Amino acid dipepetide frequency for Sebaldella termitidis (strain ATCC 33386 / NCTC 11300)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.692AlaAla: 4.692 ± 0.083	0.499AlaCys: 0.499 ± 0.022	3.464AlaAsp: 3.464 ± 0.056	4.618AlaGlu: 4.618 ± 0.073	2.421AlaPhe: 2.421 ± 0.047	5.764AlaGly: 5.764 ± 0.118	0.671AlaHis: 0.671 ± 0.023	4.012AlaIle: 4.012 ± 0.068	4.324AlaLys: 4.324 ± 0.065	5.307AlaLeu: 5.307 ± 0.08	1.394AlaMet: 1.394 ± 0.039	2.545AlaAsn: 2.545 ± 0.057	1.398AlaPro: 1.398 ± 0.036	1.344AlaGln: 1.344 ± 0.036	1.765AlaArg: 1.765 ± 0.045	3.24AlaSer: 3.24 ± 0.066	2.44AlaThr: 2.44 ± 0.07	5.267AlaVal: 5.267 ± 0.072	0.37AlaTrp: 0.37 ± 0.018	2.187AlaTyr: 2.187 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.338CysAla: 0.338 ± 0.015	0.1CysCys: 0.1 ± 0.01	0.408CysAsp: 0.408 ± 0.023	0.465CysGlu: 0.465 ± 0.023	0.369CysPhe: 0.369 ± 0.016	0.732CysGly: 0.732 ± 0.031	0.151CysHis: 0.151 ± 0.013	0.686CysIle: 0.686 ± 0.025	0.533CysLys: 0.533 ± 0.028	0.612CysLeu: 0.612 ± 0.027	0.191CysMet: 0.191 ± 0.013	0.344CysAsn: 0.344 ± 0.019	0.314CysPro: 0.314 ± 0.019	0.133CysGln: 0.133 ± 0.009	0.3CysArg: 0.3 ± 0.017	0.531CysSer: 0.531 ± 0.022	0.406CysThr: 0.406 ± 0.02	0.43CysVal: 0.43 ± 0.02	0.056CysTrp: 0.056 ± 0.007	0.25CysTyr: 0.25 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	2.495AspAla: 2.495 ± 0.053	0.368AspCys: 0.368 ± 0.018	2.476AspAsp: 2.476 ± 0.052	4.154AspGlu: 4.154 ± 0.076	3.244AspPhe: 3.244 ± 0.059	3.826AspGly: 3.826 ± 0.079	0.624AspHis: 0.624 ± 0.027	5.935AspIle: 5.935 ± 0.078	5.046AspLys: 5.046 ± 0.073	4.672AspLeu: 4.672 ± 0.071	1.446AspMet: 1.446 ± 0.034	3.426AspAsn: 3.426 ± 0.065	1.594AspPro: 1.594 ± 0.044	1.028AspGln: 1.028 ± 0.027	1.996AspArg: 1.996 ± 0.043	3.625AspSer: 3.625 ± 0.053	2.752AspThr: 2.752 ± 0.055	2.912AspVal: 2.912 ± 0.054	0.465AspTrp: 0.465 ± 0.021	2.883AspTyr: 2.883 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	4.197GluAla: 4.197 ± 0.071	0.426GluCys: 0.426 ± 0.02	3.915GluAsp: 3.915 ± 0.064	6.549GluGlu: 6.549 ± 0.109	3.24GluPhe: 3.24 ± 0.065	3.791GluGly: 3.791 ± 0.061	0.866GluHis: 0.866 ± 0.025	7.922GluIle: 7.922 ± 0.113	9.24GluLys: 9.24 ± 0.137	7.059GluLeu: 7.059 ± 0.096	1.941GluMet: 1.941 ± 0.044	6.538GluAsn: 6.538 ± 0.077	1.35GluPro: 1.35 ± 0.04	1.618GluGln: 1.618 ± 0.046	2.745GluArg: 2.745 ± 0.056	3.613GluSer: 3.613 ± 0.055	3.633GluThr: 3.633 ± 0.053	4.202GluVal: 4.202 ± 0.067	0.603GluTrp: 0.603 ± 0.023	3.598GluTyr: 3.598 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.24PheAla: 2.24 ± 0.049	0.427PheCys: 0.427 ± 0.022	2.755PheAsp: 2.755 ± 0.056	3.23PheGlu: 3.23 ± 0.053	2.455PhePhe: 2.455 ± 0.066	3.228PheGly: 3.228 ± 0.059	0.682PheHis: 0.682 ± 0.025	4.259PheIle: 4.259 ± 0.088	3.141PheLys: 3.141 ± 0.064	4.74PheLeu: 4.74 ± 0.099	1.248PheMet: 1.248 ± 0.035	2.487PheAsn: 2.487 ± 0.05	1.298PhePro: 1.298 ± 0.042	1.142PheGln: 1.142 ± 0.028	1.513PheArg: 1.513 ± 0.034	3.76PheSer: 3.76 ± 0.066	2.43PheThr: 2.43 ± 0.041	2.364PheVal: 2.364 ± 0.054	0.375PheTrp: 0.375 ± 0.02	2.174PheTyr: 2.174 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.497GlyAla: 4.497 ± 0.107	0.545GlyCys: 0.545 ± 0.022	3.58GlyAsp: 3.58 ± 0.071	4.621GlyGlu: 4.621 ± 0.068	3.139GlyPhe: 3.139 ± 0.063	5.111GlyGly: 5.111 ± 0.104	1.006GlyHis: 1.006 ± 0.031	8.042GlyIle: 8.042 ± 0.133	6.304GlyLys: 6.304 ± 0.089	5.672GlyLeu: 5.672 ± 0.081	1.999GlyMet: 1.999 ± 0.045	4.751GlyAsn: 4.751 ± 0.127	1.128GlyPro: 1.128 ± 0.04	1.617GlyGln: 1.617 ± 0.049	2.265GlyArg: 2.265 ± 0.047	4.783GlySer: 4.783 ± 0.126	5.214GlyThr: 5.214 ± 0.204	5.058GlyVal: 5.058 ± 0.109	0.517GlyTrp: 0.517 ± 0.021	3.201GlyTyr: 3.201 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	0.661HisAla: 0.661 ± 0.021	0.116HisCys: 0.116 ± 0.011	0.65HisAsp: 0.65 ± 0.026	0.852HisGlu: 0.852 ± 0.033	0.628HisPhe: 0.628 ± 0.027	1.094HisGly: 1.094 ± 0.032	0.241HisHis: 0.241 ± 0.016	1.187HisIle: 1.187 ± 0.036	0.945HisLys: 0.945 ± 0.029	1.08HisLeu: 1.08 ± 0.037	0.316HisMet: 0.316 ± 0.018	0.814HisAsn: 0.814 ± 0.025	0.492HisPro: 0.492 ± 0.02	0.277HisGln: 0.277 ± 0.018	0.457HisArg: 0.457 ± 0.02	0.816HisSer: 0.816 ± 0.026	0.778HisThr: 0.778 ± 0.021	0.675HisVal: 0.675 ± 0.024	0.111HisTrp: 0.111 ± 0.009	0.515HisTyr: 0.515 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.053IleAla: 5.053 ± 0.071	0.749IleCys: 0.749 ± 0.028	5.054IleAsp: 5.054 ± 0.076	6.523IleGlu: 6.523 ± 0.084	4.592IlePhe: 4.592 ± 0.089	5.964IleGly: 5.964 ± 0.092	1.089IleHis: 1.089 ± 0.031	8.469IleIle: 8.469 ± 0.112	8.276IleLys: 8.276 ± 0.11	8.988IleLeu: 8.988 ± 0.121	2.084IleMet: 2.084 ± 0.044	6.33IleAsn: 6.33 ± 0.12	3.112IlePro: 3.112 ± 0.057	2.04IleGln: 2.04 ± 0.043	2.881IleArg: 2.881 ± 0.052	6.425IleSer: 6.425 ± 0.074	5.547IleThr: 5.547 ± 0.104	4.835IleVal: 4.835 ± 0.065	0.6IleTrp: 0.6 ± 0.024	4.004IleTyr: 4.004 ± 0.07	0.0IleXaa: 0.0 ± 0.0
Lys	4.849LysAla: 4.849 ± 0.078	0.489LysCys: 0.489 ± 0.025	5.282LysAsp: 5.282 ± 0.076	8.364LysGlu: 8.364 ± 0.126	3.377LysPhe: 3.377 ± 0.075	4.925LysGly: 4.925 ± 0.063	0.992LysHis: 0.992 ± 0.027	9.013LysIle: 9.013 ± 0.101	9.136LysLys: 9.136 ± 0.159	7.202LysLeu: 7.202 ± 0.104	2.478LysMet: 2.478 ± 0.05	7.262LysAsn: 7.262 ± 0.099	1.998LysPro: 1.998 ± 0.04	1.906LysGln: 1.906 ± 0.044	2.876LysArg: 2.876 ± 0.058	4.672LysSer: 4.672 ± 0.075	4.538LysThr: 4.538 ± 0.064	4.874LysVal: 4.874 ± 0.075	0.648LysTrp: 0.648 ± 0.024	4.332LysTyr: 4.332 ± 0.082	0.0LysXaa: 0.0 ± 0.0
Leu	5.326LeuAla: 5.326 ± 0.08	0.665LeuCys: 0.665 ± 0.026	5.101LeuAsp: 5.101 ± 0.069	7.235LeuGlu: 7.235 ± 0.09	4.017LeuPhe: 4.017 ± 0.081	6.411LeuGly: 6.411 ± 0.099	1.134LeuHis: 1.134 ± 0.03	7.303LeuIle: 7.303 ± 0.111	8.439LeuLys: 8.439 ± 0.122	7.651LeuLeu: 7.651 ± 0.115	2.198LeuMet: 2.198 ± 0.047	5.697LeuAsn: 5.697 ± 0.072	2.591LeuPro: 2.591 ± 0.056	1.863LeuGln: 1.863 ± 0.038	2.927LeuArg: 2.927 ± 0.055	5.951LeuSer: 5.951 ± 0.083	4.893LeuThr: 4.893 ± 0.063	4.606LeuVal: 4.606 ± 0.062	0.602LeuTrp: 0.602 ± 0.021	3.344LeuTyr: 3.344 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.558MetAla: 1.558 ± 0.037	0.166MetCys: 0.166 ± 0.011	1.257MetAsp: 1.257 ± 0.034	2.056MetGlu: 2.056 ± 0.049	0.952MetPhe: 0.952 ± 0.029	1.671MetGly: 1.671 ± 0.035	0.278MetHis: 0.278 ± 0.016	1.969MetIle: 1.969 ± 0.047	2.952MetLys: 2.952 ± 0.062	2.207MetLeu: 2.207 ± 0.049	0.572MetMet: 0.572 ± 0.026	1.533MetAsn: 1.533 ± 0.034	0.8MetPro: 0.8 ± 0.028	0.546MetGln: 0.546 ± 0.023	0.873MetArg: 0.873 ± 0.031	1.475MetSer: 1.475 ± 0.03	1.421MetThr: 1.421 ± 0.035	1.308MetVal: 1.308 ± 0.036	0.154MetTrp: 0.154 ± 0.012	0.936MetTyr: 0.936 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.264AsnAla: 3.264 ± 0.066	0.426AsnCys: 0.426 ± 0.022	3.232AsnAsp: 3.232 ± 0.051	4.235AsnGlu: 4.235 ± 0.07	2.906AsnPhe: 2.906 ± 0.064	5.109AsnGly: 5.109 ± 0.154	0.724AsnHis: 0.724 ± 0.023	7.224AsnIle: 7.224 ± 0.101	5.495AsnLys: 5.495 ± 0.07	5.376AsnLeu: 5.376 ± 0.071	1.547AsnMet: 1.547 ± 0.033	4.995AsnAsn: 4.995 ± 0.121	2.176AsnPro: 2.176 ± 0.039	1.4AsnGln: 1.4 ± 0.043	1.918AsnArg: 1.918 ± 0.061	4.891AsnSer: 4.891 ± 0.135	3.774AsnThr: 3.774 ± 0.109	3.7AsnVal: 3.7 ± 0.08	0.474AsnTrp: 0.474 ± 0.022	2.894AsnTyr: 2.894 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	1.751ProAla: 1.751 ± 0.044	0.204ProCys: 0.204 ± 0.011	1.818ProAsp: 1.818 ± 0.041	2.837ProGlu: 2.837 ± 0.057	1.285ProPhe: 1.285 ± 0.039	1.915ProGly: 1.915 ± 0.044	0.433ProHis: 0.433 ± 0.023	1.671ProIle: 1.671 ± 0.042	1.856ProLys: 1.856 ± 0.046	2.256ProLeu: 2.256 ± 0.045	0.564ProMet: 0.564 ± 0.021	1.34ProAsn: 1.34 ± 0.036	0.546ProPro: 0.546 ± 0.022	0.651ProGln: 0.651 ± 0.022	0.729ProArg: 0.729 ± 0.026	1.563ProSer: 1.563 ± 0.051	1.283ProThr: 1.283 ± 0.035	2.55ProVal: 2.55 ± 0.049	0.205ProTrp: 0.205 ± 0.014	1.164ProTyr: 1.164 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	1.308GlnAla: 1.308 ± 0.029	0.143GlnCys: 0.143 ± 0.012	1.091GlnAsp: 1.091 ± 0.03	1.809GlnGlu: 1.809 ± 0.041	0.837GlnPhe: 0.837 ± 0.026	1.517GlnGly: 1.517 ± 0.037	0.236GlnHis: 0.236 ± 0.012	2.074GlnIle: 2.074 ± 0.041	2.252GlnLys: 2.252 ± 0.044	1.793GlnLeu: 1.793 ± 0.042	0.637GlnMet: 0.637 ± 0.023	1.678GlnAsn: 1.678 ± 0.064	0.495GlnPro: 0.495 ± 0.02	0.537GlnGln: 0.537 ± 0.024	0.839GlnArg: 0.839 ± 0.028	1.276GlnSer: 1.276 ± 0.031	1.129GlnThr: 1.129 ± 0.027	1.303GlnVal: 1.303 ± 0.034	0.151GlnTrp: 0.151 ± 0.012	0.923GlnTyr: 0.923 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	1.766ArgAla: 1.766 ± 0.039	0.247ArgCys: 0.247 ± 0.015	1.799ArgAsp: 1.799 ± 0.057	3.136ArgGlu: 3.136 ± 0.06	1.368ArgPhe: 1.368 ± 0.039	1.956ArgGly: 1.956 ± 0.043	0.501ArgHis: 0.501 ± 0.02	3.061ArgIle: 3.061 ± 0.061	3.152ArgLys: 3.152 ± 0.063	2.865ArgLeu: 2.865 ± 0.056	0.848ArgMet: 0.848 ± 0.03	2.196ArgAsn: 2.196 ± 0.045	0.772ArgPro: 0.772 ± 0.027	0.791ArgGln: 0.791 ± 0.03	1.187ArgArg: 1.187 ± 0.036	1.533ArgSer: 1.533 ± 0.033	1.611ArgThr: 1.611 ± 0.036	1.999ArgVal: 1.999 ± 0.037	0.239ArgTrp: 0.239 ± 0.014	1.537ArgTyr: 1.537 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.666SerAla: 3.666 ± 0.072	0.56SerCys: 0.56 ± 0.023	3.695SerAsp: 3.695 ± 0.049	4.576SerGlu: 4.576 ± 0.065	3.221SerPhe: 3.221 ± 0.06	6.195SerGly: 6.195 ± 0.144	0.837SerHis: 0.837 ± 0.028	5.318SerIle: 5.318 ± 0.084	4.855SerLys: 4.855 ± 0.067	5.458SerLeu: 5.458 ± 0.073	1.45SerMet: 1.45 ± 0.035	3.477SerAsn: 3.477 ± 0.086	1.566SerPro: 1.566 ± 0.036	1.462SerGln: 1.462 ± 0.034	2.096SerArg: 2.096 ± 0.042	4.516SerSer: 4.516 ± 0.099	3.162SerThr: 3.162 ± 0.087	4.394SerVal: 4.394 ± 0.073	0.466SerTrp: 0.466 ± 0.027	2.636SerTyr: 2.636 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.23ThrAla: 4.23 ± 0.109	0.282ThrCys: 0.282 ± 0.016	3.246ThrAsp: 3.246 ± 0.084	3.901ThrGlu: 3.901 ± 0.064	2.285ThrPhe: 2.285 ± 0.046	6.021ThrGly: 6.021 ± 0.201	0.684ThrHis: 0.684 ± 0.025	4.396ThrIle: 4.396 ± 0.101	3.609ThrLys: 3.609 ± 0.053	4.695ThrLeu: 4.695 ± 0.071	1.104ThrMet: 1.104 ± 0.033	2.947ThrAsn: 2.947 ± 0.1	1.91ThrPro: 1.91 ± 0.049	1.126ThrGln: 1.126 ± 0.031	1.479ThrArg: 1.479 ± 0.035	3.088ThrSer: 3.088 ± 0.08	2.655ThrThr: 2.655 ± 0.09	4.037ThrVal: 4.037 ± 0.083	0.367ThrTrp: 0.367 ± 0.019	2.075ThrTyr: 2.075 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	3.079ValAla: 3.079 ± 0.059	0.536ValCys: 0.536 ± 0.021	3.08ValAsp: 3.08 ± 0.054	4.005ValGlu: 4.005 ± 0.07	3.036ValPhe: 3.036 ± 0.058	4.005ValGly: 4.005 ± 0.1	0.8ValHis: 0.8 ± 0.027	5.864ValIle: 5.864 ± 0.079	5.276ValLys: 5.276 ± 0.073	5.819ValLeu: 5.819 ± 0.08	1.444ValMet: 1.444 ± 0.036	3.892ValAsn: 3.892 ± 0.081	1.802ValPro: 1.802 ± 0.039	1.3ValGln: 1.3 ± 0.032	1.954ValArg: 1.954 ± 0.039	4.248ValSer: 4.248 ± 0.063	3.671ValThr: 3.671 ± 0.097	3.497ValVal: 3.497 ± 0.07	0.425ValTrp: 0.425 ± 0.019	2.867ValTyr: 2.867 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.377TrpAla: 0.377 ± 0.018	0.071TrpCys: 0.071 ± 0.008	0.41TrpAsp: 0.41 ± 0.019	0.568TrpGlu: 0.568 ± 0.022	0.38TrpPhe: 0.38 ± 0.02	0.478TrpGly: 0.478 ± 0.021	0.127TrpHis: 0.127 ± 0.011	0.606TrpIle: 0.606 ± 0.023	0.622TrpLys: 0.622 ± 0.023	0.615TrpLeu: 0.615 ± 0.024	0.173TrpMet: 0.173 ± 0.011	0.493TrpAsn: 0.493 ± 0.02	0.155TrpPro: 0.155 ± 0.011	0.263TrpGln: 0.263 ± 0.014	0.241TrpArg: 0.241 ± 0.014	0.441TrpSer: 0.441 ± 0.019	0.371TrpThr: 0.371 ± 0.024	0.374TrpVal: 0.374 ± 0.017	0.098TrpTrp: 0.098 ± 0.01	0.388TrpTyr: 0.388 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.376TyrAla: 2.376 ± 0.056	0.332TyrCys: 0.332 ± 0.019	2.655TyrAsp: 2.655 ± 0.054	3.309TyrGlu: 3.309 ± 0.055	2.197TyrPhe: 2.197 ± 0.055	3.336TyrGly: 3.336 ± 0.074	0.63TyrHis: 0.63 ± 0.024	3.605TyrIle: 3.605 ± 0.061	3.761TyrLys: 3.761 ± 0.06	3.887TyrLeu: 3.887 ± 0.064	1.049TyrMet: 1.049 ± 0.028	3.017TyrAsn: 3.017 ± 0.052	1.123TyrPro: 1.123 ± 0.036	0.983TyrGln: 0.983 ± 0.027	1.522TyrArg: 1.522 ± 0.036	3.159TyrSer: 3.159 ± 0.058	2.429TyrThr: 2.429 ± 0.068	2.215TyrVal: 2.215 ± 0.036	0.326TyrTrp: 0.326 ± 0.016	2.264TyrTyr: 2.264 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4124 proteins (1275552 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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