Amino acid dipepetide frequency for Winogradskyella aurantia

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.063AlaAla: 4.063 ± 0.093	0.545AlaCys: 0.545 ± 0.027	3.351AlaAsp: 3.351 ± 0.07	4.029AlaGlu: 4.029 ± 0.073	3.453AlaPhe: 3.453 ± 0.063	3.919AlaGly: 3.919 ± 0.07	1.165AlaHis: 1.165 ± 0.039	5.758AlaIle: 5.758 ± 0.089	4.634AlaLys: 4.634 ± 0.08	6.745AlaLeu: 6.745 ± 0.105	1.644AlaMet: 1.644 ± 0.047	3.419AlaAsn: 3.419 ± 0.067	1.845AlaPro: 1.845 ± 0.047	2.527AlaGln: 2.527 ± 0.05	2.049AlaArg: 2.049 ± 0.053	4.068AlaSer: 4.068 ± 0.071	3.435AlaThr: 3.435 ± 0.069	4.148AlaVal: 4.148 ± 0.066	0.631AlaTrp: 0.631 ± 0.029	2.604AlaTyr: 2.604 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.49CysAla: 0.49 ± 0.027	0.103CysCys: 0.103 ± 0.011	0.447CysAsp: 0.447 ± 0.025	0.433CysGlu: 0.433 ± 0.025	0.409CysPhe: 0.409 ± 0.021	0.606CysGly: 0.606 ± 0.031	0.174CysHis: 0.174 ± 0.015	0.574CysIle: 0.574 ± 0.027	0.456CysLys: 0.456 ± 0.022	0.645CysLeu: 0.645 ± 0.025	0.112CysMet: 0.112 ± 0.011	0.366CysAsn: 0.366 ± 0.021	0.302CysPro: 0.302 ± 0.024	0.225CysGln: 0.225 ± 0.016	0.195CysArg: 0.195 ± 0.015	0.525CysSer: 0.525 ± 0.027	0.383CysThr: 0.383 ± 0.024	0.417CysVal: 0.417 ± 0.023	0.067CysTrp: 0.067 ± 0.008	0.287CysTyr: 0.287 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.778AspAla: 3.778 ± 0.083	0.416AspCys: 0.416 ± 0.022	3.34AspAsp: 3.34 ± 0.086	3.895AspGlu: 3.895 ± 0.072	3.665AspPhe: 3.665 ± 0.065	3.828AspGly: 3.828 ± 0.086	0.906AspHis: 0.906 ± 0.032	5.087AspIle: 5.087 ± 0.075	4.122AspLys: 4.122 ± 0.08	5.666AspLeu: 5.666 ± 0.097	1.282AspMet: 1.282 ± 0.041	3.427AspAsn: 3.427 ± 0.074	1.727AspPro: 1.727 ± 0.048	1.453AspGln: 1.453 ± 0.038	1.971AspArg: 1.971 ± 0.046	3.425AspSer: 3.425 ± 0.08	2.979AspThr: 2.979 ± 0.065	3.873AspVal: 3.873 ± 0.065	0.734AspTrp: 0.734 ± 0.027	3.092AspTyr: 3.092 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	4.722GluAla: 4.722 ± 0.099	0.321GluCys: 0.321 ± 0.019	4.132GluAsp: 4.132 ± 0.067	4.566GluGlu: 4.566 ± 0.092	3.065GluPhe: 3.065 ± 0.056	3.756GluGly: 3.756 ± 0.067	1.265GluHis: 1.265 ± 0.041	5.037GluIle: 5.037 ± 0.079	4.987GluLys: 4.987 ± 0.097	6.275GluLeu: 6.275 ± 0.088	1.479GluMet: 1.479 ± 0.038	4.206GluAsn: 4.206 ± 0.07	1.769GluPro: 1.769 ± 0.045	2.376GluGln: 2.376 ± 0.055	2.804GluArg: 2.804 ± 0.061	3.534GluSer: 3.534 ± 0.068	3.683GluThr: 3.683 ± 0.058	4.264GluVal: 4.264 ± 0.07	0.652GluTrp: 0.652 ± 0.024	2.146GluTyr: 2.146 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.89PheAla: 2.89 ± 0.058	0.438PheCys: 0.438 ± 0.023	3.382PheAsp: 3.382 ± 0.065	3.561PheGlu: 3.561 ± 0.063	2.743PhePhe: 2.743 ± 0.071	3.948PheGly: 3.948 ± 0.081	0.819PheHis: 0.819 ± 0.025	3.993PheIle: 3.993 ± 0.069	4.049PheLys: 4.049 ± 0.071	4.629PheLeu: 4.629 ± 0.08	1.165PheMet: 1.165 ± 0.039	3.415PheAsn: 3.415 ± 0.074	1.661PhePro: 1.661 ± 0.04	1.546PheGln: 1.546 ± 0.04	1.773PheArg: 1.773 ± 0.05	3.921PheSer: 3.921 ± 0.071	2.962PheThr: 2.962 ± 0.061	3.059PheVal: 3.059 ± 0.062	0.599PheTrp: 0.599 ± 0.028	2.068PheTyr: 2.068 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.064GlyAla: 4.064 ± 0.073	0.537GlyCys: 0.537 ± 0.03	3.556GlyAsp: 3.556 ± 0.082	3.665GlyGlu: 3.665 ± 0.058	3.813GlyPhe: 3.813 ± 0.078	4.556GlyGly: 4.556 ± 0.097	1.185GlyHis: 1.185 ± 0.034	5.404GlyIle: 5.404 ± 0.089	4.463GlyLys: 4.463 ± 0.078	6.138GlyLeu: 6.138 ± 0.091	1.563GlyMet: 1.563 ± 0.043	3.519GlyAsn: 3.519 ± 0.073	1.571GlyPro: 1.571 ± 0.045	2.048GlyGln: 2.048 ± 0.045	2.304GlyArg: 2.304 ± 0.057	3.931GlySer: 3.931 ± 0.079	3.856GlyThr: 3.856 ± 0.084	4.14GlyVal: 4.14 ± 0.075	0.788GlyTrp: 0.788 ± 0.034	2.778GlyTyr: 2.778 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	0.892HisAla: 0.892 ± 0.032	0.181HisCys: 0.181 ± 0.014	0.87HisAsp: 0.87 ± 0.032	0.949HisGlu: 0.949 ± 0.033	1.078HisPhe: 1.078 ± 0.035	1.053HisGly: 1.053 ± 0.037	0.49HisHis: 0.49 ± 0.024	1.51HisIle: 1.51 ± 0.04	1.329HisLys: 1.329 ± 0.04	1.871HisLeu: 1.871 ± 0.052	0.4HisMet: 0.4 ± 0.019	1.027HisAsn: 1.027 ± 0.036	0.926HisPro: 0.926 ± 0.033	0.689HisGln: 0.689 ± 0.029	0.678HisArg: 0.678 ± 0.029	1.077HisSer: 1.077 ± 0.034	0.879HisThr: 0.879 ± 0.029	1.035HisVal: 1.035 ± 0.031	0.227HisTrp: 0.227 ± 0.015	0.869HisTyr: 0.869 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.766IleAla: 5.766 ± 0.085	0.608IleCys: 0.608 ± 0.027	5.23IleAsp: 5.23 ± 0.077	5.714IleGlu: 5.714 ± 0.093	3.604IlePhe: 3.604 ± 0.073	5.225IleGly: 5.225 ± 0.07	1.308IleHis: 1.308 ± 0.036	6.191IleIle: 6.191 ± 0.106	5.687IleLys: 5.687 ± 0.093	7.172IleLeu: 7.172 ± 0.121	1.448IleMet: 1.448 ± 0.043	4.676IleAsn: 4.676 ± 0.077	3.237IlePro: 3.237 ± 0.055	2.351IleGln: 2.351 ± 0.048	2.585IleArg: 2.585 ± 0.058	5.705IleSer: 5.705 ± 0.095	4.79IleThr: 4.79 ± 0.077	4.974IleVal: 4.974 ± 0.077	0.709IleTrp: 0.709 ± 0.026	2.829IleTyr: 2.829 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.217LysAla: 5.217 ± 0.11	0.321LysCys: 0.321 ± 0.018	4.678LysAsp: 4.678 ± 0.089	5.237LysGlu: 5.237 ± 0.096	2.751LysPhe: 2.751 ± 0.049	4.253LysGly: 4.253 ± 0.073	1.517LysHis: 1.517 ± 0.046	5.448LysIle: 5.448 ± 0.089	5.754LysLys: 5.754 ± 0.107	6.371LysLeu: 6.371 ± 0.098	1.757LysMet: 1.757 ± 0.045	4.514LysAsn: 4.514 ± 0.069	2.57LysPro: 2.57 ± 0.055	2.684LysGln: 2.684 ± 0.053	3.218LysArg: 3.218 ± 0.068	4.773LysSer: 4.773 ± 0.086	4.72LysThr: 4.72 ± 0.081	4.492LysVal: 4.492 ± 0.077	0.747LysTrp: 0.747 ± 0.03	2.824LysTyr: 2.824 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	5.784LeuAla: 5.784 ± 0.087	0.7LeuCys: 0.7 ± 0.028	5.459LeuAsp: 5.459 ± 0.083	6.225LeuGlu: 6.225 ± 0.089	4.976LeuPhe: 4.976 ± 0.088	5.917LeuGly: 5.917 ± 0.095	1.551LeuHis: 1.551 ± 0.04	7.201LeuIle: 7.201 ± 0.106	8.006LeuLys: 8.006 ± 0.112	8.606LeuLeu: 8.606 ± 0.117	2.173LeuMet: 2.173 ± 0.054	6.05LeuAsn: 6.05 ± 0.089	3.471LeuPro: 3.471 ± 0.065	3.148LeuGln: 3.148 ± 0.057	3.536LeuArg: 3.536 ± 0.063	6.858LeuSer: 6.858 ± 0.098	5.064LeuThr: 5.064 ± 0.078	5.851LeuVal: 5.851 ± 0.079	0.883LeuTrp: 0.883 ± 0.033	3.194LeuTyr: 3.194 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	1.769MetAla: 1.769 ± 0.048	0.128MetCys: 0.128 ± 0.012	1.209MetAsp: 1.209 ± 0.033	1.345MetGlu: 1.345 ± 0.039	0.888MetPhe: 0.888 ± 0.033	1.414MetGly: 1.414 ± 0.042	0.454MetHis: 0.454 ± 0.021	1.559MetIle: 1.559 ± 0.043	1.997MetLys: 1.997 ± 0.05	1.973MetLeu: 1.973 ± 0.051	0.572MetMet: 0.572 ± 0.026	1.204MetAsn: 1.204 ± 0.031	0.864MetPro: 0.864 ± 0.029	0.797MetGln: 0.797 ± 0.032	0.938MetArg: 0.938 ± 0.032	1.481MetSer: 1.481 ± 0.038	1.238MetThr: 1.238 ± 0.031	1.473MetVal: 1.473 ± 0.037	0.16MetTrp: 0.16 ± 0.014	0.707MetTyr: 0.707 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.942AsnAla: 3.942 ± 0.07	0.465AsnCys: 0.465 ± 0.029	3.433AsnAsp: 3.433 ± 0.074	3.636AsnGlu: 3.636 ± 0.065	3.064AsnPhe: 3.064 ± 0.066	3.884AsnGly: 3.884 ± 0.085	1.028AsnHis: 1.028 ± 0.036	4.607AsnIle: 4.607 ± 0.075	3.891AsnLys: 3.891 ± 0.068	5.438AsnLeu: 5.438 ± 0.081	1.242AsnMet: 1.242 ± 0.034	3.681AsnAsn: 3.681 ± 0.098	2.877AsnPro: 2.877 ± 0.066	2.116AsnGln: 2.116 ± 0.057	2.398AsnArg: 2.398 ± 0.051	3.865AsnSer: 3.865 ± 0.076	3.603AsnThr: 3.603 ± 0.075	3.363AsnVal: 3.363 ± 0.063	0.806AsnTrp: 0.806 ± 0.029	2.849AsnTyr: 2.849 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.734ProAla: 1.734 ± 0.048	0.194ProCys: 0.194 ± 0.013	2.097ProAsp: 2.097 ± 0.061	2.908ProGlu: 2.908 ± 0.053	1.932ProPhe: 1.932 ± 0.045	1.932ProGly: 1.932 ± 0.051	0.609ProHis: 0.609 ± 0.026	2.844ProIle: 2.844 ± 0.059	2.596ProLys: 2.596 ± 0.054	3.096ProLeu: 3.096 ± 0.057	0.786ProMet: 0.786 ± 0.031	2.421ProAsn: 2.421 ± 0.064	0.903ProPro: 0.903 ± 0.042	1.145ProGln: 1.145 ± 0.033	1.022ProArg: 1.022 ± 0.031	2.188ProSer: 2.188 ± 0.052	1.967ProThr: 1.967 ± 0.049	2.198ProVal: 2.198 ± 0.048	0.367ProTrp: 0.367 ± 0.02	1.489ProTyr: 1.489 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.957GlnAla: 1.957 ± 0.052	0.197GlnCys: 0.197 ± 0.014	1.916GlnAsp: 1.916 ± 0.047	2.054GlnGlu: 2.054 ± 0.053	1.721GlnPhe: 1.721 ± 0.042	1.888GlnGly: 1.888 ± 0.047	0.618GlnHis: 0.618 ± 0.026	2.661GlnIle: 2.661 ± 0.057	2.492GlnLys: 2.492 ± 0.056	3.683GlnLeu: 3.683 ± 0.059	0.787GlnMet: 0.787 ± 0.029	2.147GlnAsn: 2.147 ± 0.052	1.199GlnPro: 1.199 ± 0.037	1.324GlnGln: 1.324 ± 0.039	1.439GlnArg: 1.439 ± 0.04	1.92GlnSer: 1.92 ± 0.046	1.876GlnThr: 1.876 ± 0.039	1.85GlnVal: 1.85 ± 0.04	0.383GlnTrp: 0.383 ± 0.018	1.252GlnTyr: 1.252 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.393ArgAla: 2.393 ± 0.054	0.195ArgCys: 0.195 ± 0.013	1.958ArgAsp: 1.958 ± 0.052	2.123ArgGlu: 2.123 ± 0.049	2.116ArgPhe: 2.116 ± 0.056	2.028ArgGly: 2.028 ± 0.051	0.741ArgHis: 0.741 ± 0.028	3.154ArgIle: 3.154 ± 0.06	2.69ArgLys: 2.69 ± 0.058	3.76ArgLeu: 3.76 ± 0.066	0.881ArgMet: 0.881 ± 0.034	2.111ArgAsn: 2.111 ± 0.052	1.263ArgPro: 1.263 ± 0.04	1.389ArgGln: 1.389 ± 0.036	1.521ArgArg: 1.521 ± 0.041	2.078ArgSer: 2.078 ± 0.054	2.013ArgThr: 2.013 ± 0.051	2.158ArgVal: 2.158 ± 0.05	0.393ArgTrp: 0.393 ± 0.022	1.761ArgTyr: 1.761 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.788SerAla: 3.788 ± 0.074	0.605SerCys: 0.605 ± 0.032	3.619SerAsp: 3.619 ± 0.068	4.133SerGlu: 4.133 ± 0.057	3.673SerPhe: 3.673 ± 0.059	4.644SerGly: 4.644 ± 0.097	1.095SerHis: 1.095 ± 0.034	5.227SerIle: 5.227 ± 0.08	4.838SerLys: 4.838 ± 0.083	6.02SerLeu: 6.02 ± 0.089	1.305SerMet: 1.305 ± 0.031	3.955SerAsn: 3.955 ± 0.086	2.073SerPro: 2.073 ± 0.05	2.213SerGln: 2.213 ± 0.047	2.223SerArg: 2.223 ± 0.052	4.218SerSer: 4.218 ± 0.072	3.632SerThr: 3.632 ± 0.073	3.939SerVal: 3.939 ± 0.07	0.697SerTrp: 0.697 ± 0.032	2.759SerTyr: 2.759 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	3.691ThrAla: 3.691 ± 0.064	0.346ThrCys: 0.346 ± 0.021	3.244ThrAsp: 3.244 ± 0.067	3.499ThrGlu: 3.499 ± 0.056	3.097ThrPhe: 3.097 ± 0.063	3.868ThrGly: 3.868 ± 0.081	1.054ThrHis: 1.054 ± 0.034	4.905ThrIle: 4.905 ± 0.076	3.755ThrLys: 3.755 ± 0.063	5.458ThrLeu: 5.458 ± 0.083	1.073ThrMet: 1.073 ± 0.034	3.122ThrAsn: 3.122 ± 0.073	2.27ThrPro: 2.27 ± 0.052	1.8ThrGln: 1.8 ± 0.044	1.78ThrArg: 1.78 ± 0.045	3.725ThrSer: 3.725 ± 0.079	3.477ThrThr: 3.477 ± 0.068	3.821ThrVal: 3.821 ± 0.079	0.643ThrTrp: 0.643 ± 0.035	2.417ThrTyr: 2.417 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	4.024ValAla: 4.024 ± 0.07	0.513ValCys: 0.513 ± 0.025	3.674ValAsp: 3.674 ± 0.061	4.109ValGlu: 4.109 ± 0.067	3.498ValPhe: 3.498 ± 0.054	3.859ValGly: 3.859 ± 0.073	0.993ValHis: 0.993 ± 0.031	5.053ValIle: 5.053 ± 0.073	4.384ValLys: 4.384 ± 0.073	6.202ValLeu: 6.202 ± 0.083	1.386ValMet: 1.386 ± 0.041	3.555ValAsn: 3.555 ± 0.065	2.179ValPro: 2.179 ± 0.049	1.663ValGln: 1.663 ± 0.039	2.097ValArg: 2.097 ± 0.054	4.238ValSer: 4.238 ± 0.063	3.537ValThr: 3.537 ± 0.086	4.356ValVal: 4.356 ± 0.072	0.602ValTrp: 0.602 ± 0.027	2.374ValTyr: 2.374 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.613TrpAla: 0.613 ± 0.025	0.095TrpCys: 0.095 ± 0.01	0.621TrpAsp: 0.621 ± 0.027	0.676TrpGlu: 0.676 ± 0.025	0.629TrpPhe: 0.629 ± 0.029	0.617TrpGly: 0.617 ± 0.033	0.238TrpHis: 0.238 ± 0.015	0.739TrpIle: 0.739 ± 0.027	0.721TrpLys: 0.721 ± 0.03	1.012TrpLeu: 1.012 ± 0.036	0.306TrpMet: 0.306 ± 0.022	0.729TrpAsn: 0.729 ± 0.03	0.26TrpPro: 0.26 ± 0.02	0.433TrpGln: 0.433 ± 0.021	0.454TrpArg: 0.454 ± 0.021	0.687TrpSer: 0.687 ± 0.03	0.595TrpThr: 0.595 ± 0.028	0.652TrpVal: 0.652 ± 0.028	0.174TrpTrp: 0.174 ± 0.014	0.464TrpTyr: 0.464 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.457TyrAla: 2.457 ± 0.053	0.307TyrCys: 0.307 ± 0.02	2.449TyrAsp: 2.449 ± 0.058	2.28TyrGlu: 2.28 ± 0.049	2.446TyrPhe: 2.446 ± 0.057	2.684TyrGly: 2.684 ± 0.053	0.823TyrHis: 0.823 ± 0.028	2.858TyrIle: 2.858 ± 0.058	2.993TyrLys: 2.993 ± 0.064	3.894TyrLeu: 3.894 ± 0.07	0.809TyrMet: 0.809 ± 0.03	2.647TyrAsn: 2.647 ± 0.064	1.46TyrPro: 1.46 ± 0.04	1.437TyrGln: 1.437 ± 0.039	1.737TyrArg: 1.737 ± 0.056	2.439TyrSer: 2.439 ± 0.048	2.356TyrThr: 2.356 ± 0.055	2.234TyrVal: 2.234 ± 0.05	0.453TyrTrp: 0.453 ± 0.022	1.857TyrTyr: 1.857 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2856 proteins (969902 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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