Amino acid dipepetide frequency for Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.282AlaAla: 9.282 ± 0.163
1.096AlaCys: 1.096 ± 0.043
4.765AlaAsp: 4.765 ± 0.11
6.182AlaGlu: 6.182 ± 0.088
3.617AlaPhe: 3.617 ± 0.076
8.162AlaGly: 8.162 ± 0.141
1.555AlaHis: 1.555 ± 0.051
5.334AlaIle: 5.334 ± 0.103
3.757AlaLys: 3.757 ± 0.089
9.429AlaLeu: 9.429 ± 0.135
2.465AlaMet: 2.465 ± 0.061
2.245AlaAsn: 2.245 ± 0.054
2.714AlaPro: 2.714 ± 0.07
2.068AlaGln: 2.068 ± 0.058
4.534AlaArg: 4.534 ± 0.101
5.546AlaSer: 5.546 ± 0.104
3.647AlaThr: 3.647 ± 0.094
6.988AlaVal: 6.988 ± 0.121
0.933AlaTrp: 0.933 ± 0.041
2.297AlaTyr: 2.297 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.838CysAla: 0.838 ± 0.037
0.212CysCys: 0.212 ± 0.018
0.65CysAsp: 0.65 ± 0.029
0.553CysGlu: 0.553 ± 0.027
0.544CysPhe: 0.544 ± 0.026
1.11CysGly: 1.11 ± 0.047
0.315CysHis: 0.315 ± 0.024
0.748CysIle: 0.748 ± 0.033
0.374CysLys: 0.374 ± 0.021
0.886CysLeu: 0.886 ± 0.037
0.309CysMet: 0.309 ± 0.02
0.434CysAsn: 0.434 ± 0.024
0.584CysPro: 0.584 ± 0.029
0.289CysGln: 0.289 ± 0.018
0.908CysArg: 0.908 ± 0.039
0.895CysSer: 0.895 ± 0.039
0.589CysThr: 0.589 ± 0.031
0.607CysVal: 0.607 ± 0.031
0.107CysTrp: 0.107 ± 0.011
0.345CysTyr: 0.345 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.83AspAla: 4.83 ± 0.123
0.638AspCys: 0.638 ± 0.036
3.074AspAsp: 3.074 ± 0.184
3.839AspGlu: 3.839 ± 0.102
2.568AspPhe: 2.568 ± 0.062
4.338AspGly: 4.338 ± 0.272
1.145AspHis: 1.145 ± 0.057
4.075AspIle: 4.075 ± 0.077
2.237AspLys: 2.237 ± 0.062
5.218AspLeu: 5.218 ± 0.092
1.386AspMet: 1.386 ± 0.05
2.023AspAsn: 2.023 ± 0.085
2.512AspPro: 2.512 ± 0.061
1.343AspGln: 1.343 ± 0.062
3.478AspArg: 3.478 ± 0.079
3.186AspSer: 3.186 ± 0.12
2.976AspThr: 2.976 ± 0.164
3.444AspVal: 3.444 ± 0.09
0.65AspTrp: 0.65 ± 0.039
1.937AspTyr: 1.937 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
5.672GluAla: 5.672 ± 0.092
0.589GluCys: 0.589 ± 0.033
2.795GluAsp: 2.795 ± 0.113
4.833GluGlu: 4.833 ± 0.095
2.327GluPhe: 2.327 ± 0.064
4.372GluGly: 4.372 ± 0.13
1.62GluHis: 1.62 ± 0.046
4.475GluIle: 4.475 ± 0.084
4.958GluLys: 4.958 ± 0.124
7.139GluLeu: 7.139 ± 0.139
1.615GluMet: 1.615 ± 0.052
2.877GluAsn: 2.877 ± 0.061
2.491GluPro: 2.491 ± 0.067
2.632GluGln: 2.632 ± 0.062
4.4GluArg: 4.4 ± 0.098
3.843GluSer: 3.843 ± 0.077
3.677GluThr: 3.677 ± 0.074
3.899GluVal: 3.899 ± 0.085
0.743GluTrp: 0.743 ± 0.034
1.952GluTyr: 1.952 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.628PheAla: 3.628 ± 0.083
0.562PheCys: 0.562 ± 0.027
2.743PheAsp: 2.743 ± 0.058
2.479PheGlu: 2.479 ± 0.064
2.37PhePhe: 2.37 ± 0.072
3.478PheGly: 3.478 ± 0.085
0.869PheHis: 0.869 ± 0.032
2.644PheIle: 2.644 ± 0.068
1.441PheLys: 1.441 ± 0.054
4.328PheLeu: 4.328 ± 0.101
1.118PheMet: 1.118 ± 0.046
1.592PheAsn: 1.592 ± 0.048
1.838PhePro: 1.838 ± 0.049
1.136PheGln: 1.136 ± 0.037
2.934PheArg: 2.934 ± 0.076
3.889PheSer: 3.889 ± 0.069
2.405PheThr: 2.405 ± 0.106
2.681PheVal: 2.681 ± 0.063
0.513PheTrp: 0.513 ± 0.027
1.38PheTyr: 1.38 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.878GlyAla: 5.878 ± 0.137
1.006GlyCys: 1.006 ± 0.036
4.132GlyAsp: 4.132 ± 0.261
4.822GlyGlu: 4.822 ± 0.146
3.748GlyPhe: 3.748 ± 0.079
6.076GlyGly: 6.076 ± 0.329
1.469GlyHis: 1.469 ± 0.045
5.971GlyIle: 5.971 ± 0.103
4.672GlyLys: 4.672 ± 0.091
6.74GlyLeu: 6.74 ± 0.116
2.434GlyMet: 2.434 ± 0.062
3.334GlyAsn: 3.334 ± 0.247
1.897GlyPro: 1.897 ± 0.055
2.084GlyGln: 2.084 ± 0.072
4.366GlyArg: 4.366 ± 0.085
5.669GlySer: 5.669 ± 0.163
4.479GlyThr: 4.479 ± 0.119
4.918GlyVal: 4.918 ± 0.112
0.834GlyTrp: 0.834 ± 0.036
2.771GlyTyr: 2.771 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.848HisAla: 1.848 ± 0.047
0.323HisCys: 0.323 ± 0.025
1.236HisAsp: 1.236 ± 0.044
1.511HisGlu: 1.511 ± 0.06
0.953HisPhe: 0.953 ± 0.037
1.532HisGly: 1.532 ± 0.052
0.624HisHis: 0.624 ± 0.031
1.251HisIle: 1.251 ± 0.046
0.837HisLys: 0.837 ± 0.035
2.028HisLeu: 2.028 ± 0.062
0.435HisMet: 0.435 ± 0.022
0.744HisAsn: 0.744 ± 0.033
1.264HisPro: 1.264 ± 0.048
0.683HisGln: 0.683 ± 0.039
1.307HisArg: 1.307 ± 0.045
1.235HisSer: 1.235 ± 0.041
1.054HisThr: 1.054 ± 0.037
1.188HisVal: 1.188 ± 0.037
0.209HisTrp: 0.209 ± 0.017
0.796HisTyr: 0.796 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.304IleAla: 6.304 ± 0.113
0.758IleCys: 0.758 ± 0.032
4.437IleAsp: 4.437 ± 0.078
4.632IleGlu: 4.632 ± 0.09
2.507IlePhe: 2.507 ± 0.072
5.204IleGly: 5.204 ± 0.094
1.265IleHis: 1.265 ± 0.045
4.016IleIle: 4.016 ± 0.081
2.423IleLys: 2.423 ± 0.072
5.452IleLeu: 5.452 ± 0.092
1.48IleMet: 1.48 ± 0.044
2.203IleAsn: 2.203 ± 0.063
3.167IlePro: 3.167 ± 0.08
1.585IleGln: 1.585 ± 0.05
4.277IleArg: 4.277 ± 0.093
4.464IleSer: 4.464 ± 0.084
3.767IleThr: 3.767 ± 0.076
4.461IleVal: 4.461 ± 0.088
0.518IleTrp: 0.518 ± 0.027
1.769IleTyr: 1.769 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
4.398LysAla: 4.398 ± 0.1
0.354LysCys: 0.354 ± 0.021
2.023LysAsp: 2.023 ± 0.065
3.505LysGlu: 3.505 ± 0.087
1.414LysPhe: 1.414 ± 0.051
3.589LysGly: 3.589 ± 0.068
0.975LysHis: 0.975 ± 0.037
3.421LysIle: 3.421 ± 0.086
3.805LysLys: 3.805 ± 0.106
4.563LysLeu: 4.563 ± 0.091
1.208LysMet: 1.208 ± 0.048
2.424LysAsn: 2.424 ± 0.073
2.457LysPro: 2.457 ± 0.064
1.838LysGln: 1.838 ± 0.055
2.842LysArg: 2.842 ± 0.066
3.113LysSer: 3.113 ± 0.079
3.248LysThr: 3.248 ± 0.085
3.148LysVal: 3.148 ± 0.075
0.434LysTrp: 0.434 ± 0.024
1.352LysTyr: 1.352 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
8.88LeuAla: 8.88 ± 0.145
1.131LeuCys: 1.131 ± 0.043
6.024LeuAsp: 6.024 ± 0.153
6.37LeuGlu: 6.37 ± 0.109
4.951LeuPhe: 4.951 ± 0.1
6.64LeuGly: 6.64 ± 0.109
2.259LeuHis: 2.259 ± 0.057
5.542LeuIle: 5.542 ± 0.106
5.283LeuLys: 5.283 ± 0.107
11.304LeuLeu: 11.304 ± 0.197
2.36LeuMet: 2.36 ± 0.064
3.434LeuAsn: 3.434 ± 0.075
4.791LeuPro: 4.791 ± 0.1
3.87LeuGln: 3.87 ± 0.082
5.833LeuArg: 5.833 ± 0.123
7.22LeuSer: 7.22 ± 0.128
4.855LeuThr: 4.855 ± 0.144
6.584LeuVal: 6.584 ± 0.116
0.922LeuTrp: 0.922 ± 0.036
3.022LeuTyr: 3.022 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
2.139MetAla: 2.139 ± 0.058
0.158MetCys: 0.158 ± 0.015
1.111MetAsp: 1.111 ± 0.044
1.399MetGlu: 1.399 ± 0.044
0.881MetPhe: 0.881 ± 0.032
1.543MetGly: 1.543 ± 0.05
0.664MetHis: 0.664 ± 0.031
1.635MetIle: 1.635 ± 0.05
1.83MetLys: 1.83 ± 0.048
2.935MetLeu: 2.935 ± 0.069
0.705MetMet: 0.705 ± 0.04
1.25MetAsn: 1.25 ± 0.042
1.31MetPro: 1.31 ± 0.043
1.24MetGln: 1.24 ± 0.044
1.414MetArg: 1.414 ± 0.037
1.616MetSer: 1.616 ± 0.05
1.436MetThr: 1.436 ± 0.047
1.681MetVal: 1.681 ± 0.049
0.174MetTrp: 0.174 ± 0.014
0.538MetTyr: 0.538 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.146AsnAla: 3.146 ± 0.072
0.413AsnCys: 0.413 ± 0.024
2.287AsnAsp: 2.287 ± 0.2
2.058AsnGlu: 2.058 ± 0.062
1.342AsnPhe: 1.342 ± 0.045
2.898AsnGly: 2.898 ± 0.087
0.776AsnHis: 0.776 ± 0.03
2.566AsnIle: 2.566 ± 0.063
1.426AsnLys: 1.426 ± 0.051
3.493AsnLeu: 3.493 ± 0.078
0.822AsnMet: 0.822 ± 0.033
1.436AsnAsn: 1.436 ± 0.061
2.395AsnPro: 2.395 ± 0.056
0.997AsnGln: 0.997 ± 0.045
2.57AsnArg: 2.57 ± 0.074
2.128AsnSer: 2.128 ± 0.064
1.878AsnThr: 1.878 ± 0.076
2.25AsnVal: 2.25 ± 0.058
0.427AsnTrp: 0.427 ± 0.023
1.086AsnTyr: 1.086 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.958ProAla: 3.958 ± 0.089
0.417ProCys: 0.417 ± 0.023
3.159ProAsp: 3.159 ± 0.09
4.457ProGlu: 4.457 ± 0.084
2.042ProPhe: 2.042 ± 0.061
3.459ProGly: 3.459 ± 0.071
0.833ProHis: 0.833 ± 0.036
1.77ProIle: 1.77 ± 0.058
1.732ProLys: 1.732 ± 0.05
4.227ProLeu: 4.227 ± 0.085
0.963ProMet: 0.963 ± 0.034
1.101ProAsn: 1.101 ± 0.038
1.619ProPro: 1.619 ± 0.049
1.199ProGln: 1.199 ± 0.04
1.544ProArg: 1.544 ± 0.051
2.682ProSer: 2.682 ± 0.065
1.483ProThr: 1.483 ± 0.065
4.151ProVal: 4.151 ± 0.084
0.459ProTrp: 0.459 ± 0.026
1.288ProTyr: 1.288 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.747GlnAla: 2.747 ± 0.073
0.326GlnCys: 0.326 ± 0.021
1.408GlnAsp: 1.408 ± 0.043
2.34GlnGlu: 2.34 ± 0.065
1.162GlnPhe: 1.162 ± 0.038
2.054GlnGly: 2.054 ± 0.06
0.698GlnHis: 0.698 ± 0.031
1.946GlnIle: 1.946 ± 0.054
1.961GlnLys: 1.961 ± 0.051
3.221GlnLeu: 3.221 ± 0.079
0.813GlnMet: 0.813 ± 0.034
1.25GlnAsn: 1.25 ± 0.044
1.276GlnPro: 1.276 ± 0.039
1.484GlnGln: 1.484 ± 0.053
1.731GlnArg: 1.731 ± 0.056
1.952GlnSer: 1.952 ± 0.058
1.586GlnThr: 1.586 ± 0.062
1.883GlnVal: 1.883 ± 0.057
0.338GlnTrp: 0.338 ± 0.023
0.925GlnTyr: 0.925 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.726ArgAla: 3.726 ± 0.08
0.608ArgCys: 0.608 ± 0.028
3.032ArgAsp: 3.032 ± 0.068
4.623ArgGlu: 4.623 ± 0.095
2.952ArgPhe: 2.952 ± 0.073
2.967ArgGly: 2.967 ± 0.074
1.496ArgHis: 1.496 ± 0.054
4.32ArgIle: 4.32 ± 0.088
4.029ArgLys: 4.029 ± 0.095
6.085ArgLeu: 6.085 ± 0.122
1.699ArgMet: 1.699 ± 0.052
2.638ArgAsn: 2.638 ± 0.075
2.176ArgPro: 2.176 ± 0.066
2.485ArgGln: 2.485 ± 0.065
3.407ArgArg: 3.407 ± 0.077
3.719ArgSer: 3.719 ± 0.078
2.914ArgThr: 2.914 ± 0.061
3.44ArgVal: 3.44 ± 0.081
0.613ArgTrp: 0.613 ± 0.032
2.297ArgTyr: 2.297 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
5.692SerAla: 5.692 ± 0.108
0.893SerCys: 0.893 ± 0.039
3.556SerAsp: 3.556 ± 0.105
3.921SerGlu: 3.921 ± 0.077
3.053SerPhe: 3.053 ± 0.069
7.057SerGly: 7.057 ± 0.19
1.218SerHis: 1.218 ± 0.043
4.208SerIle: 4.208 ± 0.086
2.625SerLys: 2.625 ± 0.065
6.883SerLeu: 6.883 ± 0.127
1.813SerMet: 1.813 ± 0.049
1.972SerAsn: 1.972 ± 0.051
2.781SerPro: 2.781 ± 0.063
1.7SerGln: 1.7 ± 0.058
4.206SerArg: 4.206 ± 0.082
4.648SerSer: 4.648 ± 0.093
2.854SerThr: 2.854 ± 0.072
4.853SerVal: 4.853 ± 0.095
0.811SerTrp: 0.811 ± 0.032
1.873SerTyr: 1.873 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
5.011ThrAla: 5.011 ± 0.082
0.516ThrCys: 0.516 ± 0.027
2.673ThrAsp: 2.673 ± 0.067
2.999ThrGlu: 2.999 ± 0.062
2.178ThrPhe: 2.178 ± 0.065
5.701ThrGly: 5.701 ± 0.175
0.885ThrHis: 0.885 ± 0.034
3.554ThrIle: 3.554 ± 0.08
1.766ThrLys: 1.766 ± 0.051
5.756ThrLeu: 5.756 ± 0.195
1.264ThrMet: 1.264 ± 0.057
1.448ThrAsn: 1.448 ± 0.049
2.466ThrPro: 2.466 ± 0.065
1.085ThrGln: 1.085 ± 0.036
2.411ThrArg: 2.411 ± 0.06
2.995ThrSer: 2.995 ± 0.077
2.631ThrThr: 2.631 ± 0.122
4.41ThrVal: 4.41 ± 0.113
0.523ThrTrp: 0.523 ± 0.027
1.47ThrTyr: 1.47 ± 0.081
0.0ThrXaa: 0.0 ± 0.0
Val
5.444ValAla: 5.444 ± 0.1
0.81ValCys: 0.81 ± 0.04
3.546ValAsp: 3.546 ± 0.082
4.008ValGlu: 4.008 ± 0.071
3.421ValPhe: 3.421 ± 0.085
3.839ValGly: 3.839 ± 0.091
1.41ValHis: 1.41 ± 0.053
4.836ValIle: 4.836 ± 0.079
3.112ValLys: 3.112 ± 0.069
7.153ValLeu: 7.153 ± 0.118
1.827ValMet: 1.827 ± 0.051
2.36ValAsn: 2.36 ± 0.061
2.996ValPro: 2.996 ± 0.073
2.036ValGln: 2.036 ± 0.057
4.017ValArg: 4.017 ± 0.079
5.217ValSer: 5.217 ± 0.138
4.189ValThr: 4.189 ± 0.135
4.843ValVal: 4.843 ± 0.102
0.632ValTrp: 0.632 ± 0.03
1.96ValTyr: 1.96 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.726TrpAla: 0.726 ± 0.033
0.103TrpCys: 0.103 ± 0.011
0.505TrpAsp: 0.505 ± 0.029
0.557TrpGlu: 0.557 ± 0.028
0.551TrpPhe: 0.551 ± 0.027
0.614TrpGly: 0.614 ± 0.031
0.277TrpHis: 0.277 ± 0.021
0.678TrpIle: 0.678 ± 0.03
0.685TrpLys: 0.685 ± 0.032
1.195TrpLeu: 1.195 ± 0.041
0.345TrpMet: 0.345 ± 0.019
0.481TrpAsn: 0.481 ± 0.026
0.359TrpPro: 0.359 ± 0.023
0.491TrpGln: 0.491 ± 0.03
0.58TrpArg: 0.58 ± 0.029
0.663TrpSer: 0.663 ± 0.029
0.482TrpThr: 0.482 ± 0.024
0.543TrpVal: 0.543 ± 0.028
0.154TrpTrp: 0.154 ± 0.015
0.355TrpTyr: 0.355 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.467TyrAla: 2.467 ± 0.054
0.384TyrCys: 0.384 ± 0.023
1.74TyrAsp: 1.74 ± 0.052
1.824TyrGlu: 1.824 ± 0.085
1.445TyrPhe: 1.445 ± 0.045
2.668TyrGly: 2.668 ± 0.113
0.705TyrHis: 0.705 ± 0.03
1.695TyrIle: 1.695 ± 0.05
1.159TyrLys: 1.159 ± 0.046
3.237TyrLeu: 3.237 ± 0.076
0.598TyrMet: 0.598 ± 0.027
1.147TyrAsn: 1.147 ± 0.04
1.454TyrPro: 1.454 ± 0.043
0.856TyrGln: 0.856 ± 0.034
2.463TyrArg: 2.463 ± 0.062
1.939TyrSer: 1.939 ± 0.06
1.595TyrThr: 1.595 ± 0.052
1.688TyrVal: 1.688 ± 0.055
0.35TyrTrp: 0.35 ± 0.022
1.137TyrTyr: 1.137 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2419 proteins (786338 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski