Amino acid dipepetide frequency for Aurantimicrobium minutum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.649AlaAla: 13.649 ± 0.215	0.564AlaCys: 0.564 ± 0.033	5.963AlaAsp: 5.963 ± 0.127	7.356AlaGlu: 7.356 ± 0.152	3.792AlaPhe: 3.792 ± 0.089	9.769AlaGly: 9.769 ± 0.149	2.217AlaHis: 2.217 ± 0.073	6.36AlaIle: 6.36 ± 0.12	4.441AlaLys: 4.441 ± 0.155	11.779AlaLeu: 11.779 ± 0.181	2.453AlaMet: 2.453 ± 0.084	3.207AlaAsn: 3.207 ± 0.085	4.729AlaPro: 4.729 ± 0.117	4.411AlaGln: 4.411 ± 0.099	5.9AlaArg: 5.9 ± 0.115	6.757AlaSer: 6.757 ± 0.126	6.777AlaThr: 6.777 ± 0.131	9.096AlaVal: 9.096 ± 0.152	1.419AlaTrp: 1.419 ± 0.057	2.417AlaTyr: 2.417 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.645CysAla: 0.645 ± 0.033	0.048CysCys: 0.048 ± 0.01	0.331CysAsp: 0.331 ± 0.025	0.292CysGlu: 0.292 ± 0.025	0.167CysPhe: 0.167 ± 0.019	0.639CysGly: 0.639 ± 0.036	0.101CysHis: 0.101 ± 0.014	0.23CysIle: 0.23 ± 0.019	0.121CysLys: 0.121 ± 0.015	0.411CysLeu: 0.411 ± 0.031	0.093CysMet: 0.093 ± 0.013	0.173CysAsn: 0.173 ± 0.02	0.298CysPro: 0.298 ± 0.028	0.135CysGln: 0.135 ± 0.018	0.25CysArg: 0.25 ± 0.022	0.403CysSer: 0.403 ± 0.033	0.371CysThr: 0.371 ± 0.029	0.458CysVal: 0.458 ± 0.037	0.064CysTrp: 0.064 ± 0.011	0.125CysTyr: 0.125 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.366AspAla: 6.366 ± 0.128	0.323AspCys: 0.323 ± 0.025	2.778AspAsp: 2.778 ± 0.1	3.836AspGlu: 3.836 ± 0.102	2.101AspPhe: 2.101 ± 0.07	4.401AspGly: 4.401 ± 0.107	1.135AspHis: 1.135 ± 0.052	3.163AspIle: 3.163 ± 0.088	1.933AspLys: 1.933 ± 0.068	5.495AspLeu: 5.495 ± 0.113	1.006AspMet: 1.006 ± 0.04	1.506AspAsn: 1.506 ± 0.057	3.137AspPro: 3.137 ± 0.087	1.649AspGln: 1.649 ± 0.064	2.905AspArg: 2.905 ± 0.097	3.09AspSer: 3.09 ± 0.078	2.679AspThr: 2.679 ± 0.071	5.128AspVal: 5.128 ± 0.077	0.804AspTrp: 0.804 ± 0.039	1.423AspTyr: 1.423 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	6.884GluAla: 6.884 ± 0.153	0.314GluCys: 0.314 ± 0.025	3.022GluAsp: 3.022 ± 0.079	4.112GluGlu: 4.112 ± 0.11	2.163GluPhe: 2.163 ± 0.075	4.27GluGly: 4.27 ± 0.094	1.508GluHis: 1.508 ± 0.056	3.788GluIle: 3.788 ± 0.101	2.677GluLys: 2.677 ± 0.079	7.529GluLeu: 7.529 ± 0.136	1.175GluMet: 1.175 ± 0.05	2.131GluAsn: 2.131 ± 0.059	2.542GluPro: 2.542 ± 0.07	2.536GluGln: 2.536 ± 0.06	3.945GluArg: 3.945 ± 0.118	3.248GluSer: 3.248 ± 0.079	3.407GluThr: 3.407 ± 0.082	5.052GluVal: 5.052 ± 0.116	0.79GluTrp: 0.79 ± 0.042	1.492GluTyr: 1.492 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.987PheAla: 3.987 ± 0.086	0.21PheCys: 0.21 ± 0.023	2.419PheAsp: 2.419 ± 0.074	2.145PheGlu: 2.145 ± 0.061	1.351PhePhe: 1.351 ± 0.059	3.498PheGly: 3.498 ± 0.089	0.605PheHis: 0.605 ± 0.036	1.947PheIle: 1.947 ± 0.062	0.941PheLys: 0.941 ± 0.045	3.157PheLeu: 3.157 ± 0.091	0.661PheMet: 0.661 ± 0.037	1.147PheAsn: 1.147 ± 0.053	1.54PhePro: 1.54 ± 0.056	0.867PheGln: 0.867 ± 0.043	1.554PheArg: 1.554 ± 0.06	2.371PheSer: 2.371 ± 0.074	2.52PheThr: 2.52 ± 0.07	3.086PheVal: 3.086 ± 0.088	0.538PheTrp: 0.538 ± 0.032	0.839PheTyr: 0.839 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	8.182GlyAla: 8.182 ± 0.145	0.514GlyCys: 0.514 ± 0.032	4.122GlyAsp: 4.122 ± 0.085	4.731GlyGlu: 4.731 ± 0.097	3.441GlyPhe: 3.441 ± 0.086	6.41GlyGly: 6.41 ± 0.157	1.792GlyHis: 1.792 ± 0.061	5.519GlyIle: 5.519 ± 0.124	3.612GlyLys: 3.612 ± 0.09	8.017GlyLeu: 8.017 ± 0.155	1.931GlyMet: 1.931 ± 0.064	2.469GlyAsn: 2.469 ± 0.072	3.195GlyPro: 3.195 ± 0.078	2.732GlyGln: 2.732 ± 0.077	4.272GlyArg: 4.272 ± 0.084	5.322GlySer: 5.322 ± 0.131	5.126GlyThr: 5.126 ± 0.116	7.056GlyVal: 7.056 ± 0.121	1.266GlyTrp: 1.266 ± 0.049	2.29GlyTyr: 2.29 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.0HisAla: 2.0 ± 0.073	0.079HisCys: 0.079 ± 0.013	1.238HisAsp: 1.238 ± 0.053	1.284HisGlu: 1.284 ± 0.065	0.633HisPhe: 0.633 ± 0.037	1.669HisGly: 1.669 ± 0.064	0.51HisHis: 0.51 ± 0.035	1.036HisIle: 1.036 ± 0.05	0.635HisLys: 0.635 ± 0.038	1.806HisLeu: 1.806 ± 0.054	0.437HisMet: 0.437 ± 0.029	0.651HisAsn: 0.651 ± 0.038	1.27HisPro: 1.27 ± 0.053	0.599HisGln: 0.599 ± 0.036	1.173HisArg: 1.173 ± 0.052	1.234HisSer: 1.234 ± 0.05	1.08HisThr: 1.08 ± 0.045	1.611HisVal: 1.611 ± 0.059	0.306HisTrp: 0.306 ± 0.026	0.494HisTyr: 0.494 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	7.164IleAla: 7.164 ± 0.132	0.312IleCys: 0.312 ± 0.023	3.798IleAsp: 3.798 ± 0.085	3.766IleGlu: 3.766 ± 0.091	1.788IlePhe: 1.788 ± 0.06	4.572IleGly: 4.572 ± 0.099	1.026IleHis: 1.026 ± 0.041	2.961IleIle: 2.961 ± 0.087	1.764IleLys: 1.764 ± 0.068	4.812IleLeu: 4.812 ± 0.096	1.03IleMet: 1.03 ± 0.046	1.818IleAsn: 1.818 ± 0.061	3.24IlePro: 3.24 ± 0.08	1.522IleGln: 1.522 ± 0.055	2.859IleArg: 2.859 ± 0.073	3.885IleSer: 3.885 ± 0.089	4.038IleThr: 4.038 ± 0.089	5.007IleVal: 5.007 ± 0.119	0.647IleTrp: 0.647 ± 0.039	1.169IleTyr: 1.169 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.159LysAla: 4.159 ± 0.104	0.157LysCys: 0.157 ± 0.015	1.939LysAsp: 1.939 ± 0.054	2.056LysGlu: 2.056 ± 0.071	1.085LysPhe: 1.085 ± 0.041	2.357LysGly: 2.357 ± 0.076	0.768LysHis: 0.768 ± 0.042	1.949LysIle: 1.949 ± 0.055	2.246LysLys: 2.246 ± 0.096	3.562LysLeu: 3.562 ± 0.096	0.945LysMet: 0.945 ± 0.053	1.324LysAsn: 1.324 ± 0.053	2.161LysPro: 2.161 ± 0.084	1.266LysGln: 1.266 ± 0.048	2.238LysArg: 2.238 ± 0.073	2.226LysSer: 2.226 ± 0.071	2.236LysThr: 2.236 ± 0.068	2.975LysVal: 2.975 ± 0.074	0.468LysTrp: 0.468 ± 0.034	0.879LysTyr: 0.879 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	12.281LeuAla: 12.281 ± 0.187	0.486LeuCys: 0.486 ± 0.032	5.719LeuAsp: 5.719 ± 0.11	6.084LeuGlu: 6.084 ± 0.114	3.048LeuPhe: 3.048 ± 0.085	8.374LeuGly: 8.374 ± 0.146	1.748LeuHis: 1.748 ± 0.052	5.711LeuIle: 5.711 ± 0.121	3.217LeuLys: 3.217 ± 0.081	8.938LeuLeu: 8.938 ± 0.189	1.992LeuMet: 1.992 ± 0.068	2.975LeuAsn: 2.975 ± 0.082	4.884LeuPro: 4.884 ± 0.109	2.679LeuGln: 2.679 ± 0.078	5.511LeuArg: 5.511 ± 0.114	6.88LeuSer: 6.88 ± 0.137	6.388LeuThr: 6.388 ± 0.117	8.324LeuVal: 8.324 ± 0.138	1.214LeuTrp: 1.214 ± 0.059	1.806LeuTyr: 1.806 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.546MetAla: 2.546 ± 0.085	0.117MetCys: 0.117 ± 0.015	1.0MetAsp: 1.0 ± 0.039	0.927MetGlu: 0.927 ± 0.049	0.697MetPhe: 0.697 ± 0.039	1.593MetGly: 1.593 ± 0.062	0.363MetHis: 0.363 ± 0.026	1.026MetIle: 1.026 ± 0.048	0.78MetLys: 0.78 ± 0.042	1.927MetLeu: 1.927 ± 0.06	0.433MetMet: 0.433 ± 0.034	0.726MetAsn: 0.726 ± 0.039	1.149MetPro: 1.149 ± 0.048	0.625MetGln: 0.625 ± 0.038	1.137MetArg: 1.137 ± 0.048	1.899MetSer: 1.899 ± 0.063	1.703MetThr: 1.703 ± 0.047	1.542MetVal: 1.542 ± 0.056	0.29MetTrp: 0.29 ± 0.026	0.389MetTyr: 0.389 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.3AsnAla: 3.3 ± 0.077	0.185AsnCys: 0.185 ± 0.021	1.633AsnAsp: 1.633 ± 0.055	1.742AsnGlu: 1.742 ± 0.065	1.145AsnPhe: 1.145 ± 0.049	2.576AsnGly: 2.576 ± 0.08	0.532AsnHis: 0.532 ± 0.033	1.802AsnIle: 1.802 ± 0.059	1.252AsnLys: 1.252 ± 0.052	2.986AsnLeu: 2.986 ± 0.081	0.687AsnMet: 0.687 ± 0.037	1.085AsnAsn: 1.085 ± 0.057	2.242AsnPro: 2.242 ± 0.068	0.966AsnGln: 0.966 ± 0.043	1.544AsnArg: 1.544 ± 0.064	1.889AsnSer: 1.889 ± 0.074	1.917AsnThr: 1.917 ± 0.073	2.524AsnVal: 2.524 ± 0.076	0.472AsnTrp: 0.472 ± 0.034	0.827AsnTyr: 0.827 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	5.663ProAla: 5.663 ± 0.131	0.222ProCys: 0.222 ± 0.021	2.742ProAsp: 2.742 ± 0.078	4.253ProGlu: 4.253 ± 0.092	1.595ProPhe: 1.595 ± 0.058	4.235ProGly: 4.235 ± 0.091	1.06ProHis: 1.06 ± 0.044	2.405ProIle: 2.405 ± 0.076	1.597ProLys: 1.597 ± 0.065	4.362ProLeu: 4.362 ± 0.099	0.837ProMet: 0.837 ± 0.045	1.443ProAsn: 1.443 ± 0.052	1.476ProPro: 1.476 ± 0.06	1.758ProGln: 1.758 ± 0.056	2.308ProArg: 2.308 ± 0.072	3.056ProSer: 3.056 ± 0.077	3.161ProThr: 3.161 ± 0.099	4.29ProVal: 4.29 ± 0.095	0.697ProTrp: 0.697 ± 0.044	1.095ProTyr: 1.095 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.016GlnAla: 4.016 ± 0.094	0.151GlnCys: 0.151 ± 0.016	1.534GlnAsp: 1.534 ± 0.056	1.861GlnGlu: 1.861 ± 0.062	1.074GlnPhe: 1.074 ± 0.044	2.502GlnGly: 2.502 ± 0.069	0.637GlnHis: 0.637 ± 0.032	1.812GlnIle: 1.812 ± 0.061	1.222GlnLys: 1.222 ± 0.053	3.709GlnLeu: 3.709 ± 0.09	0.718GlnMet: 0.718 ± 0.042	0.949GlnAsn: 0.949 ± 0.049	1.474GlnPro: 1.474 ± 0.061	1.385GlnGln: 1.385 ± 0.06	2.07GlnArg: 2.07 ± 0.07	1.75GlnSer: 1.75 ± 0.065	1.877GlnThr: 1.877 ± 0.066	2.687GlnVal: 2.687 ± 0.073	0.55GlnTrp: 0.55 ± 0.036	0.687GlnTyr: 0.687 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	5.55ArgAla: 5.55 ± 0.121	0.278ArgCys: 0.278 ± 0.024	3.074ArgAsp: 3.074 ± 0.082	3.844ArgGlu: 3.844 ± 0.097	1.953ArgPhe: 1.953 ± 0.07	3.899ArgGly: 3.899 ± 0.093	1.143ArgHis: 1.143 ± 0.049	3.346ArgIle: 3.346 ± 0.075	2.205ArgLys: 2.205 ± 0.06	5.265ArgLeu: 5.265 ± 0.121	1.391ArgMet: 1.391 ± 0.06	1.76ArgAsn: 1.76 ± 0.065	2.294ArgPro: 2.294 ± 0.086	1.778ArgGln: 1.778 ± 0.057	3.572ArgArg: 3.572 ± 0.1	3.223ArgSer: 3.223 ± 0.084	2.986ArgThr: 2.986 ± 0.087	4.453ArgVal: 4.453 ± 0.104	0.784ArgTrp: 0.784 ± 0.036	1.349ArgTyr: 1.349 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	7.015SerAla: 7.015 ± 0.129	0.323SerCys: 0.323 ± 0.029	3.292SerAsp: 3.292 ± 0.083	3.677SerGlu: 3.677 ± 0.091	2.445SerPhe: 2.445 ± 0.076	5.888SerGly: 5.888 ± 0.148	1.242SerHis: 1.242 ± 0.053	3.381SerIle: 3.381 ± 0.079	2.193SerLys: 2.193 ± 0.071	6.193SerLeu: 6.193 ± 0.126	1.399SerMet: 1.399 ± 0.05	2.016SerAsn: 2.016 ± 0.078	3.012SerPro: 3.012 ± 0.082	2.139SerGln: 2.139 ± 0.066	3.407SerArg: 3.407 ± 0.085	4.677SerSer: 4.677 ± 0.14	4.167SerThr: 4.167 ± 0.126	5.134SerVal: 5.134 ± 0.127	0.98SerTrp: 0.98 ± 0.047	1.5SerTyr: 1.5 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	6.642ThrAla: 6.642 ± 0.116	0.341ThrCys: 0.341 ± 0.029	3.106ThrAsp: 3.106 ± 0.065	3.578ThrGlu: 3.578 ± 0.09	2.189ThrPhe: 2.189 ± 0.081	5.721ThrGly: 5.721 ± 0.131	1.153ThrHis: 1.153 ± 0.051	3.544ThrIle: 3.544 ± 0.087	2.199ThrLys: 2.199 ± 0.07	5.87ThrLeu: 5.87 ± 0.108	1.165ThrMet: 1.165 ± 0.055	1.929ThrAsn: 1.929 ± 0.083	3.856ThrPro: 3.856 ± 0.108	2.038ThrGln: 2.038 ± 0.071	3.006ThrArg: 3.006 ± 0.075	3.997ThrSer: 3.997 ± 0.12	3.917ThrThr: 3.917 ± 0.117	5.618ThrVal: 5.618 ± 0.157	0.79ThrTrp: 0.79 ± 0.038	1.365ThrTyr: 1.365 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	9.293ValAla: 9.293 ± 0.148	0.502ValCys: 0.502 ± 0.03	5.092ValAsp: 5.092 ± 0.111	5.06ValGlu: 5.06 ± 0.109	3.056ValPhe: 3.056 ± 0.083	6.531ValGly: 6.531 ± 0.138	1.586ValHis: 1.586 ± 0.054	5.386ValIle: 5.386 ± 0.121	2.758ValLys: 2.758 ± 0.079	8.477ValLeu: 8.477 ± 0.14	1.756ValMet: 1.756 ± 0.057	2.649ValAsn: 2.649 ± 0.078	4.098ValPro: 4.098 ± 0.095	2.306ValGln: 2.306 ± 0.077	4.348ValArg: 4.348 ± 0.089	5.749ValSer: 5.749 ± 0.123	5.755ValThr: 5.755 ± 0.146	8.047ValVal: 8.047 ± 0.162	0.905ValTrp: 0.905 ± 0.051	1.679ValTyr: 1.679 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	1.351TrpAla: 1.351 ± 0.054	0.085TrpCys: 0.085 ± 0.013	0.689TrpAsp: 0.689 ± 0.038	0.637TrpGlu: 0.637 ± 0.036	0.645TrpPhe: 0.645 ± 0.035	1.01TrpGly: 1.01 ± 0.048	0.294TrpHis: 0.294 ± 0.026	0.839TrpIle: 0.839 ± 0.046	0.504TrpLys: 0.504 ± 0.032	1.552TrpLeu: 1.552 ± 0.062	0.369TrpMet: 0.369 ± 0.027	0.572TrpAsn: 0.572 ± 0.036	0.554TrpPro: 0.554 ± 0.031	0.494TrpGln: 0.494 ± 0.031	0.81TrpArg: 0.81 ± 0.041	0.863TrpSer: 0.863 ± 0.039	0.704TrpThr: 0.704 ± 0.036	1.052TrpVal: 1.052 ± 0.046	0.294TrpTrp: 0.294 ± 0.025	0.282TrpTyr: 0.282 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.361TyrAla: 2.361 ± 0.075	0.143TyrCys: 0.143 ± 0.018	1.367TyrAsp: 1.367 ± 0.051	1.345TyrGlu: 1.345 ± 0.055	1.016TyrPhe: 1.016 ± 0.046	2.082TyrGly: 2.082 ± 0.072	0.325TyrHis: 0.325 ± 0.026	0.974TyrIle: 0.974 ± 0.041	0.7TyrLys: 0.7 ± 0.042	2.413TyrLeu: 2.413 ± 0.074	0.389TyrMet: 0.389 ± 0.028	0.78TyrAsn: 0.78 ± 0.043	1.105TyrPro: 1.105 ± 0.051	0.78TyrGln: 0.78 ± 0.035	1.337TyrArg: 1.337 ± 0.058	1.562TyrSer: 1.562 ± 0.061	1.212TyrThr: 1.212 ± 0.058	1.891TyrVal: 1.891 ± 0.065	0.323TyrTrp: 0.323 ± 0.025	0.506TyrTyr: 0.506 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1574 proteins (503936 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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