Amino acid dipepetide frequency for Sulfurovum lithotrophicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.407AlaAla: 4.407 ± 0.193
0.622AlaCys: 0.622 ± 0.077
3.456AlaAsp: 3.456 ± 0.16
3.72AlaGlu: 3.72 ± 0.175
3.221AlaPhe: 3.221 ± 0.188
4.319AlaGly: 4.319 ± 0.192
1.408AlaHis: 1.408 ± 0.087
6.044AlaIle: 6.044 ± 0.196
6.543AlaLys: 6.543 ± 0.221
8.326AlaLeu: 8.326 ± 0.259
2.347AlaMet: 2.347 ± 0.132
3.139AlaAsn: 3.139 ± 0.144
1.948AlaPro: 1.948 ± 0.129
2.506AlaGln: 2.506 ± 0.118
2.488AlaArg: 2.488 ± 0.125
4.477AlaSer: 4.477 ± 0.169
4.09AlaThr: 4.09 ± 0.189
4.266AlaVal: 4.266 ± 0.183
0.464AlaTrp: 0.464 ± 0.053
2.775AlaTyr: 2.775 ± 0.149
0.0AlaXaa: 0.0 ± 0.0
Cys
0.634CysAla: 0.634 ± 0.06
0.076CysCys: 0.076 ± 0.025
0.669CysAsp: 0.669 ± 0.08
0.757CysGlu: 0.757 ± 0.068
0.264CysPhe: 0.264 ± 0.04
0.821CysGly: 0.821 ± 0.072
0.376CysHis: 0.376 ± 0.066
0.493CysIle: 0.493 ± 0.058
0.763CysLys: 0.763 ± 0.069
0.499CysLeu: 0.499 ± 0.059
0.235CysMet: 0.235 ± 0.04
0.446CysAsn: 0.446 ± 0.055
0.469CysPro: 0.469 ± 0.066
0.2CysGln: 0.2 ± 0.035
0.282CysArg: 0.282 ± 0.043
0.516CysSer: 0.516 ± 0.055
0.534CysThr: 0.534 ± 0.053
0.593CysVal: 0.593 ± 0.062
0.029CysTrp: 0.029 ± 0.014
0.452CysTyr: 0.452 ± 0.048
0.0CysXaa: 0.0 ± 0.0
Asp
4.853AspAla: 4.853 ± 0.194
0.417AspCys: 0.417 ± 0.049
3.456AspAsp: 3.456 ± 0.163
4.782AspGlu: 4.782 ± 0.169
2.887AspPhe: 2.887 ± 0.14
3.826AspGly: 3.826 ± 0.177
0.821AspHis: 0.821 ± 0.063
5.328AspIle: 5.328 ± 0.189
4.859AspLys: 4.859 ± 0.171
4.677AspLeu: 4.677 ± 0.166
1.796AspMet: 1.796 ± 0.114
2.641AspAsn: 2.641 ± 0.12
1.578AspPro: 1.578 ± 0.102
0.933AspGln: 0.933 ± 0.066
1.731AspArg: 1.731 ± 0.1
2.928AspSer: 2.928 ± 0.129
3.832AspThr: 3.832 ± 0.152
3.814AspVal: 3.814 ± 0.157
0.346AspTrp: 0.346 ± 0.045
2.294AspTyr: 2.294 ± 0.121
0.0AspXaa: 0.0 ± 0.0
Glu
5.234GluAla: 5.234 ± 0.195
0.775GluCys: 0.775 ± 0.07
3.926GluAsp: 3.926 ± 0.166
6.208GluGlu: 6.208 ± 0.252
2.887GluPhe: 2.887 ± 0.137
4.266GluGly: 4.266 ± 0.164
1.848GluHis: 1.848 ± 0.099
5.58GluIle: 5.58 ± 0.206
6.801GluLys: 6.801 ± 0.258
6.683GluLeu: 6.683 ± 0.268
2.007GluMet: 2.007 ± 0.109
3.785GluAsn: 3.785 ± 0.155
1.754GluPro: 1.754 ± 0.1
2.347GluGln: 2.347 ± 0.114
2.887GluArg: 2.887 ± 0.137
3.667GluSer: 3.667 ± 0.143
3.532GluThr: 3.532 ± 0.147
5.246GluVal: 5.246 ± 0.18
0.675GluTrp: 0.675 ± 0.067
2.787GluTyr: 2.787 ± 0.121
0.0GluXaa: 0.0 ± 0.0
Phe
2.928PheAla: 2.928 ± 0.146
0.376PheCys: 0.376 ± 0.05
2.922PheAsp: 2.922 ± 0.135
3.163PheGlu: 3.163 ± 0.163
2.253PhePhe: 2.253 ± 0.122
3.403PheGly: 3.403 ± 0.17
0.816PheHis: 0.816 ± 0.069
3.814PheIle: 3.814 ± 0.187
3.292PheLys: 3.292 ± 0.129
4.154PheLeu: 4.154 ± 0.175
1.414PheMet: 1.414 ± 0.098
2.247PheAsn: 2.247 ± 0.12
1.203PhePro: 1.203 ± 0.079
1.044PheGln: 1.044 ± 0.086
1.467PheArg: 1.467 ± 0.105
3.286PheSer: 3.286 ± 0.152
2.893PheThr: 2.893 ± 0.134
3.192PheVal: 3.192 ± 0.147
0.411PheTrp: 0.411 ± 0.055
1.696PheTyr: 1.696 ± 0.099
0.0PheXaa: 0.0 ± 0.0
Gly
4.46GlyAla: 4.46 ± 0.203
0.91GlyCys: 0.91 ± 0.074
3.656GlyAsp: 3.656 ± 0.165
4.031GlyGlu: 4.031 ± 0.178
3.116GlyPhe: 3.116 ± 0.134
4.049GlyGly: 4.049 ± 0.194
1.532GlyHis: 1.532 ± 0.108
4.747GlyIle: 4.747 ± 0.172
4.706GlyLys: 4.706 ± 0.158
5.768GlyLeu: 5.768 ± 0.216
2.001GlyMet: 2.001 ± 0.114
2.435GlyAsn: 2.435 ± 0.125
1.033GlyPro: 1.033 ± 0.082
1.532GlyGln: 1.532 ± 0.106
2.101GlyArg: 2.101 ± 0.126
3.82GlySer: 3.82 ± 0.192
3.532GlyThr: 3.532 ± 0.168
4.471GlyVal: 4.471 ± 0.201
0.698GlyTrp: 0.698 ± 0.07
2.635GlyTyr: 2.635 ± 0.12
0.0GlyXaa: 0.0 ± 0.0
His
1.426HisAla: 1.426 ± 0.095
0.223HisCys: 0.223 ± 0.034
1.132HisAsp: 1.132 ± 0.089
1.402HisGlu: 1.402 ± 0.087
1.185HisPhe: 1.185 ± 0.087
1.467HisGly: 1.467 ± 0.112
0.61HisHis: 0.61 ± 0.066
1.919HisIle: 1.919 ± 0.112
1.596HisLys: 1.596 ± 0.1
1.889HisLeu: 1.889 ± 0.115
0.599HisMet: 0.599 ± 0.066
1.068HisAsn: 1.068 ± 0.078
1.05HisPro: 1.05 ± 0.09
0.587HisGln: 0.587 ± 0.057
0.816HisArg: 0.816 ± 0.081
1.373HisSer: 1.373 ± 0.094
1.367HisThr: 1.367 ± 0.086
1.097HisVal: 1.097 ± 0.089
0.2HisTrp: 0.2 ± 0.034
1.115HisTyr: 1.115 ± 0.078
0.0HisXaa: 0.0 ± 0.0
Ile
6.337IleAla: 6.337 ± 0.207
0.64IleCys: 0.64 ± 0.053
5.75IleAsp: 5.75 ± 0.178
6.196IleGlu: 6.196 ± 0.194
3.286IlePhe: 3.286 ± 0.14
4.876IleGly: 4.876 ± 0.212
1.532IleHis: 1.532 ± 0.114
6.026IleIle: 6.026 ± 0.204
5.674IleLys: 5.674 ± 0.193
6.777IleLeu: 6.777 ± 0.219
1.578IleMet: 1.578 ± 0.097
3.568IleAsn: 3.568 ± 0.168
2.822IlePro: 2.822 ± 0.141
2.324IleGln: 2.324 ± 0.129
2.441IleArg: 2.441 ± 0.128
5.023IleSer: 5.023 ± 0.179
4.618IleThr: 4.618 ± 0.179
5.046IleVal: 5.046 ± 0.171
0.493IleTrp: 0.493 ± 0.059
2.805IleTyr: 2.805 ± 0.13
0.0IleXaa: 0.0 ± 0.0
Lys
5.61LysAla: 5.61 ± 0.205
0.728LysCys: 0.728 ± 0.074
4.483LysAsp: 4.483 ± 0.178
7.98LysGlu: 7.98 ± 0.255
2.723LysPhe: 2.723 ± 0.119
4.348LysGly: 4.348 ± 0.201
1.831LysHis: 1.831 ± 0.101
6.238LysIle: 6.238 ± 0.205
7.881LysLys: 7.881 ± 0.27
7.417LysLeu: 7.417 ± 0.202
2.107LysMet: 2.107 ± 0.114
4.641LysAsn: 4.641 ± 0.171
2.553LysPro: 2.553 ± 0.132
2.617LysGln: 2.617 ± 0.136
3.468LysArg: 3.468 ± 0.147
4.882LysSer: 4.882 ± 0.174
4.113LysThr: 4.113 ± 0.147
5.14LysVal: 5.14 ± 0.179
0.569LysTrp: 0.569 ± 0.053
3.051LysTyr: 3.051 ± 0.148
0.0LysXaa: 0.0 ± 0.0
Leu
6.49LeuAla: 6.49 ± 0.208
0.868LeuCys: 0.868 ± 0.07
5.569LeuAsp: 5.569 ± 0.165
7.253LeuGlu: 7.253 ± 0.254
5.099LeuPhe: 5.099 ± 0.184
6.085LeuGly: 6.085 ± 0.213
2.171LeuHis: 2.171 ± 0.123
6.173LeuIle: 6.173 ± 0.2
7.775LeuLys: 7.775 ± 0.227
10.398LeuLeu: 10.398 ± 0.3
2.599LeuMet: 2.599 ± 0.112
4.154LeuAsn: 4.154 ± 0.186
3.55LeuPro: 3.55 ± 0.128
3.151LeuGln: 3.151 ± 0.14
3.268LeuArg: 3.268 ± 0.122
7.112LeuSer: 7.112 ± 0.209
5.246LeuThr: 5.246 ± 0.182
5.516LeuVal: 5.516 ± 0.174
0.745LeuTrp: 0.745 ± 0.071
3.585LeuTyr: 3.585 ± 0.162
0.0LeuXaa: 0.0 ± 0.0
Met
2.165MetAla: 2.165 ± 0.125
0.211MetCys: 0.211 ± 0.032
1.502MetAsp: 1.502 ± 0.099
1.79MetGlu: 1.79 ± 0.119
1.127MetPhe: 1.127 ± 0.086
1.76MetGly: 1.76 ± 0.102
0.645MetHis: 0.645 ± 0.055
2.024MetIle: 2.024 ± 0.11
2.594MetLys: 2.594 ± 0.135
2.682MetLeu: 2.682 ± 0.14
0.886MetMet: 0.886 ± 0.085
1.391MetAsn: 1.391 ± 0.085
1.185MetPro: 1.185 ± 0.088
1.103MetGln: 1.103 ± 0.077
0.874MetArg: 0.874 ± 0.068
1.725MetSer: 1.725 ± 0.096
1.508MetThr: 1.508 ± 0.103
1.749MetVal: 1.749 ± 0.1
0.141MetTrp: 0.141 ± 0.03
0.91MetTyr: 0.91 ± 0.071
0.0MetXaa: 0.0 ± 0.0
Asn
3.427AsnAla: 3.427 ± 0.148
0.329AsnCys: 0.329 ± 0.042
2.435AsnAsp: 2.435 ± 0.116
3.274AsnGlu: 3.274 ± 0.147
2.036AsnPhe: 2.036 ± 0.105
2.734AsnGly: 2.734 ± 0.153
0.998AsnHis: 0.998 ± 0.084
4.665AsnIle: 4.665 ± 0.179
3.843AsnLys: 3.843 ± 0.158
4.231AsnLeu: 4.231 ± 0.195
1.144AsnMet: 1.144 ± 0.075
2.523AsnAsn: 2.523 ± 0.159
1.801AsnPro: 1.801 ± 0.105
1.402AsnGln: 1.402 ± 0.118
1.625AsnArg: 1.625 ± 0.105
2.652AsnSer: 2.652 ± 0.136
2.705AsnThr: 2.705 ± 0.12
2.781AsnVal: 2.781 ± 0.146
0.364AsnTrp: 0.364 ± 0.048
2.118AsnTyr: 2.118 ± 0.127
0.0AsnXaa: 0.0 ± 0.0
Pro
1.69ProAla: 1.69 ± 0.102
0.299ProCys: 0.299 ± 0.044
1.643ProAsp: 1.643 ± 0.099
2.359ProGlu: 2.359 ± 0.125
1.79ProPhe: 1.79 ± 0.123
1.461ProGly: 1.461 ± 0.106
0.78ProHis: 0.78 ± 0.07
2.236ProIle: 2.236 ± 0.12
2.646ProLys: 2.646 ± 0.11
3.192ProLeu: 3.192 ± 0.143
0.939ProMet: 0.939 ± 0.076
1.578ProAsn: 1.578 ± 0.134
0.798ProPro: 0.798 ± 0.057
1.115ProGln: 1.115 ± 0.083
0.91ProArg: 0.91 ± 0.07
1.925ProSer: 1.925 ± 0.106
2.177ProThr: 2.177 ± 0.127
2.23ProVal: 2.23 ± 0.126
0.317ProTrp: 0.317 ± 0.044
1.467ProTyr: 1.467 ± 0.109
0.0ProXaa: 0.0 ± 0.0
Gln
2.283GlnAla: 2.283 ± 0.136
0.188GlnCys: 0.188 ± 0.029
1.608GlnAsp: 1.608 ± 0.099
2.242GlnGlu: 2.242 ± 0.123
1.156GlnPhe: 1.156 ± 0.087
1.631GlnGly: 1.631 ± 0.108
0.657GlnHis: 0.657 ± 0.062
2.259GlnIle: 2.259 ± 0.112
2.946GlnLys: 2.946 ± 0.153
2.547GlnLeu: 2.547 ± 0.151
0.915GlnMet: 0.915 ± 0.071
1.843GlnAsn: 1.843 ± 0.106
0.898GlnPro: 0.898 ± 0.07
1.015GlnGln: 1.015 ± 0.095
1.279GlnArg: 1.279 ± 0.091
1.936GlnSer: 1.936 ± 0.121
1.925GlnThr: 1.925 ± 0.107
1.485GlnVal: 1.485 ± 0.095
0.288GlnTrp: 0.288 ± 0.042
1.309GlnTyr: 1.309 ± 0.088
0.0GlnXaa: 0.0 ± 0.0
Arg
2.488ArgAla: 2.488 ± 0.111
0.334ArgCys: 0.334 ± 0.041
1.972ArgAsp: 1.972 ± 0.107
2.711ArgGlu: 2.711 ± 0.139
1.819ArgPhe: 1.819 ± 0.097
2.095ArgGly: 2.095 ± 0.145
0.786ArgHis: 0.786 ± 0.067
2.564ArgIle: 2.564 ± 0.123
2.641ArgLys: 2.641 ± 0.134
3.415ArgLeu: 3.415 ± 0.142
1.044ArgMet: 1.044 ± 0.081
1.397ArgAsn: 1.397 ± 0.096
0.998ArgPro: 0.998 ± 0.072
0.98ArgGln: 0.98 ± 0.075
1.455ArgArg: 1.455 ± 0.098
1.637ArgSer: 1.637 ± 0.093
1.754ArgThr: 1.754 ± 0.101
2.582ArgVal: 2.582 ± 0.114
0.393ArgTrp: 0.393 ± 0.051
1.813ArgTyr: 1.813 ± 0.107
0.0ArgXaa: 0.0 ± 0.0
Ser
3.978SerAla: 3.978 ± 0.147
0.64SerCys: 0.64 ± 0.068
3.444SerAsp: 3.444 ± 0.13
3.644SerGlu: 3.644 ± 0.151
3.216SerPhe: 3.216 ± 0.145
3.873SerGly: 3.873 ± 0.139
1.361SerHis: 1.361 ± 0.084
5.117SerIle: 5.117 ± 0.18
5.334SerLys: 5.334 ± 0.225
6.056SerLeu: 6.056 ± 0.213
1.778SerMet: 1.778 ± 0.111
2.729SerAsn: 2.729 ± 0.138
1.666SerPro: 1.666 ± 0.102
1.772SerGln: 1.772 ± 0.091
2.001SerArg: 2.001 ± 0.12
4.266SerSer: 4.266 ± 0.186
3.744SerThr: 3.744 ± 0.172
3.761SerVal: 3.761 ± 0.145
0.499SerTrp: 0.499 ± 0.055
2.787SerTyr: 2.787 ± 0.133
0.0SerXaa: 0.0 ± 0.0
Thr
3.82ThrAla: 3.82 ± 0.156
0.446ThrCys: 0.446 ± 0.06
2.952ThrAsp: 2.952 ± 0.132
3.175ThrGlu: 3.175 ± 0.143
2.881ThrPhe: 2.881 ± 0.149
3.092ThrGly: 3.092 ± 0.146
1.649ThrHis: 1.649 ± 0.098
4.577ThrIle: 4.577 ± 0.17
4.319ThrLys: 4.319 ± 0.149
6.93ThrLeu: 6.93 ± 0.208
1.367ThrMet: 1.367 ± 0.089
2.459ThrAsn: 2.459 ± 0.138
2.594ThrPro: 2.594 ± 0.128
2.353ThrGln: 2.353 ± 0.126
1.854ThrArg: 1.854 ± 0.101
3.374ThrSer: 3.374 ± 0.157
3.568ThrThr: 3.568 ± 0.19
3.656ThrVal: 3.656 ± 0.16
0.511ThrTrp: 0.511 ± 0.052
2.347ThrTyr: 2.347 ± 0.127
0.0ThrXaa: 0.0 ± 0.0
Val
4.988ValAla: 4.988 ± 0.206
0.552ValCys: 0.552 ± 0.058
4.061ValAsp: 4.061 ± 0.182
5.017ValGlu: 5.017 ± 0.195
2.488ValPhe: 2.488 ± 0.111
4.149ValGly: 4.149 ± 0.15
1.103ValHis: 1.103 ± 0.077
4.46ValIle: 4.46 ± 0.169
4.688ValLys: 4.688 ± 0.175
6.179ValLeu: 6.179 ± 0.202
1.854ValMet: 1.854 ± 0.093
2.91ValAsn: 2.91 ± 0.13
2.124ValPro: 2.124 ± 0.117
1.936ValGln: 1.936 ± 0.113
2.212ValArg: 2.212 ± 0.112
4.313ValSer: 4.313 ± 0.154
3.943ValThr: 3.943 ± 0.167
4.272ValVal: 4.272 ± 0.201
0.552ValTrp: 0.552 ± 0.062
1.925ValTyr: 1.925 ± 0.106
0.0ValXaa: 0.0 ± 0.0
Trp
0.522TrpAla: 0.522 ± 0.049
0.094TrpCys: 0.094 ± 0.023
0.458TrpAsp: 0.458 ± 0.043
0.452TrpGlu: 0.452 ± 0.05
0.452TrpPhe: 0.452 ± 0.06
0.587TrpGly: 0.587 ± 0.069
0.252TrpHis: 0.252 ± 0.041
0.651TrpIle: 0.651 ± 0.071
0.475TrpLys: 0.475 ± 0.047
0.986TrpLeu: 0.986 ± 0.071
0.311TrpMet: 0.311 ± 0.054
0.323TrpAsn: 0.323 ± 0.041
0.094TrpPro: 0.094 ± 0.026
0.258TrpGln: 0.258 ± 0.044
0.299TrpArg: 0.299 ± 0.037
0.481TrpSer: 0.481 ± 0.062
0.411TrpThr: 0.411 ± 0.048
0.634TrpVal: 0.634 ± 0.068
0.111TrpTrp: 0.111 ± 0.025
0.258TrpTyr: 0.258 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.828TyrAla: 2.828 ± 0.133
0.381TyrCys: 0.381 ± 0.055
2.705TyrAsp: 2.705 ± 0.128
2.74TyrGlu: 2.74 ± 0.143
2.089TyrPhe: 2.089 ± 0.122
2.388TyrGly: 2.388 ± 0.113
0.945TyrHis: 0.945 ± 0.069
2.899TyrIle: 2.899 ± 0.137
3.004TyrLys: 3.004 ± 0.138
4.002TyrLeu: 4.002 ± 0.172
1.044TyrMet: 1.044 ± 0.071
1.813TyrAsn: 1.813 ± 0.113
1.432TyrPro: 1.432 ± 0.101
1.232TyrGln: 1.232 ± 0.1
1.42TyrArg: 1.42 ± 0.117
2.271TyrSer: 2.271 ± 0.148
2.435TyrThr: 2.435 ± 0.119
2.195TyrVal: 2.195 ± 0.116
0.305TyrTrp: 0.305 ± 0.042
1.854TyrTyr: 1.854 ± 0.12
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 666 proteins (170421 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski