Amino acid dipepetide frequency for Streptococcus phage Javan163

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.037AlaAla: 5.037 ± 1.071
0.32AlaCys: 0.32 ± 0.139
5.117AlaAsp: 5.117 ± 0.647
6.636AlaGlu: 6.636 ± 0.716
2.958AlaPhe: 2.958 ± 0.721
4.078AlaGly: 4.078 ± 0.704
0.48AlaHis: 0.48 ± 0.177
6.157AlaIle: 6.157 ± 0.807
6.636AlaLys: 6.636 ± 0.868
7.516AlaLeu: 7.516 ± 0.894
2.239AlaMet: 2.239 ± 0.548
5.757AlaAsn: 5.757 ± 1.016
1.439AlaPro: 1.439 ± 0.337
4.158AlaGln: 4.158 ± 0.713
2.798AlaArg: 2.798 ± 0.555
5.437AlaSer: 5.437 ± 1.042
5.997AlaThr: 5.997 ± 0.956
4.637AlaVal: 4.637 ± 0.844
0.24AlaTrp: 0.24 ± 0.124
3.358AlaTyr: 3.358 ± 0.496
0.0AlaXaa: 0.0 ± 0.0
Cys
0.08CysAla: 0.08 ± 0.074
0.08CysCys: 0.08 ± 0.082
0.16CysAsp: 0.16 ± 0.113
0.48CysGlu: 0.48 ± 0.206
0.16CysPhe: 0.16 ± 0.122
0.32CysGly: 0.32 ± 0.132
0.24CysHis: 0.24 ± 0.128
0.24CysIle: 0.24 ± 0.141
0.4CysLys: 0.4 ± 0.166
0.56CysLeu: 0.56 ± 0.237
0.24CysMet: 0.24 ± 0.129
0.16CysAsn: 0.16 ± 0.111
0.0CysPro: 0.0 ± 0.0
0.24CysGln: 0.24 ± 0.107
0.24CysArg: 0.24 ± 0.147
0.16CysSer: 0.16 ± 0.121
0.08CysThr: 0.08 ± 0.074
0.32CysVal: 0.32 ± 0.159
0.08CysTrp: 0.08 ± 0.081
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.477AspAla: 4.477 ± 0.582
0.0AspCys: 0.0 ± 0.0
3.198AspAsp: 3.198 ± 0.55
4.637AspGlu: 4.637 ± 0.722
3.358AspPhe: 3.358 ± 0.508
5.037AspGly: 5.037 ± 0.693
0.72AspHis: 0.72 ± 0.254
5.357AspIle: 5.357 ± 0.701
5.197AspLys: 5.197 ± 0.795
6.237AspLeu: 6.237 ± 0.971
1.599AspMet: 1.599 ± 0.375
2.559AspAsn: 2.559 ± 0.496
1.439AspPro: 1.439 ± 0.373
1.199AspGln: 1.199 ± 0.318
3.518AspArg: 3.518 ± 0.656
3.198AspSer: 3.198 ± 0.577
3.438AspThr: 3.438 ± 0.6
3.358AspVal: 3.358 ± 0.736
0.8AspTrp: 0.8 ± 0.262
2.878AspTyr: 2.878 ± 0.525
0.0AspXaa: 0.0 ± 0.0
Glu
5.437GluAla: 5.437 ± 0.687
0.16GluCys: 0.16 ± 0.098
3.198GluAsp: 3.198 ± 0.51
6.716GluGlu: 6.716 ± 0.961
2.399GluPhe: 2.399 ± 0.435
3.598GluGly: 3.598 ± 0.534
1.439GluHis: 1.439 ± 0.354
4.957GluIle: 4.957 ± 0.586
6.316GluLys: 6.316 ± 0.893
8.795GluLeu: 8.795 ± 1.419
1.999GluMet: 1.999 ± 0.449
3.518GluAsn: 3.518 ± 0.612
1.999GluPro: 1.999 ± 0.356
2.319GluGln: 2.319 ± 0.491
3.998GluArg: 3.998 ± 0.773
3.758GluSer: 3.758 ± 0.611
3.998GluThr: 3.998 ± 0.596
4.078GluVal: 4.078 ± 0.629
1.039GluTrp: 1.039 ± 0.238
3.198GluTyr: 3.198 ± 0.554
0.0GluXaa: 0.0 ± 0.0
Phe
3.198PheAla: 3.198 ± 0.826
0.24PheCys: 0.24 ± 0.152
2.878PheAsp: 2.878 ± 0.373
3.038PheGlu: 3.038 ± 0.55
1.199PhePhe: 1.199 ± 0.313
2.878PheGly: 2.878 ± 0.561
0.24PheHis: 0.24 ± 0.125
2.399PheIle: 2.399 ± 0.49
3.518PheLys: 3.518 ± 0.726
2.239PheLeu: 2.239 ± 0.556
0.64PheMet: 0.64 ± 0.206
3.038PheAsn: 3.038 ± 0.438
0.48PhePro: 0.48 ± 0.162
0.48PheGln: 0.48 ± 0.161
1.359PheArg: 1.359 ± 0.232
2.159PheSer: 2.159 ± 0.389
2.479PheThr: 2.479 ± 0.405
1.999PheVal: 1.999 ± 0.335
0.64PheTrp: 0.64 ± 0.247
1.359PheTyr: 1.359 ± 0.416
0.0PheXaa: 0.0 ± 0.0
Gly
5.517GlyAla: 5.517 ± 0.753
0.08GlyCys: 0.08 ± 0.082
3.598GlyAsp: 3.598 ± 0.716
3.598GlyGlu: 3.598 ± 0.455
2.399GlyPhe: 2.399 ± 0.56
4.078GlyGly: 4.078 ± 0.492
0.88GlyHis: 0.88 ± 0.29
4.877GlyIle: 4.877 ± 0.983
6.636GlyLys: 6.636 ± 0.742
7.036GlyLeu: 7.036 ± 0.822
2.159GlyMet: 2.159 ± 0.397
2.239GlyAsn: 2.239 ± 0.468
0.959GlyPro: 0.959 ± 0.202
1.999GlyGln: 1.999 ± 0.412
3.278GlyArg: 3.278 ± 0.564
3.358GlySer: 3.358 ± 0.434
4.238GlyThr: 4.238 ± 0.517
4.158GlyVal: 4.158 ± 0.678
0.8GlyTrp: 0.8 ± 0.3
2.559GlyTyr: 2.559 ± 0.569
0.0GlyXaa: 0.0 ± 0.0
His
0.72HisAla: 0.72 ± 0.322
0.16HisCys: 0.16 ± 0.114
0.72HisAsp: 0.72 ± 0.275
1.039HisGlu: 1.039 ± 0.244
0.64HisPhe: 0.64 ± 0.212
0.72HisGly: 0.72 ± 0.234
0.4HisHis: 0.4 ± 0.188
0.72HisIle: 0.72 ± 0.291
0.88HisLys: 0.88 ± 0.289
0.959HisLeu: 0.959 ± 0.321
0.16HisMet: 0.16 ± 0.12
0.48HisAsn: 0.48 ± 0.165
0.8HisPro: 0.8 ± 0.232
0.4HisGln: 0.4 ± 0.2
0.959HisArg: 0.959 ± 0.329
1.199HisSer: 1.199 ± 0.323
1.119HisThr: 1.119 ± 0.324
0.56HisVal: 0.56 ± 0.228
0.08HisTrp: 0.08 ± 0.079
0.56HisTyr: 0.56 ± 0.219
0.0HisXaa: 0.0 ± 0.0
Ile
5.197IleAla: 5.197 ± 0.825
0.24IleCys: 0.24 ± 0.134
7.276IleAsp: 7.276 ± 0.681
5.437IleGlu: 5.437 ± 0.882
1.759IlePhe: 1.759 ± 0.338
3.438IleGly: 3.438 ± 0.654
0.72IleHis: 0.72 ± 0.252
4.957IleIle: 4.957 ± 0.836
7.116IleLys: 7.116 ± 0.839
4.477IleLeu: 4.477 ± 0.673
1.279IleMet: 1.279 ± 0.286
4.158IleAsn: 4.158 ± 0.818
1.759IlePro: 1.759 ± 0.399
2.239IleGln: 2.239 ± 0.604
1.919IleArg: 1.919 ± 0.351
4.477IleSer: 4.477 ± 0.592
5.197IleThr: 5.197 ± 0.649
3.918IleVal: 3.918 ± 0.572
0.4IleTrp: 0.4 ± 0.173
3.598IleTyr: 3.598 ± 0.58
0.0IleXaa: 0.0 ± 0.0
Lys
7.276LysAla: 7.276 ± 0.588
0.32LysCys: 0.32 ± 0.135
5.277LysAsp: 5.277 ± 0.795
5.677LysGlu: 5.677 ± 0.839
2.159LysPhe: 2.159 ± 0.461
5.757LysGly: 5.757 ± 0.983
1.279LysHis: 1.279 ± 0.435
6.396LysIle: 6.396 ± 0.761
7.196LysLys: 7.196 ± 1.056
6.396LysLeu: 6.396 ± 0.762
2.958LysMet: 2.958 ± 0.469
5.757LysAsn: 5.757 ± 0.757
2.718LysPro: 2.718 ± 0.482
3.758LysGln: 3.758 ± 0.68
3.838LysArg: 3.838 ± 0.635
3.598LysSer: 3.598 ± 0.481
4.637LysThr: 4.637 ± 0.914
5.917LysVal: 5.917 ± 1.022
1.519LysTrp: 1.519 ± 0.421
3.518LysTyr: 3.518 ± 0.575
0.0LysXaa: 0.0 ± 0.0
Leu
6.396LeuAla: 6.396 ± 0.742
0.24LeuCys: 0.24 ± 0.13
5.837LeuAsp: 5.837 ± 0.617
7.036LeuGlu: 7.036 ± 1.068
2.798LeuPhe: 2.798 ± 0.462
5.597LeuGly: 5.597 ± 0.819
0.48LeuHis: 0.48 ± 0.222
4.557LeuIle: 4.557 ± 0.578
8.075LeuLys: 8.075 ± 0.947
5.677LeuLeu: 5.677 ± 0.702
2.239LeuMet: 2.239 ± 0.448
5.597LeuAsn: 5.597 ± 0.531
4.078LeuPro: 4.078 ± 0.657
3.838LeuGln: 3.838 ± 0.393
3.438LeuArg: 3.438 ± 0.704
7.596LeuSer: 7.596 ± 0.932
5.517LeuThr: 5.517 ± 0.614
5.197LeuVal: 5.197 ± 0.573
0.8LeuTrp: 0.8 ± 0.275
1.759LeuTyr: 1.759 ± 0.471
0.0LeuXaa: 0.0 ± 0.0
Met
3.278MetAla: 3.278 ± 0.751
0.08MetCys: 0.08 ± 0.074
0.8MetAsp: 0.8 ± 0.255
2.159MetGlu: 2.159 ± 0.402
0.959MetPhe: 0.959 ± 0.287
1.279MetGly: 1.279 ± 0.319
0.24MetHis: 0.24 ± 0.126
1.599MetIle: 1.599 ± 0.296
1.039MetLys: 1.039 ± 0.253
1.759MetLeu: 1.759 ± 0.319
0.64MetMet: 0.64 ± 0.243
1.279MetAsn: 1.279 ± 0.314
0.72MetPro: 0.72 ± 0.177
0.88MetGln: 0.88 ± 0.22
1.199MetArg: 1.199 ± 0.246
2.559MetSer: 2.559 ± 0.617
1.519MetThr: 1.519 ± 0.345
0.88MetVal: 0.88 ± 0.279
0.08MetTrp: 0.08 ± 0.063
0.32MetTyr: 0.32 ± 0.169
0.0MetXaa: 0.0 ± 0.0
Asn
4.238AsnAla: 4.238 ± 0.597
0.16AsnCys: 0.16 ± 0.099
3.038AsnAsp: 3.038 ± 0.406
2.878AsnGlu: 2.878 ± 0.559
2.319AsnPhe: 2.319 ± 0.628
3.838AsnGly: 3.838 ± 0.586
0.88AsnHis: 0.88 ± 0.292
4.318AsnIle: 4.318 ± 0.57
4.158AsnLys: 4.158 ± 0.441
4.877AsnLeu: 4.877 ± 0.595
0.72AsnMet: 0.72 ± 0.185
3.038AsnAsn: 3.038 ± 0.58
2.239AsnPro: 2.239 ± 0.445
1.519AsnGln: 1.519 ± 0.266
1.919AsnArg: 1.919 ± 0.309
4.158AsnSer: 4.158 ± 0.913
2.639AsnThr: 2.639 ± 0.372
2.878AsnVal: 2.878 ± 0.542
0.959AsnTrp: 0.959 ± 0.271
2.399AsnTyr: 2.399 ± 0.532
0.0AsnXaa: 0.0 ± 0.0
Pro
1.919ProAla: 1.919 ± 0.408
0.24ProCys: 0.24 ± 0.129
1.119ProAsp: 1.119 ± 0.343
2.479ProGlu: 2.479 ± 0.467
1.039ProPhe: 1.039 ± 0.384
1.919ProGly: 1.919 ± 0.431
0.32ProHis: 0.32 ± 0.164
1.359ProIle: 1.359 ± 0.352
2.399ProLys: 2.399 ± 0.463
1.759ProLeu: 1.759 ± 0.438
0.4ProMet: 0.4 ± 0.187
1.439ProAsn: 1.439 ± 0.344
0.48ProPro: 0.48 ± 0.192
1.919ProGln: 1.919 ± 0.365
1.439ProArg: 1.439 ± 0.382
1.919ProSer: 1.919 ± 0.302
1.519ProThr: 1.519 ± 0.397
2.399ProVal: 2.399 ± 0.495
0.24ProTrp: 0.24 ± 0.172
0.72ProTyr: 0.72 ± 0.273
0.0ProXaa: 0.0 ± 0.0
Gln
3.598GlnAla: 3.598 ± 0.641
0.16GlnCys: 0.16 ± 0.113
1.999GlnAsp: 1.999 ± 0.365
3.038GlnGlu: 3.038 ± 0.56
1.359GlnPhe: 1.359 ± 0.326
2.878GlnGly: 2.878 ± 0.456
0.72GlnHis: 0.72 ± 0.254
2.958GlnIle: 2.958 ± 0.732
3.598GlnLys: 3.598 ± 0.61
4.078GlnLeu: 4.078 ± 0.707
0.88GlnMet: 0.88 ± 0.281
2.399GlnAsn: 2.399 ± 0.459
0.4GlnPro: 0.4 ± 0.174
1.279GlnGln: 1.279 ± 0.353
0.959GlnArg: 0.959 ± 0.187
3.518GlnSer: 3.518 ± 0.802
2.479GlnThr: 2.479 ± 0.497
1.439GlnVal: 1.439 ± 0.28
0.32GlnTrp: 0.32 ± 0.183
1.039GlnTyr: 1.039 ± 0.363
0.0GlnXaa: 0.0 ± 0.0
Arg
2.958ArgAla: 2.958 ± 0.626
0.32ArgCys: 0.32 ± 0.152
2.479ArgAsp: 2.479 ± 0.485
2.878ArgGlu: 2.878 ± 0.535
2.159ArgPhe: 2.159 ± 0.472
1.919ArgGly: 1.919 ± 0.481
0.959ArgHis: 0.959 ± 0.233
3.358ArgIle: 3.358 ± 0.463
3.518ArgLys: 3.518 ± 0.64
5.117ArgLeu: 5.117 ± 0.896
0.959ArgMet: 0.959 ± 0.313
2.399ArgAsn: 2.399 ± 0.542
0.8ArgPro: 0.8 ± 0.207
1.199ArgGln: 1.199 ± 0.251
1.599ArgArg: 1.599 ± 0.353
2.079ArgSer: 2.079 ± 0.471
2.639ArgThr: 2.639 ± 0.539
2.798ArgVal: 2.798 ± 0.595
0.56ArgTrp: 0.56 ± 0.225
1.679ArgTyr: 1.679 ± 0.385
0.0ArgXaa: 0.0 ± 0.0
Ser
7.036SerAla: 7.036 ± 1.565
0.24SerCys: 0.24 ± 0.151
3.598SerAsp: 3.598 ± 0.77
4.637SerGlu: 4.637 ± 0.51
1.839SerPhe: 1.839 ± 0.475
5.677SerGly: 5.677 ± 0.917
1.039SerHis: 1.039 ± 0.356
4.797SerIle: 4.797 ± 0.746
4.797SerLys: 4.797 ± 0.61
5.597SerLeu: 5.597 ± 1.523
1.279SerMet: 1.279 ± 0.41
2.798SerAsn: 2.798 ± 0.576
1.439SerPro: 1.439 ± 0.277
2.718SerGln: 2.718 ± 0.673
2.479SerArg: 2.479 ± 0.544
5.037SerSer: 5.037 ± 1.488
3.438SerThr: 3.438 ± 0.699
4.957SerVal: 4.957 ± 0.695
0.64SerTrp: 0.64 ± 0.239
2.239SerTyr: 2.239 ± 0.415
0.0SerXaa: 0.0 ± 0.0
Thr
5.597ThrAla: 5.597 ± 0.85
0.48ThrCys: 0.48 ± 0.2
3.918ThrAsp: 3.918 ± 0.526
2.399ThrGlu: 2.399 ± 0.486
2.639ThrPhe: 2.639 ± 0.466
4.717ThrGly: 4.717 ± 0.643
0.64ThrHis: 0.64 ± 0.249
3.998ThrIle: 3.998 ± 0.465
4.717ThrLys: 4.717 ± 0.615
5.037ThrLeu: 5.037 ± 0.63
1.199ThrMet: 1.199 ± 0.342
1.679ThrAsn: 1.679 ± 0.411
1.839ThrPro: 1.839 ± 0.393
3.198ThrGln: 3.198 ± 0.524
2.319ThrArg: 2.319 ± 0.487
4.557ThrSer: 4.557 ± 1.46
4.078ThrThr: 4.078 ± 0.89
4.477ThrVal: 4.477 ± 0.55
0.88ThrTrp: 0.88 ± 0.438
2.399ThrTyr: 2.399 ± 0.494
0.0ThrXaa: 0.0 ± 0.0
Val
5.277ValAla: 5.277 ± 0.503
0.32ValCys: 0.32 ± 0.175
4.717ValAsp: 4.717 ± 0.824
4.477ValGlu: 4.477 ± 0.717
2.239ValPhe: 2.239 ± 0.369
4.078ValGly: 4.078 ± 0.555
0.8ValHis: 0.8 ± 0.226
4.158ValIle: 4.158 ± 0.557
5.037ValLys: 5.037 ± 0.553
4.637ValLeu: 4.637 ± 0.586
1.199ValMet: 1.199 ± 0.316
2.399ValAsn: 2.399 ± 0.408
1.599ValPro: 1.599 ± 0.364
2.479ValGln: 2.479 ± 0.743
2.479ValArg: 2.479 ± 0.409
4.637ValSer: 4.637 ± 0.786
3.278ValThr: 3.278 ± 0.448
4.877ValVal: 4.877 ± 0.637
0.48ValTrp: 0.48 ± 0.176
2.639ValTyr: 2.639 ± 0.623
0.0ValXaa: 0.0 ± 0.0
Trp
0.72TrpAla: 0.72 ± 0.195
0.0TrpCys: 0.0 ± 0.0
1.039TrpAsp: 1.039 ± 0.25
1.119TrpGlu: 1.119 ± 0.284
0.48TrpPhe: 0.48 ± 0.183
0.64TrpGly: 0.64 ± 0.293
0.24TrpHis: 0.24 ± 0.146
0.72TrpIle: 0.72 ± 0.249
0.88TrpLys: 0.88 ± 0.204
0.64TrpLeu: 0.64 ± 0.254
0.0TrpMet: 0.0 ± 0.0
0.48TrpAsn: 0.48 ± 0.17
0.72TrpPro: 0.72 ± 0.336
0.64TrpGln: 0.64 ± 0.222
0.48TrpArg: 0.48 ± 0.232
0.56TrpSer: 0.56 ± 0.228
0.48TrpThr: 0.48 ± 0.249
0.88TrpVal: 0.88 ± 0.353
0.0TrpTrp: 0.0 ± 0.0
0.32TrpTyr: 0.32 ± 0.18
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.038TyrAla: 3.038 ± 0.468
0.4TyrCys: 0.4 ± 0.186
2.239TyrAsp: 2.239 ± 0.554
2.559TyrGlu: 2.559 ± 0.451
1.599TyrPhe: 1.599 ± 0.3
1.999TyrGly: 1.999 ± 0.394
0.56TyrHis: 0.56 ± 0.184
1.679TyrIle: 1.679 ± 0.319
3.838TyrLys: 3.838 ± 0.726
3.358TyrLeu: 3.358 ± 0.587
0.4TyrMet: 0.4 ± 0.155
1.999TyrAsn: 1.999 ± 0.454
1.119TyrPro: 1.119 ± 0.322
2.639TyrGln: 2.639 ± 0.567
2.159TyrArg: 2.159 ± 0.393
2.319TyrSer: 2.319 ± 0.432
2.079TyrThr: 2.079 ± 0.345
2.079TyrVal: 2.079 ± 0.572
0.48TyrTrp: 0.48 ± 0.196
1.839TyrTyr: 1.839 ± 0.352
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (12508 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski