Amino acid dipepetide frequency for Jannaschia seohaensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.925AlaAla: 19.925 ± 0.206	1.201AlaCys: 1.201 ± 0.029	7.376AlaAsp: 7.376 ± 0.089	9.306AlaGlu: 9.306 ± 0.104	4.54AlaPhe: 4.54 ± 0.064	11.581AlaGly: 11.581 ± 0.112	2.465AlaHis: 2.465 ± 0.047	5.822AlaIle: 5.822 ± 0.074	2.942AlaLys: 2.942 ± 0.057	15.448AlaLeu: 15.448 ± 0.149	3.809AlaMet: 3.809 ± 0.061	2.391AlaAsn: 2.391 ± 0.046	7.338AlaPro: 7.338 ± 0.106	4.353AlaGln: 4.353 ± 0.059	11.105AlaArg: 11.105 ± 0.141	5.575AlaSer: 5.575 ± 0.072	6.608AlaThr: 6.608 ± 0.074	9.164AlaVal: 9.164 ± 0.091	1.85AlaTrp: 1.85 ± 0.042	2.45AlaTyr: 2.45 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.147CysAla: 1.147 ± 0.028	0.095CysCys: 0.095 ± 0.007	0.571CysAsp: 0.571 ± 0.02	0.426CysGlu: 0.426 ± 0.017	0.293CysPhe: 0.293 ± 0.014	0.921CysGly: 0.921 ± 0.031	0.263CysHis: 0.263 ± 0.015	0.356CysIle: 0.356 ± 0.016	0.137CysLys: 0.137 ± 0.01	0.853CysLeu: 0.853 ± 0.024	0.166CysMet: 0.166 ± 0.013	0.18CysAsn: 0.18 ± 0.012	0.516CysPro: 0.516 ± 0.02	0.203CysGln: 0.203 ± 0.012	0.603CysArg: 0.603 ± 0.025	0.376CysSer: 0.376 ± 0.017	0.41CysThr: 0.41 ± 0.018	0.608CysVal: 0.608 ± 0.023	0.112CysTrp: 0.112 ± 0.009	0.185CysTyr: 0.185 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.381AspAla: 8.381 ± 0.101	0.507AspCys: 0.507 ± 0.019	3.563AspAsp: 3.563 ± 0.103	3.318AspGlu: 3.318 ± 0.05	2.119AspPhe: 2.119 ± 0.046	6.424AspGly: 6.424 ± 0.124	1.239AspHis: 1.239 ± 0.031	2.786AspIle: 2.786 ± 0.058	1.173AspLys: 1.173 ± 0.029	6.967AspLeu: 6.967 ± 0.089	1.497AspMet: 1.497 ± 0.034	0.985AspAsn: 0.985 ± 0.03	4.285AspPro: 4.285 ± 0.066	1.491AspGln: 1.491 ± 0.034	5.367AspArg: 5.367 ± 0.069	1.972AspSer: 1.972 ± 0.049	2.912AspThr: 2.912 ± 0.059	4.346AspVal: 4.346 ± 0.073	1.326AspTrp: 1.326 ± 0.03	1.417AspTyr: 1.417 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	9.582GluAla: 9.582 ± 0.124	0.302GluCys: 0.302 ± 0.016	3.413GluAsp: 3.413 ± 0.052	3.673GluGlu: 3.673 ± 0.072	1.594GluPhe: 1.594 ± 0.031	5.685GluGly: 5.685 ± 0.071	1.027GluHis: 1.027 ± 0.03	3.767GluIle: 3.767 ± 0.053	1.529GluLys: 1.529 ± 0.039	4.89GluLeu: 4.89 ± 0.065	1.983GluMet: 1.983 ± 0.036	1.361GluAsn: 1.361 ± 0.031	2.652GluPro: 2.652 ± 0.045	1.674GluGln: 1.674 ± 0.041	4.762GluArg: 4.762 ± 0.059	2.074GluSer: 2.074 ± 0.036	4.26GluThr: 4.26 ± 0.062	4.401GluVal: 4.401 ± 0.057	0.701GluTrp: 0.701 ± 0.024	0.86GluTyr: 0.86 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.469PheAla: 4.469 ± 0.072	0.385PheCys: 0.385 ± 0.016	2.878PheAsp: 2.878 ± 0.051	2.222PheGlu: 2.222 ± 0.036	1.265PhePhe: 1.265 ± 0.033	3.583PheGly: 3.583 ± 0.065	0.699PheHis: 0.699 ± 0.026	1.192PheIle: 1.192 ± 0.034	0.653PheLys: 0.653 ± 0.022	3.363PheLeu: 3.363 ± 0.063	0.692PheMet: 0.692 ± 0.025	0.77PheAsn: 0.77 ± 0.026	1.555PhePro: 1.555 ± 0.033	0.949PheGln: 0.949 ± 0.028	2.226PheArg: 2.226 ± 0.039	1.806PheSer: 1.806 ± 0.036	1.916PheThr: 1.916 ± 0.04	2.674PheVal: 2.674 ± 0.049	0.566PheTrp: 0.566 ± 0.022	0.783PheTyr: 0.783 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.531GlyAla: 11.531 ± 0.108	0.872GlyCys: 0.872 ± 0.03	5.226GlyAsp: 5.226 ± 0.127	4.977GlyGlu: 4.977 ± 0.064	3.554GlyPhe: 3.554 ± 0.058	8.454GlyGly: 8.454 ± 0.156	1.941GlyHis: 1.941 ± 0.044	4.229GlyIle: 4.229 ± 0.06	2.407GlyLys: 2.407 ± 0.048	10.129GlyLeu: 10.129 ± 0.102	2.524GlyMet: 2.524 ± 0.044	1.904GlyAsn: 1.904 ± 0.06	4.625GlyPro: 4.625 ± 0.072	2.809GlyGln: 2.809 ± 0.051	6.95GlyArg: 6.95 ± 0.078	4.17GlySer: 4.17 ± 0.084	5.191GlyThr: 5.191 ± 0.077	6.548GlyVal: 6.548 ± 0.082	1.627GlyTrp: 1.627 ± 0.037	2.063GlyTyr: 2.063 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.521HisAla: 2.521 ± 0.05	0.209HisCys: 0.209 ± 0.011	1.224HisAsp: 1.224 ± 0.031	0.971HisGlu: 0.971 ± 0.028	0.719HisPhe: 0.719 ± 0.024	1.937HisGly: 1.937 ± 0.037	0.565HisHis: 0.565 ± 0.024	0.832HisIle: 0.832 ± 0.023	0.367HisLys: 0.367 ± 0.015	2.107HisLeu: 2.107 ± 0.04	0.458HisMet: 0.458 ± 0.019	0.352HisAsn: 0.352 ± 0.014	1.44HisPro: 1.44 ± 0.037	0.47HisGln: 0.47 ± 0.02	1.464HisArg: 1.464 ± 0.037	0.819HisSer: 0.819 ± 0.023	0.726HisThr: 0.726 ± 0.023	1.585HisVal: 1.585 ± 0.035	0.36HisTrp: 0.36 ± 0.017	0.465HisTyr: 0.465 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.814IleAla: 6.814 ± 0.079	0.499IleCys: 0.499 ± 0.019	3.496IleAsp: 3.496 ± 0.053	3.304IleGlu: 3.304 ± 0.052	1.502IlePhe: 1.502 ± 0.035	4.523IleGly: 4.523 ± 0.066	0.839IleHis: 0.839 ± 0.027	1.481IleIle: 1.481 ± 0.045	0.871IleLys: 0.871 ± 0.029	4.499IleLeu: 4.499 ± 0.069	0.841IleMet: 0.841 ± 0.026	0.928IleAsn: 0.928 ± 0.028	2.288IlePro: 2.288 ± 0.044	1.032IleGln: 1.032 ± 0.032	3.177IleArg: 3.177 ± 0.053	2.414IleSer: 2.414 ± 0.043	2.464IleThr: 2.464 ± 0.042	3.846IleVal: 3.846 ± 0.053	0.68IleTrp: 0.68 ± 0.024	0.932IleTyr: 0.932 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.988LysAla: 2.988 ± 0.057	0.115LysCys: 0.115 ± 0.008	1.239LysAsp: 1.239 ± 0.034	1.14LysGlu: 1.14 ± 0.032	0.609LysPhe: 0.609 ± 0.025	2.075LysGly: 2.075 ± 0.049	0.441LysHis: 0.441 ± 0.019	1.159LysIle: 1.159 ± 0.034	0.757LysLys: 0.757 ± 0.032	2.234LysLeu: 2.234 ± 0.047	0.627LysMet: 0.627 ± 0.024	0.491LysAsn: 0.491 ± 0.02	1.359LysPro: 1.359 ± 0.036	0.604LysGln: 0.604 ± 0.022	1.763LysArg: 1.763 ± 0.039	1.203LysSer: 1.203 ± 0.033	1.424LysThr: 1.424 ± 0.035	1.692LysVal: 1.692 ± 0.037	0.287LysTrp: 0.287 ± 0.015	0.462LysTyr: 0.462 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.555LeuAla: 14.555 ± 0.161	0.926LeuCys: 0.926 ± 0.026	6.717LeuAsp: 6.717 ± 0.083	5.626LeuGlu: 5.626 ± 0.069	3.39LeuPhe: 3.39 ± 0.055	9.019LeuGly: 9.019 ± 0.095	1.977LeuHis: 1.977 ± 0.042	4.855LeuIle: 4.855 ± 0.064	2.358LeuLys: 2.358 ± 0.049	9.683LeuLeu: 9.683 ± 0.111	2.424LeuMet: 2.424 ± 0.054	2.175LeuAsn: 2.175 ± 0.043	5.99LeuPro: 5.99 ± 0.068	2.356LeuGln: 2.356 ± 0.045	8.24LeuArg: 8.24 ± 0.091	6.55LeuSer: 6.55 ± 0.069	6.352LeuThr: 6.352 ± 0.091	7.057LeuVal: 7.057 ± 0.085	1.472LeuTrp: 1.472 ± 0.036	1.777LeuTyr: 1.777 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.421MetAla: 3.421 ± 0.052	0.161MetCys: 0.161 ± 0.011	1.311MetAsp: 1.311 ± 0.03	1.398MetGlu: 1.398 ± 0.032	0.671MetPhe: 0.671 ± 0.025	2.161MetGly: 2.161 ± 0.046	0.415MetHis: 0.415 ± 0.017	1.352MetIle: 1.352 ± 0.031	0.772MetLys: 0.772 ± 0.024	2.474MetLeu: 2.474 ± 0.043	0.633MetMet: 0.633 ± 0.024	0.607MetAsn: 0.607 ± 0.018	1.509MetPro: 1.509 ± 0.038	0.784MetGln: 0.784 ± 0.024	2.037MetArg: 2.037 ± 0.042	1.46MetSer: 1.46 ± 0.033	2.102MetThr: 2.102 ± 0.045	1.663MetVal: 1.663 ± 0.034	0.241MetTrp: 0.241 ± 0.014	0.278MetTyr: 0.278 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.691AsnAla: 2.691 ± 0.048	0.195AsnCys: 0.195 ± 0.012	1.234AsnAsp: 1.234 ± 0.047	0.927AsnGlu: 0.927 ± 0.027	0.773AsnPhe: 0.773 ± 0.025	1.934AsnGly: 1.934 ± 0.042	0.374AsnHis: 0.374 ± 0.016	0.959AsnIle: 0.959 ± 0.024	0.412AsnLys: 0.412 ± 0.016	2.091AsnLeu: 2.091 ± 0.037	0.518AsnMet: 0.518 ± 0.018	0.472AsnAsn: 0.472 ± 0.022	1.573AsnPro: 1.573 ± 0.035	0.52AsnGln: 0.52 ± 0.02	1.539AsnArg: 1.539 ± 0.036	0.858AsnSer: 0.858 ± 0.026	0.982AsnThr: 0.982 ± 0.029	1.647AsnVal: 1.647 ± 0.038	0.344AsnTrp: 0.344 ± 0.015	0.498AsnTyr: 0.498 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.79ProAla: 6.79 ± 0.093	0.387ProCys: 0.387 ± 0.016	4.375ProAsp: 4.375 ± 0.061	4.723ProGlu: 4.723 ± 0.077	2.022ProPhe: 2.022 ± 0.043	5.463ProGly: 5.463 ± 0.061	1.116ProHis: 1.116 ± 0.028	2.226ProIle: 2.226 ± 0.04	1.381ProLys: 1.381 ± 0.038	5.113ProLeu: 5.113 ± 0.074	1.256ProMet: 1.256 ± 0.032	1.203ProAsn: 1.203 ± 0.028	3.088ProPro: 3.088 ± 0.065	1.51ProGln: 1.51 ± 0.031	3.528ProArg: 3.528 ± 0.056	2.72ProSer: 2.72 ± 0.051	2.593ProThr: 2.593 ± 0.045	4.553ProVal: 4.553 ± 0.066	0.781ProTrp: 0.781 ± 0.023	1.107ProTyr: 1.107 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.961GlnAla: 3.961 ± 0.055	0.161GlnCys: 0.161 ± 0.011	1.54GlnAsp: 1.54 ± 0.035	1.457GlnGlu: 1.457 ± 0.04	0.848GlnPhe: 0.848 ± 0.025	2.548GlnGly: 2.548 ± 0.047	0.448GlnHis: 0.448 ± 0.017	1.589GlnIle: 1.589 ± 0.034	0.679GlnLys: 0.679 ± 0.022	2.416GlnLeu: 2.416 ± 0.039	0.811GlnMet: 0.811 ± 0.024	0.634GlnAsn: 0.634 ± 0.021	1.511GlnPro: 1.511 ± 0.033	0.82GlnGln: 0.82 ± 0.032	1.989GlnArg: 1.989 ± 0.036	1.455GlnSer: 1.455 ± 0.03	1.636GlnThr: 1.636 ± 0.032	2.208GlnVal: 2.208 ± 0.046	0.342GlnTrp: 0.342 ± 0.016	0.419GlnTyr: 0.419 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.37ArgAla: 10.37 ± 0.118	0.545ArgCys: 0.545 ± 0.023	4.948ArgAsp: 4.948 ± 0.057	4.143ArgGlu: 4.143 ± 0.059	2.777ArgPhe: 2.777 ± 0.043	5.606ArgGly: 5.606 ± 0.068	1.711ArgHis: 1.711 ± 0.04	3.949ArgIle: 3.949 ± 0.055	1.736ArgLys: 1.736 ± 0.037	8.619ArgLeu: 8.619 ± 0.096	2.081ArgMet: 2.081 ± 0.041	1.475ArgAsn: 1.475 ± 0.031	4.278ArgPro: 4.278 ± 0.072	2.224ArgGln: 2.224 ± 0.038	6.164ArgArg: 6.164 ± 0.105	3.445ArgSer: 3.445 ± 0.054	3.477ArgThr: 3.477 ± 0.054	5.447ArgVal: 5.447 ± 0.065	1.076ArgTrp: 1.076 ± 0.029	1.486ArgTyr: 1.486 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	5.671SerAla: 5.671 ± 0.07	0.389SerCys: 0.389 ± 0.018	3.204SerAsp: 3.204 ± 0.057	2.842SerGlu: 2.842 ± 0.04	1.997SerPhe: 1.997 ± 0.035	5.25SerGly: 5.25 ± 0.088	0.926SerHis: 0.926 ± 0.027	2.117SerIle: 2.117 ± 0.047	1.089SerLys: 1.089 ± 0.031	4.643SerLeu: 4.643 ± 0.064	1.2SerMet: 1.2 ± 0.03	1.092SerAsn: 1.092 ± 0.029	2.483SerPro: 2.483 ± 0.049	1.321SerGln: 1.321 ± 0.032	3.256SerArg: 3.256 ± 0.05	2.23SerSer: 2.23 ± 0.047	2.293SerThr: 2.293 ± 0.039	3.657SerVal: 3.657 ± 0.066	0.668SerTrp: 0.668 ± 0.021	1.062SerTyr: 1.062 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.592ThrAla: 6.592 ± 0.085	0.476ThrCys: 0.476 ± 0.02	3.236ThrAsp: 3.236 ± 0.057	3.205ThrGlu: 3.205 ± 0.052	1.948ThrPhe: 1.948 ± 0.044	5.84ThrGly: 5.84 ± 0.081	1.066ThrHis: 1.066 ± 0.026	2.575ThrIle: 2.575 ± 0.045	1.069ThrLys: 1.069 ± 0.031	6.303ThrLeu: 6.303 ± 0.091	1.226ThrMet: 1.226 ± 0.03	1.051ThrAsn: 1.051 ± 0.033	3.655ThrPro: 3.655 ± 0.052	1.426ThrGln: 1.426 ± 0.035	3.879ThrArg: 3.879 ± 0.054	2.429ThrSer: 2.429 ± 0.044	2.683ThrThr: 2.683 ± 0.055	4.574ThrVal: 4.574 ± 0.077	0.725ThrTrp: 0.725 ± 0.024	1.172ThrTyr: 1.172 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.863ValAla: 9.863 ± 0.113	0.641ValCys: 0.641 ± 0.021	4.187ValAsp: 4.187 ± 0.059	4.671ValGlu: 4.671 ± 0.064	2.736ValPhe: 2.736 ± 0.044	5.683ValGly: 5.683 ± 0.064	1.33ValHis: 1.33 ± 0.032	3.731ValIle: 3.731 ± 0.061	1.584ValLys: 1.584 ± 0.044	7.882ValLeu: 7.882 ± 0.082	1.888ValMet: 1.888 ± 0.038	1.651ValAsn: 1.651 ± 0.035	4.05ValPro: 4.05 ± 0.064	1.886ValGln: 1.886 ± 0.035	4.719ValArg: 4.719 ± 0.058	4.085ValSer: 4.085 ± 0.06	5.147ValThr: 5.147 ± 0.078	5.679ValVal: 5.679 ± 0.077	1.011ValTrp: 1.011 ± 0.028	1.362ValTyr: 1.362 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.535TrpAla: 1.535 ± 0.032	0.131TrpCys: 0.131 ± 0.009	0.863TrpAsp: 0.863 ± 0.024	0.756TrpGlu: 0.756 ± 0.026	0.556TrpPhe: 0.556 ± 0.021	1.063TrpGly: 1.063 ± 0.029	0.334TrpHis: 0.334 ± 0.017	0.721TrpIle: 0.721 ± 0.023	0.358TrpLys: 0.358 ± 0.017	1.742TrpLeu: 1.742 ± 0.038	0.412TrpMet: 0.412 ± 0.017	0.368TrpAsn: 0.368 ± 0.016	0.787TrpPro: 0.787 ± 0.027	0.543TrpGln: 0.543 ± 0.021	1.314TrpArg: 1.314 ± 0.034	0.811TrpSer: 0.811 ± 0.024	0.952TrpThr: 0.952 ± 0.029	0.996TrpVal: 0.996 ± 0.027	0.271TrpTrp: 0.271 ± 0.014	0.253TrpTyr: 0.253 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.443TyrAla: 2.443 ± 0.039	0.222TyrCys: 0.222 ± 0.013	1.478TyrAsp: 1.478 ± 0.033	1.106TyrGlu: 1.106 ± 0.028	0.731TyrPhe: 0.731 ± 0.026	1.98TyrGly: 1.98 ± 0.04	0.415TyrHis: 0.415 ± 0.018	0.734TyrIle: 0.734 ± 0.024	0.398TyrLys: 0.398 ± 0.018	2.044TyrLeu: 2.044 ± 0.041	0.403TyrMet: 0.403 ± 0.015	0.449TyrAsn: 0.449 ± 0.018	0.952TyrPro: 0.952 ± 0.026	0.495TyrGln: 0.495 ± 0.019	1.475TyrArg: 1.475 ± 0.031	0.937TyrSer: 0.937 ± 0.027	0.999TyrThr: 0.999 ± 0.029	1.441TyrVal: 1.441 ± 0.033	0.327TyrTrp: 0.327 ± 0.014	0.446TyrTyr: 0.446 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4631 proteins (1425063 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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