Amino acid dipepetide frequency for Mucilaginibacter sp. HME9299

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.122AlaAla: 7.122 ± 0.103	0.702AlaCys: 0.702 ± 0.024	4.834AlaAsp: 4.834 ± 0.069	4.54AlaGlu: 4.54 ± 0.074	3.553AlaPhe: 3.553 ± 0.049	6.204AlaGly: 6.204 ± 0.07	1.307AlaHis: 1.307 ± 0.031	5.419AlaIle: 5.419 ± 0.084	4.832AlaLys: 4.832 ± 0.068	7.49AlaLeu: 7.49 ± 0.082	1.929AlaMet: 1.929 ± 0.046	4.277AlaAsn: 4.277 ± 0.07	2.541AlaPro: 2.541 ± 0.049	3.411AlaGln: 3.411 ± 0.056	2.909AlaArg: 2.909 ± 0.049	4.597AlaSer: 4.597 ± 0.064	4.476AlaThr: 4.476 ± 0.066	5.448AlaVal: 5.448 ± 0.071	0.869AlaTrp: 0.869 ± 0.029	3.096AlaTyr: 3.096 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.557CysAla: 0.557 ± 0.022	0.117CysCys: 0.117 ± 0.01	0.398CysAsp: 0.398 ± 0.018	0.363CysGlu: 0.363 ± 0.018	0.398CysPhe: 0.398 ± 0.018	0.616CysGly: 0.616 ± 0.026	0.198CysHis: 0.198 ± 0.011	0.587CysIle: 0.587 ± 0.021	0.497CysLys: 0.497 ± 0.021	0.748CysLeu: 0.748 ± 0.022	0.167CysMet: 0.167 ± 0.01	0.395CysAsn: 0.395 ± 0.018	0.309CysPro: 0.309 ± 0.016	0.211CysGln: 0.211 ± 0.015	0.341CysArg: 0.341 ± 0.018	0.533CysSer: 0.533 ± 0.019	0.42CysThr: 0.42 ± 0.017	0.459CysVal: 0.459 ± 0.023	0.097CysTrp: 0.097 ± 0.009	0.302CysTyr: 0.302 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.369AspAla: 4.369 ± 0.063	0.353AspCys: 0.353 ± 0.019	2.85AspAsp: 2.85 ± 0.054	3.511AspGlu: 3.511 ± 0.059	2.721AspPhe: 2.721 ± 0.049	3.734AspGly: 3.734 ± 0.067	0.936AspHis: 0.936 ± 0.024	3.724AspIle: 3.724 ± 0.057	3.697AspLys: 3.697 ± 0.061	4.769AspLeu: 4.769 ± 0.07	1.211AspMet: 1.211 ± 0.03	2.741AspAsn: 2.741 ± 0.053	1.851AspPro: 1.851 ± 0.041	1.646AspGln: 1.646 ± 0.039	2.157AspArg: 2.157 ± 0.038	2.844AspSer: 2.844 ± 0.048	2.684AspThr: 2.684 ± 0.05	3.893AspVal: 3.893 ± 0.057	0.76AspTrp: 0.76 ± 0.025	2.506AspTyr: 2.506 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.5GluAla: 4.5 ± 0.071	0.316GluCys: 0.316 ± 0.017	2.667GluAsp: 2.667 ± 0.05	3.359GluGlu: 3.359 ± 0.068	2.347GluPhe: 2.347 ± 0.041	3.277GluGly: 3.277 ± 0.053	1.221GluHis: 1.221 ± 0.034	3.693GluIle: 3.693 ± 0.057	3.828GluLys: 3.828 ± 0.066	5.678GluLeu: 5.678 ± 0.081	1.327GluMet: 1.327 ± 0.034	2.902GluAsn: 2.902 ± 0.053	1.765GluPro: 1.765 ± 0.036	2.611GluGln: 2.611 ± 0.051	2.741GluArg: 2.741 ± 0.053	2.729GluSer: 2.729 ± 0.052	2.721GluThr: 2.721 ± 0.055	3.865GluVal: 3.865 ± 0.066	0.66GluTrp: 0.66 ± 0.023	2.069GluTyr: 2.069 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.567PheAla: 3.567 ± 0.055	0.432PheCys: 0.432 ± 0.019	2.894PheAsp: 2.894 ± 0.044	2.692PheGlu: 2.692 ± 0.051	2.232PhePhe: 2.232 ± 0.043	3.336PheGly: 3.336 ± 0.056	0.736PheHis: 0.736 ± 0.024	3.269PheIle: 3.269 ± 0.06	3.437PheLys: 3.437 ± 0.054	3.851PheLeu: 3.851 ± 0.06	1.112PheMet: 1.112 ± 0.031	3.102PheAsn: 3.102 ± 0.056	1.583PhePro: 1.583 ± 0.033	1.219PheGln: 1.219 ± 0.032	1.726PheArg: 1.726 ± 0.037	3.253PheSer: 3.253 ± 0.052	3.237PheThr: 3.237 ± 0.06	2.816PheVal: 2.816 ± 0.048	0.575PheTrp: 0.575 ± 0.027	2.067PheTyr: 2.067 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.848GlyAla: 4.848 ± 0.076	0.585GlyCys: 0.585 ± 0.024	3.251GlyAsp: 3.251 ± 0.043	3.293GlyGlu: 3.293 ± 0.051	3.587GlyPhe: 3.587 ± 0.062	5.009GlyGly: 5.009 ± 0.088	1.236GlyHis: 1.236 ± 0.031	5.092GlyIle: 5.092 ± 0.072	5.172GlyLys: 5.172 ± 0.067	6.195GlyLeu: 6.195 ± 0.085	1.675GlyMet: 1.675 ± 0.037	3.935GlyAsn: 3.935 ± 0.061	1.591GlyPro: 1.591 ± 0.041	2.407GlyGln: 2.407 ± 0.047	2.813GlyArg: 2.813 ± 0.048	4.45GlySer: 4.45 ± 0.069	4.229GlyThr: 4.229 ± 0.076	4.685GlyVal: 4.685 ± 0.07	1.011GlyTrp: 1.011 ± 0.03	3.211GlyTyr: 3.211 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.208HisAla: 1.208 ± 0.035	0.189HisCys: 0.189 ± 0.012	1.013HisAsp: 1.013 ± 0.031	1.104HisGlu: 1.104 ± 0.026	1.099HisPhe: 1.099 ± 0.03	1.134HisGly: 1.134 ± 0.033	0.571HisHis: 0.571 ± 0.023	1.39HisIle: 1.39 ± 0.036	1.057HisLys: 1.057 ± 0.029	1.885HisLeu: 1.885 ± 0.038	0.38HisMet: 0.38 ± 0.016	1.041HisAsn: 1.041 ± 0.032	0.98HisPro: 0.98 ± 0.026	0.835HisGln: 0.835 ± 0.026	0.769HisArg: 0.769 ± 0.027	1.025HisSer: 1.025 ± 0.029	1.042HisThr: 1.042 ± 0.027	1.086HisVal: 1.086 ± 0.031	0.249HisTrp: 0.249 ± 0.015	0.917HisTyr: 0.917 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.755IleAla: 5.755 ± 0.083	0.628IleCys: 0.628 ± 0.02	4.159IleAsp: 4.159 ± 0.063	3.96IleGlu: 3.96 ± 0.069	2.766IlePhe: 2.766 ± 0.047	4.602IleGly: 4.602 ± 0.07	1.194IleHis: 1.194 ± 0.033	4.708IleIle: 4.708 ± 0.074	4.874IleLys: 4.874 ± 0.067	5.528IleLeu: 5.528 ± 0.083	1.366IleMet: 1.366 ± 0.034	4.387IleAsn: 4.387 ± 0.065	2.767IlePro: 2.767 ± 0.044	2.209IleGln: 2.209 ± 0.043	2.699IleArg: 2.699 ± 0.051	4.561IleSer: 4.561 ± 0.061	4.498IleThr: 4.498 ± 0.058	4.096IleVal: 4.096 ± 0.058	0.7IleTrp: 0.7 ± 0.025	2.506IleTyr: 2.506 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	5.735LysAla: 5.735 ± 0.083	0.324LysCys: 0.324 ± 0.014	3.756LysAsp: 3.756 ± 0.06	3.805LysGlu: 3.805 ± 0.071	2.607LysPhe: 2.607 ± 0.049	4.355LysGly: 4.355 ± 0.062	1.392LysHis: 1.392 ± 0.033	4.299LysIle: 4.299 ± 0.06	4.604LysLys: 4.604 ± 0.064	6.406LysLeu: 6.406 ± 0.07	1.591LysMet: 1.591 ± 0.033	3.842LysAsn: 3.842 ± 0.06	3.109LysPro: 3.109 ± 0.052	3.285LysGln: 3.285 ± 0.055	2.936LysArg: 2.936 ± 0.044	3.828LysSer: 3.828 ± 0.05	3.829LysThr: 3.829 ± 0.052	4.62LysVal: 4.62 ± 0.061	0.793LysTrp: 0.793 ± 0.028	2.67LysTyr: 2.67 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	7.198LeuAla: 7.198 ± 0.092	0.813LeuCys: 0.813 ± 0.026	4.409LeuAsp: 4.409 ± 0.063	4.458LeuGlu: 4.458 ± 0.07	4.348LeuPhe: 4.348 ± 0.071	5.765LeuGly: 5.765 ± 0.074	1.749LeuHis: 1.749 ± 0.039	6.256LeuIle: 6.256 ± 0.07	7.043LeuLys: 7.043 ± 0.075	9.436LeuLeu: 9.436 ± 0.12	2.226LeuMet: 2.226 ± 0.044	6.105LeuAsn: 6.105 ± 0.079	4.233LeuPro: 4.233 ± 0.056	3.997LeuGln: 3.997 ± 0.064	3.939LeuArg: 3.939 ± 0.065	6.68LeuSer: 6.68 ± 0.074	5.762LeuThr: 5.762 ± 0.069	5.597LeuVal: 5.597 ± 0.082	0.984LeuTrp: 0.984 ± 0.033	3.35LeuTyr: 3.35 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.979MetAla: 1.979 ± 0.047	0.154MetCys: 0.154 ± 0.011	1.102MetAsp: 1.102 ± 0.032	1.168MetGlu: 1.168 ± 0.03	0.871MetPhe: 0.871 ± 0.027	1.402MetGly: 1.402 ± 0.039	0.502MetHis: 0.502 ± 0.019	1.366MetIle: 1.366 ± 0.035	1.785MetLys: 1.785 ± 0.035	2.38MetLeu: 2.38 ± 0.045	0.627MetMet: 0.627 ± 0.024	1.147MetAsn: 1.147 ± 0.031	1.1MetPro: 1.1 ± 0.034	1.104MetGln: 1.104 ± 0.03	1.083MetArg: 1.083 ± 0.028	1.355MetSer: 1.355 ± 0.03	1.01MetThr: 1.01 ± 0.028	1.495MetVal: 1.495 ± 0.035	0.193MetTrp: 0.193 ± 0.014	0.718MetTyr: 0.718 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	4.59AsnAla: 4.59 ± 0.071	0.439AsnCys: 0.439 ± 0.023	2.942AsnAsp: 2.942 ± 0.053	3.117AsnGlu: 3.117 ± 0.051	2.765AsnPhe: 2.765 ± 0.056	4.298AsnGly: 4.298 ± 0.077	1.016AsnHis: 1.016 ± 0.028	4.039AsnIle: 4.039 ± 0.07	3.77AsnLys: 3.77 ± 0.054	5.172AsnLeu: 5.172 ± 0.071	1.216AsnMet: 1.216 ± 0.027	3.621AsnAsn: 3.621 ± 0.061	2.67AsnPro: 2.67 ± 0.048	2.256AsnGln: 2.256 ± 0.047	2.563AsnArg: 2.563 ± 0.044	3.308AsnSer: 3.308 ± 0.065	3.434AsnThr: 3.434 ± 0.06	3.69AsnVal: 3.69 ± 0.064	0.797AsnTrp: 0.797 ± 0.027	2.8AsnTyr: 2.8 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	3.448ProAla: 3.448 ± 0.067	0.217ProCys: 0.217 ± 0.013	2.478ProAsp: 2.478 ± 0.044	2.734ProGlu: 2.734 ± 0.052	1.866ProPhe: 1.866 ± 0.039	2.855ProGly: 2.855 ± 0.049	0.738ProHis: 0.738 ± 0.027	2.135ProIle: 2.135 ± 0.042	2.161ProLys: 2.161 ± 0.047	3.38ProLeu: 3.38 ± 0.053	0.766ProMet: 0.766 ± 0.028	1.919ProAsn: 1.919 ± 0.042	1.109ProPro: 1.109 ± 0.035	1.73ProGln: 1.73 ± 0.038	1.168ProArg: 1.168 ± 0.029	2.19ProSer: 2.19 ± 0.047	1.965ProThr: 1.965 ± 0.041	3.47ProVal: 3.47 ± 0.053	0.433ProTrp: 0.433 ± 0.017	1.627ProTyr: 1.627 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.096GlnAla: 3.096 ± 0.055	0.2GlnCys: 0.2 ± 0.013	1.665GlnAsp: 1.665 ± 0.04	1.96GlnGlu: 1.96 ± 0.04	1.741GlnPhe: 1.741 ± 0.037	2.198GlnGly: 2.198 ± 0.041	0.883GlnHis: 0.883 ± 0.026	2.568GlnIle: 2.568 ± 0.049	2.665GlnLys: 2.665 ± 0.047	4.224GlnLeu: 4.224 ± 0.058	0.988GlnMet: 0.988 ± 0.029	2.341GlnAsn: 2.341 ± 0.041	1.705GlnPro: 1.705 ± 0.041	2.519GlnGln: 2.519 ± 0.061	1.877GlnArg: 1.877 ± 0.043	2.446GlnSer: 2.446 ± 0.041	2.342GlnThr: 2.342 ± 0.047	2.631GlnVal: 2.631 ± 0.05	0.441GlnTrp: 0.441 ± 0.019	1.569GlnTyr: 1.569 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.689ArgAla: 2.689 ± 0.047	0.261ArgCys: 0.261 ± 0.015	1.986ArgAsp: 1.986 ± 0.044	2.291ArgGlu: 2.291 ± 0.046	2.27ArgPhe: 2.27 ± 0.044	2.36ArgGly: 2.36 ± 0.049	0.78ArgHis: 0.78 ± 0.025	3.018ArgIle: 3.018 ± 0.052	2.899ArgLys: 2.899 ± 0.051	4.122ArgLeu: 4.122 ± 0.059	1.082ArgMet: 1.082 ± 0.025	2.558ArgAsn: 2.558 ± 0.047	1.463ArgPro: 1.463 ± 0.038	1.695ArgGln: 1.695 ± 0.042	1.848ArgArg: 1.848 ± 0.036	2.435ArgSer: 2.435 ± 0.049	2.215ArgThr: 2.215 ± 0.042	2.588ArgVal: 2.588 ± 0.048	0.598ArgTrp: 0.598 ± 0.024	2.059ArgTyr: 2.059 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.889SerAla: 4.889 ± 0.066	0.549SerCys: 0.549 ± 0.023	2.791SerAsp: 2.791 ± 0.049	2.77SerGlu: 2.77 ± 0.056	3.275SerPhe: 3.275 ± 0.057	4.851SerGly: 4.851 ± 0.067	1.127SerHis: 1.127 ± 0.032	4.299SerIle: 4.299 ± 0.061	3.99SerLys: 3.99 ± 0.053	5.895SerLeu: 5.895 ± 0.071	1.289SerMet: 1.289 ± 0.029	3.48SerAsn: 3.48 ± 0.059	2.259SerPro: 2.259 ± 0.045	2.079SerGln: 2.079 ± 0.04	2.516SerArg: 2.516 ± 0.049	3.965SerSer: 3.965 ± 0.06	3.58SerThr: 3.58 ± 0.051	4.338SerVal: 4.338 ± 0.055	0.725SerTrp: 0.725 ± 0.029	2.705SerTyr: 2.705 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.929ThrAla: 4.929 ± 0.09	0.35ThrCys: 0.35 ± 0.017	3.458ThrAsp: 3.458 ± 0.053	3.045ThrGlu: 3.045 ± 0.047	2.773ThrPhe: 2.773 ± 0.047	4.866ThrGly: 4.866 ± 0.064	1.087ThrHis: 1.087 ± 0.029	3.985ThrIle: 3.985 ± 0.056	3.041ThrLys: 3.041 ± 0.052	5.654ThrLeu: 5.654 ± 0.077	0.959ThrMet: 0.959 ± 0.029	3.082ThrAsn: 3.082 ± 0.059	2.677ThrPro: 2.677 ± 0.046	2.136ThrGln: 2.136 ± 0.04	2.165ThrArg: 2.165 ± 0.04	3.509ThrSer: 3.509 ± 0.054	3.477ThrThr: 3.477 ± 0.071	4.216ThrVal: 4.216 ± 0.073	0.704ThrTrp: 0.704 ± 0.026	2.451ThrTyr: 2.451 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	5.254ValAla: 5.254 ± 0.065	0.604ValCys: 0.604 ± 0.021	3.483ValAsp: 3.483 ± 0.052	3.447ValGlu: 3.447 ± 0.059	3.109ValPhe: 3.109 ± 0.055	3.85ValGly: 3.85 ± 0.067	1.14ValHis: 1.14 ± 0.031	4.875ValIle: 4.875 ± 0.061	4.88ValLys: 4.88 ± 0.071	6.198ValLeu: 6.198 ± 0.071	1.513ValMet: 1.513 ± 0.032	4.153ValAsn: 4.153 ± 0.061	2.598ValPro: 2.598 ± 0.046	2.304ValGln: 2.304 ± 0.04	2.482ValArg: 2.482 ± 0.043	4.423ValSer: 4.423 ± 0.065	4.317ValThr: 4.317 ± 0.067	4.519ValVal: 4.519 ± 0.068	0.732ValTrp: 0.732 ± 0.024	2.712ValTyr: 2.712 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.829TrpAla: 0.829 ± 0.032	0.12TrpCys: 0.12 ± 0.01	0.614TrpAsp: 0.614 ± 0.023	0.632TrpGlu: 0.632 ± 0.021	0.622TrpPhe: 0.622 ± 0.023	0.837TrpGly: 0.837 ± 0.029	0.274TrpHis: 0.274 ± 0.014	0.74TrpIle: 0.74 ± 0.028	0.8TrpLys: 0.8 ± 0.026	1.264TrpLeu: 1.264 ± 0.036	0.363TrpMet: 0.363 ± 0.02	0.722TrpAsn: 0.722 ± 0.025	0.395TrpPro: 0.395 ± 0.02	0.6TrpGln: 0.6 ± 0.023	0.554TrpArg: 0.554 ± 0.023	0.645TrpSer: 0.645 ± 0.024	0.628TrpThr: 0.628 ± 0.025	0.717TrpVal: 0.717 ± 0.026	0.206TrpTrp: 0.206 ± 0.013	0.504TrpTyr: 0.504 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.995TyrAla: 2.995 ± 0.05	0.36TyrCys: 0.36 ± 0.017	2.209TyrAsp: 2.209 ± 0.043	2.027TyrGlu: 2.027 ± 0.042	2.188TyrPhe: 2.188 ± 0.042	2.726TyrGly: 2.726 ± 0.049	0.889TyrHis: 0.889 ± 0.026	2.499TyrIle: 2.499 ± 0.046	2.753TyrLys: 2.753 ± 0.049	4.073TyrLeu: 4.073 ± 0.062	0.749TyrMet: 0.749 ± 0.024	2.753TyrAsn: 2.753 ± 0.053	1.684TyrPro: 1.684 ± 0.042	1.804TyrGln: 1.804 ± 0.037	1.929TyrArg: 1.929 ± 0.044	2.595TyrSer: 2.595 ± 0.041	2.697TyrThr: 2.697 ± 0.061	2.366TyrVal: 2.366 ± 0.042	0.541TyrTrp: 0.541 ± 0.023	1.879TyrTyr: 1.879 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3655 proteins (1293125 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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