Amino acid dipepetide frequency for I612045 virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.764AlaAla: 1.764 ± 1.936
0.504AlaCys: 0.504 ± 0.454
2.268AlaAsp: 2.268 ± 0.483
3.528AlaGlu: 3.528 ± 0.373
1.008AlaPhe: 1.008 ± 0.289
2.772AlaGly: 2.772 ± 1.155
1.26AlaHis: 1.26 ± 0.447
4.032AlaIle: 4.032 ± 0.917
5.544AlaLys: 5.544 ± 1.41
4.536AlaLeu: 4.536 ± 0.627
1.764AlaMet: 1.764 ± 0.357
2.772AlaAsn: 2.772 ± 0.369
2.016AlaPro: 2.016 ± 0.62
1.764AlaGln: 1.764 ± 0.611
2.268AlaArg: 2.268 ± 1.847
2.772AlaSer: 2.772 ± 0.369
2.52AlaThr: 2.52 ± 0.34
2.016AlaVal: 2.016 ± 1.113
0.504AlaTrp: 0.504 ± 0.124
2.268AlaTyr: 2.268 ± 1.814
0.0AlaXaa: 0.0 ± 0.0
Cys
1.512CysAla: 1.512 ± 0.322
0.252CysCys: 0.252 ± 0.227
1.008CysAsp: 1.008 ± 0.908
1.26CysGlu: 1.26 ± 0.78
1.008CysPhe: 1.008 ± 0.555
2.772CysGly: 2.772 ± 2.496
1.008CysHis: 1.008 ± 0.907
2.268CysIle: 2.268 ± 0.686
2.268CysLys: 2.268 ± 1.335
3.276CysLeu: 3.276 ± 1.224
0.504CysMet: 0.504 ± 0.66
0.756CysAsn: 0.756 ± 0.161
0.756CysPro: 0.756 ± 0.161
1.26CysGln: 1.26 ± 0.447
1.764CysArg: 1.764 ± 1.233
1.008CysSer: 1.008 ± 0.908
1.008CysThr: 1.008 ± 0.555
1.26CysVal: 1.26 ± 0.78
0.0CysTrp: 0.0 ± 0.0
1.008CysTyr: 1.008 ± 0.289
0.0CysXaa: 0.0 ± 0.0
Asp
2.52AspAla: 2.52 ± 0.584
0.504AspCys: 0.504 ± 0.124
4.032AspAsp: 4.032 ± 0.73
4.788AspGlu: 4.788 ± 2.565
4.032AspPhe: 4.032 ± 1.154
2.268AspGly: 2.268 ± 1.814
0.756AspHis: 0.756 ± 0.161
6.3AspIle: 6.3 ± 1.256
2.268AspLys: 2.268 ± 0.314
5.796AspLeu: 5.796 ± 0.642
1.512AspMet: 1.512 ± 0.582
4.536AspAsn: 4.536 ± 0.932
3.276AspPro: 3.276 ± 0.757
2.772AspGln: 2.772 ± 1.074
2.016AspArg: 2.016 ± 0.577
2.52AspSer: 2.52 ± 0.34
3.528AspThr: 3.528 ± 0.374
3.276AspVal: 3.276 ± 1.007
1.008AspTrp: 1.008 ± 0.289
3.024AspTyr: 3.024 ± 0.335
0.0AspXaa: 0.0 ± 0.0
Glu
2.268GluAla: 2.268 ± 0.314
1.512GluCys: 1.512 ± 0.664
3.78GluAsp: 3.78 ± 1.016
5.796GluGlu: 5.796 ± 0.42
5.292GluPhe: 5.292 ± 2.296
2.016GluGly: 2.016 ± 0.495
1.26GluHis: 1.26 ± 0.447
6.048GluIle: 6.048 ± 1.516
7.056GluLys: 7.056 ± 2.12
3.78GluLeu: 3.78 ± 1.016
3.528GluMet: 3.528 ± 0.839
2.52GluAsn: 2.52 ± 0.618
2.52GluPro: 2.52 ± 0.306
2.52GluGln: 2.52 ± 1.466
2.772GluArg: 2.772 ± 1.34
5.292GluSer: 5.292 ± 1.05
3.024GluThr: 3.024 ± 1.104
2.772GluVal: 2.772 ± 0.585
0.504GluTrp: 0.504 ± 0.306
3.024GluTyr: 3.024 ± 0.335
0.0GluXaa: 0.0 ± 0.0
Phe
2.772PheAla: 2.772 ± 0.728
1.764PheCys: 1.764 ± 0.441
3.024PheAsp: 3.024 ± 0.742
3.276PheGlu: 3.276 ± 1.007
2.52PhePhe: 2.52 ± 1.782
2.772PheGly: 2.772 ± 1.188
0.504PheHis: 0.504 ± 0.124
4.032PheIle: 4.032 ± 0.917
5.04PheLys: 5.04 ± 0.613
4.032PheLeu: 4.032 ± 1.548
1.764PheMet: 1.764 ± 0.611
3.528PheAsn: 3.528 ± 1.221
1.008PhePro: 1.008 ± 1.32
1.008PheGln: 1.008 ± 0.612
1.512PheArg: 1.512 ± 0.322
5.04PheSer: 5.04 ± 1.168
3.024PheThr: 3.024 ± 1.253
2.52PheVal: 2.52 ± 0.584
0.504PheTrp: 0.504 ± 0.124
2.016PheTyr: 2.016 ± 0.577
0.0PheXaa: 0.0 ± 0.0
Gly
2.268GlyAla: 2.268 ± 1.964
2.016GlyCys: 2.016 ± 0.777
4.284GlyAsp: 4.284 ± 0.442
4.536GlyGlu: 4.536 ± 0.965
3.024GlyPhe: 3.024 ± 1.527
1.764GlyGly: 1.764 ± 0.498
0.756GlyHis: 0.756 ± 0.161
2.772GlyIle: 2.772 ± 0.549
2.016GlyLys: 2.016 ± 0.495
3.276GlyLeu: 3.276 ± 0.601
0.252GlyMet: 0.252 ± 0.227
2.52GlyAsn: 2.52 ± 0.306
0.756GlyPro: 0.756 ± 0.161
2.268GlyGln: 2.268 ± 0.466
2.52GlyArg: 2.52 ± 0.486
3.276GlySer: 3.276 ± 2.348
4.536GlyThr: 4.536 ± 2.272
2.268GlyVal: 2.268 ± 0.476
0.756GlyTrp: 0.756 ± 0.332
1.512GlyTyr: 1.512 ± 0.664
0.0GlyXaa: 0.0 ± 0.0
His
1.008HisAla: 1.008 ± 0.555
1.008HisCys: 1.008 ± 0.247
0.756HisAsp: 0.756 ± 0.459
1.512HisGlu: 1.512 ± 0.582
2.016HisPhe: 2.016 ± 0.698
1.764HisGly: 1.764 ± 0.35
0.756HisHis: 0.756 ± 0.65
1.008HisIle: 1.008 ± 0.247
3.024HisLys: 3.024 ± 1.039
3.276HisLeu: 3.276 ± 0.525
0.756HisMet: 0.756 ± 0.416
0.504HisAsn: 0.504 ± 0.306
1.26HisPro: 1.26 ± 0.765
0.0HisGln: 0.0 ± 0.0
1.512HisArg: 1.512 ± 0.627
2.772HisSer: 2.772 ± 0.807
1.008HisThr: 1.008 ± 0.555
0.504HisVal: 0.504 ± 0.124
0.0HisTrp: 0.0 ± 0.0
1.512HisTyr: 1.512 ± 1.006
0.0HisXaa: 0.0 ± 0.0
Ile
4.032IleAla: 4.032 ± 0.858
2.52IleCys: 2.52 ± 1.561
5.796IleAsp: 5.796 ± 1.356
6.552IleGlu: 6.552 ± 0.845
3.78IlePhe: 3.78 ± 0.955
2.52IleGly: 2.52 ± 0.486
3.276IleHis: 3.276 ± 0.757
5.796IleIle: 5.796 ± 0.4
6.804IleLys: 6.804 ± 1.281
7.308IleLeu: 7.308 ± 1.913
2.268IleMet: 2.268 ± 0.489
5.292IleAsn: 5.292 ± 0.558
1.764IlePro: 1.764 ± 0.35
2.268IleGln: 2.268 ± 0.72
2.52IleArg: 2.52 ± 0.584
5.04IleSer: 5.04 ± 1.05
5.796IleThr: 5.796 ± 1.165
3.528IleVal: 3.528 ± 1.152
1.008IleTrp: 1.008 ± 0.289
2.016IleTyr: 2.016 ± 0.777
0.0IleXaa: 0.0 ± 0.0
Lys
5.544LysAla: 5.544 ± 2.71
3.024LysCys: 3.024 ± 2.366
4.284LysAsp: 4.284 ± 0.717
4.284LysGlu: 4.284 ± 1.827
5.544LysPhe: 5.544 ± 0.738
4.788LysGly: 4.788 ± 0.745
2.016LysHis: 2.016 ± 0.387
5.796LysIle: 5.796 ± 0.537
6.804LysLys: 6.804 ± 1.336
4.788LysLeu: 4.788 ± 0.941
2.268LysMet: 2.268 ± 0.805
4.536LysAsn: 4.536 ± 1.485
2.52LysPro: 2.52 ± 0.983
1.512LysGln: 1.512 ± 0.582
3.528LysArg: 3.528 ± 1.797
3.528LysSer: 3.528 ± 1.13
7.308LysThr: 7.308 ± 1.418
4.536LysVal: 4.536 ± 0.978
1.26LysTrp: 1.26 ± 0.447
3.024LysTyr: 3.024 ± 0.866
0.0LysXaa: 0.0 ± 0.0
Leu
4.788LeuAla: 4.788 ± 1.37
2.268LeuCys: 2.268 ± 0.996
7.56LeuAsp: 7.56 ± 1.41
3.528LeuGlu: 3.528 ± 0.737
3.024LeuPhe: 3.024 ± 0.643
4.032LeuGly: 4.032 ± 0.966
1.764LeuHis: 1.764 ± 0.565
5.544LeuIle: 5.544 ± 1.073
7.56LeuLys: 7.56 ± 0.919
6.804LeuLeu: 6.804 ± 0.882
2.52LeuMet: 2.52 ± 0.866
4.788LeuAsn: 4.788 ± 0.761
3.024LeuPro: 3.024 ± 0.742
2.52LeuGln: 2.52 ± 0.486
3.528LeuArg: 3.528 ± 1.835
6.3LeuSer: 6.3 ± 1.139
7.56LeuThr: 7.56 ± 2.689
4.284LeuVal: 4.284 ± 1.174
0.504LeuTrp: 0.504 ± 0.124
4.788LeuTyr: 4.788 ± 0.941
0.0LeuXaa: 0.0 ± 0.0
Met
2.268MetAla: 2.268 ± 0.79
0.504MetCys: 0.504 ± 0.124
2.016MetAsp: 2.016 ± 1.029
0.756MetGlu: 0.756 ± 0.459
1.008MetPhe: 1.008 ± 0.676
0.756MetGly: 0.756 ± 0.161
0.756MetHis: 0.756 ± 0.332
2.772MetIle: 2.772 ± 0.728
0.756MetLys: 0.756 ± 0.161
3.276MetLeu: 3.276 ± 1.154
0.252MetMet: 0.252 ± 0.153
1.512MetAsn: 1.512 ± 0.582
1.008MetPro: 1.008 ± 0.289
1.008MetGln: 1.008 ± 0.289
1.512MetArg: 1.512 ± 1.215
3.528MetSer: 3.528 ± 0.373
2.52MetThr: 2.52 ± 0.306
1.512MetVal: 1.512 ± 0.371
0.252MetTrp: 0.252 ± 0.227
2.016MetTyr: 2.016 ± 0.393
0.0MetXaa: 0.0 ± 0.0
Asn
2.268AsnAla: 2.268 ± 0.72
1.26AsnCys: 1.26 ± 1.135
4.788AsnAsp: 4.788 ± 1.585
3.78AsnGlu: 3.78 ± 0.827
2.52AsnPhe: 2.52 ± 1.187
2.016AsnGly: 2.016 ± 0.393
1.26AsnHis: 1.26 ± 0.243
4.536AsnIle: 4.536 ± 0.534
4.536AsnLys: 4.536 ± 0.932
6.048AsnLeu: 6.048 ± 0.619
2.52AsnMet: 2.52 ± 0.486
3.276AsnAsn: 3.276 ± 0.757
2.52AsnPro: 2.52 ± 1.77
2.016AsnGln: 2.016 ± 0.698
1.512AsnArg: 1.512 ± 2.012
2.772AsnSer: 2.772 ± 0.728
2.016AsnThr: 2.016 ± 0.62
3.528AsnVal: 3.528 ± 0.373
1.764AsnTrp: 1.764 ± 0.35
2.016AsnTyr: 2.016 ± 0.577
0.0AsnXaa: 0.0 ± 0.0
Pro
0.756ProAla: 0.756 ± 0.161
0.0ProCys: 0.0 ± 0.0
1.512ProAsp: 1.512 ± 0.582
2.016ProGlu: 2.016 ± 0.577
1.008ProPhe: 1.008 ± 0.556
2.268ProGly: 2.268 ± 0.805
0.252ProHis: 0.252 ± 0.227
4.032ProIle: 4.032 ± 1.544
2.52ProLys: 2.52 ± 0.638
2.016ProLeu: 2.016 ± 0.429
1.008ProMet: 1.008 ± 0.556
2.52ProAsn: 2.52 ± 0.983
1.26ProPro: 1.26 ± 0.243
0.252ProGln: 0.252 ± 0.153
1.008ProArg: 1.008 ± 0.247
2.52ProSer: 2.52 ± 0.34
1.764ProThr: 1.764 ± 0.498
2.268ProVal: 2.268 ± 0.466
0.504ProTrp: 0.504 ± 0.306
1.512ProTyr: 1.512 ± 0.371
0.0ProXaa: 0.0 ± 0.0
Gln
1.512GlnAla: 1.512 ± 0.552
0.252GlnCys: 0.252 ± 0.227
2.52GlnAsp: 2.52 ± 1.066
1.764GlnGlu: 1.764 ± 0.419
0.504GlnPhe: 0.504 ± 0.306
1.26GlnGly: 1.26 ± 0.447
0.504GlnHis: 0.504 ± 0.306
2.52GlnIle: 2.52 ± 0.866
3.528GlnLys: 3.528 ± 1.464
2.268GlnLeu: 2.268 ± 0.996
0.756GlnMet: 0.756 ± 0.618
2.016GlnAsn: 2.016 ± 0.883
0.504GlnPro: 0.504 ± 0.306
1.26GlnGln: 1.26 ± 0.78
2.268GlnArg: 2.268 ± 0.72
2.268GlnSer: 2.268 ± 0.314
1.764GlnThr: 1.764 ± 0.419
3.024GlnVal: 3.024 ± 0.678
0.504GlnTrp: 0.504 ± 0.306
0.252GlnTyr: 0.252 ± 0.153
0.0GlnXaa: 0.0 ± 0.0
Arg
2.268ArgAla: 2.268 ± 1.035
1.26ArgCys: 1.26 ± 0.547
2.52ArgAsp: 2.52 ± 0.306
4.284ArgGlu: 4.284 ± 1.623
1.764ArgPhe: 1.764 ± 0.732
0.756ArgGly: 0.756 ± 0.332
2.268ArgHis: 2.268 ± 0.314
3.276ArgIle: 3.276 ± 1.007
2.772ArgLys: 2.772 ± 0.227
4.788ArgLeu: 4.788 ± 1.895
0.756ArgMet: 0.756 ± 0.242
3.024ArgAsn: 3.024 ± 0.643
1.512ArgPro: 1.512 ± 0.322
1.764ArgGln: 1.764 ± 1.166
2.016ArgArg: 2.016 ± 0.577
3.528ArgSer: 3.528 ± 0.374
1.26ArgThr: 1.26 ± 0.433
1.512ArgVal: 1.512 ± 0.552
0.0ArgTrp: 0.0 ± 0.0
1.764ArgTyr: 1.764 ± 0.35
0.0ArgXaa: 0.0 ± 0.0
Ser
2.016SerAla: 2.016 ± 0.777
2.268SerCys: 2.268 ± 1.335
5.544SerAsp: 5.544 ± 1.456
3.528SerGlu: 3.528 ± 0.071
3.528SerPhe: 3.528 ± 1.835
3.024SerGly: 3.024 ± 1.665
1.512SerHis: 1.512 ± 0.463
6.804SerIle: 6.804 ± 0.898
6.552SerLys: 6.552 ± 2.308
7.812SerLeu: 7.812 ± 0.802
2.016SerMet: 2.016 ± 0.577
3.78SerAsn: 3.78 ± 1.322
1.26SerPro: 1.26 ± 0.433
0.756SerGln: 0.756 ± 0.459
3.528SerArg: 3.528 ± 0.707
5.796SerSer: 5.796 ± 1.117
3.78SerThr: 3.78 ± 0.728
2.772SerVal: 2.772 ± 0.486
0.504SerTrp: 0.504 ± 0.124
1.512SerTyr: 1.512 ± 0.664
0.0SerXaa: 0.0 ± 0.0
Thr
4.536ThrAla: 4.536 ± 1.39
2.268ThrCys: 2.268 ± 0.996
2.268ThrAsp: 2.268 ± 1.408
4.284ThrGlu: 4.284 ± 1.095
4.284ThrPhe: 4.284 ± 1.462
3.528ThrGly: 3.528 ± 1.468
1.764ThrHis: 1.764 ± 1.436
5.544ThrIle: 5.544 ± 0.49
3.528ThrLys: 3.528 ± 0.374
3.78ThrLeu: 3.78 ± 0.512
2.016ThrMet: 2.016 ± 0.495
2.52ThrAsn: 2.52 ± 0.598
1.764ThrPro: 1.764 ± 0.565
1.512ThrGln: 1.512 ± 0.371
1.512ThrArg: 1.512 ± 0.582
4.032ThrSer: 4.032 ± 1.25
3.528ThrThr: 3.528 ± 1.772
3.276ThrVal: 3.276 ± 0.188
1.512ThrTrp: 1.512 ± 0.627
4.284ThrTyr: 4.284 ± 1.295
0.0ThrXaa: 0.0 ± 0.0
Val
2.016ValAla: 2.016 ± 0.393
1.512ValCys: 1.512 ± 0.463
1.512ValAsp: 1.512 ± 0.627
4.032ValGlu: 4.032 ± 2.009
2.52ValPhe: 2.52 ± 0.866
2.772ValGly: 2.772 ± 0.369
1.512ValHis: 1.512 ± 0.322
3.024ValIle: 3.024 ± 0.59
4.032ValLys: 4.032 ± 0.786
5.04ValLeu: 5.04 ± 0.318
1.26ValMet: 1.26 ± 0.447
2.016ValAsn: 2.016 ± 0.393
1.26ValPro: 1.26 ± 0.447
2.268ValGln: 2.268 ± 0.996
2.772ValArg: 2.772 ± 0.585
3.528ValSer: 3.528 ± 0.866
2.52ValThr: 2.52 ± 1.228
3.276ValVal: 3.276 ± 0.705
0.252ValTrp: 0.252 ± 0.704
2.772ValTyr: 2.772 ± 0.486
0.0ValXaa: 0.0 ± 0.0
Trp
0.504TrpAla: 0.504 ± 0.454
0.252TrpCys: 0.252 ± 0.227
0.252TrpAsp: 0.252 ± 0.227
1.008TrpGlu: 1.008 ± 0.247
1.26TrpPhe: 1.26 ± 0.433
1.512TrpGly: 1.512 ± 0.371
0.252TrpHis: 0.252 ± 0.227
0.504TrpIle: 0.504 ± 0.124
0.756TrpLys: 0.756 ± 0.781
1.008TrpLeu: 1.008 ± 0.676
0.504TrpMet: 0.504 ± 0.454
1.008TrpAsn: 1.008 ± 0.289
0.252TrpPro: 0.252 ± 0.227
0.756TrpGln: 0.756 ± 0.459
0.0TrpArg: 0.0 ± 0.0
1.008TrpSer: 1.008 ± 0.612
0.252TrpThr: 0.252 ± 0.227
0.504TrpVal: 0.504 ± 0.306
0.0TrpTrp: 0.0 ± 0.0
0.252TrpTyr: 0.252 ± 0.153
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.26TyrAla: 1.26 ± 1.067
1.008TyrCys: 1.008 ± 0.908
1.008TyrAsp: 1.008 ± 0.289
2.772TyrGlu: 2.772 ± 0.728
2.016TyrPhe: 2.016 ± 1.224
2.016TyrGly: 2.016 ± 0.393
2.52TyrHis: 2.52 ± 0.638
3.276TyrIle: 3.276 ± 0.633
3.528TyrLys: 3.528 ± 0.996
3.78TyrLeu: 3.78 ± 1.101
1.512TyrMet: 1.512 ± 0.918
3.528TyrAsn: 3.528 ± 1.152
0.756TyrPro: 0.756 ± 0.332
1.764TyrGln: 1.764 ± 0.565
3.276TyrArg: 3.276 ± 0.757
1.764TyrSer: 1.764 ± 0.886
3.024TyrThr: 3.024 ± 0.59
1.26TyrVal: 1.26 ± 0.433
0.504TyrTrp: 0.504 ± 0.124
1.008TyrTyr: 1.008 ± 0.555
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3969 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski