Amino acid dipepetide frequency for Mycoplasma neophronis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.488AlaAla: 4.488 ± 0.226
0.457AlaCys: 0.457 ± 0.043
2.91AlaAsp: 2.91 ± 0.138
3.919AlaGlu: 3.919 ± 0.213
3.018AlaPhe: 3.018 ± 0.145
3.264AlaGly: 3.264 ± 0.161
0.937AlaHis: 0.937 ± 0.067
6.358AlaIle: 6.358 ± 0.19
6.964AlaLys: 6.964 ± 0.233
6.278AlaLeu: 6.278 ± 0.242
1.417AlaMet: 1.417 ± 0.088
4.632AlaAsn: 4.632 ± 0.211
1.681AlaPro: 1.681 ± 0.113
2.211AlaGln: 2.211 ± 0.125
2.255AlaArg: 2.255 ± 0.124
4.036AlaSer: 4.036 ± 0.15
3.506AlaThr: 3.506 ± 0.123
3.246AlaVal: 3.246 ± 0.15
0.507AlaTrp: 0.507 ± 0.059
2.408AlaTyr: 2.408 ± 0.112
0.0AlaXaa: 0.0 ± 0.0
Cys
0.408CysAla: 0.408 ± 0.045
0.067CysCys: 0.067 ± 0.018
0.399CysAsp: 0.399 ± 0.044
0.381CysGlu: 0.381 ± 0.038
0.318CysPhe: 0.318 ± 0.036
0.39CysGly: 0.39 ± 0.048
0.117CysHis: 0.117 ± 0.025
0.404CysIle: 0.404 ± 0.042
0.399CysLys: 0.399 ± 0.048
0.592CysLeu: 0.592 ± 0.049
0.058CysMet: 0.058 ± 0.016
0.318CysAsn: 0.318 ± 0.037
0.224CysPro: 0.224 ± 0.046
0.215CysGln: 0.215 ± 0.03
0.166CysArg: 0.166 ± 0.028
0.323CysSer: 0.323 ± 0.039
0.22CysThr: 0.22 ± 0.032
0.327CysVal: 0.327 ± 0.042
0.04CysTrp: 0.04 ± 0.011
0.148CysTyr: 0.148 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
3.367AspAla: 3.367 ± 0.168
0.184AspCys: 0.184 ± 0.03
2.762AspAsp: 2.762 ± 0.133
4.408AspGlu: 4.408 ± 0.139
3.358AspPhe: 3.358 ± 0.136
2.699AspGly: 2.699 ± 0.121
0.713AspHis: 0.713 ± 0.06
4.887AspIle: 4.887 ± 0.168
5.452AspLys: 5.452 ± 0.159
5.551AspLeu: 5.551 ± 0.183
0.879AspMet: 0.879 ± 0.072
4.004AspAsn: 4.004 ± 0.188
1.726AspPro: 1.726 ± 0.097
1.363AspGln: 1.363 ± 0.074
1.623AspArg: 1.623 ± 0.094
3.063AspSer: 3.063 ± 0.133
2.408AspThr: 2.408 ± 0.103
3.211AspVal: 3.211 ± 0.129
0.619AspTrp: 0.619 ± 0.055
2.753AspTyr: 2.753 ± 0.107
0.0AspXaa: 0.0 ± 0.0
Glu
4.865GluAla: 4.865 ± 0.225
0.291GluCys: 0.291 ± 0.036
3.623GluAsp: 3.623 ± 0.129
5.587GluGlu: 5.587 ± 0.197
3.314GluPhe: 3.314 ± 0.154
2.641GluGly: 2.641 ± 0.123
0.901GluHis: 0.901 ± 0.071
7.255GluIle: 7.255 ± 0.201
7.286GluLys: 7.286 ± 0.206
6.798GluLeu: 6.798 ± 0.213
1.439GluMet: 1.439 ± 0.078
6.304GluAsn: 6.304 ± 0.204
1.471GluPro: 1.471 ± 0.102
2.56GluGln: 2.56 ± 0.121
1.946GluArg: 1.946 ± 0.1
3.287GluSer: 3.287 ± 0.138
3.045GluThr: 3.045 ± 0.131
4.152GluVal: 4.152 ± 0.164
0.543GluTrp: 0.543 ± 0.052
2.995GluTyr: 2.995 ± 0.122
0.0GluXaa: 0.0 ± 0.0
Phe
3.358PheAla: 3.358 ± 0.134
0.309PheCys: 0.309 ± 0.036
3.381PheAsp: 3.381 ± 0.132
3.39PheGlu: 3.39 ± 0.131
2.399PhePhe: 2.399 ± 0.142
2.82PheGly: 2.82 ± 0.117
0.619PheHis: 0.619 ± 0.051
4.367PheIle: 4.367 ± 0.193
4.457PheLys: 4.457 ± 0.159
4.197PheLeu: 4.197 ± 0.18
0.825PheMet: 0.825 ± 0.066
3.986PheAsn: 3.986 ± 0.165
1.179PhePro: 1.179 ± 0.077
1.188PheGln: 1.188 ± 0.08
1.359PheArg: 1.359 ± 0.074
3.354PheSer: 3.354 ± 0.133
2.408PheThr: 2.408 ± 0.122
3.022PheVal: 3.022 ± 0.15
0.435PheTrp: 0.435 ± 0.043
2.031PheTyr: 2.031 ± 0.106
0.0PheXaa: 0.0 ± 0.0
Gly
3.211GlyAla: 3.211 ± 0.155
0.265GlyCys: 0.265 ± 0.044
2.493GlyAsp: 2.493 ± 0.123
2.838GlyGlu: 2.838 ± 0.118
2.686GlyPhe: 2.686 ± 0.147
2.932GlyGly: 2.932 ± 0.173
1.004GlyHis: 1.004 ± 0.071
4.636GlyIle: 4.636 ± 0.164
4.04GlyLys: 4.04 ± 0.162
4.215GlyLeu: 4.215 ± 0.162
1.063GlyMet: 1.063 ± 0.071
2.776GlyAsn: 2.776 ± 0.158
1.238GlyPro: 1.238 ± 0.088
1.749GlyGln: 1.749 ± 0.104
1.78GlyArg: 1.78 ± 0.115
3.089GlySer: 3.089 ± 0.15
2.583GlyThr: 2.583 ± 0.137
3.009GlyVal: 3.009 ± 0.131
0.534GlyTrp: 0.534 ± 0.048
2.197GlyTyr: 2.197 ± 0.094
0.0GlyXaa: 0.0 ± 0.0
His
0.991HisAla: 0.991 ± 0.068
0.112HisCys: 0.112 ± 0.026
0.726HisAsp: 0.726 ± 0.06
1.099HisGlu: 1.099 ± 0.068
0.794HisPhe: 0.794 ± 0.059
0.951HisGly: 0.951 ± 0.076
0.282HisHis: 0.282 ± 0.045
1.188HisIle: 1.188 ± 0.076
1.094HisLys: 1.094 ± 0.075
1.256HisLeu: 1.256 ± 0.099
0.238HisMet: 0.238 ± 0.036
0.951HisAsn: 0.951 ± 0.075
0.574HisPro: 0.574 ± 0.055
0.466HisGln: 0.466 ± 0.051
0.502HisArg: 0.502 ± 0.045
0.928HisSer: 0.928 ± 0.06
0.596HisThr: 0.596 ± 0.051
0.785HisVal: 0.785 ± 0.063
0.143HisTrp: 0.143 ± 0.022
0.628HisTyr: 0.628 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
5.816IleAla: 5.816 ± 0.17
0.668IleCys: 0.668 ± 0.069
5.587IleAsp: 5.587 ± 0.173
6.399IleGlu: 6.399 ± 0.245
4.215IlePhe: 4.215 ± 0.172
4.134IleGly: 4.134 ± 0.164
0.991IleHis: 0.991 ± 0.068
7.963IleIle: 7.963 ± 0.231
9.035IleLys: 9.035 ± 0.244
7.717IleLeu: 7.717 ± 0.247
1.578IleMet: 1.578 ± 0.085
7.968IleAsn: 7.968 ± 0.255
2.789IlePro: 2.789 ± 0.126
2.843IleGln: 2.843 ± 0.13
2.484IleArg: 2.484 ± 0.113
6.345IleSer: 6.345 ± 0.219
4.861IleThr: 4.861 ± 0.16
5.085IleVal: 5.085 ± 0.169
0.699IleTrp: 0.699 ± 0.064
3.605IleTyr: 3.605 ± 0.145
0.0IleXaa: 0.0 ± 0.0
Lys
5.748LysAla: 5.748 ± 0.222
0.363LysCys: 0.363 ± 0.05
5.062LysAsp: 5.062 ± 0.177
7.26LysGlu: 7.26 ± 0.195
3.722LysPhe: 3.722 ± 0.128
3.291LysGly: 3.291 ± 0.138
1.354LysHis: 1.354 ± 0.088
8.658LysIle: 8.658 ± 0.219
8.78LysLys: 8.78 ± 0.245
8.605LysLeu: 8.605 ± 0.273
2.524LysMet: 2.524 ± 0.111
8.394LysAsn: 8.394 ± 0.25
2.596LysPro: 2.596 ± 0.117
3.556LysGln: 3.556 ± 0.134
2.91LysArg: 2.91 ± 0.122
5.291LysSer: 5.291 ± 0.174
5.412LysThr: 5.412 ± 0.171
4.959LysVal: 4.959 ± 0.148
0.794LysTrp: 0.794 ± 0.066
4.672LysTyr: 4.672 ± 0.186
0.0LysXaa: 0.0 ± 0.0
Leu
6.632LeuAla: 6.632 ± 0.177
0.529LeuCys: 0.529 ± 0.051
5.282LeuAsp: 5.282 ± 0.166
6.251LeuGlu: 6.251 ± 0.207
4.399LeuPhe: 4.399 ± 0.18
4.82LeuGly: 4.82 ± 0.156
1.247LeuHis: 1.247 ± 0.08
8.824LeuIle: 8.824 ± 0.257
8.735LeuLys: 8.735 ± 0.252
8.183LeuLeu: 8.183 ± 0.221
1.789LeuMet: 1.789 ± 0.098
8.102LeuAsn: 8.102 ± 0.344
2.986LeuPro: 2.986 ± 0.119
2.547LeuGln: 2.547 ± 0.122
2.811LeuArg: 2.811 ± 0.135
6.869LeuSer: 6.869 ± 0.169
4.852LeuThr: 4.852 ± 0.148
5.26LeuVal: 5.26 ± 0.166
0.659LeuTrp: 0.659 ± 0.059
3.054LeuTyr: 3.054 ± 0.12
0.0LeuXaa: 0.0 ± 0.0
Met
1.556MetAla: 1.556 ± 0.1
0.108MetCys: 0.108 ± 0.024
0.83MetAsp: 0.83 ± 0.069
1.067MetGlu: 1.067 ± 0.084
1.009MetPhe: 1.009 ± 0.074
0.892MetGly: 0.892 ± 0.073
0.314MetHis: 0.314 ± 0.04
1.668MetIle: 1.668 ± 0.09
1.897MetLys: 1.897 ± 0.094
1.735MetLeu: 1.735 ± 0.098
0.448MetMet: 0.448 ± 0.044
1.525MetAsn: 1.525 ± 0.082
0.906MetPro: 0.906 ± 0.067
0.776MetGln: 0.776 ± 0.059
0.664MetArg: 0.664 ± 0.062
1.421MetSer: 1.421 ± 0.092
1.022MetThr: 1.022 ± 0.07
1.0MetVal: 1.0 ± 0.054
0.179MetTrp: 0.179 ± 0.026
0.641MetTyr: 0.641 ± 0.053
0.0MetXaa: 0.0 ± 0.0
Asn
4.417AsnAla: 4.417 ± 0.246
0.265AsnCys: 0.265 ± 0.038
4.439AsnAsp: 4.439 ± 0.174
6.04AsnGlu: 6.04 ± 0.244
3.659AsnPhe: 3.659 ± 0.159
3.52AsnGly: 3.52 ± 0.131
1.166AsnHis: 1.166 ± 0.067
7.228AsnIle: 7.228 ± 0.248
8.215AsnLys: 8.215 ± 0.266
7.493AsnLeu: 7.493 ± 0.265
1.381AsnMet: 1.381 ± 0.078
7.147AsnAsn: 7.147 ± 0.381
2.865AsnPro: 2.865 ± 0.138
3.211AsnGln: 3.211 ± 0.184
2.022AsnArg: 2.022 ± 0.095
4.879AsnSer: 4.879 ± 0.217
3.489AsnThr: 3.489 ± 0.149
4.045AsnVal: 4.045 ± 0.144
0.744AsnTrp: 0.744 ± 0.052
3.466AsnTyr: 3.466 ± 0.158
0.0AsnXaa: 0.0 ± 0.0
Pro
1.968ProAla: 1.968 ± 0.122
0.148ProCys: 0.148 ± 0.029
1.534ProAsp: 1.534 ± 0.093
2.435ProGlu: 2.435 ± 0.112
1.453ProPhe: 1.453 ± 0.092
1.56ProGly: 1.56 ± 0.107
0.516ProHis: 0.516 ± 0.056
2.376ProIle: 2.376 ± 0.108
2.345ProLys: 2.345 ± 0.109
2.654ProLeu: 2.654 ± 0.134
0.637ProMet: 0.637 ± 0.058
2.157ProAsn: 2.157 ± 0.116
0.547ProPro: 0.547 ± 0.086
1.013ProGln: 1.013 ± 0.062
0.906ProArg: 0.906 ± 0.064
1.847ProSer: 1.847 ± 0.079
1.69ProThr: 1.69 ± 0.086
1.897ProVal: 1.897 ± 0.108
0.381ProTrp: 0.381 ± 0.053
1.35ProTyr: 1.35 ± 0.087
0.0ProXaa: 0.0 ± 0.0
Gln
2.327GlnAla: 2.327 ± 0.153
0.103GlnCys: 0.103 ± 0.022
1.829GlnAsp: 1.829 ± 0.093
2.273GlnGlu: 2.273 ± 0.108
1.507GlnPhe: 1.507 ± 0.083
1.273GlnGly: 1.273 ± 0.081
0.444GlnHis: 0.444 ± 0.053
3.031GlnIle: 3.031 ± 0.126
3.336GlnLys: 3.336 ± 0.134
3.018GlnLeu: 3.018 ± 0.14
0.65GlnMet: 0.65 ± 0.066
2.986GlnAsn: 2.986 ± 0.142
0.969GlnPro: 0.969 ± 0.065
0.977GlnGln: 0.977 ± 0.071
1.022GlnArg: 1.022 ± 0.077
1.861GlnSer: 1.861 ± 0.096
1.919GlnThr: 1.919 ± 0.092
1.785GlnVal: 1.785 ± 0.085
0.3GlnTrp: 0.3 ± 0.036
1.565GlnTyr: 1.565 ± 0.079
0.0GlnXaa: 0.0 ± 0.0
Arg
2.027ArgAla: 2.027 ± 0.102
0.211ArgCys: 0.211 ± 0.038
1.722ArgAsp: 1.722 ± 0.108
2.376ArgGlu: 2.376 ± 0.102
1.466ArgPhe: 1.466 ± 0.093
1.646ArgGly: 1.646 ± 0.092
0.439ArgHis: 0.439 ± 0.054
2.587ArgIle: 2.587 ± 0.131
2.744ArgLys: 2.744 ± 0.122
2.807ArgLeu: 2.807 ± 0.128
0.735ArgMet: 0.735 ± 0.075
2.004ArgAsn: 2.004 ± 0.102
1.04ArgPro: 1.04 ± 0.083
1.117ArgGln: 1.117 ± 0.065
1.291ArgArg: 1.291 ± 0.093
1.735ArgSer: 1.735 ± 0.106
1.309ArgThr: 1.309 ± 0.084
1.924ArgVal: 1.924 ± 0.123
0.35ArgTrp: 0.35 ± 0.04
1.305ArgTyr: 1.305 ± 0.093
0.0ArgXaa: 0.0 ± 0.0
Ser
3.838SerAla: 3.838 ± 0.14
0.489SerCys: 0.489 ± 0.054
3.542SerAsp: 3.542 ± 0.128
4.331SerGlu: 4.331 ± 0.168
3.471SerPhe: 3.471 ± 0.151
3.219SerGly: 3.219 ± 0.146
0.897SerHis: 0.897 ± 0.067
5.385SerIle: 5.385 ± 0.169
5.421SerLys: 5.421 ± 0.167
6.417SerLeu: 6.417 ± 0.16
1.072SerMet: 1.072 ± 0.074
4.704SerAsn: 4.704 ± 0.198
1.641SerPro: 1.641 ± 0.092
2.471SerGln: 2.471 ± 0.113
1.982SerArg: 1.982 ± 0.119
4.166SerSer: 4.166 ± 0.152
3.125SerThr: 3.125 ± 0.123
3.385SerVal: 3.385 ± 0.125
0.583SerTrp: 0.583 ± 0.05
2.717SerTyr: 2.717 ± 0.13
0.0SerXaa: 0.0 ± 0.0
Thr
2.637ThrAla: 2.637 ± 0.123
0.233ThrCys: 0.233 ± 0.035
2.462ThrAsp: 2.462 ± 0.122
3.089ThrGlu: 3.089 ± 0.129
2.659ThrPhe: 2.659 ± 0.133
2.708ThrGly: 2.708 ± 0.153
0.838ThrHis: 0.838 ± 0.062
4.654ThrIle: 4.654 ± 0.171
4.636ThrLys: 4.636 ± 0.17
5.296ThrLeu: 5.296 ± 0.148
0.888ThrMet: 0.888 ± 0.071
3.856ThrAsn: 3.856 ± 0.157
1.758ThrPro: 1.758 ± 0.115
1.592ThrGln: 1.592 ± 0.104
1.534ThrArg: 1.534 ± 0.097
3.287ThrSer: 3.287 ± 0.122
2.726ThrThr: 2.726 ± 0.13
3.103ThrVal: 3.103 ± 0.141
0.475ThrTrp: 0.475 ± 0.053
2.107ThrTyr: 2.107 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
3.901ValAla: 3.901 ± 0.146
0.417ValCys: 0.417 ± 0.05
3.291ValAsp: 3.291 ± 0.131
3.578ValGlu: 3.578 ± 0.151
2.973ValPhe: 2.973 ± 0.118
2.982ValGly: 2.982 ± 0.151
0.767ValHis: 0.767 ± 0.06
5.035ValIle: 5.035 ± 0.174
4.789ValLys: 4.789 ± 0.172
5.65ValLeu: 5.65 ± 0.18
1.094ValMet: 1.094 ± 0.075
4.143ValAsn: 4.143 ± 0.127
1.664ValPro: 1.664 ± 0.102
1.435ValGln: 1.435 ± 0.077
1.704ValArg: 1.704 ± 0.105
3.906ValSer: 3.906 ± 0.135
2.959ValThr: 2.959 ± 0.125
3.645ValVal: 3.645 ± 0.164
0.552ValTrp: 0.552 ± 0.054
2.282ValTyr: 2.282 ± 0.104
0.0ValXaa: 0.0 ± 0.0
Trp
0.529TrpAla: 0.529 ± 0.048
0.054TrpCys: 0.054 ± 0.015
0.547TrpAsp: 0.547 ± 0.054
0.592TrpGlu: 0.592 ± 0.058
0.48TrpPhe: 0.48 ± 0.047
0.413TrpGly: 0.413 ± 0.046
0.13TrpHis: 0.13 ± 0.026
0.771TrpIle: 0.771 ± 0.066
0.856TrpLys: 0.856 ± 0.067
0.852TrpLeu: 0.852 ± 0.079
0.282TrpMet: 0.282 ± 0.034
0.78TrpAsn: 0.78 ± 0.064
0.274TrpPro: 0.274 ± 0.04
0.22TrpGln: 0.22 ± 0.03
0.323TrpArg: 0.323 ± 0.037
0.493TrpSer: 0.493 ± 0.059
0.493TrpThr: 0.493 ± 0.051
0.516TrpVal: 0.516 ± 0.054
0.103TrpTrp: 0.103 ± 0.026
0.413TrpTyr: 0.413 ± 0.046
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.408TyrAla: 2.408 ± 0.109
0.242TyrCys: 0.242 ± 0.033
2.61TyrAsp: 2.61 ± 0.116
2.995TyrGlu: 2.995 ± 0.119
2.188TyrPhe: 2.188 ± 0.111
2.179TyrGly: 2.179 ± 0.107
0.628TyrHis: 0.628 ± 0.059
3.502TyrIle: 3.502 ± 0.135
3.471TyrLys: 3.471 ± 0.139
4.52TyrLeu: 4.52 ± 0.187
0.655TyrMet: 0.655 ± 0.059
2.95TyrAsn: 2.95 ± 0.119
1.287TyrPro: 1.287 ± 0.072
1.668TyrGln: 1.668 ± 0.092
1.551TyrArg: 1.551 ± 0.082
2.677TyrSer: 2.677 ± 0.121
1.915TyrThr: 1.915 ± 0.1
2.412TyrVal: 2.412 ± 0.1
0.48TyrTrp: 0.48 ± 0.05
1.973TyrTyr: 1.973 ± 0.108
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 623 proteins (223019 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski