Amino acid dipepetide frequency for Hydrogenivirga caldilitoris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.277AlaAla: 3.277 ± 0.096
0.666AlaCys: 0.666 ± 0.044
2.606AlaAsp: 2.606 ± 0.067
4.454AlaGlu: 4.454 ± 0.102
3.209AlaPhe: 3.209 ± 0.086
4.864AlaGly: 4.864 ± 0.104
1.108AlaHis: 1.108 ± 0.045
4.262AlaIle: 4.262 ± 0.094
4.8AlaLys: 4.8 ± 0.102
8.025AlaLeu: 8.025 ± 0.14
1.393AlaMet: 1.393 ± 0.049
1.829AlaAsn: 1.829 ± 0.065
2.023AlaPro: 2.023 ± 0.063
2.148AlaGln: 2.148 ± 0.063
3.149AlaArg: 3.149 ± 0.077
3.197AlaSer: 3.197 ± 0.074
2.517AlaThr: 2.517 ± 0.07
5.526AlaVal: 5.526 ± 0.113
0.52AlaTrp: 0.52 ± 0.034
2.645AlaTyr: 2.645 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.536CysAla: 0.536 ± 0.037
0.105CysCys: 0.105 ± 0.014
0.385CysAsp: 0.385 ± 0.028
0.629CysGlu: 0.629 ± 0.038
0.272CysPhe: 0.272 ± 0.025
0.901CysGly: 0.901 ± 0.051
0.232CysHis: 0.232 ± 0.021
0.504CysIle: 0.504 ± 0.032
0.463CysLys: 0.463 ± 0.027
0.666CysLeu: 0.666 ± 0.038
0.212CysMet: 0.212 ± 0.018
0.274CysAsn: 0.274 ± 0.021
0.648CysPro: 0.648 ± 0.041
0.191CysGln: 0.191 ± 0.019
0.443CysArg: 0.443 ± 0.032
0.545CysSer: 0.545 ± 0.037
0.41CysThr: 0.41 ± 0.028
0.572CysVal: 0.572 ± 0.035
0.073CysTrp: 0.073 ± 0.011
0.312CysTyr: 0.312 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
2.518AspAla: 2.518 ± 0.064
0.367AspCys: 0.367 ± 0.026
1.517AspAsp: 1.517 ± 0.06
3.444AspGlu: 3.444 ± 0.085
2.691AspPhe: 2.691 ± 0.066
2.748AspGly: 2.748 ± 0.071
0.497AspHis: 0.497 ± 0.03
4.791AspIle: 4.791 ± 0.114
3.343AspLys: 3.343 ± 0.078
4.739AspLeu: 4.739 ± 0.101
1.268AspMet: 1.268 ± 0.049
1.355AspAsn: 1.355 ± 0.057
2.394AspPro: 2.394 ± 0.073
0.641AspGln: 0.641 ± 0.032
3.404AspArg: 3.404 ± 0.077
2.093AspSer: 2.093 ± 0.071
2.337AspThr: 2.337 ± 0.075
3.822AspVal: 3.822 ± 0.091
0.559AspTrp: 0.559 ± 0.029
2.167AspTyr: 2.167 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
5.544GluAla: 5.544 ± 0.107
0.524GluCys: 0.524 ± 0.035
4.64GluAsp: 4.64 ± 0.091
10.916GluGlu: 10.916 ± 0.214
4.007GluPhe: 4.007 ± 0.078
6.919GluGly: 6.919 ± 0.129
1.364GluHis: 1.364 ± 0.051
5.608GluIle: 5.608 ± 0.1
7.322GluLys: 7.322 ± 0.149
10.658GluLeu: 10.658 ± 0.157
1.485GluMet: 1.485 ± 0.051
3.208GluAsn: 3.208 ± 0.082
2.595GluPro: 2.595 ± 0.065
1.526GluGln: 1.526 ± 0.054
6.185GluArg: 6.185 ± 0.118
3.699GluSer: 3.699 ± 0.078
3.302GluThr: 3.302 ± 0.086
7.819GluVal: 7.819 ± 0.109
0.698GluTrp: 0.698 ± 0.039
2.465GluTyr: 2.465 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
2.796PheAla: 2.796 ± 0.08
0.458PheCys: 0.458 ± 0.031
2.004PheAsp: 2.004 ± 0.059
3.224PheGlu: 3.224 ± 0.073
2.702PhePhe: 2.702 ± 0.088
3.806PheGly: 3.806 ± 0.093
0.81PheHis: 0.81 ± 0.039
3.582PheIle: 3.582 ± 0.095
3.204PheLys: 3.204 ± 0.075
6.401PheLeu: 6.401 ± 0.154
1.22PheMet: 1.22 ± 0.049
1.615PheAsn: 1.615 ± 0.062
2.011PhePro: 2.011 ± 0.067
1.004PheGln: 1.004 ± 0.041
2.497PheArg: 2.497 ± 0.065
3.323PheSer: 3.323 ± 0.093
2.31PheThr: 2.31 ± 0.068
3.551PheVal: 3.551 ± 0.09
0.552PheTrp: 0.552 ± 0.038
2.075PheTyr: 2.075 ± 0.072
0.0PheXaa: 0.0 ± 0.0
Gly
4.704GlyAla: 4.704 ± 0.104
0.794GlyCys: 0.794 ± 0.042
3.583GlyAsp: 3.583 ± 0.082
5.966GlyGlu: 5.966 ± 0.122
3.998GlyPhe: 3.998 ± 0.083
5.384GlyGly: 5.384 ± 0.114
1.191GlyHis: 1.191 ± 0.048
5.918GlyIle: 5.918 ± 0.122
6.285GlyLys: 6.285 ± 0.111
6.638GlyLeu: 6.638 ± 0.122
1.84GlyMet: 1.84 ± 0.06
2.492GlyAsn: 2.492 ± 0.078
1.362GlyPro: 1.362 ± 0.049
1.375GlyGln: 1.375 ± 0.057
4.061GlyArg: 4.061 ± 0.086
3.835GlySer: 3.835 ± 0.102
3.382GlyThr: 3.382 ± 0.084
6.33GlyVal: 6.33 ± 0.111
0.823GlyTrp: 0.823 ± 0.041
3.176GlyTyr: 3.176 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
0.917HisAla: 0.917 ± 0.048
0.176HisCys: 0.176 ± 0.017
0.595HisAsp: 0.595 ± 0.032
1.015HisGlu: 1.015 ± 0.044
0.798HisPhe: 0.798 ± 0.041
1.174HisGly: 1.174 ± 0.053
0.385HisHis: 0.385 ± 0.029
1.254HisIle: 1.254 ± 0.049
0.805HisLys: 0.805 ± 0.037
1.696HisLeu: 1.696 ± 0.058
0.427HisMet: 0.427 ± 0.028
0.52HisAsn: 0.52 ± 0.035
1.061HisPro: 1.061 ± 0.052
0.353HisGln: 0.353 ± 0.026
1.074HisArg: 1.074 ± 0.042
0.819HisSer: 0.819 ± 0.04
0.853HisThr: 0.853 ± 0.039
0.994HisVal: 0.994 ± 0.036
0.166HisTrp: 0.166 ± 0.017
0.668HisTyr: 0.668 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
4.944IleAla: 4.944 ± 0.093
0.454IleCys: 0.454 ± 0.026
4.013IleAsp: 4.013 ± 0.088
6.554IleGlu: 6.554 ± 0.109
2.702IlePhe: 2.702 ± 0.091
4.729IleGly: 4.729 ± 0.099
1.136IleHis: 1.136 ± 0.042
3.733IleIle: 3.733 ± 0.102
5.206IleLys: 5.206 ± 0.118
7.033IleLeu: 7.033 ± 0.121
1.101IleMet: 1.101 ± 0.047
2.561IleAsn: 2.561 ± 0.059
3.566IlePro: 3.566 ± 0.072
1.398IleGln: 1.398 ± 0.053
3.831IleArg: 3.831 ± 0.081
3.744IleSer: 3.744 ± 0.078
3.469IleThr: 3.469 ± 0.084
5.106IleVal: 5.106 ± 0.095
0.447IleTrp: 0.447 ± 0.028
2.499IleTyr: 2.499 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.99LysAla: 4.99 ± 0.107
0.351LysCys: 0.351 ± 0.027
3.811LysAsp: 3.811 ± 0.098
9.088LysGlu: 9.088 ± 0.164
2.68LysPhe: 2.68 ± 0.06
5.965LysGly: 5.965 ± 0.111
1.158LysHis: 1.158 ± 0.043
3.895LysIle: 3.895 ± 0.086
5.366LysLys: 5.366 ± 0.116
7.949LysLeu: 7.949 ± 0.132
1.078LysMet: 1.078 ± 0.042
2.558LysAsn: 2.558 ± 0.071
3.295LysPro: 3.295 ± 0.084
1.252LysGln: 1.252 ± 0.045
4.705LysArg: 4.705 ± 0.1
3.119LysSer: 3.119 ± 0.068
3.179LysThr: 3.179 ± 0.075
7.023LysVal: 7.023 ± 0.125
0.557LysTrp: 0.557 ± 0.038
2.048LysTyr: 2.048 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
6.681LeuAla: 6.681 ± 0.139
0.775LeuCys: 0.775 ± 0.044
4.406LeuAsp: 4.406 ± 0.102
8.898LeuGlu: 8.898 ± 0.159
5.557LeuPhe: 5.557 ± 0.13
7.822LeuGly: 7.822 ± 0.126
1.519LeuHis: 1.519 ± 0.051
7.788LeuIle: 7.788 ± 0.16
9.489LeuLys: 9.489 ± 0.14
11.974LeuLeu: 11.974 ± 0.23
2.399LeuMet: 2.399 ± 0.072
3.448LeuAsn: 3.448 ± 0.079
4.474LeuPro: 4.474 ± 0.092
2.376LeuGln: 2.376 ± 0.069
6.476LeuArg: 6.476 ± 0.109
8.189LeuSer: 8.189 ± 0.166
4.926LeuThr: 4.926 ± 0.092
7.304LeuVal: 7.304 ± 0.143
1.147LeuTrp: 1.147 ± 0.052
4.079LeuTyr: 4.079 ± 0.106
0.0LeuXaa: 0.0 ± 0.0
Met
1.387MetAla: 1.387 ± 0.052
0.151MetCys: 0.151 ± 0.016
1.083MetAsp: 1.083 ± 0.044
2.052MetGlu: 2.052 ± 0.063
0.853MetPhe: 0.853 ± 0.035
1.683MetGly: 1.683 ± 0.049
0.317MetHis: 0.317 ± 0.024
1.081MetIle: 1.081 ± 0.047
1.875MetLys: 1.875 ± 0.055
2.096MetLeu: 2.096 ± 0.065
0.354MetMet: 0.354 ± 0.027
0.882MetAsn: 0.882 ± 0.037
0.88MetPro: 0.88 ± 0.044
0.353MetGln: 0.353 ± 0.028
1.373MetArg: 1.373 ± 0.049
1.263MetSer: 1.263 ± 0.048
0.885MetThr: 0.885 ± 0.04
1.571MetVal: 1.571 ± 0.05
0.198MetTrp: 0.198 ± 0.016
0.572MetTyr: 0.572 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.023AsnAla: 2.023 ± 0.067
0.331AsnCys: 0.331 ± 0.026
1.079AsnAsp: 1.079 ± 0.053
2.029AsnGlu: 2.029 ± 0.06
1.82AsnPhe: 1.82 ± 0.059
1.808AsnGly: 1.808 ± 0.059
0.46AsnHis: 0.46 ± 0.028
2.509AsnIle: 2.509 ± 0.07
1.633AsnLys: 1.633 ± 0.057
4.508AsnLeu: 4.508 ± 0.103
0.746AsnMet: 0.746 ± 0.037
0.937AsnAsn: 0.937 ± 0.053
2.394AsnPro: 2.394 ± 0.07
0.606AsnGln: 0.606 ± 0.036
2.155AsnArg: 2.155 ± 0.061
1.647AsnSer: 1.647 ± 0.059
1.647AsnThr: 1.647 ± 0.055
2.73AsnVal: 2.73 ± 0.076
0.44AsnTrp: 0.44 ± 0.025
1.441AsnTyr: 1.441 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
2.228ProAla: 2.228 ± 0.065
0.326ProCys: 0.326 ± 0.024
2.326ProAsp: 2.326 ± 0.066
4.636ProGlu: 4.636 ± 0.098
2.173ProPhe: 2.173 ± 0.066
2.333ProGly: 2.333 ± 0.067
0.801ProHis: 0.801 ± 0.036
2.501ProIle: 2.501 ± 0.067
2.696ProLys: 2.696 ± 0.066
3.835ProLeu: 3.835 ± 0.088
0.839ProMet: 0.839 ± 0.04
1.318ProAsn: 1.318 ± 0.045
1.982ProPro: 1.982 ± 0.059
1.136ProGln: 1.136 ± 0.043
1.692ProArg: 1.692 ± 0.05
2.31ProSer: 2.31 ± 0.065
1.988ProThr: 1.988 ± 0.06
3.658ProVal: 3.658 ± 0.092
0.388ProTrp: 0.388 ± 0.03
1.815ProTyr: 1.815 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
1.487GlnAla: 1.487 ± 0.049
0.148GlnCys: 0.148 ± 0.017
0.944GlnAsp: 0.944 ± 0.041
2.356GlnGlu: 2.356 ± 0.067
0.764GlnPhe: 0.764 ± 0.036
1.4GlnGly: 1.4 ± 0.047
0.319GlnHis: 0.319 ± 0.025
1.478GlnIle: 1.478 ± 0.058
1.635GlnLys: 1.635 ± 0.051
2.045GlnLeu: 2.045 ± 0.052
0.447GlnMet: 0.447 ± 0.031
0.839GlnAsn: 0.839 ± 0.039
0.812GlnPro: 0.812 ± 0.044
0.543GlnGln: 0.543 ± 0.035
1.48GlnArg: 1.48 ± 0.052
0.962GlnSer: 0.962 ± 0.042
1.017GlnThr: 1.017 ± 0.044
1.754GlnVal: 1.754 ± 0.055
0.189GlnTrp: 0.189 ± 0.018
0.522GlnTyr: 0.522 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
3.692ArgAla: 3.692 ± 0.086
0.454ArgCys: 0.454 ± 0.031
3.195ArgAsp: 3.195 ± 0.085
7.065ArgGlu: 7.065 ± 0.122
2.955ArgPhe: 2.955 ± 0.067
4.054ArgGly: 4.054 ± 0.095
0.73ArgHis: 0.73 ± 0.034
4.289ArgIle: 4.289 ± 0.082
4.493ArgLys: 4.493 ± 0.088
5.776ArgLeu: 5.776 ± 0.099
1.17ArgMet: 1.17 ± 0.043
1.961ArgAsn: 1.961 ± 0.055
1.485ArgPro: 1.485 ± 0.051
1.031ArgGln: 1.031 ± 0.039
3.713ArgArg: 3.713 ± 0.091
2.493ArgSer: 2.493 ± 0.066
2.212ArgThr: 2.212 ± 0.061
5.067ArgVal: 5.067 ± 0.094
0.664ArgTrp: 0.664 ± 0.035
2.294ArgTyr: 2.294 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
3.275SerAla: 3.275 ± 0.077
0.652SerCys: 0.652 ± 0.044
2.23SerAsp: 2.23 ± 0.073
4.132SerGlu: 4.132 ± 0.08
3.35SerPhe: 3.35 ± 0.098
4.146SerGly: 4.146 ± 0.104
0.858SerHis: 0.858 ± 0.042
3.498SerIle: 3.498 ± 0.079
3.402SerLys: 3.402 ± 0.072
6.937SerLeu: 6.937 ± 0.136
1.3SerMet: 1.3 ± 0.049
1.437SerAsn: 1.437 ± 0.054
2.353SerPro: 2.353 ± 0.06
1.428SerGln: 1.428 ± 0.05
2.68SerArg: 2.68 ± 0.067
3.261SerSer: 3.261 ± 0.101
2.216SerThr: 2.216 ± 0.071
4.315SerVal: 4.315 ± 0.082
0.531SerTrp: 0.531 ± 0.035
2.431SerTyr: 2.431 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
3.044ThrAla: 3.044 ± 0.083
0.438ThrCys: 0.438 ± 0.033
2.135ThrAsp: 2.135 ± 0.062
3.063ThrGlu: 3.063 ± 0.079
2.317ThrPhe: 2.317 ± 0.073
4.023ThrGly: 4.023 ± 0.103
0.819ThrHis: 0.819 ± 0.039
2.474ThrIle: 2.474 ± 0.079
2.465ThrLys: 2.465 ± 0.061
5.379ThrLeu: 5.379 ± 0.103
0.85ThrMet: 0.85 ± 0.038
1.329ThrAsn: 1.329 ± 0.051
2.445ThrPro: 2.445 ± 0.068
1.056ThrGln: 1.056 ± 0.045
1.865ThrArg: 1.865 ± 0.058
2.208ThrSer: 2.208 ± 0.067
2.13ThrThr: 2.13 ± 0.07
3.599ThrVal: 3.599 ± 0.084
0.362ThrTrp: 0.362 ± 0.024
1.941ThrTyr: 1.941 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
5.354ValAla: 5.354 ± 0.12
0.778ValCys: 0.778 ± 0.038
3.761ValAsp: 3.761 ± 0.073
6.499ValGlu: 6.499 ± 0.124
4.132ValPhe: 4.132 ± 0.093
5.794ValGly: 5.794 ± 0.119
1.22ValHis: 1.22 ± 0.037
5.726ValIle: 5.726 ± 0.106
6.556ValLys: 6.556 ± 0.112
8.456ValLeu: 8.456 ± 0.136
1.681ValMet: 1.681 ± 0.059
2.769ValAsn: 2.769 ± 0.077
3.348ValPro: 3.348 ± 0.089
1.674ValGln: 1.674 ± 0.049
4.8ValArg: 4.8 ± 0.094
5.031ValSer: 5.031 ± 0.108
2.871ValThr: 2.871 ± 0.082
7.211ValVal: 7.211 ± 0.12
0.748ValTrp: 0.748 ± 0.037
3.09ValTyr: 3.09 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.613TrpAla: 0.613 ± 0.035
0.093TrpCys: 0.093 ± 0.014
0.515TrpAsp: 0.515 ± 0.031
0.953TrpGlu: 0.953 ± 0.04
0.47TrpPhe: 0.47 ± 0.034
0.766TrpGly: 0.766 ± 0.042
0.164TrpHis: 0.164 ± 0.021
0.68TrpIle: 0.68 ± 0.038
0.826TrpLys: 0.826 ± 0.041
0.951TrpLeu: 0.951 ± 0.047
0.205TrpMet: 0.205 ± 0.017
0.379TrpAsn: 0.379 ± 0.024
0.144TrpPro: 0.144 ± 0.017
0.255TrpGln: 0.255 ± 0.022
0.476TrpArg: 0.476 ± 0.032
0.47TrpSer: 0.47 ± 0.032
0.388TrpThr: 0.388 ± 0.028
0.823TrpVal: 0.823 ± 0.043
0.121TrpTrp: 0.121 ± 0.018
0.285TrpTyr: 0.285 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.207TyrAla: 2.207 ± 0.071
0.331TyrCys: 0.331 ± 0.025
1.868TyrAsp: 1.868 ± 0.06
3.51TyrGlu: 3.51 ± 0.072
1.694TyrPhe: 1.694 ± 0.058
2.819TyrGly: 2.819 ± 0.069
0.661TyrHis: 0.661 ± 0.032
2.654TyrIle: 2.654 ± 0.076
2.201TyrLys: 2.201 ± 0.073
3.966TyrLeu: 3.966 ± 0.096
0.892TyrMet: 0.892 ± 0.039
1.232TyrAsn: 1.232 ± 0.049
1.708TyrPro: 1.708 ± 0.056
0.794TyrGln: 0.794 ± 0.04
2.736TyrArg: 2.736 ± 0.07
2.224TyrSer: 2.224 ± 0.07
1.904TyrThr: 1.904 ± 0.061
2.727TyrVal: 2.727 ± 0.072
0.394TyrTrp: 0.394 ± 0.028
1.434TyrTyr: 1.434 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1885 proteins (561480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski