Amino acid dipepetide frequency for Acinetobacter phage vB_AbaM_IME512

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.884AlaAla: 4.884 ± 0.939
0.425AlaCys: 0.425 ± 0.183
3.397AlaAsp: 3.397 ± 0.428
3.751AlaGlu: 3.751 ± 0.467
3.114AlaPhe: 3.114 ± 0.534
4.317AlaGly: 4.317 ± 0.616
1.132AlaHis: 1.132 ± 0.302
5.237AlaIle: 5.237 ± 0.492
5.167AlaLys: 5.167 ± 0.642
5.804AlaLeu: 5.804 ± 0.629
2.194AlaMet: 2.194 ± 0.404
4.317AlaAsn: 4.317 ± 0.61
2.477AlaPro: 2.477 ± 0.347
3.468AlaGln: 3.468 ± 0.594
2.336AlaArg: 2.336 ± 0.385
3.468AlaSer: 3.468 ± 0.546
4.459AlaThr: 4.459 ± 0.724
3.963AlaVal: 3.963 ± 0.51
0.779AlaTrp: 0.779 ± 0.186
2.831AlaTyr: 2.831 ± 0.473
0.0AlaXaa: 0.0 ± 0.0
Cys
0.637CysAla: 0.637 ± 0.191
0.071CysCys: 0.071 ± 0.078
1.203CysAsp: 1.203 ± 0.327
0.92CysGlu: 0.92 ± 0.217
0.566CysPhe: 0.566 ± 0.188
0.779CysGly: 0.779 ± 0.214
0.212CysHis: 0.212 ± 0.117
0.708CysIle: 0.708 ± 0.233
1.132CysLys: 1.132 ± 0.324
0.991CysLeu: 0.991 ± 0.283
0.283CysMet: 0.283 ± 0.136
0.212CysAsn: 0.212 ± 0.105
0.283CysPro: 0.283 ± 0.151
0.212CysGln: 0.212 ± 0.124
0.849CysArg: 0.849 ± 0.223
0.566CysSer: 0.566 ± 0.213
0.495CysThr: 0.495 ± 0.223
1.132CysVal: 1.132 ± 0.267
0.212CysTrp: 0.212 ± 0.111
0.708CysTyr: 0.708 ± 0.261
0.0CysXaa: 0.0 ± 0.0
Asp
4.247AspAla: 4.247 ± 0.475
0.991AspCys: 0.991 ± 0.295
3.963AspAsp: 3.963 ± 0.488
5.025AspGlu: 5.025 ± 0.651
3.468AspPhe: 3.468 ± 0.425
5.45AspGly: 5.45 ± 0.732
0.779AspHis: 0.779 ± 0.205
3.397AspIle: 3.397 ± 0.432
4.884AspLys: 4.884 ± 0.678
4.813AspLeu: 4.813 ± 0.649
1.769AspMet: 1.769 ± 0.299
2.265AspAsn: 2.265 ± 0.34
1.557AspPro: 1.557 ± 0.295
2.619AspGln: 2.619 ± 0.405
2.548AspArg: 2.548 ± 0.328
3.256AspSer: 3.256 ± 0.462
2.194AspThr: 2.194 ± 0.364
4.388AspVal: 4.388 ± 0.49
1.132AspTrp: 1.132 ± 0.288
2.619AspTyr: 2.619 ± 0.423
0.0AspXaa: 0.0 ± 0.0
Glu
4.317GluAla: 4.317 ± 0.573
0.637GluCys: 0.637 ± 0.222
3.539GluAsp: 3.539 ± 0.652
4.247GluGlu: 4.247 ± 0.571
3.326GluPhe: 3.326 ± 0.545
3.468GluGly: 3.468 ± 0.518
0.991GluHis: 0.991 ± 0.297
4.954GluIle: 4.954 ± 0.677
5.025GluLys: 5.025 ± 0.571
6.582GluLeu: 6.582 ± 0.736
1.699GluMet: 1.699 ± 0.335
3.61GluAsn: 3.61 ± 0.437
1.132GluPro: 1.132 ± 0.308
3.822GluGln: 3.822 ± 0.615
1.982GluArg: 1.982 ± 0.32
4.742GluSer: 4.742 ± 0.439
2.902GluThr: 2.902 ± 0.531
5.237GluVal: 5.237 ± 0.661
1.416GluTrp: 1.416 ± 0.312
3.468GluTyr: 3.468 ± 0.448
0.0GluXaa: 0.0 ± 0.0
Phe
3.114PheAla: 3.114 ± 0.51
0.92PheCys: 0.92 ± 0.236
3.61PheAsp: 3.61 ± 0.562
2.548PheGlu: 2.548 ± 0.39
1.132PhePhe: 1.132 ± 0.305
3.185PheGly: 3.185 ± 0.45
0.637PheHis: 0.637 ± 0.234
3.397PheIle: 3.397 ± 0.478
3.539PheLys: 3.539 ± 0.604
2.619PheLeu: 2.619 ± 0.392
1.628PheMet: 1.628 ± 0.294
2.831PheAsn: 2.831 ± 0.463
0.779PhePro: 0.779 ± 0.219
1.203PheGln: 1.203 ± 0.335
1.769PheArg: 1.769 ± 0.353
2.548PheSer: 2.548 ± 0.456
2.76PheThr: 2.76 ± 0.418
3.043PheVal: 3.043 ± 0.436
0.849PheTrp: 0.849 ± 0.317
2.477PheTyr: 2.477 ± 0.439
0.0PheXaa: 0.0 ± 0.0
Gly
5.308GlyAla: 5.308 ± 0.785
0.708GlyCys: 0.708 ± 0.23
3.326GlyAsp: 3.326 ± 0.488
3.893GlyGlu: 3.893 ± 0.579
4.388GlyPhe: 4.388 ± 0.623
4.884GlyGly: 4.884 ± 0.546
1.416GlyHis: 1.416 ± 0.297
5.521GlyIle: 5.521 ± 0.474
4.813GlyLys: 4.813 ± 0.584
6.158GlyLeu: 6.158 ± 0.468
1.982GlyMet: 1.982 ± 0.382
3.397GlyAsn: 3.397 ± 0.46
0.708GlyPro: 0.708 ± 0.311
2.194GlyGln: 2.194 ± 0.423
3.468GlyArg: 3.468 ± 0.418
4.813GlySer: 4.813 ± 0.751
3.185GlyThr: 3.185 ± 0.58
5.874GlyVal: 5.874 ± 0.569
1.062GlyTrp: 1.062 ± 0.273
2.902GlyTyr: 2.902 ± 0.413
0.0GlyXaa: 0.0 ± 0.0
His
1.132HisAla: 1.132 ± 0.269
0.142HisCys: 0.142 ± 0.105
1.062HisAsp: 1.062 ± 0.23
1.769HisGlu: 1.769 ± 0.332
0.283HisPhe: 0.283 ± 0.134
0.991HisGly: 0.991 ± 0.257
0.354HisHis: 0.354 ± 0.143
1.345HisIle: 1.345 ± 0.268
1.557HisLys: 1.557 ± 0.37
1.062HisLeu: 1.062 ± 0.23
0.495HisMet: 0.495 ± 0.195
1.062HisAsn: 1.062 ± 0.283
0.495HisPro: 0.495 ± 0.24
0.708HisGln: 0.708 ± 0.258
0.354HisArg: 0.354 ± 0.164
1.203HisSer: 1.203 ± 0.303
0.92HisThr: 0.92 ± 0.215
1.132HisVal: 1.132 ± 0.309
0.142HisTrp: 0.142 ± 0.095
1.132HisTyr: 1.132 ± 0.273
0.0HisXaa: 0.0 ± 0.0
Ile
4.317IleAla: 4.317 ± 0.635
0.991IleCys: 0.991 ± 0.265
4.742IleAsp: 4.742 ± 0.477
6.865IleGlu: 6.865 ± 0.758
2.477IlePhe: 2.477 ± 0.46
5.025IleGly: 5.025 ± 0.565
1.557IleHis: 1.557 ± 0.331
3.751IleIle: 3.751 ± 0.503
7.361IleLys: 7.361 ± 0.936
4.459IleLeu: 4.459 ± 0.567
1.486IleMet: 1.486 ± 0.29
4.6IleAsn: 4.6 ± 0.472
3.68IlePro: 3.68 ± 0.471
2.265IleGln: 2.265 ± 0.396
1.982IleArg: 1.982 ± 0.331
4.813IleSer: 4.813 ± 0.532
4.813IleThr: 4.813 ± 0.748
4.6IleVal: 4.6 ± 0.446
0.708IleTrp: 0.708 ± 0.216
1.982IleTyr: 1.982 ± 0.433
0.0IleXaa: 0.0 ± 0.0
Lys
6.228LysAla: 6.228 ± 0.667
0.637LysCys: 0.637 ± 0.24
4.954LysAsp: 4.954 ± 0.598
5.167LysGlu: 5.167 ± 0.716
2.69LysPhe: 2.69 ± 0.426
5.521LysGly: 5.521 ± 0.637
1.274LysHis: 1.274 ± 0.355
5.874LysIle: 5.874 ± 0.708
6.016LysLys: 6.016 ± 0.755
6.511LysLeu: 6.511 ± 0.616
2.902LysMet: 2.902 ± 0.549
4.388LysAsn: 4.388 ± 0.509
2.477LysPro: 2.477 ± 0.45
2.76LysGln: 2.76 ± 0.477
4.388LysArg: 4.388 ± 0.588
3.751LysSer: 3.751 ± 0.652
4.247LysThr: 4.247 ± 0.491
4.459LysVal: 4.459 ± 0.6
0.991LysTrp: 0.991 ± 0.269
2.831LysTyr: 2.831 ± 0.506
0.0LysXaa: 0.0 ± 0.0
Leu
5.945LeuAla: 5.945 ± 0.77
1.203LeuCys: 1.203 ± 0.311
5.521LeuAsp: 5.521 ± 0.618
6.653LeuGlu: 6.653 ± 0.699
2.831LeuPhe: 2.831 ± 0.439
5.945LeuGly: 5.945 ± 0.636
1.345LeuHis: 1.345 ± 0.33
6.441LeuIle: 6.441 ± 0.659
7.502LeuLys: 7.502 ± 0.843
5.237LeuLeu: 5.237 ± 0.702
1.982LeuMet: 1.982 ± 0.347
6.653LeuAsn: 6.653 ± 0.702
1.628LeuPro: 1.628 ± 0.365
1.486LeuGln: 1.486 ± 0.349
3.61LeuArg: 3.61 ± 0.503
4.671LeuSer: 4.671 ± 0.4
4.459LeuThr: 4.459 ± 0.439
4.459LeuVal: 4.459 ± 0.454
0.566LeuTrp: 0.566 ± 0.227
2.69LeuTyr: 2.69 ± 0.383
0.0LeuXaa: 0.0 ± 0.0
Met
1.84MetAla: 1.84 ± 0.321
0.425MetCys: 0.425 ± 0.152
1.628MetAsp: 1.628 ± 0.401
1.486MetGlu: 1.486 ± 0.255
0.92MetPhe: 0.92 ± 0.299
1.628MetGly: 1.628 ± 0.454
0.566MetHis: 0.566 ± 0.197
1.699MetIle: 1.699 ± 0.302
2.265MetLys: 2.265 ± 0.361
2.123MetLeu: 2.123 ± 0.352
0.495MetMet: 0.495 ± 0.172
2.619MetAsn: 2.619 ± 0.422
0.991MetPro: 0.991 ± 0.218
1.699MetGln: 1.699 ± 0.38
1.274MetArg: 1.274 ± 0.356
2.76MetSer: 2.76 ± 0.464
2.053MetThr: 2.053 ± 0.339
1.062MetVal: 1.062 ± 0.34
0.212MetTrp: 0.212 ± 0.111
0.708MetTyr: 0.708 ± 0.213
0.0MetXaa: 0.0 ± 0.0
Asn
3.893AsnAla: 3.893 ± 0.55
0.495AsnCys: 0.495 ± 0.181
4.176AsnAsp: 4.176 ± 0.535
3.751AsnGlu: 3.751 ± 0.556
2.053AsnPhe: 2.053 ± 0.426
5.379AsnGly: 5.379 ± 0.731
1.062AsnHis: 1.062 ± 0.258
4.813AsnIle: 4.813 ± 0.533
3.397AsnLys: 3.397 ± 0.527
4.954AsnLeu: 4.954 ± 0.574
1.699AsnMet: 1.699 ± 0.372
3.963AsnAsn: 3.963 ± 0.598
3.043AsnPro: 3.043 ± 0.584
2.548AsnGln: 2.548 ± 0.519
2.053AsnArg: 2.053 ± 0.307
3.822AsnSer: 3.822 ± 0.512
3.68AsnThr: 3.68 ± 0.496
2.477AsnVal: 2.477 ± 0.357
0.637AsnTrp: 0.637 ± 0.196
2.548AsnTyr: 2.548 ± 0.459
0.0AsnXaa: 0.0 ± 0.0
Pro
1.557ProAla: 1.557 ± 0.288
0.354ProCys: 0.354 ± 0.192
2.053ProAsp: 2.053 ± 0.416
2.477ProGlu: 2.477 ± 0.329
1.274ProPhe: 1.274 ± 0.332
0.495ProGly: 0.495 ± 0.209
0.566ProHis: 0.566 ± 0.19
2.053ProIle: 2.053 ± 0.381
2.548ProLys: 2.548 ± 0.362
2.902ProLeu: 2.902 ± 0.458
0.92ProMet: 0.92 ± 0.272
2.123ProAsn: 2.123 ± 0.352
0.566ProPro: 0.566 ± 0.181
1.062ProGln: 1.062 ± 0.273
0.92ProArg: 0.92 ± 0.238
2.053ProSer: 2.053 ± 0.399
1.416ProThr: 1.416 ± 0.257
1.911ProVal: 1.911 ± 0.269
0.142ProTrp: 0.142 ± 0.099
2.406ProTyr: 2.406 ± 0.388
0.0ProXaa: 0.0 ± 0.0
Gln
3.185GlnAla: 3.185 ± 0.561
0.283GlnCys: 0.283 ± 0.135
2.336GlnAsp: 2.336 ± 0.432
2.548GlnGlu: 2.548 ± 0.471
2.123GlnPhe: 2.123 ± 0.446
2.548GlnGly: 2.548 ± 0.523
0.637GlnHis: 0.637 ± 0.192
1.84GlnIle: 1.84 ± 0.4
2.548GlnLys: 2.548 ± 0.322
3.68GlnLeu: 3.68 ± 0.672
0.92GlnMet: 0.92 ± 0.328
1.699GlnAsn: 1.699 ± 0.378
0.779GlnPro: 0.779 ± 0.2
1.486GlnGln: 1.486 ± 0.367
1.699GlnArg: 1.699 ± 0.373
2.194GlnSer: 2.194 ± 0.413
2.336GlnThr: 2.336 ± 0.364
1.84GlnVal: 1.84 ± 0.396
0.991GlnTrp: 0.991 ± 0.277
1.911GlnTyr: 1.911 ± 0.334
0.0GlnXaa: 0.0 ± 0.0
Arg
2.053ArgAla: 2.053 ± 0.414
0.991ArgCys: 0.991 ± 0.294
2.336ArgAsp: 2.336 ± 0.436
2.831ArgGlu: 2.831 ± 0.527
1.84ArgPhe: 1.84 ± 0.305
1.769ArgGly: 1.769 ± 0.355
0.92ArgHis: 0.92 ± 0.221
3.185ArgIle: 3.185 ± 0.491
4.105ArgLys: 4.105 ± 0.574
3.61ArgLeu: 3.61 ± 0.475
0.779ArgMet: 0.779 ± 0.238
1.699ArgAsn: 1.699 ± 0.319
1.203ArgPro: 1.203 ± 0.22
1.416ArgGln: 1.416 ± 0.328
1.274ArgArg: 1.274 ± 0.33
3.114ArgSer: 3.114 ± 0.51
1.628ArgThr: 1.628 ± 0.335
2.76ArgVal: 2.76 ± 0.417
0.637ArgTrp: 0.637 ± 0.167
1.203ArgTyr: 1.203 ± 0.373
0.0ArgXaa: 0.0 ± 0.0
Ser
3.114SerAla: 3.114 ± 0.489
0.495SerCys: 0.495 ± 0.178
3.68SerAsp: 3.68 ± 0.447
3.397SerGlu: 3.397 ± 0.559
3.256SerPhe: 3.256 ± 0.572
5.237SerGly: 5.237 ± 0.658
0.92SerHis: 0.92 ± 0.257
6.016SerIle: 6.016 ± 0.675
4.105SerLys: 4.105 ± 0.596
5.945SerLeu: 5.945 ± 0.47
1.84SerMet: 1.84 ± 0.41
3.751SerAsn: 3.751 ± 0.494
1.628SerPro: 1.628 ± 0.312
2.336SerGln: 2.336 ± 0.407
2.265SerArg: 2.265 ± 0.327
2.973SerSer: 2.973 ± 0.507
3.326SerThr: 3.326 ± 0.534
4.034SerVal: 4.034 ± 0.511
0.991SerTrp: 0.991 ± 0.268
1.557SerTyr: 1.557 ± 0.3
0.0SerXaa: 0.0 ± 0.0
Thr
3.893ThrAla: 3.893 ± 0.545
0.849ThrCys: 0.849 ± 0.218
2.973ThrAsp: 2.973 ± 0.411
2.053ThrGlu: 2.053 ± 0.388
1.982ThrPhe: 1.982 ± 0.42
4.671ThrGly: 4.671 ± 0.692
1.132ThrHis: 1.132 ± 0.293
3.68ThrIle: 3.68 ± 0.564
3.751ThrLys: 3.751 ± 0.487
4.742ThrLeu: 4.742 ± 0.687
1.699ThrMet: 1.699 ± 0.384
2.902ThrAsn: 2.902 ± 0.589
2.548ThrPro: 2.548 ± 0.378
1.911ThrGln: 1.911 ± 0.389
1.769ThrArg: 1.769 ± 0.356
2.831ThrSer: 2.831 ± 0.424
3.397ThrThr: 3.397 ± 0.648
3.751ThrVal: 3.751 ± 0.583
1.628ThrTrp: 1.628 ± 0.331
1.416ThrTyr: 1.416 ± 0.278
0.0ThrXaa: 0.0 ± 0.0
Val
4.884ValAla: 4.884 ± 0.605
0.425ValCys: 0.425 ± 0.204
3.893ValAsp: 3.893 ± 0.469
3.963ValGlu: 3.963 ± 0.611
3.751ValPhe: 3.751 ± 0.529
4.742ValGly: 4.742 ± 0.55
0.708ValHis: 0.708 ± 0.193
5.167ValIle: 5.167 ± 0.678
4.6ValLys: 4.6 ± 0.522
4.742ValLeu: 4.742 ± 0.828
1.911ValMet: 1.911 ± 0.357
4.6ValAsn: 4.6 ± 0.528
1.628ValPro: 1.628 ± 0.334
2.123ValGln: 2.123 ± 0.57
2.053ValArg: 2.053 ± 0.38
3.68ValSer: 3.68 ± 0.471
2.973ValThr: 2.973 ± 0.539
4.247ValVal: 4.247 ± 0.542
0.708ValTrp: 0.708 ± 0.214
2.76ValTyr: 2.76 ± 0.434
0.0ValXaa: 0.0 ± 0.0
Trp
1.062TrpAla: 1.062 ± 0.3
0.354TrpCys: 0.354 ± 0.147
0.991TrpAsp: 0.991 ± 0.218
0.92TrpGlu: 0.92 ± 0.253
0.849TrpPhe: 0.849 ± 0.223
0.637TrpGly: 0.637 ± 0.181
0.283TrpHis: 0.283 ± 0.126
0.708TrpIle: 0.708 ± 0.231
1.062TrpLys: 1.062 ± 0.307
1.203TrpLeu: 1.203 ± 0.311
0.566TrpMet: 0.566 ± 0.196
0.779TrpAsn: 0.779 ± 0.236
0.071TrpPro: 0.071 ± 0.069
0.708TrpGln: 0.708 ± 0.206
0.849TrpArg: 0.849 ± 0.235
1.132TrpSer: 1.132 ± 0.296
0.637TrpThr: 0.637 ± 0.201
1.203TrpVal: 1.203 ± 0.29
0.354TrpTrp: 0.354 ± 0.13
0.425TrpTyr: 0.425 ± 0.206
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.982TyrAla: 1.982 ± 0.334
0.779TyrCys: 0.779 ± 0.244
1.982TyrAsp: 1.982 ± 0.428
2.831TyrGlu: 2.831 ± 0.503
2.265TyrPhe: 2.265 ± 0.425
3.326TyrGly: 3.326 ± 0.528
0.849TyrHis: 0.849 ± 0.237
2.69TyrIle: 2.69 ± 0.386
2.69TyrLys: 2.69 ± 0.383
2.69TyrLeu: 2.69 ± 0.522
1.132TyrMet: 1.132 ± 0.285
2.973TyrAsn: 2.973 ± 0.441
2.123TyrPro: 2.123 ± 0.417
1.557TyrGln: 1.557 ± 0.346
1.911TyrArg: 1.911 ± 0.436
2.477TyrSer: 2.477 ± 0.409
1.699TyrThr: 1.699 ± 0.362
1.982TyrVal: 1.982 ± 0.36
0.637TyrTrp: 0.637 ± 0.173
1.557TyrTyr: 1.557 ± 0.32
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 91 proteins (14130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski