Amino acid dipepetide frequency for Broad bean necrosis virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.539AlaAla: 6.539 ± 2.717
1.055AlaCys: 1.055 ± 0.288
3.375AlaAsp: 3.375 ± 0.408
4.429AlaGlu: 4.429 ± 0.765
0.844AlaPhe: 0.844 ± 0.317
1.266AlaGly: 1.266 ± 0.225
2.109AlaHis: 2.109 ± 1.217
2.953AlaIle: 2.953 ± 0.365
6.117AlaLys: 6.117 ± 0.843
5.906AlaLeu: 5.906 ± 1.378
2.953AlaMet: 2.953 ± 0.65
2.531AlaAsn: 2.531 ± 0.633
0.633AlaPro: 0.633 ± 0.319
1.898AlaGln: 1.898 ± 0.352
2.109AlaArg: 2.109 ± 0.447
4.219AlaSer: 4.219 ± 0.893
2.742AlaThr: 2.742 ± 0.35
4.008AlaVal: 4.008 ± 1.276
0.844AlaTrp: 0.844 ± 0.377
2.742AlaTyr: 2.742 ± 0.509
0.211AlaXaa: 0.211 ± 0.24
Cys
0.844CysAla: 0.844 ± 0.265
1.055CysCys: 1.055 ± 0.452
2.109CysAsp: 2.109 ± 0.685
1.266CysGlu: 1.266 ± 0.479
1.055CysPhe: 1.055 ± 0.52
2.32CysGly: 2.32 ± 0.62
0.0CysHis: 0.0 ± 0.0
0.633CysIle: 0.633 ± 0.439
1.055CysLys: 1.055 ± 0.328
0.633CysLeu: 0.633 ± 0.24
0.633CysMet: 0.633 ± 0.267
0.422CysAsn: 0.422 ± 0.597
0.633CysPro: 0.633 ± 0.287
2.531CysGln: 2.531 ± 0.83
1.266CysArg: 1.266 ± 0.579
2.742CysSer: 2.742 ± 1.327
0.0CysThr: 0.0 ± 0.0
1.266CysVal: 1.266 ± 0.405
0.0CysTrp: 0.0 ± 0.0
0.844CysTyr: 0.844 ± 0.824
0.0CysXaa: 0.0 ± 0.0
Asp
2.953AspAla: 2.953 ± 1.296
2.531AspCys: 2.531 ± 0.557
4.219AspAsp: 4.219 ± 0.796
4.64AspGlu: 4.64 ± 1.398
3.375AspPhe: 3.375 ± 0.689
3.797AspGly: 3.797 ± 0.92
0.422AspHis: 0.422 ± 0.385
6.328AspIle: 6.328 ± 0.936
3.797AspLys: 3.797 ± 0.57
4.851AspLeu: 4.851 ± 0.528
2.953AspMet: 2.953 ± 0.966
2.953AspAsn: 2.953 ± 0.469
1.898AspPro: 1.898 ± 0.498
0.211AspGln: 0.211 ± 0.298
2.531AspArg: 2.531 ± 0.722
3.164AspSer: 3.164 ± 0.483
2.742AspThr: 2.742 ± 0.501
7.171AspVal: 7.171 ± 1.884
0.633AspTrp: 0.633 ± 0.267
2.531AspTyr: 2.531 ± 0.999
0.0AspXaa: 0.0 ± 0.0
Glu
5.273GluAla: 5.273 ± 0.686
0.844GluCys: 0.844 ± 1.193
6.961GluAsp: 6.961 ± 1.901
9.07GluGlu: 9.07 ± 2.63
1.898GluPhe: 1.898 ± 0.387
2.953GluGly: 2.953 ± 0.498
0.633GluHis: 0.633 ± 0.641
5.484GluIle: 5.484 ± 1.32
5.273GluLys: 5.273 ± 1.009
4.64GluLeu: 4.64 ± 0.765
1.476GluMet: 1.476 ± 0.433
4.851GluAsn: 4.851 ± 1.246
2.742GluPro: 2.742 ± 0.465
2.953GluGln: 2.953 ± 0.458
3.797GluArg: 3.797 ± 0.615
4.429GluSer: 4.429 ± 0.456
2.953GluThr: 2.953 ± 0.419
5.273GluVal: 5.273 ± 0.813
0.422GluTrp: 0.422 ± 0.385
2.742GluTyr: 2.742 ± 0.729
0.0GluXaa: 0.0 ± 0.0
Phe
2.109PheAla: 2.109 ± 0.543
0.633PheCys: 0.633 ± 0.267
4.219PheAsp: 4.219 ± 0.971
4.008PheGlu: 4.008 ± 0.628
2.32PhePhe: 2.32 ± 0.652
2.742PheGly: 2.742 ± 0.481
0.422PheHis: 0.422 ± 0.385
3.164PheIle: 3.164 ± 1.675
2.32PheLys: 2.32 ± 0.635
4.429PheLeu: 4.429 ± 1.037
0.844PheMet: 0.844 ± 0.699
2.109PheAsn: 2.109 ± 0.567
1.898PhePro: 1.898 ± 0.328
1.687PheGln: 1.687 ± 1.098
1.476PheArg: 1.476 ± 1.138
3.797PheSer: 3.797 ± 1.529
2.109PheThr: 2.109 ± 0.705
3.375PheVal: 3.375 ± 0.613
0.0PheTrp: 0.0 ± 0.0
0.422PheTyr: 0.422 ± 0.169
0.0PheXaa: 0.0 ± 0.0
Gly
3.164GlyAla: 3.164 ± 0.341
1.055GlyCys: 1.055 ± 0.805
4.219GlyAsp: 4.219 ± 0.729
2.953GlyGlu: 2.953 ± 0.413
1.898GlyPhe: 1.898 ± 0.604
3.375GlyGly: 3.375 ± 1.021
0.422GlyHis: 0.422 ± 0.169
2.32GlyIle: 2.32 ± 0.51
6.117GlyLys: 6.117 ± 1.143
2.953GlyLeu: 2.953 ± 0.479
2.742GlyMet: 2.742 ± 0.613
2.531GlyAsn: 2.531 ± 0.505
1.687GlyPro: 1.687 ± 0.752
1.476GlyGln: 1.476 ± 0.801
3.586GlyArg: 3.586 ± 0.76
4.64GlySer: 4.64 ± 1.899
2.109GlyThr: 2.109 ± 0.825
3.375GlyVal: 3.375 ± 0.757
0.0GlyTrp: 0.0 ± 0.0
2.109GlyTyr: 2.109 ± 0.994
0.0GlyXaa: 0.0 ± 0.0
His
1.687HisAla: 1.687 ± 0.49
1.687HisCys: 1.687 ± 0.443
0.211HisAsp: 0.211 ± 0.24
1.476HisGlu: 1.476 ± 0.408
1.055HisPhe: 1.055 ± 0.646
1.266HisGly: 1.266 ± 0.596
0.422HisHis: 0.422 ± 0.595
0.633HisIle: 0.633 ± 0.267
1.266HisLys: 1.266 ± 0.284
1.476HisLeu: 1.476 ± 0.701
0.422HisMet: 0.422 ± 0.479
2.109HisAsn: 2.109 ± 0.523
0.422HisPro: 0.422 ± 0.479
0.0HisGln: 0.0 ± 0.0
0.211HisArg: 0.211 ± 0.298
1.266HisSer: 1.266 ± 0.386
0.633HisThr: 0.633 ± 0.201
1.266HisVal: 1.266 ± 1.015
0.0HisTrp: 0.0 ± 0.0
0.422HisTyr: 0.422 ± 0.479
0.0HisXaa: 0.0 ± 0.0
Ile
2.531IleAla: 2.531 ± 0.472
1.266IleCys: 1.266 ± 0.923
3.375IleAsp: 3.375 ± 0.95
5.906IleGlu: 5.906 ± 1.469
1.055IlePhe: 1.055 ± 0.288
1.898IleGly: 1.898 ± 0.332
2.32IleHis: 2.32 ± 0.413
5.695IleIle: 5.695 ± 1.569
4.008IleLys: 4.008 ± 0.743
6.539IleLeu: 6.539 ± 0.987
0.844IleMet: 0.844 ± 0.611
4.851IleAsn: 4.851 ± 0.881
2.742IlePro: 2.742 ± 0.604
2.109IleGln: 2.109 ± 0.402
1.476IleArg: 1.476 ± 0.356
4.851IleSer: 4.851 ± 0.899
4.64IleThr: 4.64 ± 1.445
3.164IleVal: 3.164 ± 0.776
0.633IleTrp: 0.633 ± 0.201
2.953IleTyr: 2.953 ± 1.162
0.0IleXaa: 0.0 ± 0.0
Lys
4.429LysAla: 4.429 ± 0.988
1.055LysCys: 1.055 ± 0.284
3.797LysAsp: 3.797 ± 0.606
6.961LysGlu: 6.961 ± 1.051
4.429LysPhe: 4.429 ± 0.671
3.797LysGly: 3.797 ± 0.424
1.687LysHis: 1.687 ± 0.296
3.797LysIle: 3.797 ± 0.777
5.062LysLys: 5.062 ± 1.135
6.539LysLeu: 6.539 ± 1.09
1.687LysMet: 1.687 ± 0.395
1.898LysAsn: 1.898 ± 0.577
2.742LysPro: 2.742 ± 0.878
2.742LysGln: 2.742 ± 0.755
5.906LysArg: 5.906 ± 0.921
4.64LysSer: 4.64 ± 0.401
4.429LysThr: 4.429 ± 1.13
3.375LysVal: 3.375 ± 1.207
0.422LysTrp: 0.422 ± 0.169
4.219LysTyr: 4.219 ± 0.814
0.211LysXaa: 0.211 ± 0.156
Leu
3.797LeuAla: 3.797 ± 0.902
1.055LeuCys: 1.055 ± 0.514
7.171LeuAsp: 7.171 ± 1.484
4.219LeuGlu: 4.219 ± 1.406
5.484LeuPhe: 5.484 ± 1.468
6.117LeuGly: 6.117 ± 2.572
1.476LeuHis: 1.476 ± 0.433
4.219LeuIle: 4.219 ± 1.058
8.437LeuLys: 8.437 ± 1.219
7.804LeuLeu: 7.804 ± 3.29
3.375LeuMet: 3.375 ± 0.922
5.695LeuAsn: 5.695 ± 1.164
3.586LeuPro: 3.586 ± 0.907
3.164LeuGln: 3.164 ± 0.924
6.117LeuArg: 6.117 ± 1.302
6.961LeuSer: 6.961 ± 1.006
3.375LeuThr: 3.375 ± 0.919
3.375LeuVal: 3.375 ± 0.938
2.109LeuTrp: 2.109 ± 0.464
2.109LeuTyr: 2.109 ± 0.522
0.0LeuXaa: 0.0 ± 0.0
Met
2.32MetAla: 2.32 ± 0.486
0.844MetCys: 0.844 ± 0.339
1.476MetAsp: 1.476 ± 0.501
1.687MetGlu: 1.687 ± 0.753
2.109MetPhe: 2.109 ± 0.567
1.266MetGly: 1.266 ± 0.401
0.422MetHis: 0.422 ± 0.169
1.266MetIle: 1.266 ± 0.587
2.109MetLys: 2.109 ± 0.643
1.687MetLeu: 1.687 ± 0.692
1.266MetMet: 1.266 ± 0.508
1.055MetAsn: 1.055 ± 0.419
0.844MetPro: 0.844 ± 0.404
0.633MetGln: 0.633 ± 0.439
1.266MetArg: 1.266 ± 0.401
2.109MetSer: 2.109 ± 0.586
2.32MetThr: 2.32 ± 1.009
2.109MetVal: 2.109 ± 0.523
0.422MetTrp: 0.422 ± 0.169
1.687MetTyr: 1.687 ± 0.677
0.0MetXaa: 0.0 ± 0.0
Asn
2.953AsnAla: 2.953 ± 0.646
1.898AsnCys: 1.898 ± 0.431
2.953AsnAsp: 2.953 ± 0.844
3.797AsnGlu: 3.797 ± 0.52
2.531AsnPhe: 2.531 ± 0.555
3.586AsnGly: 3.586 ± 0.807
0.844AsnHis: 0.844 ± 0.632
3.375AsnIle: 3.375 ± 0.72
2.32AsnLys: 2.32 ± 0.397
5.695AsnLeu: 5.695 ± 1.888
1.266AsnMet: 1.266 ± 0.353
2.32AsnAsn: 2.32 ± 0.893
1.266AsnPro: 1.266 ± 0.708
1.476AsnGln: 1.476 ± 0.635
2.531AsnArg: 2.531 ± 0.684
3.797AsnSer: 3.797 ± 0.888
3.797AsnThr: 3.797 ± 1.009
4.219AsnVal: 4.219 ± 0.625
1.055AsnTrp: 1.055 ± 0.284
1.266AsnTyr: 1.266 ± 0.419
0.0AsnXaa: 0.0 ± 0.0
Pro
0.633ProAla: 0.633 ± 0.5
0.633ProCys: 0.633 ± 0.267
1.476ProAsp: 1.476 ± 0.7
2.32ProGlu: 2.32 ± 0.458
1.687ProPhe: 1.687 ± 1.095
1.476ProGly: 1.476 ± 0.228
1.476ProHis: 1.476 ± 0.431
1.687ProIle: 1.687 ± 0.465
3.375ProLys: 3.375 ± 0.757
4.851ProLeu: 4.851 ± 0.679
1.266ProMet: 1.266 ± 0.535
1.687ProAsn: 1.687 ± 0.421
0.422ProPro: 0.422 ± 0.532
1.055ProGln: 1.055 ± 0.41
1.476ProArg: 1.476 ± 0.572
0.422ProSer: 0.422 ± 0.522
1.476ProThr: 1.476 ± 0.931
2.32ProVal: 2.32 ± 1.137
0.0ProTrp: 0.0 ± 0.0
0.422ProTyr: 0.422 ± 0.169
0.0ProXaa: 0.0 ± 0.0
Gln
1.476GlnAla: 1.476 ± 0.505
1.266GlnCys: 1.266 ± 0.32
1.476GlnAsp: 1.476 ± 0.918
2.531GlnGlu: 2.531 ± 0.44
0.211GlnPhe: 0.211 ± 0.289
2.109GlnGly: 2.109 ± 1.061
0.633GlnHis: 0.633 ± 0.409
2.953GlnIle: 2.953 ± 0.599
2.109GlnLys: 2.109 ± 0.602
2.742GlnLeu: 2.742 ± 0.607
0.422GlnMet: 0.422 ± 0.25
3.164GlnAsn: 3.164 ± 0.624
0.211GlnPro: 0.211 ± 0.24
0.844GlnGln: 0.844 ± 0.417
2.531GlnArg: 2.531 ± 0.405
2.953GlnSer: 2.953 ± 1.23
2.32GlnThr: 2.32 ± 1.029
2.953GlnVal: 2.953 ± 0.479
0.844GlnTrp: 0.844 ± 0.265
1.055GlnTyr: 1.055 ± 0.446
0.0GlnXaa: 0.0 ± 0.0
Arg
4.008ArgAla: 4.008 ± 1.031
1.266ArgCys: 1.266 ± 0.568
2.742ArgAsp: 2.742 ± 0.516
2.109ArgGlu: 2.109 ± 0.884
2.32ArgPhe: 2.32 ± 0.959
2.953ArgGly: 2.953 ± 1.708
0.844ArgHis: 0.844 ± 0.339
4.851ArgIle: 4.851 ± 0.726
5.484ArgLys: 5.484 ± 0.884
5.062ArgLeu: 5.062 ± 0.881
0.422ArgMet: 0.422 ± 0.312
2.953ArgAsn: 2.953 ± 1.181
1.687ArgPro: 1.687 ± 1.066
1.898ArgGln: 1.898 ± 0.538
3.586ArgArg: 3.586 ± 0.641
3.586ArgSer: 3.586 ± 0.877
2.531ArgThr: 2.531 ± 0.917
3.586ArgVal: 3.586 ± 0.951
0.211ArgTrp: 0.211 ± 0.156
0.844ArgTyr: 0.844 ± 0.355
0.0ArgXaa: 0.0 ± 0.0
Ser
2.953SerAla: 2.953 ± 0.836
0.844SerCys: 0.844 ± 0.417
4.219SerAsp: 4.219 ± 0.549
6.539SerGlu: 6.539 ± 0.948
2.109SerPhe: 2.109 ± 0.315
4.008SerGly: 4.008 ± 1.382
0.422SerHis: 0.422 ± 0.473
3.375SerIle: 3.375 ± 0.73
4.429SerLys: 4.429 ± 0.509
5.695SerLeu: 5.695 ± 1.061
2.109SerMet: 2.109 ± 0.618
4.429SerAsn: 4.429 ± 1.652
1.898SerPro: 1.898 ± 0.489
3.586SerGln: 3.586 ± 0.653
4.851SerArg: 4.851 ± 1.044
6.75SerSer: 6.75 ± 1.356
4.851SerThr: 4.851 ± 0.927
5.906SerVal: 5.906 ± 1.688
2.531SerTrp: 2.531 ± 0.605
1.898SerTyr: 1.898 ± 0.712
0.0SerXaa: 0.0 ± 0.0
Thr
4.429ThrAla: 4.429 ± 1.351
0.422ThrCys: 0.422 ± 0.463
3.375ThrAsp: 3.375 ± 0.997
4.64ThrGlu: 4.64 ± 0.637
2.953ThrPhe: 2.953 ± 0.599
2.742ThrGly: 2.742 ± 0.626
1.476ThrHis: 1.476 ± 0.408
2.742ThrIle: 2.742 ± 0.815
3.797ThrLys: 3.797 ± 0.959
4.429ThrLeu: 4.429 ± 1.677
0.422ThrMet: 0.422 ± 0.169
1.476ThrAsn: 1.476 ± 0.52
0.633ThrPro: 0.633 ± 0.24
0.422ThrGln: 0.422 ± 0.169
2.531ThrArg: 2.531 ± 0.767
4.219ThrSer: 4.219 ± 1.409
2.32ThrThr: 2.32 ± 0.458
4.64ThrVal: 4.64 ± 0.973
0.422ThrTrp: 0.422 ± 0.267
2.742ThrTyr: 2.742 ± 0.626
0.0ThrXaa: 0.0 ± 0.0
Val
2.531ValAla: 2.531 ± 0.761
1.476ValCys: 1.476 ± 0.778
5.062ValAsp: 5.062 ± 1.158
3.164ValGlu: 3.164 ± 0.916
4.219ValPhe: 4.219 ± 0.549
2.109ValGly: 2.109 ± 0.494
1.476ValHis: 1.476 ± 0.408
4.64ValIle: 4.64 ± 0.772
4.429ValLys: 4.429 ± 0.496
7.382ValLeu: 7.382 ± 1.795
2.32ValMet: 2.32 ± 0.661
4.008ValAsn: 4.008 ± 0.863
1.898ValPro: 1.898 ± 0.474
4.008ValGln: 4.008 ± 0.97
2.531ValArg: 2.531 ± 0.636
5.906ValSer: 5.906 ± 1.548
3.164ValThr: 3.164 ± 0.813
2.953ValVal: 2.953 ± 1.158
0.211ValTrp: 0.211 ± 0.156
3.164ValTyr: 3.164 ± 0.724
0.0ValXaa: 0.0 ± 0.0
Trp
1.055TrpAla: 1.055 ± 0.288
0.0TrpCys: 0.0 ± 0.0
0.211TrpAsp: 0.211 ± 0.24
0.844TrpGlu: 0.844 ± 0.404
1.687TrpPhe: 1.687 ± 0.385
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.844TrpIle: 0.844 ± 0.339
0.211TrpLys: 0.211 ± 0.24
0.844TrpLeu: 0.844 ± 0.266
0.844TrpMet: 0.844 ± 0.369
0.211TrpAsn: 0.211 ± 0.156
0.211TrpPro: 0.211 ± 0.289
0.422TrpGln: 0.422 ± 0.267
0.0TrpArg: 0.0 ± 0.0
1.476TrpSer: 1.476 ± 0.228
0.844TrpThr: 0.844 ± 0.339
1.055TrpVal: 1.055 ± 0.483
0.211TrpTrp: 0.211 ± 0.156
0.844TrpTyr: 0.844 ± 0.339
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.797TyrAla: 3.797 ± 1.104
0.422TyrCys: 0.422 ± 0.169
1.055TyrAsp: 1.055 ± 0.374
2.109TyrGlu: 2.109 ± 0.42
0.844TyrPhe: 0.844 ± 0.397
2.953TyrGly: 2.953 ± 0.762
0.422TyrHis: 0.422 ± 0.522
1.898TyrIle: 1.898 ± 0.746
2.109TyrLys: 2.109 ± 0.494
5.484TyrLeu: 5.484 ± 0.927
0.422TyrMet: 0.422 ± 0.169
1.687TyrAsn: 1.687 ± 0.767
2.109TyrPro: 2.109 ± 0.533
1.476TyrGln: 1.476 ± 0.732
2.953TyrArg: 2.953 ± 1.162
1.476TyrSer: 1.476 ± 0.584
1.476TyrThr: 1.476 ± 0.408
1.266TyrVal: 1.266 ± 0.401
1.055TyrTrp: 1.055 ± 0.373
1.898TyrTyr: 1.898 ± 1.226
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.211XaaGln: 0.211 ± 0.24
0.211XaaArg: 0.211 ± 0.156
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (4742 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski