Amino acid dipepetide frequency for Phenylobacterium hankyongense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.119AlaAla: 23.119 ± 0.247	1.185AlaCys: 1.185 ± 0.036	7.797AlaAsp: 7.797 ± 0.092	8.368AlaGlu: 8.368 ± 0.107	4.837AlaPhe: 4.837 ± 0.072	12.759AlaGly: 12.759 ± 0.132	2.41AlaHis: 2.41 ± 0.055	5.34AlaIle: 5.34 ± 0.077	4.146AlaLys: 4.146 ± 0.083	14.615AlaLeu: 14.615 ± 0.158	3.388AlaMet: 3.388 ± 0.058	2.996AlaAsn: 2.996 ± 0.058	7.89AlaPro: 7.89 ± 0.112	5.062AlaGln: 5.062 ± 0.066	10.815AlaArg: 10.815 ± 0.139	6.574AlaSer: 6.574 ± 0.09	6.413AlaThr: 6.413 ± 0.094	10.09AlaVal: 10.09 ± 0.113	1.984AlaTrp: 1.984 ± 0.042	2.894AlaTyr: 2.894 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.066CysAla: 1.066 ± 0.036	0.086CysCys: 0.086 ± 0.008	0.504CysAsp: 0.504 ± 0.022	0.431CysGlu: 0.431 ± 0.018	0.246CysPhe: 0.246 ± 0.015	0.815CysGly: 0.815 ± 0.032	0.2CysHis: 0.2 ± 0.014	0.27CysIle: 0.27 ± 0.016	0.141CysLys: 0.141 ± 0.012	0.641CysLeu: 0.641 ± 0.023	0.122CysMet: 0.122 ± 0.01	0.158CysAsn: 0.158 ± 0.013	0.39CysPro: 0.39 ± 0.021	0.192CysGln: 0.192 ± 0.012	0.516CysArg: 0.516 ± 0.024	0.356CysSer: 0.356 ± 0.02	0.324CysThr: 0.324 ± 0.017	0.603CysVal: 0.603 ± 0.023	0.089CysTrp: 0.089 ± 0.009	0.155CysTyr: 0.155 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.493AspAla: 7.493 ± 0.088	0.364AspCys: 0.364 ± 0.018	3.006AspAsp: 3.006 ± 0.049	3.214AspGlu: 3.214 ± 0.054	2.037AspPhe: 2.037 ± 0.051	5.367AspGly: 5.367 ± 0.083	1.212AspHis: 1.212 ± 0.035	2.266AspIle: 2.266 ± 0.048	1.458AspLys: 1.458 ± 0.042	6.333AspLeu: 6.333 ± 0.091	1.049AspMet: 1.049 ± 0.034	1.122AspAsn: 1.122 ± 0.034	4.133AspPro: 4.133 ± 0.07	1.965AspGln: 1.965 ± 0.045	4.531AspArg: 4.531 ± 0.071	1.915AspSer: 1.915 ± 0.044	2.479AspThr: 2.479 ± 0.065	4.246AspVal: 4.246 ± 0.069	0.984AspTrp: 0.984 ± 0.028	1.517AspTyr: 1.517 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.734GluAla: 8.734 ± 0.111	0.242GluCys: 0.242 ± 0.014	2.672GluAsp: 2.672 ± 0.057	2.652GluGlu: 2.652 ± 0.053	1.624GluPhe: 1.624 ± 0.044	4.364GluGly: 4.364 ± 0.067	1.156GluHis: 1.156 ± 0.035	2.864GluIle: 2.864 ± 0.053	1.657GluLys: 1.657 ± 0.047	5.46GluLeu: 5.46 ± 0.079	1.304GluMet: 1.304 ± 0.038	1.1GluAsn: 1.1 ± 0.031	3.064GluPro: 3.064 ± 0.06	1.9GluGln: 1.9 ± 0.048	4.974GluArg: 4.974 ± 0.077	2.042GluSer: 2.042 ± 0.047	3.189GluThr: 3.189 ± 0.053	4.186GluVal: 4.186 ± 0.06	0.561GluTrp: 0.561 ± 0.023	0.849GluTyr: 0.849 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.724PheAla: 4.724 ± 0.069	0.357PheCys: 0.357 ± 0.019	2.615PheAsp: 2.615 ± 0.047	2.159PheGlu: 2.159 ± 0.048	1.128PhePhe: 1.128 ± 0.037	3.471PheGly: 3.471 ± 0.062	0.705PheHis: 0.705 ± 0.025	1.297PheIle: 1.297 ± 0.036	0.924PheLys: 0.924 ± 0.025	2.936PheLeu: 2.936 ± 0.065	0.733PheMet: 0.733 ± 0.023	0.996PheAsn: 0.996 ± 0.035	1.509PhePro: 1.509 ± 0.032	1.07PheGln: 1.07 ± 0.028	2.181PheArg: 2.181 ± 0.044	1.921PheSer: 1.921 ± 0.049	1.935PheThr: 1.935 ± 0.045	2.622PheVal: 2.622 ± 0.047	0.46PheTrp: 0.46 ± 0.021	0.854PheTyr: 0.854 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	12.012GlyAla: 12.012 ± 0.139	0.791GlyCys: 0.791 ± 0.027	4.727GlyAsp: 4.727 ± 0.066	5.131GlyGlu: 5.131 ± 0.085	3.581GlyPhe: 3.581 ± 0.056	8.825GlyGly: 8.825 ± 0.14	1.816GlyHis: 1.816 ± 0.043	2.777GlyIle: 2.777 ± 0.052	2.832GlyLys: 2.832 ± 0.06	9.696GlyLeu: 9.696 ± 0.115	2.103GlyMet: 2.103 ± 0.044	1.62GlyAsn: 1.62 ± 0.057	4.748GlyPro: 4.748 ± 0.128	3.395GlyGln: 3.395 ± 0.063	7.353GlyArg: 7.353 ± 0.091	4.437GlySer: 4.437 ± 0.091	3.425GlyThr: 3.425 ± 0.122	7.704GlyVal: 7.704 ± 0.082	1.503GlyTrp: 1.503 ± 0.039	2.375GlyTyr: 2.375 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.472HisAla: 2.472 ± 0.045	0.162HisCys: 0.162 ± 0.012	1.117HisAsp: 1.117 ± 0.031	1.053HisGlu: 1.053 ± 0.03	0.667HisPhe: 0.667 ± 0.025	1.902HisGly: 1.902 ± 0.045	0.515HisHis: 0.515 ± 0.023	0.703HisIle: 0.703 ± 0.025	0.455HisLys: 0.455 ± 0.02	1.873HisLeu: 1.873 ± 0.042	0.457HisMet: 0.457 ± 0.021	0.437HisAsn: 0.437 ± 0.021	1.393HisPro: 1.393 ± 0.033	0.58HisGln: 0.58 ± 0.02	1.336HisArg: 1.336 ± 0.033	0.742HisSer: 0.742 ± 0.025	0.77HisThr: 0.77 ± 0.025	1.404HisVal: 1.404 ± 0.038	0.309HisTrp: 0.309 ± 0.018	0.486HisTyr: 0.486 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.06IleAla: 6.06 ± 0.076	0.395IleCys: 0.395 ± 0.021	2.854IleAsp: 2.854 ± 0.054	2.675IleGlu: 2.675 ± 0.053	1.289IlePhe: 1.289 ± 0.039	3.974IleGly: 3.974 ± 0.061	0.754IleHis: 0.754 ± 0.027	1.373IleIle: 1.373 ± 0.034	1.069IleLys: 1.069 ± 0.035	3.583IleLeu: 3.583 ± 0.058	0.712IleMet: 0.712 ± 0.026	1.065IleAsn: 1.065 ± 0.033	1.991IlePro: 1.991 ± 0.036	1.113IleGln: 1.113 ± 0.032	2.732IleArg: 2.732 ± 0.05	2.225IleSer: 2.225 ± 0.048	2.276IleThr: 2.276 ± 0.044	3.412IleVal: 3.412 ± 0.058	0.512IleTrp: 0.512 ± 0.023	0.88IleTyr: 0.88 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.342LysAla: 4.342 ± 0.079	0.11LysCys: 0.11 ± 0.009	1.559LysAsp: 1.559 ± 0.044	1.12LysGlu: 1.12 ± 0.042	0.803LysPhe: 0.803 ± 0.025	2.545LysGly: 2.545 ± 0.051	0.444LysHis: 0.444 ± 0.021	1.354LysIle: 1.354 ± 0.037	0.859LysLys: 0.859 ± 0.034	3.015LysLeu: 3.015 ± 0.058	0.601LysMet: 0.601 ± 0.024	0.671LysAsn: 0.671 ± 0.029	2.156LysPro: 2.156 ± 0.053	0.789LysGln: 0.789 ± 0.028	2.048LysArg: 2.048 ± 0.049	1.43LysSer: 1.43 ± 0.036	1.868LysThr: 1.868 ± 0.047	2.387LysVal: 2.387 ± 0.052	0.316LysTrp: 0.316 ± 0.018	0.53LysTyr: 0.53 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.35LeuAla: 15.35 ± 0.148	0.758LeuCys: 0.758 ± 0.026	6.02LeuAsp: 6.02 ± 0.089	5.407LeuGlu: 5.407 ± 0.083	3.293LeuPhe: 3.293 ± 0.056	8.606LeuGly: 8.606 ± 0.106	1.762LeuHis: 1.762 ± 0.04	4.293LeuIle: 4.293 ± 0.06	3.655LeuLys: 3.655 ± 0.059	8.606LeuLeu: 8.606 ± 0.12	2.178LeuMet: 2.178 ± 0.04	2.518LeuAsn: 2.518 ± 0.055	5.321LeuPro: 5.321 ± 0.063	2.99LeuGln: 2.99 ± 0.054	7.069LeuArg: 7.069 ± 0.086	5.941LeuSer: 5.941 ± 0.088	5.912LeuThr: 5.912 ± 0.125	7.546LeuVal: 7.546 ± 0.106	1.177LeuTrp: 1.177 ± 0.03	2.055LeuTyr: 2.055 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.193MetAla: 3.193 ± 0.059	0.148MetCys: 0.148 ± 0.013	1.145MetAsp: 1.145 ± 0.037	0.919MetGlu: 0.919 ± 0.026	0.644MetPhe: 0.644 ± 0.026	1.833MetGly: 1.833 ± 0.039	0.367MetHis: 0.367 ± 0.018	1.047MetIle: 1.047 ± 0.031	0.819MetLys: 0.819 ± 0.027	2.03MetLeu: 2.03 ± 0.046	0.473MetMet: 0.473 ± 0.022	0.595MetAsn: 0.595 ± 0.027	1.301MetPro: 1.301 ± 0.035	0.663MetGln: 0.663 ± 0.025	1.655MetArg: 1.655 ± 0.033	1.575MetSer: 1.575 ± 0.041	1.622MetThr: 1.622 ± 0.042	1.448MetVal: 1.448 ± 0.041	0.178MetTrp: 0.178 ± 0.013	0.246MetTyr: 0.246 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.019AsnAla: 3.019 ± 0.057	0.179AsnCys: 0.179 ± 0.015	1.189AsnAsp: 1.189 ± 0.044	0.879AsnGlu: 0.879 ± 0.029	0.84AsnPhe: 0.84 ± 0.029	2.125AsnGly: 2.125 ± 0.05	0.444AsnHis: 0.444 ± 0.022	1.079AsnIle: 1.079 ± 0.036	0.479AsnLys: 0.479 ± 0.025	2.532AsnLeu: 2.532 ± 0.056	0.466AsnMet: 0.466 ± 0.018	0.629AsnAsn: 0.629 ± 0.029	1.687AsnPro: 1.687 ± 0.049	0.696AsnGln: 0.696 ± 0.027	1.573AsnArg: 1.573 ± 0.038	1.048AsnSer: 1.048 ± 0.035	1.204AsnThr: 1.204 ± 0.041	1.806AsnVal: 1.806 ± 0.047	0.305AsnTrp: 0.305 ± 0.02	0.647AsnTyr: 0.647 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	8.201ProAla: 8.201 ± 0.106	0.322ProCys: 0.322 ± 0.016	3.776ProAsp: 3.776 ± 0.06	3.792ProGlu: 3.792 ± 0.064	1.978ProPhe: 1.978 ± 0.045	5.448ProGly: 5.448 ± 0.069	1.101ProHis: 1.101 ± 0.028	2.253ProIle: 2.253 ± 0.045	1.82ProLys: 1.82 ± 0.043	5.026ProLeu: 5.026 ± 0.069	1.234ProMet: 1.234 ± 0.033	1.33ProAsn: 1.33 ± 0.041	3.645ProPro: 3.645 ± 0.074	2.036ProGln: 2.036 ± 0.046	3.538ProArg: 3.538 ± 0.057	2.745ProSer: 2.745 ± 0.049	3.09ProThr: 3.09 ± 0.115	4.285ProVal: 4.285 ± 0.071	0.779ProTrp: 0.779 ± 0.027	1.177ProTyr: 1.177 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.44GlnAla: 5.44 ± 0.079	0.163GlnCys: 0.163 ± 0.013	1.495GlnAsp: 1.495 ± 0.037	1.307GlnGlu: 1.307 ± 0.036	1.002GlnPhe: 1.002 ± 0.03	2.922GlnGly: 2.922 ± 0.057	0.61GlnHis: 0.61 ± 0.021	1.611GlnIle: 1.611 ± 0.048	0.885GlnLys: 0.885 ± 0.032	3.264GlnLeu: 3.264 ± 0.091	0.798GlnMet: 0.798 ± 0.023	0.71GlnAsn: 0.71 ± 0.027	2.087GlnPro: 2.087 ± 0.046	1.135GlnGln: 1.135 ± 0.037	2.374GlnArg: 2.374 ± 0.053	1.554GlnSer: 1.554 ± 0.043	1.854GlnThr: 1.854 ± 0.042	2.798GlnVal: 2.798 ± 0.081	0.367GlnTrp: 0.367 ± 0.019	0.587GlnTyr: 0.587 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.577ArgAla: 9.577 ± 0.127	0.458ArgCys: 0.458 ± 0.021	4.057ArgAsp: 4.057 ± 0.068	4.235ArgGlu: 4.235 ± 0.068	2.871ArgPhe: 2.871 ± 0.048	5.572ArgGly: 5.572 ± 0.086	1.513ArgHis: 1.513 ± 0.034	3.482ArgIle: 3.482 ± 0.054	2.037ArgLys: 2.037 ± 0.043	9.046ArgLeu: 9.046 ± 0.116	1.84ArgMet: 1.84 ± 0.038	1.57ArgAsn: 1.57 ± 0.034	4.406ArgPro: 4.406 ± 0.077	2.575ArgGln: 2.575 ± 0.049	6.715ArgArg: 6.715 ± 0.108	3.468ArgSer: 3.468 ± 0.053	3.791ArgThr: 3.791 ± 0.063	5.052ArgVal: 5.052 ± 0.074	1.171ArgTrp: 1.171 ± 0.034	1.774ArgTyr: 1.774 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.367SerAla: 6.367 ± 0.09	0.322SerCys: 0.322 ± 0.018	2.655SerAsp: 2.655 ± 0.051	2.398SerGlu: 2.398 ± 0.043	1.88SerPhe: 1.88 ± 0.036	5.287SerGly: 5.287 ± 0.091	0.953SerHis: 0.953 ± 0.032	1.953SerIle: 1.953 ± 0.042	1.328SerLys: 1.328 ± 0.035	5.034SerLeu: 5.034 ± 0.08	1.095SerMet: 1.095 ± 0.028	1.213SerAsn: 1.213 ± 0.039	2.967SerPro: 2.967 ± 0.057	1.668SerGln: 1.668 ± 0.047	3.459SerArg: 3.459 ± 0.051	2.426SerSer: 2.426 ± 0.059	2.564SerThr: 2.564 ± 0.144	3.662SerVal: 3.662 ± 0.061	0.752SerTrp: 0.752 ± 0.029	1.212SerTyr: 1.212 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.794ThrAla: 6.794 ± 0.092	0.351ThrCys: 0.351 ± 0.02	2.772ThrAsp: 2.772 ± 0.061	2.286ThrGlu: 2.286 ± 0.043	1.836ThrPhe: 1.836 ± 0.039	5.385ThrGly: 5.385 ± 0.298	0.951ThrHis: 0.951 ± 0.032	2.1ThrIle: 2.1 ± 0.049	1.188ThrLys: 1.188 ± 0.037	5.601ThrLeu: 5.601 ± 0.075	0.915ThrMet: 0.915 ± 0.028	1.219ThrAsn: 1.219 ± 0.05	3.918ThrPro: 3.918 ± 0.069	1.749ThrGln: 1.749 ± 0.173	3.247ThrArg: 3.247 ± 0.058	2.65ThrSer: 2.65 ± 0.072	3.123ThrThr: 3.123 ± 0.232	4.271ThrVal: 4.271 ± 0.07	0.684ThrTrp: 0.684 ± 0.028	1.25ThrTyr: 1.25 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.443ValAla: 10.443 ± 0.111	0.618ValCys: 0.618 ± 0.023	4.448ValAsp: 4.448 ± 0.068	4.764ValGlu: 4.764 ± 0.074	2.698ValPhe: 2.698 ± 0.053	6.396ValGly: 6.396 ± 0.082	1.293ValHis: 1.293 ± 0.037	3.553ValIle: 3.553 ± 0.058	2.206ValLys: 2.206 ± 0.054	7.537ValLeu: 7.537 ± 0.084	1.652ValMet: 1.652 ± 0.042	1.881ValAsn: 1.881 ± 0.036	3.182ValPro: 3.182 ± 0.053	2.253ValGln: 2.253 ± 0.049	5.817ValArg: 5.817 ± 0.08	4.213ValSer: 4.213 ± 0.052	4.572ValThr: 4.572 ± 0.073	6.564ValVal: 6.564 ± 0.09	0.999ValTrp: 0.999 ± 0.032	1.53ValTyr: 1.53 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.51TrpAla: 1.51 ± 0.043	0.113TrpCys: 0.113 ± 0.009	0.683TrpAsp: 0.683 ± 0.023	0.561TrpGlu: 0.561 ± 0.021	0.517TrpPhe: 0.517 ± 0.021	1.008TrpGly: 1.008 ± 0.033	0.221TrpHis: 0.221 ± 0.014	0.643TrpIle: 0.643 ± 0.027	0.426TrpLys: 0.426 ± 0.02	1.544TrpLeu: 1.544 ± 0.04	0.374TrpMet: 0.374 ± 0.017	0.437TrpAsn: 0.437 ± 0.02	0.744TrpPro: 0.744 ± 0.027	0.378TrpGln: 0.378 ± 0.018	1.499TrpArg: 1.499 ± 0.04	0.836TrpSer: 0.836 ± 0.027	0.91TrpThr: 0.91 ± 0.027	0.824TrpVal: 0.824 ± 0.028	0.22TrpTrp: 0.22 ± 0.014	0.241TrpTyr: 0.241 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.765TyrAla: 2.765 ± 0.054	0.182TyrCys: 0.182 ± 0.014	1.599TyrAsp: 1.599 ± 0.041	1.244TyrGlu: 1.244 ± 0.036	0.825TyrPhe: 0.825 ± 0.026	2.245TyrGly: 2.245 ± 0.052	0.405TyrHis: 0.405 ± 0.02	0.688TyrIle: 0.688 ± 0.026	0.562TyrLys: 0.562 ± 0.02	2.088TyrLeu: 2.088 ± 0.042	0.406TyrMet: 0.406 ± 0.018	0.559TyrAsn: 0.559 ± 0.029	1.045TyrPro: 1.045 ± 0.029	0.754TyrGln: 0.754 ± 0.027	1.776TyrArg: 1.776 ± 0.044	1.094TyrSer: 1.094 ± 0.038	0.968TyrThr: 0.968 ± 0.031	1.711TyrVal: 1.711 ± 0.04	0.34TyrTrp: 0.34 ± 0.016	0.571TyrTyr: 0.571 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3638 proteins (1152277 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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