Amino acid dipepetide frequency for Faecalicatena orotica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.444AlaAla: 7.444 ± 0.087
1.143AlaCys: 1.143 ± 0.022
4.464AlaAsp: 4.464 ± 0.058
5.487AlaGlu: 5.487 ± 0.067
3.044AlaPhe: 3.044 ± 0.043
6.781AlaGly: 6.781 ± 0.062
1.063AlaHis: 1.063 ± 0.024
4.643AlaIle: 4.643 ± 0.063
4.537AlaLys: 4.537 ± 0.059
6.753AlaLeu: 6.753 ± 0.068
2.321AlaMet: 2.321 ± 0.039
2.347AlaAsn: 2.347 ± 0.04
1.997AlaPro: 1.997 ± 0.039
2.136AlaGln: 2.136 ± 0.043
2.842AlaArg: 2.842 ± 0.043
3.906AlaSer: 3.906 ± 0.058
2.71AlaThr: 2.71 ± 0.045
6.91AlaVal: 6.91 ± 0.067
0.643AlaTrp: 0.643 ± 0.02
2.735AlaTyr: 2.735 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
1.044CysAla: 1.044 ± 0.026
0.28CysCys: 0.28 ± 0.012
0.798CysAsp: 0.798 ± 0.023
0.967CysGlu: 0.967 ± 0.026
0.683CysPhe: 0.683 ± 0.019
1.495CysGly: 1.495 ± 0.037
0.322CysHis: 0.322 ± 0.015
1.246CysIle: 1.246 ± 0.029
0.763CysLys: 0.763 ± 0.023
1.208CysLeu: 1.208 ± 0.03
0.524CysMet: 0.524 ± 0.015
0.556CysAsn: 0.556 ± 0.018
0.635CysPro: 0.635 ± 0.023
0.41CysGln: 0.41 ± 0.016
0.824CysArg: 0.824 ± 0.024
0.944CysSer: 0.944 ± 0.027
0.807CysThr: 0.807 ± 0.023
1.011CysVal: 1.011 ± 0.024
0.128CysTrp: 0.128 ± 0.008
0.588CysTyr: 0.588 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.057AspAla: 4.057 ± 0.056
0.824AspCys: 0.824 ± 0.025
2.78AspAsp: 2.78 ± 0.047
4.553AspGlu: 4.553 ± 0.062
2.634AspPhe: 2.634 ± 0.043
4.484AspGly: 4.484 ± 0.055
0.855AspHis: 0.855 ± 0.022
4.745AspIle: 4.745 ± 0.05
3.532AspLys: 3.532 ± 0.054
4.33AspLeu: 4.33 ± 0.055
1.959AspMet: 1.959 ± 0.039
2.106AspAsn: 2.106 ± 0.039
1.719AspPro: 1.719 ± 0.032
1.341AspGln: 1.341 ± 0.029
2.338AspArg: 2.338 ± 0.037
3.156AspSer: 3.156 ± 0.047
3.151AspThr: 3.151 ± 0.042
3.841AspVal: 3.841 ± 0.048
0.65AspTrp: 0.65 ± 0.021
2.799AspTyr: 2.799 ± 0.041
0.001AspXaa: 0.001 ± 0.001
Glu
5.474GluAla: 5.474 ± 0.066
0.903GluCys: 0.903 ± 0.024
4.413GluAsp: 4.413 ± 0.069
7.465GluGlu: 7.465 ± 0.095
2.703GluPhe: 2.703 ± 0.039
4.653GluGly: 4.653 ± 0.054
1.382GluHis: 1.382 ± 0.032
5.694GluIle: 5.694 ± 0.067
6.572GluLys: 6.572 ± 0.064
6.896GluLeu: 6.896 ± 0.074
2.599GluMet: 2.599 ± 0.041
4.06GluAsn: 4.06 ± 0.048
1.997GluPro: 1.997 ± 0.039
2.888GluGln: 2.888 ± 0.048
3.252GluArg: 3.252 ± 0.047
3.416GluSer: 3.416 ± 0.046
3.698GluThr: 3.698 ± 0.05
4.547GluVal: 4.547 ± 0.06
0.74GluTrp: 0.74 ± 0.022
3.356GluTyr: 3.356 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
2.943PheAla: 2.943 ± 0.041
0.782PheCys: 0.782 ± 0.019
2.42PheAsp: 2.42 ± 0.039
2.7PheGlu: 2.7 ± 0.04
1.875PhePhe: 1.875 ± 0.036
3.156PheGly: 3.156 ± 0.046
0.897PheHis: 0.897 ± 0.025
3.028PheIle: 3.028 ± 0.045
2.084PheLys: 2.084 ± 0.035
4.091PheLeu: 4.091 ± 0.051
1.243PheMet: 1.243 ± 0.024
1.52PheAsn: 1.52 ± 0.031
1.512PhePro: 1.512 ± 0.029
1.407PheGln: 1.407 ± 0.031
1.765PheArg: 1.765 ± 0.031
2.984PheSer: 2.984 ± 0.045
2.495PheThr: 2.495 ± 0.042
2.745PheVal: 2.745 ± 0.038
0.456PheTrp: 0.456 ± 0.016
1.868PheTyr: 1.868 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
5.135GlyAla: 5.135 ± 0.061
1.334GlyCys: 1.334 ± 0.026
3.516GlyAsp: 3.516 ± 0.05
4.909GlyGlu: 4.909 ± 0.062
3.259GlyPhe: 3.259 ± 0.051
5.229GlyGly: 5.229 ± 0.073
1.28GlyHis: 1.28 ± 0.03
6.647GlyIle: 6.647 ± 0.062
5.258GlyLys: 5.258 ± 0.059
6.052GlyLeu: 6.052 ± 0.064
2.726GlyMet: 2.726 ± 0.044
3.14GlyAsn: 3.14 ± 0.047
1.424GlyPro: 1.424 ± 0.029
2.188GlyGln: 2.188 ± 0.039
3.373GlyArg: 3.373 ± 0.048
4.178GlySer: 4.178 ± 0.049
4.387GlyThr: 4.387 ± 0.054
5.002GlyVal: 5.002 ± 0.06
0.737GlyTrp: 0.737 ± 0.019
3.395GlyTyr: 3.395 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.134HisAla: 1.134 ± 0.028
0.305HisCys: 0.305 ± 0.013
0.931HisAsp: 0.931 ± 0.024
1.116HisGlu: 1.116 ± 0.025
0.928HisPhe: 0.928 ± 0.025
1.243HisGly: 1.243 ± 0.029
0.413HisHis: 0.413 ± 0.017
1.494HisIle: 1.494 ± 0.031
0.914HisLys: 0.914 ± 0.023
1.561HisLeu: 1.561 ± 0.033
0.582HisMet: 0.582 ± 0.018
0.707HisAsn: 0.707 ± 0.02
0.851HisPro: 0.851 ± 0.022
0.55HisGln: 0.55 ± 0.018
0.74HisArg: 0.74 ± 0.021
0.94HisSer: 0.94 ± 0.023
0.999HisThr: 0.999 ± 0.024
1.133HisVal: 1.133 ± 0.027
0.186HisTrp: 0.186 ± 0.011
0.802HisTyr: 0.802 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.646IleAla: 5.646 ± 0.065
1.38IleCys: 1.38 ± 0.029
3.93IleAsp: 3.93 ± 0.05
4.888IleGlu: 4.888 ± 0.062
3.124IlePhe: 3.124 ± 0.045
5.222IleGly: 5.222 ± 0.063
1.397IleHis: 1.397 ± 0.029
5.216IleIle: 5.216 ± 0.067
3.891IleLys: 3.891 ± 0.051
7.445IleLeu: 7.445 ± 0.086
2.188IleMet: 2.188 ± 0.035
2.783IleAsn: 2.783 ± 0.042
3.237IlePro: 3.237 ± 0.051
2.546IleGln: 2.546 ± 0.043
3.704IleArg: 3.704 ± 0.054
4.986IleSer: 4.986 ± 0.066
4.231IleThr: 4.231 ± 0.053
4.941IleVal: 4.941 ± 0.056
0.709IleTrp: 0.709 ± 0.022
2.911IleTyr: 2.911 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
4.913LysAla: 4.913 ± 0.056
0.737LysCys: 0.737 ± 0.025
3.883LysAsp: 3.883 ± 0.048
6.832LysGlu: 6.832 ± 0.068
1.9LysPhe: 1.9 ± 0.031
4.272LysGly: 4.272 ± 0.052
1.021LysHis: 1.021 ± 0.022
4.554LysIle: 4.554 ± 0.053
5.888LysLys: 5.888 ± 0.059
5.111LysLeu: 5.111 ± 0.056
2.243LysMet: 2.243 ± 0.039
3.465LysAsn: 3.465 ± 0.049
1.974LysPro: 1.974 ± 0.039
2.267LysGln: 2.267 ± 0.039
2.984LysArg: 2.984 ± 0.047
3.322LysSer: 3.322 ± 0.047
3.536LysThr: 3.536 ± 0.043
4.225LysVal: 4.225 ± 0.061
0.639LysTrp: 0.639 ± 0.021
2.798LysTyr: 2.798 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
6.638LeuAla: 6.638 ± 0.064
1.523LeuCys: 1.523 ± 0.033
5.296LeuAsp: 5.296 ± 0.063
6.502LeuGlu: 6.502 ± 0.075
3.959LeuPhe: 3.959 ± 0.053
6.189LeuGly: 6.189 ± 0.07
1.551LeuHis: 1.551 ± 0.03
6.084LeuIle: 6.084 ± 0.072
6.476LeuLys: 6.476 ± 0.061
8.657LeuLeu: 8.657 ± 0.093
2.721LeuMet: 2.721 ± 0.046
3.938LeuAsn: 3.938 ± 0.052
3.539LeuPro: 3.539 ± 0.043
2.679LeuGln: 2.679 ± 0.042
3.592LeuArg: 3.592 ± 0.047
6.195LeuSer: 6.195 ± 0.066
5.081LeuThr: 5.081 ± 0.054
5.392LeuVal: 5.392 ± 0.062
0.795LeuTrp: 0.795 ± 0.022
3.389LeuTyr: 3.389 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.467MetAla: 2.467 ± 0.039
0.382MetCys: 0.382 ± 0.015
1.926MetAsp: 1.926 ± 0.034
2.684MetGlu: 2.684 ± 0.045
1.129MetPhe: 1.129 ± 0.031
2.207MetGly: 2.207 ± 0.039
0.472MetHis: 0.472 ± 0.017
2.242MetIle: 2.242 ± 0.038
2.762MetLys: 2.762 ± 0.042
2.971MetLeu: 2.971 ± 0.05
1.017MetMet: 1.017 ± 0.025
1.649MetAsn: 1.649 ± 0.029
1.216MetPro: 1.216 ± 0.028
1.104MetGln: 1.104 ± 0.028
1.261MetArg: 1.261 ± 0.027
1.867MetSer: 1.867 ± 0.032
1.852MetThr: 1.852 ± 0.033
1.965MetVal: 1.965 ± 0.036
0.252MetTrp: 0.252 ± 0.015
1.026MetTyr: 1.026 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.912AsnAla: 2.912 ± 0.045
0.6AsnCys: 0.6 ± 0.018
2.054AsnAsp: 2.054 ± 0.038
2.785AsnGlu: 2.785 ± 0.042
1.54AsnPhe: 1.54 ± 0.032
3.374AsnGly: 3.374 ± 0.044
0.829AsnHis: 0.829 ± 0.023
3.407AsnIle: 3.407 ± 0.044
2.383AsnLys: 2.383 ± 0.044
3.724AsnLeu: 3.724 ± 0.052
1.454AsnMet: 1.454 ± 0.028
1.649AsnAsn: 1.649 ± 0.036
1.975AsnPro: 1.975 ± 0.033
1.545AsnGln: 1.545 ± 0.03
1.923AsnArg: 1.923 ± 0.031
2.301AsnSer: 2.301 ± 0.042
2.324AsnThr: 2.324 ± 0.04
2.78AsnVal: 2.78 ± 0.041
0.426AsnTrp: 0.426 ± 0.016
1.913AsnTyr: 1.913 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
2.635ProAla: 2.635 ± 0.045
0.483ProCys: 0.483 ± 0.018
2.566ProAsp: 2.566 ± 0.04
3.253ProGlu: 3.253 ± 0.048
1.555ProPhe: 1.555 ± 0.031
2.46ProGly: 2.46 ± 0.042
0.616ProHis: 0.616 ± 0.02
1.935ProIle: 1.935 ± 0.036
1.815ProLys: 1.815 ± 0.036
2.871ProLeu: 2.871 ± 0.044
0.921ProMet: 0.921 ± 0.024
1.2ProAsn: 1.2 ± 0.029
0.831ProPro: 0.831 ± 0.035
1.026ProGln: 1.026 ± 0.025
1.003ProArg: 1.003 ± 0.024
1.811ProSer: 1.811 ± 0.032
1.424ProThr: 1.424 ± 0.029
3.202ProVal: 3.202 ± 0.046
0.334ProTrp: 0.334 ± 0.013
1.547ProTyr: 1.547 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
2.381GlnAla: 2.381 ± 0.039
0.387GlnCys: 0.387 ± 0.017
1.614GlnAsp: 1.614 ± 0.031
2.721GlnGlu: 2.721 ± 0.042
1.273GlnPhe: 1.273 ± 0.023
2.007GlnGly: 2.007 ± 0.035
0.497GlnHis: 0.497 ± 0.018
2.675GlnIle: 2.675 ± 0.043
2.651GlnLys: 2.651 ± 0.038
2.675GlnLeu: 2.675 ± 0.036
1.215GlnMet: 1.215 ± 0.024
1.654GlnAsn: 1.654 ± 0.037
0.904GlnPro: 0.904 ± 0.024
1.09GlnGln: 1.09 ± 0.031
1.322GlnArg: 1.322 ± 0.029
1.663GlnSer: 1.663 ± 0.03
1.675GlnThr: 1.675 ± 0.038
2.068GlnVal: 2.068 ± 0.034
0.29GlnTrp: 0.29 ± 0.013
1.421GlnTyr: 1.421 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
2.614ArgAla: 2.614 ± 0.037
0.565ArgCys: 0.565 ± 0.018
2.22ArgAsp: 2.22 ± 0.039
3.832ArgGlu: 3.832 ± 0.056
1.887ArgPhe: 1.887 ± 0.035
2.539ArgGly: 2.539 ± 0.043
0.774ArgHis: 0.774 ± 0.022
3.544ArgIle: 3.544 ± 0.049
3.379ArgLys: 3.379 ± 0.049
3.947ArgLeu: 3.947 ± 0.046
1.596ArgMet: 1.596 ± 0.03
1.945ArgAsn: 1.945 ± 0.035
1.292ArgPro: 1.292 ± 0.032
1.746ArgGln: 1.746 ± 0.037
2.237ArgArg: 2.237 ± 0.047
2.092ArgSer: 2.092 ± 0.038
2.284ArgThr: 2.284 ± 0.039
2.632ArgVal: 2.632 ± 0.038
0.378ArgTrp: 0.378 ± 0.014
1.847ArgTyr: 1.847 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
4.24SerAla: 4.24 ± 0.058
0.831SerCys: 0.831 ± 0.022
3.182SerAsp: 3.182 ± 0.048
3.793SerGlu: 3.793 ± 0.055
2.685SerPhe: 2.685 ± 0.04
5.128SerGly: 5.128 ± 0.056
1.043SerHis: 1.043 ± 0.029
4.222SerIle: 4.222 ± 0.058
3.203SerLys: 3.203 ± 0.041
5.272SerLeu: 5.272 ± 0.057
1.847SerMet: 1.847 ± 0.03
2.043SerAsn: 2.043 ± 0.04
1.849SerPro: 1.849 ± 0.033
1.78SerGln: 1.78 ± 0.034
2.823SerArg: 2.823 ± 0.037
3.468SerSer: 3.468 ± 0.06
2.688SerThr: 2.688 ± 0.043
4.443SerVal: 4.443 ± 0.05
0.584SerTrp: 0.584 ± 0.021
2.483SerTyr: 2.483 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
4.543ThrAla: 4.543 ± 0.055
0.642ThrCys: 0.642 ± 0.018
3.22ThrAsp: 3.22 ± 0.046
3.746ThrGlu: 3.746 ± 0.055
2.26ThrPhe: 2.26 ± 0.038
4.776ThrGly: 4.776 ± 0.059
0.83ThrHis: 0.83 ± 0.022
3.823ThrIle: 3.823 ± 0.047
2.993ThrLys: 2.993 ± 0.039
4.853ThrLeu: 4.853 ± 0.054
1.474ThrMet: 1.474 ± 0.028
1.92ThrAsn: 1.92 ± 0.037
2.102ThrPro: 2.102 ± 0.042
1.424ThrGln: 1.424 ± 0.028
1.878ThrArg: 1.878 ± 0.035
2.776ThrSer: 2.776 ± 0.042
2.606ThrThr: 2.606 ± 0.044
4.387ThrVal: 4.387 ± 0.058
0.505ThrTrp: 0.505 ± 0.019
2.158ThrTyr: 2.158 ± 0.042
0.001ThrXaa: 0.001 ± 0.001
Val
4.294ValAla: 4.294 ± 0.056
1.297ValCys: 1.297 ± 0.027
3.531ValAsp: 3.531 ± 0.049
4.563ValGlu: 4.563 ± 0.061
3.203ValPhe: 3.203 ± 0.053
4.132ValGly: 4.132 ± 0.055
1.16ValHis: 1.16 ± 0.023
5.453ValIle: 5.453 ± 0.062
4.524ValLys: 4.524 ± 0.061
6.945ValLeu: 6.945 ± 0.063
2.219ValMet: 2.219 ± 0.035
2.872ValAsn: 2.872 ± 0.044
2.672ValPro: 2.672 ± 0.038
2.083ValGln: 2.083 ± 0.035
3.043ValArg: 3.043 ± 0.044
4.672ValSer: 4.672 ± 0.056
4.155ValThr: 4.155 ± 0.056
4.5ValVal: 4.5 ± 0.063
0.687ValTrp: 0.687 ± 0.023
2.777ValTyr: 2.777 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.56TrpAla: 0.56 ± 0.021
0.18TrpCys: 0.18 ± 0.011
0.623TrpAsp: 0.623 ± 0.019
0.736TrpGlu: 0.736 ± 0.024
0.405TrpPhe: 0.405 ± 0.014
0.743TrpGly: 0.743 ± 0.022
0.18TrpHis: 0.18 ± 0.011
0.686TrpIle: 0.686 ± 0.023
0.741TrpLys: 0.741 ± 0.023
0.903TrpLeu: 0.903 ± 0.023
0.357TrpMet: 0.357 ± 0.013
0.562TrpAsn: 0.562 ± 0.016
0.244TrpPro: 0.244 ± 0.011
0.366TrpGln: 0.366 ± 0.013
0.374TrpArg: 0.374 ± 0.016
0.509TrpSer: 0.509 ± 0.019
0.459TrpThr: 0.459 ± 0.018
0.531TrpVal: 0.531 ± 0.019
0.109TrpTrp: 0.109 ± 0.009
0.405TrpTyr: 0.405 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.832TyrAla: 2.832 ± 0.042
0.658TyrCys: 0.658 ± 0.02
2.486TyrAsp: 2.486 ± 0.04
3.178TyrGlu: 3.178 ± 0.043
1.923TyrPhe: 1.923 ± 0.036
3.083TyrGly: 3.083 ± 0.044
0.95TyrHis: 0.95 ± 0.028
3.034TyrIle: 3.034 ± 0.042
2.201TyrLys: 2.201 ± 0.04
3.929TyrLeu: 3.929 ± 0.052
1.241TyrMet: 1.241 ± 0.028
1.783TyrAsn: 1.783 ± 0.036
1.516TyrPro: 1.516 ± 0.033
1.604TyrGln: 1.604 ± 0.029
2.07TyrArg: 2.07 ± 0.036
2.425TyrSer: 2.425 ± 0.037
2.356TyrThr: 2.356 ± 0.044
2.525TyrVal: 2.525 ± 0.037
0.422TyrTrp: 0.422 ± 0.017
1.931TyrTyr: 1.931 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.002
Statistics based on 5138 proteins (1715350 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski