Amino acid dipepetide frequency for Hydrogenothermus marinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.864AlaAla: 2.864 ± 0.099
0.457AlaCys: 0.457 ± 0.031
2.604AlaAsp: 2.604 ± 0.087
3.796AlaGlu: 3.796 ± 0.101
2.856AlaPhe: 2.856 ± 0.084
3.941AlaGly: 3.941 ± 0.098
0.817AlaHis: 0.817 ± 0.043
6.032AlaIle: 6.032 ± 0.136
6.065AlaLys: 6.065 ± 0.127
5.981AlaLeu: 5.981 ± 0.123
1.206AlaMet: 1.206 ± 0.058
2.232AlaAsn: 2.232 ± 0.08
1.544AlaPro: 1.544 ± 0.063
1.321AlaGln: 1.321 ± 0.06
1.904AlaArg: 1.904 ± 0.073
2.834AlaSer: 2.834 ± 0.086
2.684AlaThr: 2.684 ± 0.074
4.109AlaVal: 4.109 ± 0.093
0.362AlaTrp: 0.362 ± 0.026
2.539AlaTyr: 2.539 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.297CysAla: 0.297 ± 0.027
0.084CysCys: 0.084 ± 0.014
0.336CysAsp: 0.336 ± 0.028
0.459CysGlu: 0.459 ± 0.031
0.274CysPhe: 0.274 ± 0.026
0.588CysGly: 0.588 ± 0.04
0.195CysHis: 0.195 ± 0.025
0.534CysIle: 0.534 ± 0.032
0.622CysLys: 0.622 ± 0.036
0.414CysLeu: 0.414 ± 0.03
0.137CysMet: 0.137 ± 0.017
0.383CysAsn: 0.383 ± 0.028
0.444CysPro: 0.444 ± 0.037
0.213CysGln: 0.213 ± 0.023
0.199CysArg: 0.199 ± 0.021
0.448CysSer: 0.448 ± 0.031
0.246CysThr: 0.246 ± 0.023
0.334CysVal: 0.334 ± 0.029
0.053CysTrp: 0.053 ± 0.011
0.268CysTyr: 0.268 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
2.482AspAla: 2.482 ± 0.08
0.348AspCys: 0.348 ± 0.028
1.853AspAsp: 1.853 ± 0.069
3.915AspGlu: 3.915 ± 0.097
3.558AspPhe: 3.558 ± 0.098
2.611AspGly: 2.611 ± 0.079
0.524AspHis: 0.524 ± 0.035
7.664AspIle: 7.664 ± 0.143
5.788AspLys: 5.788 ± 0.119
5.366AspLeu: 5.366 ± 0.101
1.02AspMet: 1.02 ± 0.045
2.391AspAsn: 2.391 ± 0.077
1.82AspPro: 1.82 ± 0.068
0.721AspGln: 0.721 ± 0.032
1.667AspArg: 1.667 ± 0.061
1.941AspSer: 1.941 ± 0.071
2.152AspThr: 2.152 ± 0.066
2.846AspVal: 2.846 ± 0.08
0.51AspTrp: 0.51 ± 0.032
2.748AspTyr: 2.748 ± 0.086
0.0AspXaa: 0.0 ± 0.0
Glu
4.375GluAla: 4.375 ± 0.112
0.405GluCys: 0.405 ± 0.027
4.93GluAsp: 4.93 ± 0.107
8.962GluGlu: 8.962 ± 0.207
3.423GluPhe: 3.423 ± 0.097
4.726GluGly: 4.726 ± 0.111
0.96GluHis: 0.96 ± 0.048
8.73GluIle: 8.73 ± 0.154
12.09GluLys: 12.09 ± 0.195
6.327GluLeu: 6.327 ± 0.135
1.271GluMet: 1.271 ± 0.058
6.331GluAsn: 6.331 ± 0.135
1.57GluPro: 1.57 ± 0.062
1.353GluGln: 1.353 ± 0.054
2.93GluArg: 2.93 ± 0.088
2.899GluSer: 2.899 ± 0.076
3.26GluThr: 3.26 ± 0.095
4.713GluVal: 4.713 ± 0.11
0.487GluTrp: 0.487 ± 0.034
2.969GluTyr: 2.969 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
2.754PheAla: 2.754 ± 0.083
0.369PheCys: 0.369 ± 0.023
2.699PheAsp: 2.699 ± 0.074
3.634PheGlu: 3.634 ± 0.081
2.811PhePhe: 2.811 ± 0.1
3.098PheGly: 3.098 ± 0.085
0.659PheHis: 0.659 ± 0.038
5.379PheIle: 5.379 ± 0.135
4.631PheLys: 4.631 ± 0.113
5.886PheLeu: 5.886 ± 0.161
0.925PheMet: 0.925 ± 0.047
2.617PheAsn: 2.617 ± 0.074
1.828PhePro: 1.828 ± 0.054
1.124PheGln: 1.124 ± 0.054
1.429PheArg: 1.429 ± 0.057
3.536PheSer: 3.536 ± 0.115
2.289PheThr: 2.289 ± 0.065
2.916PheVal: 2.916 ± 0.091
0.477PheTrp: 0.477 ± 0.033
2.426PheTyr: 2.426 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
3.528GlyAla: 3.528 ± 0.109
0.506GlyCys: 0.506 ± 0.042
2.709GlyAsp: 2.709 ± 0.084
3.874GlyGlu: 3.874 ± 0.106
3.554GlyPhe: 3.554 ± 0.091
3.823GlyGly: 3.823 ± 0.117
0.973GlyHis: 0.973 ± 0.056
6.427GlyIle: 6.427 ± 0.134
6.554GlyLys: 6.554 ± 0.118
5.258GlyLeu: 5.258 ± 0.117
1.302GlyMet: 1.302 ± 0.053
2.936GlyAsn: 2.936 ± 0.081
1.081GlyPro: 1.081 ± 0.051
1.308GlyGln: 1.308 ± 0.056
2.191GlyArg: 2.191 ± 0.079
2.928GlySer: 2.928 ± 0.086
2.801GlyThr: 2.801 ± 0.085
3.649GlyVal: 3.649 ± 0.092
0.581GlyTrp: 0.581 ± 0.037
2.928GlyTyr: 2.928 ± 0.086
0.0GlyXaa: 0.0 ± 0.0
His
0.733HisAla: 0.733 ± 0.038
0.119HisCys: 0.119 ± 0.016
0.461HisAsp: 0.461 ± 0.031
0.663HisGlu: 0.663 ± 0.037
0.846HisPhe: 0.846 ± 0.04
0.854HisGly: 0.854 ± 0.043
0.317HisHis: 0.317 ± 0.027
1.531HisIle: 1.531 ± 0.062
1.188HisLys: 1.188 ± 0.049
1.491HisLeu: 1.491 ± 0.056
0.244HisMet: 0.244 ± 0.026
0.633HisAsn: 0.633 ± 0.036
0.817HisPro: 0.817 ± 0.04
0.373HisGln: 0.373 ± 0.026
0.547HisArg: 0.547 ± 0.031
0.698HisSer: 0.698 ± 0.039
0.629HisThr: 0.629 ± 0.039
0.655HisVal: 0.655 ± 0.041
0.113HisTrp: 0.113 ± 0.015
0.627HisTyr: 0.627 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.179IleAla: 6.179 ± 0.122
0.653IleCys: 0.653 ± 0.043
5.972IleAsp: 5.972 ± 0.114
8.186IleGlu: 8.186 ± 0.149
5.489IlePhe: 5.489 ± 0.157
6.011IleGly: 6.011 ± 0.144
1.425IleHis: 1.425 ± 0.051
9.349IleIle: 9.349 ± 0.178
11.488IleLys: 11.488 ± 0.214
10.233IleLeu: 10.233 ± 0.191
1.488IleMet: 1.488 ± 0.053
5.702IleAsn: 5.702 ± 0.121
4.56IlePro: 4.56 ± 0.093
2.258IleGln: 2.258 ± 0.072
3.075IleArg: 3.075 ± 0.087
6.255IleSer: 6.255 ± 0.134
5.047IleThr: 5.047 ± 0.112
5.886IleVal: 5.886 ± 0.132
0.651IleTrp: 0.651 ± 0.037
4.357IleTyr: 4.357 ± 0.111
0.0IleXaa: 0.0 ± 0.0
Lys
6.48LysAla: 6.48 ± 0.111
0.538LysCys: 0.538 ± 0.039
7.156LysAsp: 7.156 ± 0.138
12.737LysGlu: 12.737 ± 0.233
4.171LysPhe: 4.171 ± 0.107
5.934LysGly: 5.934 ± 0.117
1.314LysHis: 1.314 ± 0.054
10.88LysIle: 10.88 ± 0.177
11.912LysLys: 11.912 ± 0.213
9.23LysLeu: 9.23 ± 0.147
1.88LysMet: 1.88 ± 0.064
7.158LysAsn: 7.158 ± 0.169
3.497LysPro: 3.497 ± 0.078
3.038LysGln: 3.038 ± 0.102
3.573LysArg: 3.573 ± 0.093
4.629LysSer: 4.629 ± 0.102
4.605LysThr: 4.605 ± 0.098
6.445LysVal: 6.445 ± 0.121
0.811LysTrp: 0.811 ± 0.04
4.652LysTyr: 4.652 ± 0.118
0.0LysXaa: 0.0 ± 0.0
Leu
5.635LeuAla: 5.635 ± 0.128
0.424LeuCys: 0.424 ± 0.034
4.84LeuAsp: 4.84 ± 0.097
8.061LeuGlu: 8.061 ± 0.142
4.672LeuPhe: 4.672 ± 0.151
5.465LeuGly: 5.465 ± 0.118
1.226LeuHis: 1.226 ± 0.05
8.949LeuIle: 8.949 ± 0.197
11.89LeuLys: 11.89 ± 0.163
7.989LeuLeu: 7.989 ± 0.144
1.683LeuMet: 1.683 ± 0.055
5.6LeuAsn: 5.6 ± 0.13
3.765LeuPro: 3.765 ± 0.097
2.201LeuGln: 2.201 ± 0.067
3.3LeuArg: 3.3 ± 0.089
5.878LeuSer: 5.878 ± 0.117
4.523LeuThr: 4.523 ± 0.083
5.121LeuVal: 5.121 ± 0.101
0.758LeuTrp: 0.758 ± 0.042
3.73LeuTyr: 3.73 ± 0.086
0.0LeuXaa: 0.0 ± 0.0
Met
1.384MetAla: 1.384 ± 0.053
0.098MetCys: 0.098 ± 0.014
0.925MetAsp: 0.925 ± 0.044
1.519MetGlu: 1.519 ± 0.06
0.799MetPhe: 0.799 ± 0.042
1.044MetGly: 1.044 ± 0.046
0.248MetHis: 0.248 ± 0.023
1.574MetIle: 1.574 ± 0.063
2.158MetLys: 2.158 ± 0.071
1.513MetLeu: 1.513 ± 0.058
0.35MetMet: 0.35 ± 0.031
0.776MetAsn: 0.776 ± 0.036
0.766MetPro: 0.766 ± 0.037
0.491MetGln: 0.491 ± 0.031
0.717MetArg: 0.717 ± 0.032
0.946MetSer: 0.946 ± 0.043
0.688MetThr: 0.688 ± 0.036
1.048MetVal: 1.048 ± 0.045
0.156MetTrp: 0.156 ± 0.017
0.624MetTyr: 0.624 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
2.422AsnAla: 2.422 ± 0.071
0.371AsnCys: 0.371 ± 0.03
1.779AsnAsp: 1.779 ± 0.065
3.54AsnGlu: 3.54 ± 0.085
2.879AsnPhe: 2.879 ± 0.087
2.471AsnGly: 2.471 ± 0.074
0.571AsnHis: 0.571 ± 0.037
7.373AsnIle: 7.373 ± 0.154
5.845AsnLys: 5.845 ± 0.129
6.466AsnLeu: 6.466 ± 0.132
0.807AsnMet: 0.807 ± 0.036
2.67AsnAsn: 2.67 ± 0.1
2.813AsnPro: 2.813 ± 0.074
1.579AsnGln: 1.579 ± 0.069
1.57AsnArg: 1.57 ± 0.058
2.4AsnSer: 2.4 ± 0.086
2.301AsnThr: 2.301 ± 0.076
2.75AsnVal: 2.75 ± 0.086
0.528AsnTrp: 0.528 ± 0.037
2.377AsnTyr: 2.377 ± 0.087
0.0AsnXaa: 0.0 ± 0.0
Pro
1.767ProAla: 1.767 ± 0.068
0.233ProCys: 0.233 ± 0.023
2.144ProAsp: 2.144 ± 0.065
3.558ProGlu: 3.558 ± 0.092
1.98ProPhe: 1.98 ± 0.063
1.523ProGly: 1.523 ± 0.068
0.616ProHis: 0.616 ± 0.031
3.427ProIle: 3.427 ± 0.089
3.167ProLys: 3.167 ± 0.086
3.192ProLeu: 3.192 ± 0.087
0.557ProMet: 0.557 ± 0.037
1.648ProAsn: 1.648 ± 0.05
1.288ProPro: 1.288 ± 0.05
0.985ProGln: 0.985 ± 0.043
0.975ProArg: 0.975 ± 0.049
2.004ProSer: 2.004 ± 0.064
1.847ProThr: 1.847 ± 0.061
2.668ProVal: 2.668 ± 0.072
0.258ProTrp: 0.258 ± 0.025
1.753ProTyr: 1.753 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
1.507GlnAla: 1.507 ± 0.063
0.117GlnCys: 0.117 ± 0.016
1.069GlnAsp: 1.069 ± 0.05
2.097GlnGlu: 2.097 ± 0.077
1.067GlnPhe: 1.067 ± 0.04
1.063GlnGly: 1.063 ± 0.039
0.328GlnHis: 0.328 ± 0.026
2.723GlnIle: 2.723 ± 0.084
2.67GlnLys: 2.67 ± 0.074
2.326GlnLeu: 2.326 ± 0.077
0.551GlnMet: 0.551 ± 0.031
1.304GlnAsn: 1.304 ± 0.055
0.772GlnPro: 0.772 ± 0.039
0.698GlnGln: 0.698 ± 0.036
0.88GlnArg: 0.88 ± 0.043
0.917GlnSer: 0.917 ± 0.054
1.071GlnThr: 1.071 ± 0.046
1.48GlnVal: 1.48 ± 0.061
0.197GlnTrp: 0.197 ± 0.02
0.835GlnTyr: 0.835 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
1.744ArgAla: 1.744 ± 0.062
0.192ArgCys: 0.192 ± 0.021
1.665ArgAsp: 1.665 ± 0.058
2.633ArgGlu: 2.633 ± 0.095
1.931ArgPhe: 1.931 ± 0.065
1.853ArgGly: 1.853 ± 0.066
0.491ArgHis: 0.491 ± 0.04
3.133ArgIle: 3.133 ± 0.092
3.712ArgLys: 3.712 ± 0.101
3.223ArgLeu: 3.223 ± 0.081
0.727ArgMet: 0.727 ± 0.043
1.663ArgAsn: 1.663 ± 0.059
1.134ArgPro: 1.134 ± 0.052
0.899ArgGln: 0.899 ± 0.043
1.378ArgArg: 1.378 ± 0.065
1.132ArgSer: 1.132 ± 0.042
1.351ArgThr: 1.351 ± 0.052
1.955ArgVal: 1.955 ± 0.066
0.344ArgTrp: 0.344 ± 0.025
1.534ArgTyr: 1.534 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
2.596SerAla: 2.596 ± 0.078
0.465SerCys: 0.465 ± 0.03
2.369SerAsp: 2.369 ± 0.076
3.192SerGlu: 3.192 ± 0.076
3.294SerPhe: 3.294 ± 0.098
3.1SerGly: 3.1 ± 0.09
0.725SerHis: 0.725 ± 0.042
5.299SerIle: 5.299 ± 0.121
5.026SerLys: 5.026 ± 0.106
5.653SerLeu: 5.653 ± 0.117
1.016SerMet: 1.016 ± 0.046
2.289SerAsn: 2.289 ± 0.076
1.892SerPro: 1.892 ± 0.065
1.394SerGln: 1.394 ± 0.069
1.501SerArg: 1.501 ± 0.059
3.024SerSer: 3.024 ± 0.092
2.217SerThr: 2.217 ± 0.068
2.918SerVal: 2.918 ± 0.079
0.452SerTrp: 0.452 ± 0.031
2.529SerTyr: 2.529 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
2.932ThrAla: 2.932 ± 0.09
0.33ThrCys: 0.33 ± 0.028
2.522ThrAsp: 2.522 ± 0.082
3.055ThrGlu: 3.055 ± 0.089
2.121ThrPhe: 2.121 ± 0.071
3.571ThrGly: 3.571 ± 0.094
0.616ThrHis: 0.616 ± 0.036
3.945ThrIle: 3.945 ± 0.089
4.093ThrLys: 4.093 ± 0.094
4.099ThrLeu: 4.099 ± 0.099
0.627ThrMet: 0.627 ± 0.033
1.847ThrAsn: 1.847 ± 0.061
1.964ThrPro: 1.964 ± 0.071
1.04ThrGln: 1.04 ± 0.039
1.188ThrArg: 1.188 ± 0.047
2.09ThrSer: 2.09 ± 0.07
2.26ThrThr: 2.26 ± 0.073
2.979ThrVal: 2.979 ± 0.091
0.293ThrTrp: 0.293 ± 0.026
1.726ThrTyr: 1.726 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
3.95ValAla: 3.95 ± 0.115
0.434ValCys: 0.434 ± 0.033
3.311ValAsp: 3.311 ± 0.089
4.898ValGlu: 4.898 ± 0.106
2.825ValPhe: 2.825 ± 0.083
4.142ValGly: 4.142 ± 0.115
0.794ValHis: 0.794 ± 0.042
5.798ValIle: 5.798 ± 0.116
6.089ValLys: 6.089 ± 0.11
5.774ValLeu: 5.774 ± 0.119
1.097ValMet: 1.097 ± 0.048
2.746ValAsn: 2.746 ± 0.071
2.015ValPro: 2.015 ± 0.068
1.112ValGln: 1.112 ± 0.047
1.978ValArg: 1.978 ± 0.07
3.733ValSer: 3.733 ± 0.101
1.185ValThr: 1.185 ± 0.063
4.05ValVal: 4.05 ± 0.11
0.483ValTrp: 0.483 ± 0.04
2.598ValTyr: 2.598 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.452TrpAla: 0.452 ± 0.029
0.068TrpCys: 0.068 ± 0.013
0.485TrpAsp: 0.485 ± 0.035
0.698TrpGlu: 0.698 ± 0.039
0.393TrpPhe: 0.393 ± 0.031
0.51TrpGly: 0.51 ± 0.032
0.149TrpHis: 0.149 ± 0.018
0.88TrpIle: 0.88 ± 0.042
0.772TrpLys: 0.772 ± 0.043
0.78TrpLeu: 0.78 ± 0.044
0.158TrpMet: 0.158 ± 0.016
0.412TrpAsn: 0.412 ± 0.028
0.149TrpPro: 0.149 ± 0.02
0.332TrpGln: 0.332 ± 0.025
0.272TrpArg: 0.272 ± 0.026
0.338TrpSer: 0.338 ± 0.028
0.326TrpThr: 0.326 ± 0.03
0.399TrpVal: 0.399 ± 0.03
0.1TrpTrp: 0.1 ± 0.014
0.311TrpTyr: 0.311 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.066TyrAla: 2.066 ± 0.061
0.317TyrCys: 0.317 ± 0.025
2.095TyrAsp: 2.095 ± 0.066
3.237TyrGlu: 3.237 ± 0.072
2.543TyrPhe: 2.543 ± 0.073
2.584TyrGly: 2.584 ± 0.083
0.586TyrHis: 0.586 ± 0.037
4.637TyrIle: 4.637 ± 0.116
4.881TyrLys: 4.881 ± 0.135
4.511TyrLeu: 4.511 ± 0.109
0.778TyrMet: 0.778 ± 0.038
2.176TyrAsn: 2.176 ± 0.07
1.871TyrPro: 1.871 ± 0.065
1.231TyrGln: 1.231 ± 0.053
1.421TyrArg: 1.421 ± 0.059
2.32TyrSer: 2.32 ± 0.077
1.816TyrThr: 1.816 ± 0.062
2.09TyrVal: 2.09 ± 0.066
0.371TyrTrp: 0.371 ± 0.027
2.072TyrTyr: 2.072 ± 0.084
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1621 proteins (488413 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski