Amino acid dipepetide frequency for Pseudodesulfovibrio mercurii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.882AlaAla: 11.882 ± 0.144	1.534AlaCys: 1.534 ± 0.045	6.111AlaAsp: 6.111 ± 0.084	6.896AlaGlu: 6.896 ± 0.09	3.958AlaPhe: 3.958 ± 0.07	8.986AlaGly: 8.986 ± 0.108	1.913AlaHis: 1.913 ± 0.043	4.531AlaIle: 4.531 ± 0.072	3.944AlaLys: 3.944 ± 0.069	11.193AlaLeu: 11.193 ± 0.122	3.435AlaMet: 3.435 ± 0.059	2.421AlaAsn: 2.421 ± 0.054	4.283AlaPro: 4.283 ± 0.081	2.934AlaGln: 2.934 ± 0.058	7.107AlaArg: 7.107 ± 0.105	4.593AlaSer: 4.593 ± 0.067	4.457AlaThr: 4.457 ± 0.07	8.327AlaVal: 8.327 ± 0.097	1.352AlaTrp: 1.352 ± 0.037	2.558AlaTyr: 2.558 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.318CysAla: 1.318 ± 0.04	0.247CysCys: 0.247 ± 0.019	0.642CysAsp: 0.642 ± 0.025	0.633CysGlu: 0.633 ± 0.025	0.492CysPhe: 0.492 ± 0.021	1.367CysGly: 1.367 ± 0.041	0.416CysHis: 0.416 ± 0.028	0.636CysIle: 0.636 ± 0.026	0.433CysLys: 0.433 ± 0.021	1.415CysLeu: 1.415 ± 0.039	0.335CysMet: 0.335 ± 0.016	0.358CysAsn: 0.358 ± 0.019	0.881CysPro: 0.881 ± 0.033	0.279CysGln: 0.279 ± 0.017	0.925CysArg: 0.925 ± 0.032	0.678CysSer: 0.678 ± 0.026	0.631CysThr: 0.631 ± 0.026	0.887CysVal: 0.887 ± 0.024	0.153CysTrp: 0.153 ± 0.012	0.327CysTyr: 0.327 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.561AspAla: 5.561 ± 0.085	0.651AspCys: 0.651 ± 0.027	3.21AspAsp: 3.21 ± 0.072	4.106AspGlu: 4.106 ± 0.071	2.576AspPhe: 2.576 ± 0.047	5.075AspGly: 5.075 ± 0.087	1.228AspHis: 1.228 ± 0.041	3.436AspIle: 3.436 ± 0.065	2.746AspLys: 2.746 ± 0.052	6.174AspLeu: 6.174 ± 0.09	1.928AspMet: 1.928 ± 0.043	1.737AspAsn: 1.737 ± 0.037	3.329AspPro: 3.329 ± 0.056	1.71AspGln: 1.71 ± 0.043	4.169AspArg: 4.169 ± 0.069	2.315AspSer: 2.315 ± 0.046	2.671AspThr: 2.671 ± 0.056	4.27AspVal: 4.27 ± 0.07	0.796AspTrp: 0.796 ± 0.03	1.881AspTyr: 1.881 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.032GluAla: 7.032 ± 0.097	0.602GluCys: 0.602 ± 0.026	3.49GluAsp: 3.49 ± 0.064	4.225GluGlu: 4.225 ± 0.079	2.282GluPhe: 2.282 ± 0.053	4.513GluGly: 4.513 ± 0.068	1.314GluHis: 1.314 ± 0.034	3.596GluIle: 3.596 ± 0.065	3.148GluLys: 3.148 ± 0.062	6.438GluLeu: 6.438 ± 0.094	1.843GluMet: 1.843 ± 0.037	2.045GluAsn: 2.045 ± 0.046	2.917GluPro: 2.917 ± 0.055	2.181GluGln: 2.181 ± 0.05	4.616GluArg: 4.616 ± 0.079	2.919GluSer: 2.919 ± 0.057	3.612GluThr: 3.612 ± 0.052	4.405GluVal: 4.405 ± 0.065	0.621GluTrp: 0.621 ± 0.025	1.699GluTyr: 1.699 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.857PheAla: 3.857 ± 0.064	0.609PheCys: 0.609 ± 0.025	2.645PheAsp: 2.645 ± 0.047	2.432PheGlu: 2.432 ± 0.044	1.83PhePhe: 1.83 ± 0.046	3.442PheGly: 3.442 ± 0.06	0.867PheHis: 0.867 ± 0.03	2.03PheIle: 2.03 ± 0.047	1.611PheLys: 1.611 ± 0.041	4.559PheLeu: 4.559 ± 0.079	1.12PheMet: 1.12 ± 0.032	1.271PheAsn: 1.271 ± 0.035	1.767PhePro: 1.767 ± 0.041	1.066PheGln: 1.066 ± 0.03	2.381PheArg: 2.381 ± 0.045	2.346PheSer: 2.346 ± 0.048	2.417PheThr: 2.417 ± 0.049	2.928PheVal: 2.928 ± 0.056	0.544PheTrp: 0.544 ± 0.025	1.156PheTyr: 1.156 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.375GlyAla: 7.375 ± 0.091	1.313GlyCys: 1.313 ± 0.04	4.48GlyAsp: 4.48 ± 0.08	5.121GlyGlu: 5.121 ± 0.07	3.678GlyPhe: 3.678 ± 0.064	6.692GlyGly: 6.692 ± 0.096	1.731GlyHis: 1.731 ± 0.045	4.342GlyIle: 4.342 ± 0.062	3.943GlyLys: 3.943 ± 0.069	9.548GlyLeu: 9.548 ± 0.106	2.739GlyMet: 2.739 ± 0.048	2.32GlyAsn: 2.32 ± 0.053	3.298GlyPro: 3.298 ± 0.061	2.611GlyGln: 2.611 ± 0.052	5.804GlyArg: 5.804 ± 0.074	4.092GlySer: 4.092 ± 0.073	4.319GlyThr: 4.319 ± 0.066	6.422GlyVal: 6.422 ± 0.091	1.158GlyTrp: 1.158 ± 0.033	2.513GlyTyr: 2.513 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.823HisAla: 1.823 ± 0.04	0.335HisCys: 0.335 ± 0.018	1.198HisAsp: 1.198 ± 0.034	1.147HisGlu: 1.147 ± 0.038	0.949HisPhe: 0.949 ± 0.033	1.811HisGly: 1.811 ± 0.041	0.483HisHis: 0.483 ± 0.024	1.001HisIle: 1.001 ± 0.03	0.682HisLys: 0.682 ± 0.026	2.096HisLeu: 2.096 ± 0.045	0.552HisMet: 0.552 ± 0.023	0.595HisAsn: 0.595 ± 0.022	1.354HisPro: 1.354 ± 0.034	0.54HisGln: 0.54 ± 0.021	1.268HisArg: 1.268 ± 0.04	0.888HisSer: 0.888 ± 0.029	0.932HisThr: 0.932 ± 0.031	1.362HisVal: 1.362 ± 0.038	0.271HisTrp: 0.271 ± 0.016	0.636HisTyr: 0.636 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.716IleAla: 4.716 ± 0.07	0.677IleCys: 0.677 ± 0.024	2.923IleAsp: 2.923 ± 0.056	3.206IleGlu: 3.206 ± 0.059	2.036IlePhe: 2.036 ± 0.041	4.215IleGly: 4.215 ± 0.069	1.069IleHis: 1.069 ± 0.034	2.758IleIle: 2.758 ± 0.057	2.128IleLys: 2.128 ± 0.051	5.628IleLeu: 5.628 ± 0.08	1.374IleMet: 1.374 ± 0.039	1.639IleAsn: 1.639 ± 0.044	2.73IlePro: 2.73 ± 0.051	1.428IleGln: 1.428 ± 0.035	3.495IleArg: 3.495 ± 0.053	2.803IleSer: 2.803 ± 0.049	2.671IleThr: 2.671 ± 0.054	3.675IleVal: 3.675 ± 0.063	0.534IleTrp: 0.534 ± 0.022	1.254IleTyr: 1.254 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.576LysAla: 4.576 ± 0.069	0.417LysCys: 0.417 ± 0.021	2.514LysAsp: 2.514 ± 0.061	2.779LysGlu: 2.779 ± 0.058	1.334LysPhe: 1.334 ± 0.035	3.545LysGly: 3.545 ± 0.062	0.726LysHis: 0.726 ± 0.027	2.231LysIle: 2.231 ± 0.044	2.372LysLys: 2.372 ± 0.066	3.95LysLeu: 3.95 ± 0.065	1.176LysMet: 1.176 ± 0.029	1.369LysAsn: 1.369 ± 0.035	2.113LysPro: 2.113 ± 0.049	1.3LysGln: 1.3 ± 0.037	2.829LysArg: 2.829 ± 0.051	2.122LysSer: 2.122 ± 0.044	2.457LysThr: 2.457 ± 0.049	3.216LysVal: 3.216 ± 0.061	0.444LysTrp: 0.444 ± 0.021	1.209LysTyr: 1.209 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	12.488LeuAla: 12.488 ± 0.133	1.455LeuCys: 1.455 ± 0.038	6.971LeuAsp: 6.971 ± 0.081	6.217LeuGlu: 6.217 ± 0.082	4.49LeuPhe: 4.49 ± 0.083	8.816LeuGly: 8.816 ± 0.093	1.976LeuHis: 1.976 ± 0.043	4.936LeuIle: 4.936 ± 0.082	4.862LeuLys: 4.862 ± 0.077	10.814LeuLeu: 10.814 ± 0.133	2.61LeuMet: 2.61 ± 0.051	3.234LeuAsn: 3.234 ± 0.055	5.378LeuPro: 5.378 ± 0.088	2.399LeuGln: 2.399 ± 0.043	6.282LeuArg: 6.282 ± 0.077	6.063LeuSer: 6.063 ± 0.07	6.006LeuThr: 6.006 ± 0.079	7.662LeuVal: 7.662 ± 0.096	1.119LeuTrp: 1.119 ± 0.035	2.52LeuTyr: 2.52 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.332MetAla: 3.332 ± 0.056	0.264MetCys: 0.264 ± 0.014	1.92MetAsp: 1.92 ± 0.041	1.767MetGlu: 1.767 ± 0.044	0.91MetPhe: 0.91 ± 0.031	2.352MetGly: 2.352 ± 0.054	0.558MetHis: 0.558 ± 0.022	1.365MetIle: 1.365 ± 0.034	1.305MetLys: 1.305 ± 0.031	2.655MetLeu: 2.655 ± 0.053	0.547MetMet: 0.547 ± 0.024	0.976MetAsn: 0.976 ± 0.028	1.495MetPro: 1.495 ± 0.036	0.887MetGln: 0.887 ± 0.029	1.785MetArg: 1.785 ± 0.041	1.693MetSer: 1.693 ± 0.036	1.779MetThr: 1.779 ± 0.041	2.102MetVal: 2.102 ± 0.044	0.2MetTrp: 0.2 ± 0.013	0.551MetTyr: 0.551 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.789AsnAla: 2.789 ± 0.051	0.442AsnCys: 0.442 ± 0.02	1.54AsnAsp: 1.54 ± 0.043	1.601AsnGlu: 1.601 ± 0.037	1.16AsnPhe: 1.16 ± 0.029	2.344AsnGly: 2.344 ± 0.045	0.537AsnHis: 0.537 ± 0.021	1.742AsnIle: 1.742 ± 0.039	1.175AsnLys: 1.175 ± 0.031	3.175AsnLeu: 3.175 ± 0.054	0.853AsnMet: 0.853 ± 0.029	0.911AsnAsn: 0.911 ± 0.041	1.938AsnPro: 1.938 ± 0.045	0.889AsnGln: 0.889 ± 0.027	2.025AsnArg: 2.025 ± 0.047	1.277AsnSer: 1.277 ± 0.038	1.435AsnThr: 1.435 ± 0.04	2.209AsnVal: 2.209 ± 0.053	0.405AsnTrp: 0.405 ± 0.019	0.859AsnTyr: 0.859 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.267ProAla: 5.267 ± 0.095	0.543ProCys: 0.543 ± 0.024	3.891ProAsp: 3.891 ± 0.059	4.441ProGlu: 4.441 ± 0.074	2.082ProPhe: 2.082 ± 0.039	4.607ProGly: 4.607 ± 0.074	0.912ProHis: 0.912 ± 0.026	1.947ProIle: 1.947 ± 0.049	1.795ProLys: 1.795 ± 0.04	4.689ProLeu: 4.689 ± 0.069	1.262ProMet: 1.262 ± 0.032	1.187ProAsn: 1.187 ± 0.031	2.072ProPro: 2.072 ± 0.048	1.294ProGln: 1.294 ± 0.038	2.598ProArg: 2.598 ± 0.045	2.317ProSer: 2.317 ± 0.045	2.05ProThr: 2.05 ± 0.044	4.375ProVal: 4.375 ± 0.064	0.672ProTrp: 0.672 ± 0.025	1.282ProTyr: 1.282 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.589GlnAla: 3.589 ± 0.074	0.351GlnCys: 0.351 ± 0.022	1.481GlnAsp: 1.481 ± 0.03	1.715GlnGlu: 1.715 ± 0.04	1.034GlnPhe: 1.034 ± 0.029	2.463GlnGly: 2.463 ± 0.045	0.52GlnHis: 0.52 ± 0.022	1.408GlnIle: 1.408 ± 0.038	1.223GlnLys: 1.223 ± 0.035	2.675GlnLeu: 2.675 ± 0.049	0.794GlnMet: 0.794 ± 0.026	0.84GlnAsn: 0.84 ± 0.03	1.269GlnPro: 1.269 ± 0.039	0.92GlnGln: 0.92 ± 0.035	1.784GlnArg: 1.784 ± 0.039	1.458GlnSer: 1.458 ± 0.036	1.511GlnThr: 1.511 ± 0.034	2.165GlnVal: 2.165 ± 0.043	0.379GlnTrp: 0.379 ± 0.022	0.802GlnTyr: 0.802 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.09ArgAla: 6.09 ± 0.095	0.784ArgCys: 0.784 ± 0.03	3.967ArgAsp: 3.967 ± 0.064	4.957ArgGlu: 4.957 ± 0.069	2.949ArgPhe: 2.949 ± 0.057	4.218ArgGly: 4.218 ± 0.073	1.456ArgHis: 1.456 ± 0.042	3.87ArgIle: 3.87 ± 0.062	3.118ArgLys: 3.118 ± 0.05	7.178ArgLeu: 7.178 ± 0.104	1.897ArgMet: 1.897 ± 0.041	2.055ArgAsn: 2.055 ± 0.046	3.187ArgPro: 3.187 ± 0.061	2.098ArgGln: 2.098 ± 0.052	4.692ArgArg: 4.692 ± 0.074	3.098ArgSer: 3.098 ± 0.056	3.589ArgThr: 3.589 ± 0.068	4.331ArgVal: 4.331 ± 0.066	0.683ArgTrp: 0.683 ± 0.027	1.862ArgTyr: 1.862 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.535SerAla: 4.535 ± 0.073	0.596SerCys: 0.596 ± 0.026	2.719SerAsp: 2.719 ± 0.057	2.701SerGlu: 2.701 ± 0.053	2.064SerPhe: 2.064 ± 0.044	5.144SerGly: 5.144 ± 0.063	0.971SerHis: 0.971 ± 0.03	2.661SerIle: 2.661 ± 0.056	1.871SerLys: 1.871 ± 0.038	5.771SerLeu: 5.771 ± 0.078	1.563SerMet: 1.563 ± 0.041	1.289SerAsn: 1.289 ± 0.041	2.598SerPro: 2.598 ± 0.042	1.356SerGln: 1.356 ± 0.037	3.303SerArg: 3.303 ± 0.054	2.545SerSer: 2.545 ± 0.058	2.41SerThr: 2.41 ± 0.056	3.821SerVal: 3.821 ± 0.062	0.628SerTrp: 0.628 ± 0.024	1.218SerTyr: 1.218 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.088ThrAla: 5.088 ± 0.072	0.645ThrCys: 0.645 ± 0.024	2.994ThrAsp: 2.994 ± 0.053	2.709ThrGlu: 2.709 ± 0.059	2.101ThrPhe: 2.101 ± 0.043	5.228ThrGly: 5.228 ± 0.068	0.96ThrHis: 0.96 ± 0.03	2.711ThrIle: 2.711 ± 0.059	1.714ThrLys: 1.714 ± 0.04	5.811ThrLeu: 5.811 ± 0.085	1.397ThrMet: 1.397 ± 0.033	1.354ThrAsn: 1.354 ± 0.037	3.126ThrPro: 3.126 ± 0.047	1.276ThrGln: 1.276 ± 0.033	3.098ThrArg: 3.098 ± 0.056	2.454ThrSer: 2.454 ± 0.047	2.64ThrThr: 2.64 ± 0.061	4.448ThrVal: 4.448 ± 0.072	0.632ThrTrp: 0.632 ± 0.025	1.397ThrTyr: 1.397 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	7.326ValAla: 7.326 ± 0.1	1.073ValCys: 1.073 ± 0.027	4.509ValAsp: 4.509 ± 0.068	4.711ValGlu: 4.711 ± 0.076	3.167ValPhe: 3.167 ± 0.056	5.469ValGly: 5.469 ± 0.072	1.475ValHis: 1.475 ± 0.037	4.03ValIle: 4.03 ± 0.07	2.974ValLys: 2.974 ± 0.059	8.329ValLeu: 8.329 ± 0.101	1.991ValMet: 1.991 ± 0.05	2.464ValAsn: 2.464 ± 0.051	3.544ValPro: 3.544 ± 0.061	2.027ValGln: 2.027 ± 0.039	5.265ValArg: 5.265 ± 0.081	4.141ValSer: 4.141 ± 0.065	4.112ValThr: 4.112 ± 0.063	6.09ValVal: 6.09 ± 0.09	0.792ValTrp: 0.792 ± 0.029	1.879ValTyr: 1.879 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.096TrpAla: 1.096 ± 0.036	0.141TrpCys: 0.141 ± 0.012	0.691TrpAsp: 0.691 ± 0.027	0.682TrpGlu: 0.682 ± 0.027	0.538TrpPhe: 0.538 ± 0.023	0.954TrpGly: 0.954 ± 0.036	0.231TrpHis: 0.231 ± 0.014	0.54TrpIle: 0.54 ± 0.024	0.583TrpLys: 0.583 ± 0.025	1.391TrpLeu: 1.391 ± 0.042	0.333TrpMet: 0.333 ± 0.017	0.408TrpAsn: 0.408 ± 0.017	0.65TrpPro: 0.65 ± 0.024	0.426TrpGln: 0.426 ± 0.019	0.806TrpArg: 0.806 ± 0.032	0.568TrpSer: 0.568 ± 0.025	0.682TrpThr: 0.682 ± 0.024	0.776TrpVal: 0.776 ± 0.026	0.222TrpTrp: 0.222 ± 0.013	0.311TrpTyr: 0.311 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.678TyrAla: 2.678 ± 0.056	0.374TyrCys: 0.374 ± 0.019	1.675TyrAsp: 1.675 ± 0.048	1.45TyrGlu: 1.45 ± 0.041	1.248TyrPhe: 1.248 ± 0.037	2.261TyrGly: 2.261 ± 0.048	0.578TyrHis: 0.578 ± 0.022	1.188TyrIle: 1.188 ± 0.036	1.052TyrLys: 1.052 ± 0.035	2.807TyrLeu: 2.807 ± 0.051	0.696TyrMet: 0.696 ± 0.023	0.83TyrAsn: 0.83 ± 0.024	1.352TyrPro: 1.352 ± 0.036	0.763TyrGln: 0.763 ± 0.025	1.845TyrArg: 1.845 ± 0.044	1.393TyrSer: 1.393 ± 0.036	1.4TyrThr: 1.4 ± 0.041	1.898TyrVal: 1.898 ± 0.045	0.425TyrTrp: 0.425 ± 0.026	0.878TyrTyr: 0.878 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3451 proteins (1132766 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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