Amino acid dipepetide frequency for Bizionia paragorgiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.169AlaAla: 4.169 ± 0.079	0.593AlaCys: 0.593 ± 0.026	3.239AlaAsp: 3.239 ± 0.064	3.998AlaGlu: 3.998 ± 0.071	3.751AlaPhe: 3.751 ± 0.062	3.912AlaGly: 3.912 ± 0.076	1.216AlaHis: 1.216 ± 0.04	5.791AlaIle: 5.791 ± 0.077	4.823AlaLys: 4.823 ± 0.077	7.224AlaLeu: 7.224 ± 0.088	1.605AlaMet: 1.605 ± 0.043	3.499AlaAsn: 3.499 ± 0.06	1.863AlaPro: 1.863 ± 0.05	2.6AlaGln: 2.6 ± 0.049	1.869AlaArg: 1.869 ± 0.05	4.267AlaSer: 4.267 ± 0.071	3.838AlaThr: 3.838 ± 0.081	4.475AlaVal: 4.475 ± 0.075	0.562AlaTrp: 0.562 ± 0.027	2.608AlaTyr: 2.608 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.458CysAla: 0.458 ± 0.022	0.095CysCys: 0.095 ± 0.012	0.489CysAsp: 0.489 ± 0.03	0.489CysGlu: 0.489 ± 0.024	0.433CysPhe: 0.433 ± 0.022	0.596CysGly: 0.596 ± 0.026	0.167CysHis: 0.167 ± 0.015	0.591CysIle: 0.591 ± 0.026	0.505CysLys: 0.505 ± 0.026	0.651CysLeu: 0.651 ± 0.026	0.14CysMet: 0.14 ± 0.012	0.447CysAsn: 0.447 ± 0.025	0.371CysPro: 0.371 ± 0.023	0.196CysGln: 0.196 ± 0.014	0.184CysArg: 0.184 ± 0.015	0.564CysSer: 0.564 ± 0.034	0.428CysThr: 0.428 ± 0.026	0.476CysVal: 0.476 ± 0.023	0.06CysTrp: 0.06 ± 0.008	0.293CysTyr: 0.293 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.026AspAla: 4.026 ± 0.075	0.483AspCys: 0.483 ± 0.031	3.12AspAsp: 3.12 ± 0.066	3.458AspGlu: 3.458 ± 0.074	3.57AspPhe: 3.57 ± 0.066	3.419AspGly: 3.419 ± 0.085	0.954AspHis: 0.954 ± 0.032	4.517AspIle: 4.517 ± 0.071	4.142AspLys: 4.142 ± 0.08	5.568AspLeu: 5.568 ± 0.077	1.094AspMet: 1.094 ± 0.032	3.141AspAsn: 3.141 ± 0.071	1.663AspPro: 1.663 ± 0.046	1.429AspGln: 1.429 ± 0.034	1.831AspArg: 1.831 ± 0.044	3.442AspSer: 3.442 ± 0.068	3.222AspThr: 3.222 ± 0.057	3.692AspVal: 3.692 ± 0.069	0.685AspTrp: 0.685 ± 0.029	2.98AspTyr: 2.98 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	4.928GluAla: 4.928 ± 0.087	0.326GluCys: 0.326 ± 0.02	3.846GluAsp: 3.846 ± 0.074	4.504GluGlu: 4.504 ± 0.089	2.939GluPhe: 2.939 ± 0.063	3.579GluGly: 3.579 ± 0.066	1.278GluHis: 1.278 ± 0.04	4.977GluIle: 4.977 ± 0.089	5.213GluLys: 5.213 ± 0.091	6.275GluLeu: 6.275 ± 0.082	1.388GluMet: 1.388 ± 0.037	4.449GluAsn: 4.449 ± 0.073	1.588GluPro: 1.588 ± 0.042	2.351GluGln: 2.351 ± 0.045	2.611GluArg: 2.611 ± 0.06	3.519GluSer: 3.519 ± 0.06	4.058GluThr: 4.058 ± 0.062	4.242GluVal: 4.242 ± 0.071	0.594GluTrp: 0.594 ± 0.026	2.328GluTyr: 2.328 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.856PheAla: 2.856 ± 0.062	0.416PheCys: 0.416 ± 0.022	3.181PheAsp: 3.181 ± 0.059	3.196PheGlu: 3.196 ± 0.054	2.489PhePhe: 2.489 ± 0.062	3.524PheGly: 3.524 ± 0.069	0.829PheHis: 0.829 ± 0.031	3.942PheIle: 3.942 ± 0.083	4.123PheLys: 4.123 ± 0.077	4.498PheLeu: 4.498 ± 0.075	1.071PheMet: 1.071 ± 0.034	3.608PheAsn: 3.608 ± 0.065	1.653PhePro: 1.653 ± 0.042	1.442PheGln: 1.442 ± 0.04	1.486PheArg: 1.486 ± 0.039	4.109PheSer: 4.109 ± 0.068	3.26PheThr: 3.26 ± 0.069	2.985PheVal: 2.985 ± 0.065	0.529PheTrp: 0.529 ± 0.025	2.192PheTyr: 2.192 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	4.041GlyAla: 4.041 ± 0.072	0.646GlyCys: 0.646 ± 0.043	3.547GlyAsp: 3.547 ± 0.066	3.58GlyGlu: 3.58 ± 0.069	3.55GlyPhe: 3.55 ± 0.072	4.315GlyGly: 4.315 ± 0.103	1.19GlyHis: 1.19 ± 0.038	4.861GlyIle: 4.861 ± 0.084	4.457GlyLys: 4.457 ± 0.069	5.833GlyLeu: 5.833 ± 0.089	1.448GlyMet: 1.448 ± 0.048	3.201GlyAsn: 3.201 ± 0.067	1.304GlyPro: 1.304 ± 0.037	1.846GlyGln: 1.846 ± 0.046	1.939GlyArg: 1.939 ± 0.049	3.777GlySer: 3.777 ± 0.072	3.941GlyThr: 3.941 ± 0.088	4.654GlyVal: 4.654 ± 0.08	0.636GlyTrp: 0.636 ± 0.029	2.64GlyTyr: 2.64 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.012HisAla: 1.012 ± 0.03	0.192HisCys: 0.192 ± 0.018	0.832HisAsp: 0.832 ± 0.036	0.923HisGlu: 0.923 ± 0.03	1.267HisPhe: 1.267 ± 0.034	0.965HisGly: 0.965 ± 0.033	0.515HisHis: 0.515 ± 0.021	1.658HisIle: 1.658 ± 0.044	1.301HisLys: 1.301 ± 0.038	1.943HisLeu: 1.943 ± 0.053	0.321HisMet: 0.321 ± 0.018	1.061HisAsn: 1.061 ± 0.036	0.882HisPro: 0.882 ± 0.03	0.73HisGln: 0.73 ± 0.027	0.671HisArg: 0.671 ± 0.029	1.168HisSer: 1.168 ± 0.036	1.079HisThr: 1.079 ± 0.035	0.973HisVal: 0.973 ± 0.034	0.192HisTrp: 0.192 ± 0.014	0.981HisTyr: 0.981 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.693IleAla: 5.693 ± 0.092	0.566IleCys: 0.566 ± 0.026	4.97IleAsp: 4.97 ± 0.069	5.466IleGlu: 5.466 ± 0.076	3.167IlePhe: 3.167 ± 0.064	4.825IleGly: 4.825 ± 0.08	1.349IleHis: 1.349 ± 0.041	6.078IleIle: 6.078 ± 0.111	6.127IleLys: 6.127 ± 0.09	6.814IleLeu: 6.814 ± 0.099	1.349IleMet: 1.349 ± 0.038	4.817IleAsn: 4.817 ± 0.084	3.187IlePro: 3.187 ± 0.052	2.561IleGln: 2.561 ± 0.059	2.285IleArg: 2.285 ± 0.044	5.501IleSer: 5.501 ± 0.086	5.224IleThr: 5.224 ± 0.094	4.69IleVal: 4.69 ± 0.076	0.589IleTrp: 0.589 ± 0.024	2.626IleTyr: 2.626 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	5.532LysAla: 5.532 ± 0.095	0.322LysCys: 0.322 ± 0.018	4.611LysAsp: 4.611 ± 0.08	5.927LysGlu: 5.927 ± 0.094	2.691LysPhe: 2.691 ± 0.049	4.419LysGly: 4.419 ± 0.075	1.668LysHis: 1.668 ± 0.048	5.607LysIle: 5.607 ± 0.086	6.521LysLys: 6.521 ± 0.106	6.523LysLeu: 6.523 ± 0.102	1.914LysMet: 1.914 ± 0.046	5.087LysAsn: 5.087 ± 0.088	2.503LysPro: 2.503 ± 0.05	3.111LysGln: 3.111 ± 0.064	3.07LysArg: 3.07 ± 0.064	4.695LysSer: 4.695 ± 0.079	5.314LysThr: 5.314 ± 0.086	4.608LysVal: 4.608 ± 0.071	0.697LysTrp: 0.697 ± 0.031	2.931LysTyr: 2.931 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	6.052LeuAla: 6.052 ± 0.079	0.753LeuCys: 0.753 ± 0.031	5.23LeuAsp: 5.23 ± 0.089	6.516LeuGlu: 6.516 ± 0.085	4.947LeuPhe: 4.947 ± 0.086	5.678LeuGly: 5.678 ± 0.08	1.64LeuHis: 1.64 ± 0.046	7.159LeuIle: 7.159 ± 0.104	8.233LeuLys: 8.233 ± 0.105	9.089LeuLeu: 9.089 ± 0.139	2.038LeuMet: 2.038 ± 0.058	5.81LeuAsn: 5.81 ± 0.08	3.46LeuPro: 3.46 ± 0.059	3.402LeuGln: 3.402 ± 0.074	3.147LeuArg: 3.147 ± 0.061	6.863LeuSer: 6.863 ± 0.094	5.281LeuThr: 5.281 ± 0.078	5.71LeuVal: 5.71 ± 0.093	0.75LeuTrp: 0.75 ± 0.028	3.209LeuTyr: 3.209 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.634MetAla: 1.634 ± 0.048	0.142MetCys: 0.142 ± 0.013	1.071MetAsp: 1.071 ± 0.036	1.266MetGlu: 1.266 ± 0.034	0.794MetPhe: 0.794 ± 0.033	1.268MetGly: 1.268 ± 0.037	0.397MetHis: 0.397 ± 0.025	1.368MetIle: 1.368 ± 0.041	1.979MetLys: 1.979 ± 0.05	1.892MetLeu: 1.892 ± 0.047	0.526MetMet: 0.526 ± 0.027	1.159MetAsn: 1.159 ± 0.036	0.803MetPro: 0.803 ± 0.03	0.884MetGln: 0.884 ± 0.033	0.827MetArg: 0.827 ± 0.027	1.5MetSer: 1.5 ± 0.042	1.184MetThr: 1.184 ± 0.037	1.282MetVal: 1.282 ± 0.032	0.143MetTrp: 0.143 ± 0.013	0.686MetTyr: 0.686 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	4.161AsnAla: 4.161 ± 0.066	0.475AsnCys: 0.475 ± 0.026	3.389AsnAsp: 3.389 ± 0.061	3.598AsnGlu: 3.598 ± 0.066	2.78AsnPhe: 2.78 ± 0.062	3.881AsnGly: 3.881 ± 0.074	1.098AsnHis: 1.098 ± 0.031	4.503AsnIle: 4.503 ± 0.076	4.568AsnLys: 4.568 ± 0.083	5.175AsnLeu: 5.175 ± 0.096	1.161AsnMet: 1.161 ± 0.038	3.889AsnAsn: 3.889 ± 0.089	2.624AsnPro: 2.624 ± 0.065	2.073AsnGln: 2.073 ± 0.052	2.136AsnArg: 2.136 ± 0.047	3.832AsnSer: 3.832 ± 0.073	4.38AsnThr: 4.38 ± 0.081	3.437AsnVal: 3.437 ± 0.066	0.666AsnTrp: 0.666 ± 0.027	2.816AsnTyr: 2.816 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	1.775ProAla: 1.775 ± 0.047	0.231ProCys: 0.231 ± 0.016	1.824ProAsp: 1.824 ± 0.052	2.882ProGlu: 2.882 ± 0.061	1.882ProPhe: 1.882 ± 0.052	1.778ProGly: 1.778 ± 0.052	0.603ProHis: 0.603 ± 0.023	2.67ProIle: 2.67 ± 0.048	2.658ProLys: 2.658 ± 0.064	3.032ProLeu: 3.032 ± 0.063	0.701ProMet: 0.701 ± 0.028	2.221ProAsn: 2.221 ± 0.051	0.771ProPro: 0.771 ± 0.041	1.14ProGln: 1.14 ± 0.039	0.865ProArg: 0.865 ± 0.032	2.193ProSer: 2.193 ± 0.051	2.052ProThr: 2.052 ± 0.048	2.253ProVal: 2.253 ± 0.047	0.276ProTrp: 0.276 ± 0.018	1.345ProTyr: 1.345 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.273GlnAla: 2.273 ± 0.05	0.186GlnCys: 0.186 ± 0.015	1.838GlnAsp: 1.838 ± 0.04	2.296GlnGlu: 2.296 ± 0.048	1.76GlnPhe: 1.76 ± 0.043	1.914GlnGly: 1.914 ± 0.049	0.694GlnHis: 0.694 ± 0.03	2.458GlnIle: 2.458 ± 0.058	2.566GlnLys: 2.566 ± 0.052	3.656GlnLeu: 3.656 ± 0.075	0.791GlnMet: 0.791 ± 0.031	2.044GlnAsn: 2.044 ± 0.05	1.114GlnPro: 1.114 ± 0.039	1.449GlnGln: 1.449 ± 0.045	1.269GlnArg: 1.269 ± 0.042	2.022GlnSer: 2.022 ± 0.047	2.008GlnThr: 2.008 ± 0.049	2.107GlnVal: 2.107 ± 0.046	0.345GlnTrp: 0.345 ± 0.02	1.351GlnTyr: 1.351 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	2.2ArgAla: 2.2 ± 0.051	0.21ArgCys: 0.21 ± 0.015	1.751ArgAsp: 1.751 ± 0.041	2.185ArgGlu: 2.185 ± 0.051	1.876ArgPhe: 1.876 ± 0.048	1.894ArgGly: 1.894 ± 0.048	0.652ArgHis: 0.652 ± 0.029	2.704ArgIle: 2.704 ± 0.052	2.603ArgLys: 2.603 ± 0.059	3.357ArgLeu: 3.357 ± 0.06	0.764ArgMet: 0.764 ± 0.03	1.89ArgAsn: 1.89 ± 0.047	1.063ArgPro: 1.063 ± 0.035	1.112ArgGln: 1.112 ± 0.035	1.303ArgArg: 1.303 ± 0.047	1.883ArgSer: 1.883 ± 0.054	1.82ArgThr: 1.82 ± 0.048	2.123ArgVal: 2.123 ± 0.052	0.325ArgTrp: 0.325 ± 0.021	1.46ArgTyr: 1.46 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.962SerAla: 3.962 ± 0.069	0.619SerCys: 0.619 ± 0.027	3.668SerAsp: 3.668 ± 0.065	4.231SerGlu: 4.231 ± 0.07	3.633SerPhe: 3.633 ± 0.061	4.609SerGly: 4.609 ± 0.082	1.202SerHis: 1.202 ± 0.036	5.205SerIle: 5.205 ± 0.081	5.172SerLys: 5.172 ± 0.092	6.1SerLeu: 6.1 ± 0.082	1.167SerMet: 1.167 ± 0.041	3.726SerAsn: 3.726 ± 0.074	2.084SerPro: 2.084 ± 0.052	2.236SerGln: 2.236 ± 0.047	2.112SerArg: 2.112 ± 0.053	4.164SerSer: 4.164 ± 0.077	3.853SerThr: 3.853 ± 0.083	4.221SerVal: 4.221 ± 0.072	0.616SerTrp: 0.616 ± 0.031	2.802SerTyr: 2.802 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.01ThrAla: 4.01 ± 0.082	0.424ThrCys: 0.424 ± 0.029	3.404ThrAsp: 3.404 ± 0.066	3.711ThrGlu: 3.711 ± 0.065	3.202ThrPhe: 3.202 ± 0.065	3.963ThrGly: 3.963 ± 0.088	1.204ThrHis: 1.204 ± 0.038	5.292ThrIle: 5.292 ± 0.099	4.243ThrLys: 4.243 ± 0.067	6.147ThrLeu: 6.147 ± 0.083	1.044ThrMet: 1.044 ± 0.037	3.46ThrAsn: 3.46 ± 0.078	2.651ThrPro: 2.651 ± 0.064	2.066ThrGln: 2.066 ± 0.054	1.756ThrArg: 1.756 ± 0.055	3.953ThrSer: 3.953 ± 0.083	4.13ThrThr: 4.13 ± 0.104	4.399ThrVal: 4.399 ± 0.107	0.5ThrTrp: 0.5 ± 0.026	2.567ThrTyr: 2.567 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	4.141ValAla: 4.141 ± 0.071	0.537ValCys: 0.537 ± 0.024	3.601ValAsp: 3.601 ± 0.058	3.908ValGlu: 3.908 ± 0.072	3.66ValPhe: 3.66 ± 0.077	3.842ValGly: 3.842 ± 0.066	0.992ValHis: 0.992 ± 0.036	5.056ValIle: 5.056 ± 0.078	4.573ValLys: 4.573 ± 0.092	6.494ValLeu: 6.494 ± 0.096	1.324ValMet: 1.324 ± 0.041	3.688ValAsn: 3.688 ± 0.079	2.076ValPro: 2.076 ± 0.049	1.736ValGln: 1.736 ± 0.045	1.953ValArg: 1.953 ± 0.052	4.682ValSer: 4.682 ± 0.063	3.906ValThr: 3.906 ± 0.113	4.614ValVal: 4.614 ± 0.09	0.509ValTrp: 0.509 ± 0.024	2.503ValTyr: 2.503 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.524TrpAla: 0.524 ± 0.024	0.1TrpCys: 0.1 ± 0.012	0.515TrpAsp: 0.515 ± 0.027	0.619TrpGlu: 0.619 ± 0.031	0.545TrpPhe: 0.545 ± 0.025	0.472TrpGly: 0.472 ± 0.022	0.196TrpHis: 0.196 ± 0.015	0.666TrpIle: 0.666 ± 0.029	0.685TrpLys: 0.685 ± 0.027	0.968TrpLeu: 0.968 ± 0.036	0.268TrpMet: 0.268 ± 0.017	0.597TrpAsn: 0.597 ± 0.025	0.191TrpPro: 0.191 ± 0.012	0.361TrpGln: 0.361 ± 0.018	0.353TrpArg: 0.353 ± 0.019	0.559TrpSer: 0.559 ± 0.023	0.517TrpThr: 0.517 ± 0.025	0.571TrpVal: 0.571 ± 0.031	0.112TrpTrp: 0.112 ± 0.013	0.401TrpTyr: 0.401 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.459TyrAla: 2.459 ± 0.05	0.322TyrCys: 0.322 ± 0.019	2.31TyrAsp: 2.31 ± 0.051	2.24TyrGlu: 2.24 ± 0.053	2.453TyrPhe: 2.453 ± 0.055	2.555TyrGly: 2.555 ± 0.053	0.82TyrHis: 0.82 ± 0.032	2.782TyrIle: 2.782 ± 0.052	3.259TyrLys: 3.259 ± 0.061	3.725TyrLeu: 3.725 ± 0.069	0.687TyrMet: 0.687 ± 0.026	2.85TyrAsn: 2.85 ± 0.063	1.3TyrPro: 1.3 ± 0.04	1.417TyrGln: 1.417 ± 0.043	1.505TyrArg: 1.505 ± 0.048	2.691TyrSer: 2.691 ± 0.065	2.63TyrThr: 2.63 ± 0.076	2.283TyrVal: 2.283 ± 0.052	0.435TyrTrp: 0.435 ± 0.02	1.809TyrTyr: 1.809 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2859 proteins (932437 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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