Amino acid dipepetide frequency for Kineobactrum sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.079AlaAla: 13.079 ± 0.139	1.203AlaCys: 1.203 ± 0.031	6.367AlaAsp: 6.367 ± 0.083	6.995AlaGlu: 6.995 ± 0.076	3.517AlaPhe: 3.517 ± 0.055	9.809AlaGly: 9.809 ± 0.112	2.073AlaHis: 2.073 ± 0.043	5.399AlaIle: 5.399 ± 0.073	2.418AlaLys: 2.418 ± 0.058	12.476AlaLeu: 12.476 ± 0.14	2.95AlaMet: 2.95 ± 0.057	2.984AlaAsn: 2.984 ± 0.058	4.435AlaPro: 4.435 ± 0.055	4.033AlaGln: 4.033 ± 0.056	7.435AlaArg: 7.435 ± 0.097	5.982AlaSer: 5.982 ± 0.072	5.836AlaThr: 5.836 ± 0.074	7.758AlaVal: 7.758 ± 0.094	1.443AlaTrp: 1.443 ± 0.038	2.412AlaTyr: 2.412 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.045CysAla: 1.045 ± 0.031	0.152CysCys: 0.152 ± 0.012	0.613CysAsp: 0.613 ± 0.021	0.593CysGlu: 0.593 ± 0.023	0.381CysPhe: 0.381 ± 0.019	0.971CysGly: 0.971 ± 0.03	0.356CysHis: 0.356 ± 0.026	0.486CysIle: 0.486 ± 0.017	0.278CysLys: 0.278 ± 0.016	1.046CysLeu: 1.046 ± 0.034	0.202CysMet: 0.202 ± 0.013	0.306CysAsn: 0.306 ± 0.015	0.514CysPro: 0.514 ± 0.022	0.361CysGln: 0.361 ± 0.02	0.706CysArg: 0.706 ± 0.026	0.679CysSer: 0.679 ± 0.027	0.484CysThr: 0.484 ± 0.019	0.676CysVal: 0.676 ± 0.026	0.132CysTrp: 0.132 ± 0.01	0.308CysTyr: 0.308 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.576AspAla: 5.576 ± 0.073	0.607AspCys: 0.607 ± 0.024	3.329AspAsp: 3.329 ± 0.066	3.662AspGlu: 3.662 ± 0.066	2.378AspPhe: 2.378 ± 0.046	4.547AspGly: 4.547 ± 0.077	1.299AspHis: 1.299 ± 0.037	3.655AspIle: 3.655 ± 0.064	1.752AspLys: 1.752 ± 0.036	5.781AspLeu: 5.781 ± 0.078	1.436AspMet: 1.436 ± 0.034	2.088AspAsn: 2.088 ± 0.058	3.125AspPro: 3.125 ± 0.052	2.007AspGln: 2.007 ± 0.035	3.479AspArg: 3.479 ± 0.06	3.366AspSer: 3.366 ± 0.061	3.211AspThr: 3.211 ± 0.058	3.915AspVal: 3.915 ± 0.06	1.022AspTrp: 1.022 ± 0.031	2.107AspTyr: 2.107 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.48GluAla: 6.48 ± 0.08	0.492GluCys: 0.492 ± 0.02	3.21GluAsp: 3.21 ± 0.057	3.723GluGlu: 3.723 ± 0.066	2.225GluPhe: 2.225 ± 0.051	4.367GluGly: 4.367 ± 0.062	1.637GluHis: 1.637 ± 0.04	3.172GluIle: 3.172 ± 0.049	1.927GluLys: 1.927 ± 0.047	7.084GluLeu: 7.084 ± 0.078	1.42GluMet: 1.42 ± 0.037	1.769GluAsn: 1.769 ± 0.04	2.748GluPro: 2.748 ± 0.055	3.57GluGln: 3.57 ± 0.062	4.574GluArg: 4.574 ± 0.069	3.318GluSer: 3.318 ± 0.055	3.105GluThr: 3.105 ± 0.054	4.477GluVal: 4.477 ± 0.073	0.759GluTrp: 0.759 ± 0.024	1.579GluTyr: 1.579 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.733PheAla: 3.733 ± 0.064	0.42PheCys: 0.42 ± 0.02	2.512PheAsp: 2.512 ± 0.045	2.148PheGlu: 2.148 ± 0.048	1.42PhePhe: 1.42 ± 0.039	3.373PheGly: 3.373 ± 0.059	0.808PheHis: 0.808 ± 0.024	1.822PheIle: 1.822 ± 0.037	0.925PheLys: 0.925 ± 0.029	3.322PheLeu: 3.322 ± 0.055	0.888PheMet: 0.888 ± 0.025	1.411PheAsn: 1.411 ± 0.037	1.543PhePro: 1.543 ± 0.035	1.177PheGln: 1.177 ± 0.034	2.117PheArg: 2.117 ± 0.045	2.619PheSer: 2.619 ± 0.048	2.059PheThr: 2.059 ± 0.043	2.399PheVal: 2.399 ± 0.05	0.46PheTrp: 0.46 ± 0.02	1.15PheTyr: 1.15 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.773GlyAla: 7.773 ± 0.084	0.952GlyCys: 0.952 ± 0.027	4.773GlyAsp: 4.773 ± 0.082	5.165GlyGlu: 5.165 ± 0.059	3.488GlyPhe: 3.488 ± 0.055	6.525GlyGly: 6.525 ± 0.099	1.883GlyHis: 1.883 ± 0.04	4.68GlyIle: 4.68 ± 0.068	2.997GlyLys: 2.997 ± 0.059	8.508GlyLeu: 8.508 ± 0.105	2.255GlyMet: 2.255 ± 0.049	2.682GlyAsn: 2.682 ± 0.057	2.887GlyPro: 2.887 ± 0.045	2.955GlyGln: 2.955 ± 0.056	5.134GlyArg: 5.134 ± 0.072	5.054GlySer: 5.054 ± 0.07	4.259GlyThr: 4.259 ± 0.074	5.992GlyVal: 5.992 ± 0.079	1.248GlyTrp: 1.248 ± 0.034	2.497GlyTyr: 2.497 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.066HisAla: 2.066 ± 0.041	0.345HisCys: 0.345 ± 0.017	1.128HisAsp: 1.128 ± 0.033	1.152HisGlu: 1.152 ± 0.031	0.981HisPhe: 0.981 ± 0.029	1.877HisGly: 1.877 ± 0.045	0.674HisHis: 0.674 ± 0.026	1.194HisIle: 1.194 ± 0.037	0.624HisLys: 0.624 ± 0.022	2.262HisLeu: 2.262 ± 0.046	0.52HisMet: 0.52 ± 0.021	0.74HisAsn: 0.74 ± 0.024	1.403HisPro: 1.403 ± 0.037	0.92HisGln: 0.92 ± 0.028	1.61HisArg: 1.61 ± 0.036	1.286HisSer: 1.286 ± 0.031	1.14HisThr: 1.14 ± 0.035	1.25HisVal: 1.25 ± 0.029	0.442HisTrp: 0.442 ± 0.018	0.873HisTyr: 0.873 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.09IleAla: 6.09 ± 0.075	0.519IleCys: 0.519 ± 0.019	3.496IleAsp: 3.496 ± 0.052	3.386IleGlu: 3.386 ± 0.057	1.602IlePhe: 1.602 ± 0.043	4.1IleGly: 4.1 ± 0.064	1.093IleHis: 1.093 ± 0.033	2.498IleIle: 2.498 ± 0.049	1.468IleLys: 1.468 ± 0.04	4.433IleLeu: 4.433 ± 0.062	1.104IleMet: 1.104 ± 0.031	2.049IleAsn: 2.049 ± 0.05	2.501IlePro: 2.501 ± 0.048	1.486IleGln: 1.486 ± 0.04	3.049IleArg: 3.049 ± 0.054	3.239IleSer: 3.239 ± 0.054	3.065IleThr: 3.065 ± 0.047	3.485IleVal: 3.485 ± 0.055	0.535IleTrp: 0.535 ± 0.021	1.304IleTyr: 1.304 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.052LysAla: 3.052 ± 0.065	0.201LysCys: 0.201 ± 0.015	1.358LysAsp: 1.358 ± 0.037	1.433LysGlu: 1.433 ± 0.046	0.746LysPhe: 0.746 ± 0.025	2.032LysGly: 2.032 ± 0.045	0.659LysHis: 0.659 ± 0.024	1.497LysIle: 1.497 ± 0.04	1.073LysLys: 1.073 ± 0.036	2.993LysLeu: 2.993 ± 0.05	0.666LysMet: 0.666 ± 0.026	0.846LysAsn: 0.846 ± 0.028	1.628LysPro: 1.628 ± 0.039	1.212LysGln: 1.212 ± 0.033	2.049LysArg: 2.049 ± 0.047	1.64LysSer: 1.64 ± 0.041	1.648LysThr: 1.648 ± 0.042	2.172LysVal: 2.172 ± 0.052	0.313LysTrp: 0.313 ± 0.014	0.693LysTyr: 0.693 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.463LeuAla: 13.463 ± 0.136	1.148LeuCys: 1.148 ± 0.031	6.425LeuAsp: 6.425 ± 0.08	6.96LeuGlu: 6.96 ± 0.086	3.86LeuPhe: 3.86 ± 0.069	8.451LeuGly: 8.451 ± 0.092	2.296LeuHis: 2.296 ± 0.04	4.407LeuIle: 4.407 ± 0.06	2.928LeuLys: 2.928 ± 0.06	12.076LeuLeu: 12.076 ± 0.163	2.32LeuMet: 2.32 ± 0.047	3.058LeuAsn: 3.058 ± 0.057	5.835LeuPro: 5.835 ± 0.088	4.969LeuGln: 4.969 ± 0.076	7.278LeuArg: 7.278 ± 0.103	6.124LeuSer: 6.124 ± 0.069	5.168LeuThr: 5.168 ± 0.07	7.902LeuVal: 7.902 ± 0.097	1.366LeuTrp: 1.366 ± 0.035	2.572LeuTyr: 2.572 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.915MetAla: 2.915 ± 0.051	0.196MetCys: 0.196 ± 0.013	1.304MetAsp: 1.304 ± 0.03	1.259MetGlu: 1.259 ± 0.031	0.68MetPhe: 0.68 ± 0.024	1.833MetGly: 1.833 ± 0.04	0.519MetHis: 0.519 ± 0.021	1.203MetIle: 1.203 ± 0.038	0.892MetLys: 0.892 ± 0.028	2.549MetLeu: 2.549 ± 0.045	0.578MetMet: 0.578 ± 0.022	0.808MetAsn: 0.808 ± 0.024	1.3MetPro: 1.3 ± 0.036	0.987MetGln: 0.987 ± 0.027	1.476MetArg: 1.476 ± 0.034	1.607MetSer: 1.607 ± 0.038	1.47MetThr: 1.47 ± 0.037	1.675MetVal: 1.675 ± 0.039	0.192MetTrp: 0.192 ± 0.012	0.393MetTyr: 0.393 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.158AsnAla: 3.158 ± 0.052	0.372AsnCys: 0.372 ± 0.018	1.667AsnAsp: 1.667 ± 0.047	1.559AsnGlu: 1.559 ± 0.035	1.1AsnPhe: 1.1 ± 0.031	2.456AsnGly: 2.456 ± 0.058	0.648AsnHis: 0.648 ± 0.023	1.765AsnIle: 1.765 ± 0.039	0.865AsnLys: 0.865 ± 0.031	3.227AsnLeu: 3.227 ± 0.052	0.691AsnMet: 0.691 ± 0.025	1.071AsnAsn: 1.071 ± 0.034	2.089AsnPro: 2.089 ± 0.039	1.044AsnGln: 1.044 ± 0.031	2.088AsnArg: 2.088 ± 0.047	1.833AsnSer: 1.833 ± 0.053	1.804AsnThr: 1.804 ± 0.044	1.98AsnVal: 1.98 ± 0.04	0.524AsnTrp: 0.524 ± 0.022	0.915AsnTyr: 0.915 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.53ProAla: 5.53 ± 0.071	0.381ProCys: 0.381 ± 0.017	3.398ProAsp: 3.398 ± 0.061	3.961ProGlu: 3.961 ± 0.051	1.697ProPhe: 1.697 ± 0.037	4.806ProGly: 4.806 ± 0.07	0.95ProHis: 0.95 ± 0.027	1.936ProIle: 1.936 ± 0.036	1.097ProLys: 1.097 ± 0.036	5.14ProLeu: 5.14 ± 0.07	1.138ProMet: 1.138 ± 0.035	1.191ProAsn: 1.191 ± 0.03	2.132ProPro: 2.132 ± 0.044	1.806ProGln: 1.806 ± 0.04	2.759ProArg: 2.759 ± 0.055	2.266ProSer: 2.266 ± 0.036	2.155ProThr: 2.155 ± 0.041	4.242ProVal: 4.242 ± 0.06	0.726ProTrp: 0.726 ± 0.023	1.143ProTyr: 1.143 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.682GlnAla: 4.682 ± 0.06	0.323GlnCys: 0.323 ± 0.018	1.827GlnAsp: 1.827 ± 0.04	2.092GlnGlu: 2.092 ± 0.045	1.286GlnPhe: 1.286 ± 0.034	3.01GlnGly: 3.01 ± 0.051	0.981GlnHis: 0.981 ± 0.031	1.769GlnIle: 1.769 ± 0.037	1.021GlnLys: 1.021 ± 0.03	5.007GlnLeu: 5.007 ± 0.083	0.884GlnMet: 0.884 ± 0.026	0.875GlnAsn: 0.875 ± 0.026	2.159GlnPro: 2.159 ± 0.04	2.48GlnGln: 2.48 ± 0.054	3.403GlnArg: 3.403 ± 0.062	2.017GlnSer: 2.017 ± 0.039	1.747GlnThr: 1.747 ± 0.04	3.086GlnVal: 3.086 ± 0.05	0.661GlnTrp: 0.661 ± 0.026	0.938GlnTyr: 0.938 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.336ArgAla: 6.336 ± 0.084	0.651ArgCys: 0.651 ± 0.022	4.023ArgAsp: 4.023 ± 0.06	4.977ArgGlu: 4.977 ± 0.077	2.728ArgPhe: 2.728 ± 0.05	4.574ArgGly: 4.574 ± 0.06	1.709ArgHis: 1.709 ± 0.042	3.566ArgIle: 3.566 ± 0.053	2.226ArgLys: 2.226 ± 0.047	7.473ArgLeu: 7.473 ± 0.093	1.631ArgMet: 1.631 ± 0.033	2.147ArgAsn: 2.147 ± 0.039	2.777ArgPro: 2.777 ± 0.054	3.193ArgGln: 3.193 ± 0.057	4.754ArgArg: 4.754 ± 0.078	3.654ArgSer: 3.654 ± 0.061	2.807ArgThr: 2.807 ± 0.046	4.544ArgVal: 4.544 ± 0.058	1.079ArgTrp: 1.079 ± 0.031	2.262ArgTyr: 2.262 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.044SerAla: 6.044 ± 0.076	0.611SerCys: 0.611 ± 0.021	3.178SerAsp: 3.178 ± 0.07	3.124SerGlu: 3.124 ± 0.052	2.105SerPhe: 2.105 ± 0.049	5.706SerGly: 5.706 ± 0.076	1.299SerHis: 1.299 ± 0.033	2.921SerIle: 2.921 ± 0.055	1.528SerLys: 1.528 ± 0.032	6.306SerLeu: 6.306 ± 0.077	1.403SerMet: 1.403 ± 0.032	1.724SerAsn: 1.724 ± 0.045	2.807SerPro: 2.807 ± 0.048	2.054SerGln: 2.054 ± 0.049	4.069SerArg: 4.069 ± 0.057	3.398SerSer: 3.398 ± 0.061	2.884SerThr: 2.884 ± 0.049	4.069SerVal: 4.069 ± 0.057	0.895SerTrp: 0.895 ± 0.031	1.609SerTyr: 1.609 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.746ThrAla: 5.746 ± 0.072	0.454ThrCys: 0.454 ± 0.02	3.095ThrAsp: 3.095 ± 0.054	2.945ThrGlu: 2.945 ± 0.045	1.757ThrPhe: 1.757 ± 0.045	5.026ThrGly: 5.026 ± 0.069	1.015ThrHis: 1.015 ± 0.029	2.644ThrIle: 2.644 ± 0.055	0.91ThrLys: 0.91 ± 0.028	6.358ThrLeu: 6.358 ± 0.079	1.132ThrMet: 1.132 ± 0.03	1.352ThrAsn: 1.352 ± 0.036	2.982ThrPro: 2.982 ± 0.051	1.53ThrGln: 1.53 ± 0.04	3.372ThrArg: 3.372 ± 0.054	2.792ThrSer: 2.792 ± 0.053	2.874ThrThr: 2.874 ± 0.052	4.307ThrVal: 4.307 ± 0.069	0.691ThrTrp: 0.691 ± 0.024	1.189ThrTyr: 1.189 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.271ValAla: 8.271 ± 0.094	0.743ValCys: 0.743 ± 0.023	4.365ValAsp: 4.365 ± 0.066	4.376ValGlu: 4.376 ± 0.055	2.776ValPhe: 2.776 ± 0.05	5.057ValGly: 5.057 ± 0.066	1.518ValHis: 1.518 ± 0.039	4.113ValIle: 4.113 ± 0.059	1.968ValLys: 1.968 ± 0.043	7.567ValLeu: 7.567 ± 0.094	1.733ValMet: 1.733 ± 0.041	2.508ValAsn: 2.508 ± 0.044	3.531ValPro: 3.531 ± 0.057	2.302ValGln: 2.302 ± 0.047	4.32ValArg: 4.32 ± 0.058	4.385ValSer: 4.385 ± 0.058	4.37ValThr: 4.37 ± 0.057	5.724ValVal: 5.724 ± 0.083	0.837ValTrp: 0.837 ± 0.027	1.758ValTyr: 1.758 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.102TrpAla: 1.102 ± 0.03	0.178TrpCys: 0.178 ± 0.013	0.716TrpAsp: 0.716 ± 0.026	0.697TrpGlu: 0.697 ± 0.024	0.532TrpPhe: 0.532 ± 0.021	0.915TrpGly: 0.915 ± 0.031	0.392TrpHis: 0.392 ± 0.019	0.628TrpIle: 0.628 ± 0.022	0.319TrpLys: 0.319 ± 0.017	1.957TrpLeu: 1.957 ± 0.045	0.341TrpMet: 0.341 ± 0.017	0.399TrpAsn: 0.399 ± 0.017	0.671TrpPro: 0.671 ± 0.023	0.921TrpGln: 0.921 ± 0.03	1.142TrpArg: 1.142 ± 0.037	0.82TrpSer: 0.82 ± 0.026	0.644TrpThr: 0.644 ± 0.026	0.956TrpVal: 0.956 ± 0.029	0.237TrpTrp: 0.237 ± 0.015	0.427TrpTyr: 0.427 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.462TyrAla: 2.462 ± 0.041	0.343TyrCys: 0.343 ± 0.017	1.557TyrAsp: 1.557 ± 0.04	1.431TyrGlu: 1.431 ± 0.043	1.046TyrPhe: 1.046 ± 0.031	2.273TyrGly: 2.273 ± 0.042	0.676TyrHis: 0.676 ± 0.026	1.147TyrIle: 1.147 ± 0.031	0.696TyrLys: 0.696 ± 0.026	3.041TyrLeu: 3.041 ± 0.051	0.542TyrMet: 0.542 ± 0.021	0.849TyrAsn: 0.849 ± 0.029	1.387TyrPro: 1.387 ± 0.037	1.241TyrGln: 1.241 ± 0.032	2.298TyrArg: 2.298 ± 0.047	1.657TyrSer: 1.657 ± 0.043	1.441TyrThr: 1.441 ± 0.035	1.612TyrVal: 1.612 ± 0.035	0.429TyrTrp: 0.429 ± 0.016	0.853TyrTyr: 0.853 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3544 proteins (1232078 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---