Amino acid dipepetide frequency for Roseomonas mucosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.512AlaAla: 21.512 ± 0.239	1.283AlaCys: 1.283 ± 0.035	5.99AlaAsp: 5.99 ± 0.071	9.452AlaGlu: 9.452 ± 0.099	4.152AlaPhe: 4.152 ± 0.071	13.267AlaGly: 13.267 ± 0.117	2.379AlaHis: 2.379 ± 0.045	5.356AlaIle: 5.356 ± 0.066	2.842AlaLys: 2.842 ± 0.052	16.855AlaLeu: 16.855 ± 0.159	4.098AlaMet: 4.098 ± 0.06	2.226AlaAsn: 2.226 ± 0.051	7.507AlaPro: 7.507 ± 0.103	4.338AlaGln: 4.338 ± 0.067	11.732AlaArg: 11.732 ± 0.117	6.163AlaSer: 6.163 ± 0.081	6.311AlaThr: 6.311 ± 0.074	9.797AlaVal: 9.797 ± 0.096	1.986AlaTrp: 1.986 ± 0.042	2.32AlaTyr: 2.32 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.064CysAla: 1.064 ± 0.025	0.115CysCys: 0.115 ± 0.009	0.506CysAsp: 0.506 ± 0.02	0.396CysGlu: 0.396 ± 0.017	0.311CysPhe: 0.311 ± 0.014	0.974CysGly: 0.974 ± 0.028	0.26CysHis: 0.26 ± 0.016	0.331CysIle: 0.331 ± 0.017	0.098CysLys: 0.098 ± 0.01	0.922CysLeu: 0.922 ± 0.024	0.155CysMet: 0.155 ± 0.011	0.18CysAsn: 0.18 ± 0.011	0.481CysPro: 0.481 ± 0.021	0.179CysGln: 0.179 ± 0.013	0.751CysArg: 0.751 ± 0.025	0.398CysSer: 0.398 ± 0.017	0.416CysThr: 0.416 ± 0.021	0.573CysVal: 0.573 ± 0.022	0.135CysTrp: 0.135 ± 0.011	0.155CysTyr: 0.155 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.554AspAla: 6.554 ± 0.075	0.414AspCys: 0.414 ± 0.018	2.147AspAsp: 2.147 ± 0.046	2.746AspGlu: 2.746 ± 0.053	1.775AspPhe: 1.775 ± 0.034	5.095AspGly: 5.095 ± 0.067	1.055AspHis: 1.055 ± 0.031	2.015AspIle: 2.015 ± 0.039	0.931AspLys: 0.931 ± 0.03	5.752AspLeu: 5.752 ± 0.07	1.135AspMet: 1.135 ± 0.031	0.871AspAsn: 0.871 ± 0.027	4.049AspPro: 4.049 ± 0.056	1.258AspGln: 1.258 ± 0.032	4.39AspArg: 4.39 ± 0.057	1.962AspSer: 1.962 ± 0.035	2.304AspThr: 2.304 ± 0.047	3.297AspVal: 3.297 ± 0.051	1.019AspTrp: 1.019 ± 0.031	1.103AspTyr: 1.103 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	9.979GluAla: 9.979 ± 0.123	0.323GluCys: 0.323 ± 0.016	2.775GluAsp: 2.775 ± 0.047	3.814GluGlu: 3.814 ± 0.063	1.507GluPhe: 1.507 ± 0.034	5.337GluGly: 5.337 ± 0.06	1.133GluHis: 1.133 ± 0.032	2.796GluIle: 2.796 ± 0.049	1.595GluLys: 1.595 ± 0.044	4.939GluLeu: 4.939 ± 0.06	1.568GluMet: 1.568 ± 0.038	1.193GluAsn: 1.193 ± 0.031	2.977GluPro: 2.977 ± 0.058	1.945GluGln: 1.945 ± 0.039	5.476GluArg: 5.476 ± 0.075	2.28GluSer: 2.28 ± 0.047	2.932GluThr: 2.932 ± 0.049	4.175GluVal: 4.175 ± 0.06	0.767GluTrp: 0.767 ± 0.025	0.78GluTyr: 0.78 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.343PheAla: 4.343 ± 0.06	0.368PheCys: 0.368 ± 0.018	2.073PheAsp: 2.073 ± 0.037	1.615PheGlu: 1.615 ± 0.036	1.164PhePhe: 1.164 ± 0.036	3.416PheGly: 3.416 ± 0.052	0.756PheHis: 0.756 ± 0.024	1.138PheIle: 1.138 ± 0.029	0.49PheLys: 0.49 ± 0.018	3.652PheLeu: 3.652 ± 0.055	0.612PheMet: 0.612 ± 0.021	0.802PheAsn: 0.802 ± 0.027	1.755PhePro: 1.755 ± 0.036	0.899PheGln: 0.899 ± 0.028	2.673PheArg: 2.673 ± 0.044	1.786PheSer: 1.786 ± 0.041	1.764PheThr: 1.764 ± 0.035	2.359PheVal: 2.359 ± 0.043	0.552PheTrp: 0.552 ± 0.017	0.653PheTyr: 0.653 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	11.204GlyAla: 11.204 ± 0.107	0.919GlyCys: 0.919 ± 0.027	4.086GlyAsp: 4.086 ± 0.06	5.423GlyGlu: 5.423 ± 0.073	3.848GlyPhe: 3.848 ± 0.055	8.749GlyGly: 8.749 ± 0.09	2.087GlyHis: 2.087 ± 0.046	4.422GlyIle: 4.422 ± 0.059	2.402GlyLys: 2.402 ± 0.047	10.945GlyLeu: 10.945 ± 0.104	2.925GlyMet: 2.925 ± 0.047	1.99GlyAsn: 1.99 ± 0.041	4.62GlyPro: 4.62 ± 0.066	3.258GlyGln: 3.258 ± 0.049	8.036GlyArg: 8.036 ± 0.082	4.526GlySer: 4.526 ± 0.06	5.093GlyThr: 5.093 ± 0.068	6.314GlyVal: 6.314 ± 0.074	1.837GlyTrp: 1.837 ± 0.04	2.007GlyTyr: 2.007 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.66HisAla: 2.66 ± 0.05	0.246HisCys: 0.246 ± 0.014	1.209HisAsp: 1.209 ± 0.026	0.987HisGlu: 0.987 ± 0.027	0.747HisPhe: 0.747 ± 0.028	2.223HisGly: 2.223 ± 0.046	0.586HisHis: 0.586 ± 0.021	0.643HisIle: 0.643 ± 0.022	0.315HisLys: 0.315 ± 0.016	2.269HisLeu: 2.269 ± 0.042	0.447HisMet: 0.447 ± 0.017	0.389HisAsn: 0.389 ± 0.019	1.652HisPro: 1.652 ± 0.036	0.497HisGln: 0.497 ± 0.018	1.736HisArg: 1.736 ± 0.036	0.857HisSer: 0.857 ± 0.029	0.754HisThr: 0.754 ± 0.026	1.463HisVal: 1.463 ± 0.033	0.376HisTrp: 0.376 ± 0.015	0.456HisTyr: 0.456 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.229IleAla: 6.229 ± 0.072	0.382IleCys: 0.382 ± 0.017	2.097IleAsp: 2.097 ± 0.042	2.42IleGlu: 2.42 ± 0.045	1.107IlePhe: 1.107 ± 0.03	4.306IleGly: 4.306 ± 0.062	0.768IleHis: 0.768 ± 0.022	1.231IleIle: 1.231 ± 0.038	0.677IleLys: 0.677 ± 0.025	4.232IleLeu: 4.232 ± 0.06	0.702IleMet: 0.702 ± 0.026	0.842IleAsn: 0.842 ± 0.026	2.362IlePro: 2.362 ± 0.046	1.006IleGln: 1.006 ± 0.024	3.183IleArg: 3.183 ± 0.048	1.788IleSer: 1.788 ± 0.039	2.042IleThr: 2.042 ± 0.041	2.971IleVal: 2.971 ± 0.053	0.473IleTrp: 0.473 ± 0.019	0.759IleTyr: 0.759 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.902LysAla: 2.902 ± 0.059	0.1LysCys: 0.1 ± 0.009	1.084LysAsp: 1.084 ± 0.031	1.086LysGlu: 1.086 ± 0.033	0.452LysPhe: 0.452 ± 0.022	1.988LysGly: 1.988 ± 0.041	0.388LysHis: 0.388 ± 0.018	0.854LysIle: 0.854 ± 0.028	0.544LysLys: 0.544 ± 0.022	2.297LysLeu: 2.297 ± 0.048	0.408LysMet: 0.408 ± 0.017	0.425LysAsn: 0.425 ± 0.019	1.547LysPro: 1.547 ± 0.041	0.636LysGln: 0.636 ± 0.022	1.763LysArg: 1.763 ± 0.037	0.991LysSer: 0.991 ± 0.032	1.067LysThr: 1.067 ± 0.03	1.712LysVal: 1.712 ± 0.044	0.2LysTrp: 0.2 ± 0.011	0.332LysTyr: 0.332 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	17.215LeuAla: 17.215 ± 0.142	1.092LeuCys: 1.092 ± 0.031	6.108LeuAsp: 6.108 ± 0.073	5.908LeuGlu: 5.908 ± 0.073	3.348LeuPhe: 3.348 ± 0.053	10.183LeuGly: 10.183 ± 0.093	2.259LeuHis: 2.259 ± 0.043	3.744LeuIle: 3.744 ± 0.054	2.227LeuLys: 2.227 ± 0.044	13.03LeuLeu: 13.03 ± 0.149	2.223LeuMet: 2.223 ± 0.046	2.184LeuAsn: 2.184 ± 0.042	7.89LeuPro: 7.89 ± 0.095	2.74LeuGln: 2.74 ± 0.045	10.534LeuArg: 10.534 ± 0.103	6.403LeuSer: 6.403 ± 0.078	5.089LeuThr: 5.089 ± 0.064	8.021LeuVal: 8.021 ± 0.083	1.427LeuTrp: 1.427 ± 0.038	1.939LeuTyr: 1.939 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.429MetAla: 3.429 ± 0.049	0.131MetCys: 0.131 ± 0.01	1.096MetAsp: 1.096 ± 0.031	1.257MetGlu: 1.257 ± 0.032	0.542MetPhe: 0.542 ± 0.022	1.908MetGly: 1.908 ± 0.037	0.376MetHis: 0.376 ± 0.017	0.977MetIle: 0.977 ± 0.027	0.601MetLys: 0.601 ± 0.023	2.791MetLeu: 2.791 ± 0.049	0.557MetMet: 0.557 ± 0.023	0.603MetAsn: 0.603 ± 0.024	1.769MetPro: 1.769 ± 0.035	0.804MetGln: 0.804 ± 0.024	2.076MetArg: 2.076 ± 0.037	1.465MetSer: 1.465 ± 0.035	1.471MetThr: 1.471 ± 0.034	1.704MetVal: 1.704 ± 0.035	0.183MetTrp: 0.183 ± 0.011	0.261MetTyr: 0.261 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.573AsnAla: 2.573 ± 0.05	0.187AsnCys: 0.187 ± 0.012	0.951AsnAsp: 0.951 ± 0.03	0.824AsnGlu: 0.824 ± 0.025	0.689AsnPhe: 0.689 ± 0.022	1.929AsnGly: 1.929 ± 0.042	0.441AsnHis: 0.441 ± 0.019	0.913AsnIle: 0.913 ± 0.028	0.392AsnLys: 0.392 ± 0.019	2.389AsnLeu: 2.389 ± 0.045	0.465AsnMet: 0.465 ± 0.023	0.493AsnAsn: 0.493 ± 0.021	1.645AsnPro: 1.645 ± 0.034	0.55AsnGln: 0.55 ± 0.021	1.676AsnArg: 1.676 ± 0.037	0.866AsnSer: 0.866 ± 0.029	1.049AsnThr: 1.049 ± 0.028	1.447AsnVal: 1.447 ± 0.035	0.354AsnTrp: 0.354 ± 0.017	0.448AsnTyr: 0.448 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	8.721ProAla: 8.721 ± 0.104	0.365ProCys: 0.365 ± 0.016	3.94ProAsp: 3.94 ± 0.051	4.933ProGlu: 4.933 ± 0.068	2.045ProPhe: 2.045 ± 0.048	7.033ProGly: 7.033 ± 0.092	1.246ProHis: 1.246 ± 0.027	1.797ProIle: 1.797 ± 0.035	1.186ProLys: 1.186 ± 0.03	6.159ProLeu: 6.159 ± 0.08	1.32ProMet: 1.32 ± 0.033	1.158ProAsn: 1.158 ± 0.029	4.305ProPro: 4.305 ± 0.08	1.782ProGln: 1.782 ± 0.037	4.319ProArg: 4.319 ± 0.057	2.8ProSer: 2.8 ± 0.045	2.245ProThr: 2.245 ± 0.045	5.184ProVal: 5.184 ± 0.063	0.983ProTrp: 0.983 ± 0.03	1.129ProTyr: 1.129 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.762GlnAla: 4.762 ± 0.066	0.158GlnCys: 0.158 ± 0.012	1.516GlnAsp: 1.516 ± 0.032	1.555GlnGlu: 1.555 ± 0.03	0.836GlnPhe: 0.836 ± 0.028	2.966GlnGly: 2.966 ± 0.053	0.624GlnHis: 0.624 ± 0.02	1.343GlnIle: 1.343 ± 0.032	0.706GlnLys: 0.706 ± 0.027	2.394GlnLeu: 2.394 ± 0.042	0.672GlnMet: 0.672 ± 0.022	0.67GlnAsn: 0.67 ± 0.024	2.03GlnPro: 2.03 ± 0.042	1.129GlnGln: 1.129 ± 0.035	2.66GlnArg: 2.66 ± 0.053	1.358GlnSer: 1.358 ± 0.035	1.255GlnThr: 1.255 ± 0.032	2.4GlnVal: 2.4 ± 0.045	0.34GlnTrp: 0.34 ± 0.016	0.466GlnTyr: 0.466 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.459ArgAla: 10.459 ± 0.096	0.655ArgCys: 0.655 ± 0.025	4.69ArgAsp: 4.69 ± 0.06	5.063ArgGlu: 5.063 ± 0.065	3.318ArgPhe: 3.318 ± 0.054	6.385ArgGly: 6.385 ± 0.069	2.149ArgHis: 2.149 ± 0.037	4.058ArgIle: 4.058 ± 0.061	1.791ArgLys: 1.791 ± 0.039	10.646ArgLeu: 10.646 ± 0.108	2.152ArgMet: 2.152 ± 0.041	1.811ArgAsn: 1.811 ± 0.039	5.09ArgPro: 5.09 ± 0.072	3.036ArgGln: 3.036 ± 0.054	8.283ArgArg: 8.283 ± 0.092	3.615ArgSer: 3.615 ± 0.055	3.376ArgThr: 3.376 ± 0.051	5.486ArgVal: 5.486 ± 0.069	1.31ArgTrp: 1.31 ± 0.035	1.629ArgTyr: 1.629 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.691SerAla: 5.691 ± 0.067	0.396SerCys: 0.396 ± 0.019	2.161SerAsp: 2.161 ± 0.04	2.165SerGlu: 2.165 ± 0.044	1.995SerPhe: 1.995 ± 0.039	5.408SerGly: 5.408 ± 0.078	0.987SerHis: 0.987 ± 0.026	1.922SerIle: 1.922 ± 0.038	0.817SerLys: 0.817 ± 0.03	5.547SerLeu: 5.547 ± 0.075	1.053SerMet: 1.053 ± 0.025	0.976SerAsn: 0.976 ± 0.028	3.043SerPro: 3.043 ± 0.048	1.354SerGln: 1.354 ± 0.033	3.742SerArg: 3.742 ± 0.049	2.232SerSer: 2.232 ± 0.044	2.2SerThr: 2.2 ± 0.04	3.374SerVal: 3.374 ± 0.056	0.834SerTrp: 0.834 ± 0.028	0.998SerTyr: 0.998 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.2ThrAla: 6.2 ± 0.073	0.353ThrCys: 0.353 ± 0.016	2.285ThrAsp: 2.285 ± 0.045	2.522ThrGlu: 2.522 ± 0.046	1.374ThrPhe: 1.374 ± 0.035	5.216ThrGly: 5.216 ± 0.066	0.947ThrHis: 0.947 ± 0.028	1.938ThrIle: 1.938 ± 0.037	0.871ThrLys: 0.871 ± 0.027	5.882ThrLeu: 5.882 ± 0.072	1.004ThrMet: 1.004 ± 0.026	0.942ThrAsn: 0.942 ± 0.028	3.466ThrPro: 3.466 ± 0.055	1.239ThrGln: 1.239 ± 0.035	3.458ThrArg: 3.458 ± 0.056	2.019ThrSer: 2.019 ± 0.042	2.273ThrThr: 2.273 ± 0.044	4.013ThrVal: 4.013 ± 0.066	0.587ThrTrp: 0.587 ± 0.023	0.956ThrTyr: 0.956 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.075ValAla: 10.075 ± 0.091	0.571ValCys: 0.571 ± 0.021	3.341ValAsp: 3.341 ± 0.05	4.472ValGlu: 4.472 ± 0.062	2.496ValPhe: 2.496 ± 0.045	5.278ValGly: 5.278 ± 0.07	1.301ValHis: 1.301 ± 0.03	2.989ValIle: 2.989 ± 0.052	1.537ValLys: 1.537 ± 0.04	8.976ValLeu: 8.976 ± 0.094	1.783ValMet: 1.783 ± 0.044	1.676ValAsn: 1.676 ± 0.036	4.568ValPro: 4.568 ± 0.066	2.103ValGln: 2.103 ± 0.044	5.266ValArg: 5.266 ± 0.064	3.777ValSer: 3.777 ± 0.051	4.307ValThr: 4.307 ± 0.062	6.14ValVal: 6.14 ± 0.085	0.933ValTrp: 0.933 ± 0.026	1.067ValTyr: 1.067 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.553TrpAla: 1.553 ± 0.038	0.155TrpCys: 0.155 ± 0.011	0.659TrpAsp: 0.659 ± 0.02	0.683TrpGlu: 0.683 ± 0.025	0.521TrpPhe: 0.521 ± 0.021	1.093TrpGly: 1.093 ± 0.033	0.385TrpHis: 0.385 ± 0.018	0.551TrpIle: 0.551 ± 0.02	0.397TrpLys: 0.397 ± 0.018	1.979TrpLeu: 1.979 ± 0.038	0.383TrpMet: 0.383 ± 0.019	0.437TrpAsn: 0.437 ± 0.019	0.919TrpPro: 0.919 ± 0.026	0.591TrpGln: 0.591 ± 0.019	1.582TrpArg: 1.582 ± 0.037	0.794TrpSer: 0.794 ± 0.025	0.746TrpThr: 0.746 ± 0.022	0.919TrpVal: 0.919 ± 0.028	0.263TrpTrp: 0.263 ± 0.016	0.26TrpTyr: 0.26 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.442TyrAla: 2.442 ± 0.041	0.185TyrCys: 0.185 ± 0.01	1.16TyrAsp: 1.16 ± 0.029	0.97TyrGlu: 0.97 ± 0.027	0.645TyrPhe: 0.645 ± 0.023	1.937TyrGly: 1.937 ± 0.045	0.386TyrHis: 0.386 ± 0.016	0.559TyrIle: 0.559 ± 0.021	0.356TyrLys: 0.356 ± 0.018	1.91TyrLeu: 1.91 ± 0.043	0.339TyrMet: 0.339 ± 0.015	0.412TyrAsn: 0.412 ± 0.016	0.973TyrPro: 0.973 ± 0.027	0.495TyrGln: 0.495 ± 0.019	1.669TyrArg: 1.669 ± 0.034	0.816TyrSer: 0.816 ± 0.03	0.85TyrThr: 0.85 ± 0.031	1.305TyrVal: 1.305 ± 0.03	0.311TyrTrp: 0.311 ± 0.016	0.422TyrTyr: 0.422 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4204 proteins (1351983 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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