeu: 3.867 ± 0.369
0.945ArgMet: 0.945 ± 0.199
3.265ArgAsn: 3.265 ± 0.403
1.461ArgPro: 1.461 ± 0.257
1.933ArgGln: 1.933 ± 0.322
2.105ArgArg: 2.105 ± 0.388
2.793ArgSer: 2.793 ± 0.367
3.094ArgThr: 3.094 ± 0.399
3.051ArgVal: 3.051 ± 0.316
0.73ArgTrp: 0.73 ± 0.174
1.332ArgTyr: 1.332 ± 0.231
0.0ArgXaa: 0.0 ± 0.0
Ser
4.469SerAla: 4.469 ± 0.548
0.43SerCys: 0.43 ± 0.16
4.168SerAsp: 4.168 ± 0.5
4.039SerGlu: 4.039 ± 0.462
2.492SerPhe: 2.492 ± 0.299
5.285SerGly: 5.285 ± 0.591
0.988SerHis: 0.988 ± 0.234
3.523SerIle: 3.523 ± 0.396
3.137SerLys: 3.137 ± 0.456
4.941SerLeu: 4.941 ± 0.546
1.676SerMet: 1.676 ± 0.239
3.094SerAsn: 3.094 ± 0.335
2.277SerPro: 2.277 ± 0.333
1.891SerGln: 1.891 ± 0.275
2.191SerArg: 2.191 ± 0.297
3.308SerSer: 3.308 ± 0.439
3.437SerThr: 3.437 ± 0.4
4.769SerVal: 4.769 ± 0.501
0.43SerTrp: 0.43 ± 0.123
2.535SerTyr: 2.535 ± 0.327
0.0SerXaa: 0.0 ± 0.0
Thr
4.125ThrAla: 4.125 ± 0.394
0.473ThrCys: 0.473 ± 0.174
3.824ThrAsp: 3.824 ± 0.335
4.597ThrGlu: 4.597 ± 0.478
2.578ThrPhe: 2.578 ± 0.234
4.984ThrGly: 4.984 ± 0.363
1.16ThrHis: 1.16 ± 0.185
4.211ThrIle: 4.211 ± 0.432
4.511ThrLys: 4.511 ± 0.342
4.984ThrLeu: 4.984 ± 0.518
1.246ThrMet: 1.246 ± 0.221
3.137ThrAsn: 3.137 ± 0.295
4.211ThrPro: 4.211 ± 0.478
2.879ThrGln: 2.879 ± 0.345
2.879ThrArg: 2.879 ± 0.383
3.308ThrSer: 3.308 ± 0.478
3.824ThrThr: 3.824 ± 0.524
4.168ThrVal: 4.168 ± 0.425
0.859ThrTrp: 0.859 ± 0.214
2.406ThrTyr: 2.406 ± 0.475
0.0ThrXaa: 0.0 ± 0.0
Val
5.414ValAla: 5.414 ± 0.672
0.773ValCys: 0.773 ± 0.216
4.812ValAsp: 4.812 ± 0.48
4.168ValGlu: 4.168 ± 0.398
1.891ValPhe: 1.891 ± 0.282
3.738ValGly: 3.738 ± 0.515
1.418ValHis: 1.418 ± 0.232
3.953ValIle: 3.953 ± 0.42
4.383ValLys: 4.383 ± 0.363
4.683ValLeu: 4.683 ± 0.4
1.719ValMet: 1.719 ± 0.251
4.039ValAsn: 4.039 ± 0.385
2.75ValPro: 2.75 ± 0.247
3.265ValGln: 3.265 ± 0.445
3.008ValArg: 3.008 ± 0.449
3.609ValSer: 3.609 ± 0.518
4.683ValThr: 4.683 ± 0.496
4.383ValVal: 4.383 ± 0.543
0.602ValTrp: 0.602 ± 0.192
2.234ValTyr: 2.234 ± 0.328
0.0ValXaa: 0.0 ± 0.0
Trp
0.816TrpAla: 0.816 ± 0.236
0.172TrpCys: 0.172 ± 0.09
0.773TrpAsp: 0.773 ± 0.226
0.43TrpGlu: 0.43 ± 0.153
0.816TrpPhe: 0.816 ± 0.21
0.473TrpGly: 0.473 ± 0.14
0.129TrpHis: 0.129 ± 0.08
0.644TrpIle: 0.644 ± 0.176
1.117TrpLys: 1.117 ± 0.271
1.074TrpLeu: 1.074 ± 0.245
0.473TrpMet: 0.473 ± 0.117
1.031TrpAsn: 1.031 ± 0.202
0.043TrpPro: 0.043 ± 0.042
0.559TrpGln: 0.559 ± 0.176
0.387TrpArg: 0.387 ± 0.122
0.816TrpSer: 0.816 ± 0.206
0.43TrpThr: 0.43 ± 0.14
0.859TrpVal: 0.859 ± 0.185
0.129TrpTrp: 0.129 ± 0.08
0.43TrpTyr: 0.43 ± 0.135
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.793TyrAla: 2.793 ± 0.375
0.516TyrCys: 0.516 ± 0.178
2.449TyrAsp: 2.449 ± 0.352
2.75TyrGlu: 2.75 ± 0.425
1.074TyrPhe: 1.074 ± 0.215
2.449TyrGly: 2.449 ± 0.334
0.988TyrHis: 0.988 ± 0.192
2.363TyrIle: 2.363 ± 0.336
2.234TyrLys: 2.234 ± 0.393
3.308TyrLeu: 3.308 ± 0.409
0.945TyrMet: 0.945 ± 0.203
1.461TyrAsn: 1.461 ± 0.281
1.246TyrPro: 1.246 ± 0.231
1.676TyrGln: 1.676 ± 0.306
1.289TyrArg: 1.289 ± 0.177
1.676TyrSer: 1.676 ± 0.277
1.848TyrThr: 1.848 ± 0.284
2.277TyrVal: 2.277 ± 0.299
0.258TyrTrp: 0.258 ± 0.126
1.59TyrTyr: 1.59 ± 0.259
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 103 proteins (23275 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski