Amino acid dipepetide frequency for Enterobacillus tribolii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.969AlaAla: 10.969 ± 0.122
1.217AlaCys: 1.217 ± 0.032
5.153AlaAsp: 5.153 ± 0.075
5.873AlaGlu: 5.873 ± 0.073
3.655AlaPhe: 3.655 ± 0.06
8.609AlaGly: 8.609 ± 0.125
1.844AlaHis: 1.844 ± 0.043
5.417AlaIle: 5.417 ± 0.072
3.32AlaLys: 3.32 ± 0.062
12.307AlaLeu: 12.307 ± 0.103
2.867AlaMet: 2.867 ± 0.045
2.971AlaAsn: 2.971 ± 0.046
4.072AlaPro: 4.072 ± 0.069
4.812AlaGln: 4.812 ± 0.07
5.969AlaArg: 5.969 ± 0.077
5.297AlaSer: 5.297 ± 0.062
4.52AlaThr: 4.52 ± 0.065
6.809AlaVal: 6.809 ± 0.073
1.453AlaTrp: 1.453 ± 0.038
2.356AlaTyr: 2.356 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.131CysAla: 1.131 ± 0.03
0.189CysCys: 0.189 ± 0.012
0.603CysAsp: 0.603 ± 0.018
0.553CysGlu: 0.553 ± 0.02
0.487CysPhe: 0.487 ± 0.019
1.143CysGly: 1.143 ± 0.029
0.348CysHis: 0.348 ± 0.019
0.613CysIle: 0.613 ± 0.023
0.314CysLys: 0.314 ± 0.016
1.102CysLeu: 1.102 ± 0.027
0.234CysMet: 0.234 ± 0.013
0.343CysAsn: 0.343 ± 0.017
0.545CysPro: 0.545 ± 0.022
0.42CysGln: 0.42 ± 0.019
0.761CysArg: 0.761 ± 0.022
0.677CysSer: 0.677 ± 0.024
0.527CysThr: 0.527 ± 0.02
0.779CysVal: 0.779 ± 0.023
0.203CysTrp: 0.203 ± 0.013
0.352CysTyr: 0.352 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
5.532AspAla: 5.532 ± 0.074
0.555AspCys: 0.555 ± 0.021
3.078AspAsp: 3.078 ± 0.055
3.453AspGlu: 3.453 ± 0.055
2.16AspPhe: 2.16 ± 0.038
4.365AspGly: 4.365 ± 0.087
0.965AspHis: 0.965 ± 0.028
3.443AspIle: 3.443 ± 0.054
2.266AspLys: 2.266 ± 0.05
4.709AspLeu: 4.709 ± 0.061
1.392AspMet: 1.392 ± 0.03
2.127AspAsn: 2.127 ± 0.048
2.293AspPro: 2.293 ± 0.041
1.551AspGln: 1.551 ± 0.033
2.734AspArg: 2.734 ± 0.044
2.641AspSer: 2.641 ± 0.045
2.54AspThr: 2.54 ± 0.049
3.984AspVal: 3.984 ± 0.063
0.778AspTrp: 0.778 ± 0.021
1.917AspTyr: 1.917 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
5.098GluAla: 5.098 ± 0.071
0.498GluCys: 0.498 ± 0.021
2.297GluAsp: 2.297 ± 0.048
3.393GluGlu: 3.393 ± 0.062
1.738GluPhe: 1.738 ± 0.037
3.584GluGly: 3.584 ± 0.046
1.423GluHis: 1.423 ± 0.034
3.223GluIle: 3.223 ± 0.056
3.037GluLys: 3.037 ± 0.06
5.751GluLeu: 5.751 ± 0.08
1.66GluMet: 1.66 ± 0.032
2.404GluAsn: 2.404 ± 0.046
2.108GluPro: 2.108 ± 0.044
3.497GluGln: 3.497 ± 0.057
3.902GluArg: 3.902 ± 0.062
2.952GluSer: 2.952 ± 0.048
2.908GluThr: 2.908 ± 0.048
3.478GluVal: 3.478 ± 0.055
0.744GluTrp: 0.744 ± 0.025
1.518GluTyr: 1.518 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.494PheAla: 3.494 ± 0.063
0.552PheCys: 0.552 ± 0.019
2.273PheAsp: 2.273 ± 0.04
1.697PheGlu: 1.697 ± 0.035
1.65PhePhe: 1.65 ± 0.043
3.201PheGly: 3.201 ± 0.05
0.773PheHis: 0.773 ± 0.024
2.505PheIle: 2.505 ± 0.048
1.11PheLys: 1.11 ± 0.03
3.421PheLeu: 3.421 ± 0.07
0.95PheMet: 0.95 ± 0.025
1.628PheAsn: 1.628 ± 0.034
1.591PhePro: 1.591 ± 0.038
1.058PheGln: 1.058 ± 0.026
2.013PheArg: 2.013 ± 0.038
3.28PheSer: 3.28 ± 0.055
2.38PheThr: 2.38 ± 0.049
2.373PheVal: 2.373 ± 0.047
0.582PheTrp: 0.582 ± 0.021
1.258PheTyr: 1.258 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
6.887GlyAla: 6.887 ± 0.082
1.086GlyCys: 1.086 ± 0.031
4.044GlyAsp: 4.044 ± 0.078
4.835GlyGlu: 4.835 ± 0.083
3.249GlyPhe: 3.249 ± 0.049
6.038GlyGly: 6.038 ± 0.089
1.675GlyHis: 1.675 ± 0.035
5.081GlyIle: 5.081 ± 0.073
4.078GlyLys: 4.078 ± 0.061
7.596GlyLeu: 7.596 ± 0.086
2.488GlyMet: 2.488 ± 0.046
3.036GlyAsn: 3.036 ± 0.086
2.097GlyPro: 2.097 ± 0.044
3.11GlyGln: 3.11 ± 0.049
4.085GlyArg: 4.085 ± 0.056
4.574GlySer: 4.574 ± 0.068
3.803GlyThr: 3.803 ± 0.068
5.99GlyVal: 5.99 ± 0.067
1.274GlyTrp: 1.274 ± 0.037
2.807GlyTyr: 2.807 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.938HisAla: 1.938 ± 0.038
0.353HisCys: 0.353 ± 0.016
1.201HisAsp: 1.201 ± 0.032
1.016HisGlu: 1.016 ± 0.031
1.022HisPhe: 1.022 ± 0.03
1.79HisGly: 1.79 ± 0.041
0.734HisHis: 0.734 ± 0.027
1.234HisIle: 1.234 ± 0.025
0.657HisLys: 0.657 ± 0.022
2.166HisLeu: 2.166 ± 0.045
0.515HisMet: 0.515 ± 0.018
0.825HisAsn: 0.825 ± 0.029
1.364HisPro: 1.364 ± 0.031
1.186HisGln: 1.186 ± 0.033
1.24HisArg: 1.24 ± 0.03
1.224HisSer: 1.224 ± 0.032
1.106HisThr: 1.106 ± 0.023
1.235HisVal: 1.235 ± 0.033
0.421HisTrp: 0.421 ± 0.019
0.905HisTyr: 0.905 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.195IleAla: 6.195 ± 0.075
0.654IleCys: 0.654 ± 0.024
3.461IleAsp: 3.461 ± 0.048
3.064IleGlu: 3.064 ± 0.06
1.96IlePhe: 1.96 ± 0.044
4.746IleGly: 4.746 ± 0.067
1.136IleHis: 1.136 ± 0.03
3.183IleIle: 3.183 ± 0.06
2.105IleLys: 2.105 ± 0.045
4.903IleLeu: 4.903 ± 0.072
1.295IleMet: 1.295 ± 0.036
2.444IleAsn: 2.444 ± 0.048
2.714IlePro: 2.714 ± 0.042
1.767IleGln: 1.767 ± 0.036
3.213IleArg: 3.213 ± 0.056
3.877IleSer: 3.877 ± 0.063
3.425IleThr: 3.425 ± 0.058
3.808IleVal: 3.808 ± 0.053
0.641IleTrp: 0.641 ± 0.024
1.58IleTyr: 1.58 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.891LysAla: 3.891 ± 0.07
0.264LysCys: 0.264 ± 0.015
1.979LysAsp: 1.979 ± 0.044
2.178LysGlu: 2.178 ± 0.045
1.031LysPhe: 1.031 ± 0.03
2.754LysGly: 2.754 ± 0.051
0.776LysHis: 0.776 ± 0.024
2.197LysIle: 2.197 ± 0.042
2.004LysLys: 2.004 ± 0.053
3.887LysLeu: 3.887 ± 0.06
1.155LysMet: 1.155 ± 0.031
1.676LysAsn: 1.676 ± 0.035
1.946LysPro: 1.946 ± 0.04
1.884LysGln: 1.884 ± 0.041
2.365LysArg: 2.365 ± 0.05
2.137LysSer: 2.137 ± 0.044
2.378LysThr: 2.378 ± 0.044
2.738LysVal: 2.738 ± 0.049
0.392LysTrp: 0.392 ± 0.019
1.095LysTyr: 1.095 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
11.433LeuAla: 11.433 ± 0.107
1.346LeuCys: 1.346 ± 0.034
5.447LeuAsp: 5.447 ± 0.077
5.447LeuGlu: 5.447 ± 0.069
4.225LeuPhe: 4.225 ± 0.064
7.626LeuGly: 7.626 ± 0.091
2.318LeuHis: 2.318 ± 0.041
5.842LeuIle: 5.842 ± 0.073
4.298LeuLys: 4.298 ± 0.068
12.296LeuLeu: 12.296 ± 0.154
2.97LeuMet: 2.97 ± 0.049
4.346LeuAsn: 4.346 ± 0.072
5.976LeuPro: 5.976 ± 0.082
4.116LeuGln: 4.116 ± 0.066
6.531LeuArg: 6.531 ± 0.087
7.613LeuSer: 7.613 ± 0.089
6.536LeuThr: 6.536 ± 0.088
6.718LeuVal: 6.718 ± 0.081
1.398LeuTrp: 1.398 ± 0.038
2.774LeuTyr: 2.774 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.82MetAla: 2.82 ± 0.053
0.211MetCys: 0.211 ± 0.011
1.21MetAsp: 1.21 ± 0.031
1.218MetGlu: 1.218 ± 0.026
0.891MetPhe: 0.891 ± 0.026
1.85MetGly: 1.85 ± 0.041
0.51MetHis: 0.51 ± 0.019
1.448MetIle: 1.448 ± 0.035
1.376MetLys: 1.376 ± 0.027
3.172MetLeu: 3.172 ± 0.053
0.941MetMet: 0.941 ± 0.03
1.071MetAsn: 1.071 ± 0.029
1.454MetPro: 1.454 ± 0.035
1.17MetGln: 1.17 ± 0.028
1.555MetArg: 1.555 ± 0.034
1.854MetSer: 1.854 ± 0.039
1.743MetThr: 1.743 ± 0.033
1.821MetVal: 1.821 ± 0.037
0.262MetTrp: 0.262 ± 0.014
0.549MetTyr: 0.549 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.779AsnAla: 3.779 ± 0.065
0.338AsnCys: 0.338 ± 0.016
2.05AsnAsp: 2.05 ± 0.035
1.756AsnGlu: 1.756 ± 0.035
1.246AsnPhe: 1.246 ± 0.032
3.173AsnGly: 3.173 ± 0.062
0.807AsnHis: 0.807 ± 0.028
2.261AsnIle: 2.261 ± 0.044
1.452AsnLys: 1.452 ± 0.037
3.478AsnLeu: 3.478 ± 0.053
0.957AsnMet: 0.957 ± 0.031
1.591AsnAsn: 1.591 ± 0.048
2.083AsnPro: 2.083 ± 0.038
1.565AsnGln: 1.565 ± 0.04
2.043AsnArg: 2.043 ± 0.043
1.933AsnSer: 1.933 ± 0.042
2.001AsnThr: 2.001 ± 0.043
2.682AsnVal: 2.682 ± 0.05
0.518AsnTrp: 0.518 ± 0.02
1.261AsnTyr: 1.261 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
5.12ProAla: 5.12 ± 0.086
0.411ProCys: 0.411 ± 0.016
3.039ProAsp: 3.039 ± 0.057
3.44ProGlu: 3.44 ± 0.051
1.8ProPhe: 1.8 ± 0.034
3.722ProGly: 3.722 ± 0.053
1.011ProHis: 1.011 ± 0.026
1.782ProIle: 1.782 ± 0.039
1.351ProLys: 1.351 ± 0.035
5.379ProLeu: 5.379 ± 0.073
1.048ProMet: 1.048 ± 0.027
1.25ProAsn: 1.25 ± 0.03
1.904ProPro: 1.904 ± 0.046
2.318ProGln: 2.318 ± 0.042
2.135ProArg: 2.135 ± 0.041
2.293ProSer: 2.293 ± 0.045
1.925ProThr: 1.925 ± 0.039
4.014ProVal: 4.014 ± 0.058
0.689ProTrp: 0.689 ± 0.024
1.425ProTyr: 1.425 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
4.847GlnAla: 4.847 ± 0.073
0.392GlnCys: 0.392 ± 0.017
1.962GlnAsp: 1.962 ± 0.041
2.39GlnGlu: 2.39 ± 0.046
1.311GlnPhe: 1.311 ± 0.03
3.236GlnGly: 3.236 ± 0.06
1.176GlnHis: 1.176 ± 0.028
2.253GlnIle: 2.253 ± 0.043
1.753GlnLys: 1.753 ± 0.04
4.856GlnLeu: 4.856 ± 0.067
1.18GlnMet: 1.18 ± 0.029
1.42GlnAsn: 1.42 ± 0.033
2.169GlnPro: 2.169 ± 0.045
3.157GlnGln: 3.157 ± 0.081
3.215GlnArg: 3.215 ± 0.054
2.318GlnSer: 2.318 ± 0.05
2.196GlnThr: 2.196 ± 0.043
3.038GlnVal: 3.038 ± 0.047
0.651GlnTrp: 0.651 ± 0.02
1.159GlnTyr: 1.159 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
5.052ArgAla: 5.052 ± 0.06
0.667ArgCys: 0.667 ± 0.022
3.206ArgAsp: 3.206 ± 0.05
3.822ArgGlu: 3.822 ± 0.064
2.694ArgPhe: 2.694 ± 0.051
3.6ArgGly: 3.6 ± 0.051
1.638ArgHis: 1.638 ± 0.042
3.473ArgIle: 3.473 ± 0.049
2.142ArgLys: 2.142 ± 0.045
6.871ArgLeu: 6.871 ± 0.093
1.624ArgMet: 1.624 ± 0.039
2.136ArgAsn: 2.136 ± 0.042
2.411ArgPro: 2.411 ± 0.048
3.236ArgGln: 3.236 ± 0.059
4.043ArgArg: 4.043 ± 0.065
2.872ArgSer: 2.872 ± 0.053
2.558ArgThr: 2.558 ± 0.048
3.955ArgVal: 3.955 ± 0.06
1.001ArgTrp: 1.001 ± 0.028
2.379ArgTyr: 2.379 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.029SerAla: 6.029 ± 0.075
0.609SerCys: 0.609 ± 0.021
3.093SerAsp: 3.093 ± 0.049
2.952SerGlu: 2.952 ± 0.048
2.227SerPhe: 2.227 ± 0.047
5.827SerGly: 5.827 ± 0.078
1.336SerHis: 1.336 ± 0.031
2.851SerIle: 2.851 ± 0.054
1.851SerLys: 1.851 ± 0.046
6.756SerLeu: 6.756 ± 0.087
1.48SerMet: 1.48 ± 0.033
1.923SerAsn: 1.923 ± 0.04
2.712SerPro: 2.712 ± 0.048
2.391SerGln: 2.391 ± 0.05
3.468SerArg: 3.468 ± 0.064
3.545SerSer: 3.545 ± 0.068
2.813SerThr: 2.813 ± 0.048
4.497SerVal: 4.497 ± 0.057
0.948SerTrp: 0.948 ± 0.029
1.775SerTyr: 1.775 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
4.858ThrAla: 4.858 ± 0.081
0.519ThrCys: 0.519 ± 0.018
2.593ThrAsp: 2.593 ± 0.047
2.628ThrGlu: 2.628 ± 0.044
1.982ThrPhe: 1.982 ± 0.046
4.493ThrGly: 4.493 ± 0.069
1.193ThrHis: 1.193 ± 0.029
2.723ThrIle: 2.723 ± 0.05
1.399ThrLys: 1.399 ± 0.036
7.534ThrLeu: 7.534 ± 0.114
1.099ThrMet: 1.099 ± 0.03
1.509ThrAsn: 1.509 ± 0.039
3.39ThrPro: 3.39 ± 0.057
2.218ThrGln: 2.218 ± 0.046
2.984ThrArg: 2.984 ± 0.052
2.735ThrSer: 2.735 ± 0.042
2.706ThrThr: 2.706 ± 0.057
3.826ThrVal: 3.826 ± 0.084
0.706ThrTrp: 0.706 ± 0.026
1.297ThrTyr: 1.297 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
6.823ValAla: 6.823 ± 0.079
0.862ValCys: 0.862 ± 0.025
3.519ValAsp: 3.519 ± 0.056
3.687ValGlu: 3.687 ± 0.048
2.578ValPhe: 2.578 ± 0.048
4.73ValGly: 4.73 ± 0.061
1.262ValHis: 1.262 ± 0.03
4.552ValIle: 4.552 ± 0.062
2.865ValLys: 2.865 ± 0.056
7.524ValLeu: 7.524 ± 0.07
2.2ValMet: 2.2 ± 0.048
2.746ValAsn: 2.746 ± 0.049
3.068ValPro: 3.068 ± 0.049
2.324ValGln: 2.324 ± 0.046
3.896ValArg: 3.896 ± 0.06
4.719ValSer: 4.719 ± 0.067
4.27ValThr: 4.27 ± 0.078
5.428ValVal: 5.428 ± 0.068
0.924ValTrp: 0.924 ± 0.028
1.888ValTyr: 1.888 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.951TrpAla: 0.951 ± 0.027
0.173TrpCys: 0.173 ± 0.011
0.631TrpAsp: 0.631 ± 0.023
0.61TrpGlu: 0.61 ± 0.022
0.606TrpPhe: 0.606 ± 0.024
0.947TrpGly: 0.947 ± 0.026
0.417TrpHis: 0.417 ± 0.017
0.689TrpIle: 0.689 ± 0.022
0.478TrpLys: 0.478 ± 0.018
2.216TrpLeu: 2.216 ± 0.046
0.421TrpMet: 0.421 ± 0.016
0.459TrpAsn: 0.459 ± 0.018
0.625TrpPro: 0.625 ± 0.021
1.102TrpGln: 1.102 ± 0.031
1.12TrpArg: 1.12 ± 0.03
0.791TrpSer: 0.791 ± 0.032
0.543TrpThr: 0.543 ± 0.026
0.889TrpVal: 0.889 ± 0.028
0.228TrpTrp: 0.228 ± 0.013
0.398TrpTyr: 0.398 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.644TyrAla: 2.644 ± 0.044
0.424TyrCys: 0.424 ± 0.017
1.642TyrAsp: 1.642 ± 0.043
1.204TyrGlu: 1.204 ± 0.028
1.276TyrPhe: 1.276 ± 0.032
2.401TyrGly: 2.401 ± 0.05
0.787TyrHis: 0.787 ± 0.024
1.404TyrIle: 1.404 ± 0.031
0.871TyrLys: 0.871 ± 0.027
3.331TyrLeu: 3.331 ± 0.048
0.649TyrMet: 0.649 ± 0.025
1.07TyrAsn: 1.07 ± 0.031
1.534TyrPro: 1.534 ± 0.033
1.801TyrGln: 1.801 ± 0.036
2.11TyrArg: 2.11 ± 0.041
1.748TyrSer: 1.748 ± 0.035
1.514TyrThr: 1.514 ± 0.039
1.805TyrVal: 1.805 ± 0.034
0.481TyrTrp: 0.481 ± 0.022
1.041TyrTyr: 1.041 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4233 proteins (1406953 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski