Amino acid dipepetide frequency for Pseudopuniceibacterium sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.945AlaAla: 16.945 ± 0.155	1.1AlaCys: 1.1 ± 0.035	7.037AlaAsp: 7.037 ± 0.087	7.771AlaGlu: 7.771 ± 0.087	4.337AlaPhe: 4.337 ± 0.058	10.722AlaGly: 10.722 ± 0.104	2.371AlaHis: 2.371 ± 0.047	6.122AlaIle: 6.122 ± 0.078	3.293AlaLys: 3.293 ± 0.063	14.31AlaLeu: 14.31 ± 0.121	4.014AlaMet: 4.014 ± 0.056	2.662AlaAsn: 2.662 ± 0.047	6.121AlaPro: 6.121 ± 0.084	4.737AlaGln: 4.737 ± 0.071	9.427AlaArg: 9.427 ± 0.101	5.935AlaSer: 5.935 ± 0.078	6.414AlaThr: 6.414 ± 0.072	8.347AlaVal: 8.347 ± 0.083	1.426AlaTrp: 1.426 ± 0.038	2.529AlaTyr: 2.529 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.112CysAla: 1.112 ± 0.032	0.103CysCys: 0.103 ± 0.01	0.632CysAsp: 0.632 ± 0.022	0.415CysGlu: 0.415 ± 0.019	0.332CysPhe: 0.332 ± 0.016	0.914CysGly: 0.914 ± 0.031	0.27CysHis: 0.27 ± 0.015	0.423CysIle: 0.423 ± 0.017	0.207CysLys: 0.207 ± 0.013	0.894CysLeu: 0.894 ± 0.03	0.164CysMet: 0.164 ± 0.012	0.216CysAsn: 0.216 ± 0.013	0.467CysPro: 0.467 ± 0.021	0.218CysGln: 0.218 ± 0.013	0.579CysArg: 0.579 ± 0.022	0.432CysSer: 0.432 ± 0.02	0.441CysThr: 0.441 ± 0.023	0.633CysVal: 0.633 ± 0.021	0.113CysTrp: 0.113 ± 0.009	0.188CysTyr: 0.188 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.527AspAla: 7.527 ± 0.091	0.487AspCys: 0.487 ± 0.018	3.491AspAsp: 3.491 ± 0.069	3.288AspGlu: 3.288 ± 0.058	2.33AspPhe: 2.33 ± 0.047	5.403AspGly: 5.403 ± 0.087	1.417AspHis: 1.417 ± 0.041	3.157AspIle: 3.157 ± 0.047	1.594AspLys: 1.594 ± 0.043	6.653AspLeu: 6.653 ± 0.085	1.808AspMet: 1.808 ± 0.037	1.203AspAsn: 1.203 ± 0.032	3.673AspPro: 3.673 ± 0.049	1.902AspGln: 1.902 ± 0.041	4.298AspArg: 4.298 ± 0.059	2.325AspSer: 2.325 ± 0.049	3.213AspThr: 3.213 ± 0.061	4.336AspVal: 4.336 ± 0.061	1.141AspTrp: 1.141 ± 0.033	1.435AspTyr: 1.435 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.677GluAla: 7.677 ± 0.09	0.346GluCys: 0.346 ± 0.016	3.103GluAsp: 3.103 ± 0.052	3.247GluGlu: 3.247 ± 0.066	1.606GluPhe: 1.606 ± 0.037	4.53GluGly: 4.53 ± 0.058	1.029GluHis: 1.029 ± 0.028	3.37GluIle: 3.37 ± 0.063	1.977GluLys: 1.977 ± 0.05	4.68GluLeu: 4.68 ± 0.065	1.844GluMet: 1.844 ± 0.036	1.595GluAsn: 1.595 ± 0.038	2.25GluPro: 2.25 ± 0.045	1.97GluGln: 1.97 ± 0.042	3.928GluArg: 3.928 ± 0.063	2.142GluSer: 2.142 ± 0.048	3.686GluThr: 3.686 ± 0.052	4.206GluVal: 4.206 ± 0.062	0.674GluTrp: 0.674 ± 0.022	1.04GluTyr: 1.04 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.421PheAla: 4.421 ± 0.068	0.407PheCys: 0.407 ± 0.017	2.777PheAsp: 2.777 ± 0.051	2.031PheGlu: 2.031 ± 0.039	1.429PhePhe: 1.429 ± 0.044	3.613PheGly: 3.613 ± 0.061	0.749PheHis: 0.749 ± 0.027	1.578PheIle: 1.578 ± 0.038	0.84PheLys: 0.84 ± 0.029	3.417PheLeu: 3.417 ± 0.061	0.857PheMet: 0.857 ± 0.027	1.001PheAsn: 1.001 ± 0.032	1.616PhePro: 1.616 ± 0.038	1.029PheGln: 1.029 ± 0.027	2.251PheArg: 2.251 ± 0.049	2.173PheSer: 2.173 ± 0.044	1.998PheThr: 1.998 ± 0.048	2.615PheVal: 2.615 ± 0.047	0.553PheTrp: 0.553 ± 0.023	0.891PheTyr: 0.891 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.291GlyAla: 10.291 ± 0.113	0.877GlyCys: 0.877 ± 0.027	4.714GlyAsp: 4.714 ± 0.074	4.386GlyGlu: 4.386 ± 0.065	3.525GlyPhe: 3.525 ± 0.05	7.414GlyGly: 7.414 ± 0.088	1.957GlyHis: 1.957 ± 0.043	4.652GlyIle: 4.652 ± 0.066	2.955GlyLys: 2.955 ± 0.053	9.385GlyLeu: 9.385 ± 0.104	2.739GlyMet: 2.739 ± 0.05	2.057GlyAsn: 2.057 ± 0.047	3.844GlyPro: 3.844 ± 0.055	3.253GlyGln: 3.253 ± 0.057	5.916GlyArg: 5.916 ± 0.073	4.202GlySer: 4.202 ± 0.054	4.973GlyThr: 4.973 ± 0.075	6.494GlyVal: 6.494 ± 0.067	1.45GlyTrp: 1.45 ± 0.041	2.327GlyTyr: 2.327 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.285HisAla: 2.285 ± 0.044	0.235HisCys: 0.235 ± 0.013	1.421HisAsp: 1.421 ± 0.035	1.001HisGlu: 1.001 ± 0.029	0.834HisPhe: 0.834 ± 0.028	1.843HisGly: 1.843 ± 0.039	0.596HisHis: 0.596 ± 0.026	0.912HisIle: 0.912 ± 0.026	0.485HisLys: 0.485 ± 0.019	2.218HisLeu: 2.218 ± 0.042	0.576HisMet: 0.576 ± 0.023	0.449HisAsn: 0.449 ± 0.02	1.458HisPro: 1.458 ± 0.037	0.569HisGln: 0.569 ± 0.022	1.372HisArg: 1.372 ± 0.03	0.954HisSer: 0.954 ± 0.03	0.803HisThr: 0.803 ± 0.026	1.565HisVal: 1.565 ± 0.04	0.342HisTrp: 0.342 ± 0.016	0.508HisTyr: 0.508 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.239IleAla: 7.239 ± 0.073	0.648IleCys: 0.648 ± 0.022	3.38IleAsp: 3.38 ± 0.052	3.358IleGlu: 3.358 ± 0.061	1.773IlePhe: 1.773 ± 0.042	4.989IleGly: 4.989 ± 0.071	0.887IleHis: 0.887 ± 0.027	2.214IleIle: 2.214 ± 0.053	1.239IleLys: 1.239 ± 0.033	4.915IleLeu: 4.915 ± 0.086	1.106IleMet: 1.106 ± 0.032	1.36IleAsn: 1.36 ± 0.039	2.396IlePro: 2.396 ± 0.047	1.188IleGln: 1.188 ± 0.034	3.268IleArg: 3.268 ± 0.054	3.117IleSer: 3.117 ± 0.052	2.963IleThr: 2.963 ± 0.05	3.82IleVal: 3.82 ± 0.06	0.716IleTrp: 0.716 ± 0.023	1.204IleTyr: 1.204 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.472LysAla: 3.472 ± 0.065	0.166LysCys: 0.166 ± 0.01	1.581LysAsp: 1.581 ± 0.042	1.32LysGlu: 1.32 ± 0.035	0.848LysPhe: 0.848 ± 0.027	2.539LysGly: 2.539 ± 0.051	0.489LysHis: 0.489 ± 0.018	1.55LysIle: 1.55 ± 0.035	1.016LysLys: 1.016 ± 0.04	2.706LysLeu: 2.706 ± 0.051	0.838LysMet: 0.838 ± 0.026	0.681LysAsn: 0.681 ± 0.026	1.697LysPro: 1.697 ± 0.04	0.829LysGln: 0.829 ± 0.028	1.999LysArg: 1.999 ± 0.048	1.716LysSer: 1.716 ± 0.04	1.807LysThr: 1.807 ± 0.038	2.221LysVal: 2.221 ± 0.048	0.359LysTrp: 0.359 ± 0.018	0.602LysTyr: 0.602 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.306LeuAla: 13.306 ± 0.128	0.989LeuCys: 0.989 ± 0.03	6.073LeuAsp: 6.073 ± 0.077	5.022LeuGlu: 5.022 ± 0.069	3.478LeuPhe: 3.478 ± 0.059	8.676LeuGly: 8.676 ± 0.105	1.975LeuHis: 1.975 ± 0.044	5.36LeuIle: 5.36 ± 0.088	3.027LeuLys: 3.027 ± 0.059	9.391LeuLeu: 9.391 ± 0.113	2.773LeuMet: 2.773 ± 0.048	2.66LeuAsn: 2.66 ± 0.048	5.785LeuPro: 5.785 ± 0.082	2.765LeuGln: 2.765 ± 0.044	7.492LeuArg: 7.492 ± 0.101	7.098LeuSer: 7.098 ± 0.078	6.046LeuThr: 6.046 ± 0.076	7.078LeuVal: 7.078 ± 0.086	1.3LeuTrp: 1.3 ± 0.035	1.977LeuTyr: 1.977 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.629MetAla: 3.629 ± 0.053	0.179MetCys: 0.179 ± 0.012	1.454MetAsp: 1.454 ± 0.036	1.302MetGlu: 1.302 ± 0.034	0.911MetPhe: 0.911 ± 0.029	2.33MetGly: 2.33 ± 0.044	0.452MetHis: 0.452 ± 0.019	1.688MetIle: 1.688 ± 0.042	1.013MetLys: 1.013 ± 0.031	2.753MetLeu: 2.753 ± 0.049	0.869MetMet: 0.869 ± 0.027	0.837MetAsn: 0.837 ± 0.029	1.608MetPro: 1.608 ± 0.031	1.158MetGln: 1.158 ± 0.029	2.024MetArg: 2.024 ± 0.037	1.87MetSer: 1.87 ± 0.035	2.225MetThr: 2.225 ± 0.04	1.923MetVal: 1.923 ± 0.041	0.234MetTrp: 0.234 ± 0.014	0.357MetTyr: 0.357 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.098AsnAla: 3.098 ± 0.045	0.215AsnCys: 0.215 ± 0.013	1.424AsnAsp: 1.424 ± 0.035	1.061AsnGlu: 1.061 ± 0.028	0.923AsnPhe: 0.923 ± 0.026	2.331AsnGly: 2.331 ± 0.051	0.485AsnHis: 0.485 ± 0.02	1.338AsnIle: 1.338 ± 0.033	0.554AsnLys: 0.554 ± 0.021	2.484AsnLeu: 2.484 ± 0.043	0.703AsnMet: 0.703 ± 0.025	0.586AsnAsn: 0.586 ± 0.025	1.695AsnPro: 1.695 ± 0.035	0.661AsnGln: 0.661 ± 0.021	1.666AsnArg: 1.666 ± 0.037	1.152AsnSer: 1.152 ± 0.032	1.355AsnThr: 1.355 ± 0.033	1.822AsnVal: 1.822 ± 0.041	0.399AsnTrp: 0.399 ± 0.019	0.606AsnTyr: 0.606 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.029ProAla: 6.029 ± 0.081	0.352ProCys: 0.352 ± 0.017	4.202ProAsp: 4.202 ± 0.056	4.01ProGlu: 4.01 ± 0.066	1.941ProPhe: 1.941 ± 0.044	4.801ProGly: 4.801 ± 0.071	1.086ProHis: 1.086 ± 0.033	2.272ProIle: 2.272 ± 0.041	1.478ProLys: 1.478 ± 0.034	4.837ProLeu: 4.837 ± 0.065	1.396ProMet: 1.396 ± 0.032	1.229ProAsn: 1.229 ± 0.032	2.378ProPro: 2.378 ± 0.057	1.786ProGln: 1.786 ± 0.04	3.006ProArg: 3.006 ± 0.054	2.492ProSer: 2.492 ± 0.041	2.523ProThr: 2.523 ± 0.044	4.365ProVal: 4.365 ± 0.059	0.635ProTrp: 0.635 ± 0.023	1.167ProTyr: 1.167 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.383GlnAla: 4.383 ± 0.064	0.21GlnCys: 0.21 ± 0.014	1.917GlnAsp: 1.917 ± 0.037	1.568GlnGlu: 1.568 ± 0.038	1.041GlnPhe: 1.041 ± 0.033	2.824GlnGly: 2.824 ± 0.048	0.565GlnHis: 0.565 ± 0.022	2.045GlnIle: 2.045 ± 0.041	1.018GlnLys: 1.018 ± 0.03	2.87GlnLeu: 2.87 ± 0.05	1.195GlnMet: 1.195 ± 0.03	0.805GlnAsn: 0.805 ± 0.027	1.663GlnPro: 1.663 ± 0.038	1.221GlnGln: 1.221 ± 0.035	2.309GlnArg: 2.309 ± 0.049	1.783GlnSer: 1.783 ± 0.036	1.973GlnThr: 1.973 ± 0.038	2.458GlnVal: 2.458 ± 0.047	0.399GlnTrp: 0.399 ± 0.015	0.599GlnTyr: 0.599 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.686ArgAla: 8.686 ± 0.098	0.462ArgCys: 0.462 ± 0.02	4.58ArgAsp: 4.58 ± 0.066	3.48ArgGlu: 3.48 ± 0.05	2.52ArgPhe: 2.52 ± 0.045	4.827ArgGly: 4.827 ± 0.061	1.65ArgHis: 1.65 ± 0.037	3.967ArgIle: 3.967 ± 0.059	2.083ArgLys: 2.083 ± 0.047	7.473ArgLeu: 7.473 ± 0.098	2.066ArgMet: 2.066 ± 0.042	1.821ArgAsn: 1.821 ± 0.038	3.509ArgPro: 3.509 ± 0.064	2.488ArgGln: 2.488 ± 0.047	5.193ArgArg: 5.193 ± 0.077	3.441ArgSer: 3.441 ± 0.06	3.272ArgThr: 3.272 ± 0.049	4.76ArgVal: 4.76 ± 0.072	0.879ArgTrp: 0.879 ± 0.027	1.631ArgTyr: 1.631 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.172SerAla: 6.172 ± 0.074	0.464SerCys: 0.464 ± 0.019	3.439SerAsp: 3.439 ± 0.048	2.916SerGlu: 2.916 ± 0.051	2.211SerPhe: 2.211 ± 0.046	5.601SerGly: 5.601 ± 0.067	1.124SerHis: 1.124 ± 0.033	2.474SerIle: 2.474 ± 0.048	1.358SerLys: 1.358 ± 0.036	5.302SerLeu: 5.302 ± 0.071	1.426SerMet: 1.426 ± 0.031	1.291SerAsn: 1.291 ± 0.038	2.51SerPro: 2.51 ± 0.044	1.708SerGln: 1.708 ± 0.037	3.462SerArg: 3.462 ± 0.052	2.734SerSer: 2.734 ± 0.053	2.587SerThr: 2.587 ± 0.046	3.903SerVal: 3.903 ± 0.058	0.702SerTrp: 0.702 ± 0.023	1.347SerTyr: 1.347 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.427ThrAla: 6.427 ± 0.076	0.491ThrCys: 0.491 ± 0.02	3.195ThrAsp: 3.195 ± 0.055	2.869ThrGlu: 2.869 ± 0.051	2.023ThrPhe: 2.023 ± 0.043	5.594ThrGly: 5.594 ± 0.064	1.14ThrHis: 1.14 ± 0.031	2.692ThrIle: 2.692 ± 0.048	1.304ThrLys: 1.304 ± 0.033	6.423ThrLeu: 6.423 ± 0.083	1.333ThrMet: 1.333 ± 0.031	1.248ThrAsn: 1.248 ± 0.035	3.783ThrPro: 3.783 ± 0.062	1.72ThrGln: 1.72 ± 0.039	3.71ThrArg: 3.71 ± 0.051	2.906ThrSer: 2.906 ± 0.053	3.0ThrThr: 3.0 ± 0.052	4.001ThrVal: 4.001 ± 0.052	0.729ThrTrp: 0.729 ± 0.028	1.263ThrTyr: 1.263 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.023ValAla: 9.023 ± 0.084	0.653ValCys: 0.653 ± 0.024	3.895ValAsp: 3.895 ± 0.058	4.088ValGlu: 4.088 ± 0.056	2.741ValPhe: 2.741 ± 0.05	5.321ValGly: 5.321 ± 0.07	1.343ValHis: 1.343 ± 0.029	4.379ValIle: 4.379 ± 0.074	2.007ValLys: 2.007 ± 0.047	7.659ValLeu: 7.659 ± 0.093	2.169ValMet: 2.169 ± 0.046	1.906ValAsn: 1.906 ± 0.042	3.731ValPro: 3.731 ± 0.061	2.26ValGln: 2.26 ± 0.041	4.305ValArg: 4.305 ± 0.063	4.279ValSer: 4.279 ± 0.061	4.813ValThr: 4.813 ± 0.074	5.553ValVal: 5.553 ± 0.071	0.899ValTrp: 0.899 ± 0.029	1.426ValTyr: 1.426 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.306TrpAla: 1.306 ± 0.032	0.133TrpCys: 0.133 ± 0.01	0.738TrpAsp: 0.738 ± 0.023	0.565TrpGlu: 0.565 ± 0.025	0.523TrpPhe: 0.523 ± 0.021	0.991TrpGly: 0.991 ± 0.028	0.362TrpHis: 0.362 ± 0.019	0.673TrpIle: 0.673 ± 0.023	0.441TrpLys: 0.441 ± 0.019	1.602TrpLeu: 1.602 ± 0.037	0.428TrpMet: 0.428 ± 0.017	0.385TrpAsn: 0.385 ± 0.019	0.705TrpPro: 0.705 ± 0.024	0.701TrpGln: 0.701 ± 0.022	1.071TrpArg: 1.071 ± 0.027	0.823TrpSer: 0.823 ± 0.026	0.677TrpThr: 0.677 ± 0.024	0.862TrpVal: 0.862 ± 0.028	0.212TrpTrp: 0.212 ± 0.014	0.287TrpTyr: 0.287 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.591TyrAla: 2.591 ± 0.051	0.238TyrCys: 0.238 ± 0.012	1.627TyrAsp: 1.627 ± 0.039	1.204TyrGlu: 1.204 ± 0.034	0.918TyrPhe: 0.918 ± 0.03	2.148TyrGly: 2.148 ± 0.042	0.481TyrHis: 0.481 ± 0.02	0.914TyrIle: 0.914 ± 0.024	0.544TyrLys: 0.544 ± 0.021	2.3TyrLeu: 2.3 ± 0.048	0.509TyrMet: 0.509 ± 0.019	0.568TyrAsn: 0.568 ± 0.024	1.098TyrPro: 1.098 ± 0.029	0.682TyrGln: 0.682 ± 0.021	1.51TyrArg: 1.51 ± 0.034	1.157TyrSer: 1.157 ± 0.032	1.082TyrThr: 1.082 ± 0.031	1.488TyrVal: 1.488 ± 0.034	0.324TyrTrp: 0.324 ± 0.018	0.589TyrTyr: 0.589 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3986 proteins (1282358 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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