Amino acid dipepetide frequency for Equine foamy virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.664AlaAla: 3.664 ± 0.788
0.916AlaCys: 0.916 ± 0.694
2.748AlaAsp: 2.748 ± 0.819
3.053AlaGlu: 3.053 ± 0.553
1.221AlaPhe: 1.221 ± 0.617
4.275AlaGly: 4.275 ± 1.474
1.527AlaHis: 1.527 ± 0.581
3.969AlaIle: 3.969 ± 0.482
2.748AlaLys: 2.748 ± 0.838
7.328AlaLeu: 7.328 ± 1.22
1.221AlaMet: 1.221 ± 0.426
1.832AlaAsn: 1.832 ± 0.552
1.832AlaPro: 1.832 ± 1.013
4.58AlaGln: 4.58 ± 1.388
3.969AlaArg: 3.969 ± 1.553
3.053AlaSer: 3.053 ± 0.944
3.359AlaThr: 3.359 ± 0.482
3.969AlaVal: 3.969 ± 0.958
0.611AlaTrp: 0.611 ± 0.225
1.527AlaTyr: 1.527 ± 0.576
0.0AlaXaa: 0.0 ± 0.0
Cys
1.221CysAla: 1.221 ± 0.687
0.305CysCys: 0.305 ± 0.347
0.0CysAsp: 0.0 ± 0.0
0.916CysGlu: 0.916 ± 0.513
0.305CysPhe: 0.305 ± 0.217
0.916CysGly: 0.916 ± 0.513
0.305CysHis: 0.305 ± 0.232
1.527CysIle: 1.527 ± 0.576
0.916CysLys: 0.916 ± 0.774
1.527CysLeu: 1.527 ± 0.733
0.0CysMet: 0.0 ± 0.0
0.916CysAsn: 0.916 ± 0.774
1.527CysPro: 1.527 ± 0.541
0.611CysGln: 0.611 ± 0.225
0.305CysArg: 0.305 ± 0.217
0.611CysSer: 0.611 ± 0.435
0.611CysThr: 0.611 ± 0.225
0.916CysVal: 0.916 ± 0.238
0.305CysTrp: 0.305 ± 0.423
1.221CysTyr: 1.221 ± 0.69
0.0CysXaa: 0.0 ± 0.0
Asp
1.221AspAla: 1.221 ± 0.628
2.443AspCys: 2.443 ± 0.873
3.359AspAsp: 3.359 ± 1.345
2.443AspGlu: 2.443 ± 1.134
2.137AspPhe: 2.137 ± 0.76
2.748AspGly: 2.748 ± 0.722
1.221AspHis: 1.221 ± 0.497
3.359AspIle: 3.359 ± 1.524
2.443AspLys: 2.443 ± 0.635
6.718AspLeu: 6.718 ± 1.277
1.221AspMet: 1.221 ± 0.679
2.137AspAsn: 2.137 ± 0.521
3.053AspPro: 3.053 ± 1.266
3.053AspGln: 3.053 ± 0.811
1.527AspArg: 1.527 ± 0.314
3.359AspSer: 3.359 ± 0.823
2.748AspThr: 2.748 ± 0.536
3.664AspVal: 3.664 ± 0.513
0.916AspTrp: 0.916 ± 0.538
2.137AspTyr: 2.137 ± 0.731
0.0AspXaa: 0.0 ± 0.0
Glu
3.664GluAla: 3.664 ± 1.556
0.916GluCys: 0.916 ± 0.376
3.053GluAsp: 3.053 ± 1.58
4.275GluGlu: 4.275 ± 1.11
1.221GluPhe: 1.221 ± 0.907
2.443GluGly: 2.443 ± 0.764
0.916GluHis: 0.916 ± 0.238
4.275GluIle: 4.275 ± 0.783
1.221GluLys: 1.221 ± 0.929
5.802GluLeu: 5.802 ± 1.819
1.221GluMet: 1.221 ± 0.704
2.443GluAsn: 2.443 ± 0.661
3.053GluPro: 3.053 ± 1.082
2.137GluGln: 2.137 ± 0.825
3.359GluArg: 3.359 ± 0.956
0.916GluSer: 0.916 ± 0.452
2.748GluThr: 2.748 ± 1.089
3.359GluVal: 3.359 ± 1.035
1.527GluTrp: 1.527 ± 0.541
1.832GluTyr: 1.832 ± 0.405
0.0GluXaa: 0.0 ± 0.0
Phe
2.137PheAla: 2.137 ± 0.877
0.611PheCys: 0.611 ± 0.435
1.221PheAsp: 1.221 ± 0.817
1.832PheGlu: 1.832 ± 0.698
0.611PhePhe: 0.611 ± 0.55
1.527PheGly: 1.527 ± 0.738
0.305PheHis: 0.305 ± 0.232
1.221PheIle: 1.221 ± 0.426
0.611PheLys: 0.611 ± 0.385
1.832PheLeu: 1.832 ± 0.674
0.0PheMet: 0.0 ± 0.0
0.305PheAsn: 0.305 ± 0.336
1.832PhePro: 1.832 ± 0.796
2.137PheGln: 2.137 ± 0.619
1.832PheArg: 1.832 ± 0.83
1.527PheSer: 1.527 ± 0.501
2.443PheThr: 2.443 ± 0.632
1.527PheVal: 1.527 ± 0.568
0.916PheTrp: 0.916 ± 0.402
1.221PheTyr: 1.221 ± 0.45
0.0PheXaa: 0.0 ± 0.0
Gly
1.527GlyAla: 1.527 ± 0.863
0.916GlyCys: 0.916 ± 0.513
3.053GlyAsp: 3.053 ± 1.131
2.443GlyGlu: 2.443 ± 0.962
2.137GlyPhe: 2.137 ± 0.936
2.137GlyGly: 2.137 ± 1.313
2.137GlyHis: 2.137 ± 0.664
5.496GlyIle: 5.496 ± 0.99
3.359GlyLys: 3.359 ± 0.791
4.885GlyLeu: 4.885 ± 1.006
1.527GlyMet: 1.527 ± 0.908
2.443GlyAsn: 2.443 ± 0.736
5.191GlyPro: 5.191 ± 2.039
5.496GlyGln: 5.496 ± 1.927
4.58GlyArg: 4.58 ± 1.521
3.969GlySer: 3.969 ± 0.48
3.664GlyThr: 3.664 ± 0.344
1.527GlyVal: 1.527 ± 0.513
0.611GlyTrp: 0.611 ± 0.694
2.443GlyTyr: 2.443 ± 0.788
0.0GlyXaa: 0.0 ± 0.0
His
0.305HisAla: 0.305 ± 0.336
0.305HisCys: 0.305 ± 0.217
1.221HisAsp: 1.221 ± 0.374
1.221HisGlu: 1.221 ± 0.33
0.916HisPhe: 0.916 ± 0.678
0.916HisGly: 0.916 ± 0.238
1.527HisHis: 1.527 ± 0.964
1.221HisIle: 1.221 ± 0.65
2.443HisLys: 2.443 ± 1.078
4.275HisLeu: 4.275 ± 1.085
0.0HisMet: 0.0 ± 0.0
0.611HisAsn: 0.611 ± 0.314
3.053HisPro: 3.053 ± 0.768
1.527HisGln: 1.527 ± 0.682
0.611HisArg: 0.611 ± 0.357
1.221HisSer: 1.221 ± 0.929
2.748HisThr: 2.748 ± 0.819
2.137HisVal: 2.137 ± 0.641
0.305HisTrp: 0.305 ± 0.217
0.611HisTyr: 0.611 ± 0.385
0.0HisXaa: 0.0 ± 0.0
Ile
5.496IleAla: 5.496 ± 0.983
0.611IleCys: 0.611 ± 0.38
3.053IleAsp: 3.053 ± 1.032
1.221IleGlu: 1.221 ± 0.374
1.527IlePhe: 1.527 ± 0.319
3.664IleGly: 3.664 ± 0.423
2.443IleHis: 2.443 ± 0.852
4.58IleIle: 4.58 ± 0.957
5.802IleLys: 5.802 ± 1.841
3.969IleLeu: 3.969 ± 0.896
0.305IleMet: 0.305 ± 0.217
2.137IleAsn: 2.137 ± 0.913
6.412IlePro: 6.412 ± 0.754
5.496IleGln: 5.496 ± 0.951
4.58IleArg: 4.58 ± 1.144
3.664IleSer: 3.664 ± 1.643
4.58IleThr: 4.58 ± 1.329
5.496IleVal: 5.496 ± 0.888
0.916IleTrp: 0.916 ± 0.238
1.527IleTyr: 1.527 ± 0.541
0.0IleXaa: 0.0 ± 0.0
Lys
4.275LysAla: 4.275 ± 1.825
0.305LysCys: 0.305 ± 0.217
3.359LysAsp: 3.359 ± 1.031
1.832LysGlu: 1.832 ± 0.471
0.611LysPhe: 0.611 ± 0.465
4.885LysGly: 4.885 ± 0.806
1.527LysHis: 1.527 ± 0.581
5.496LysIle: 5.496 ± 1.612
4.275LysLys: 4.275 ± 1.706
2.443LysLeu: 2.443 ± 1.155
0.916LysMet: 0.916 ± 0.376
1.832LysAsn: 1.832 ± 0.471
3.359LysPro: 3.359 ± 1.266
2.748LysGln: 2.748 ± 1.759
3.359LysArg: 3.359 ± 1.337
2.443LysSer: 2.443 ± 1.529
3.053LysThr: 3.053 ± 1.679
3.053LysVal: 3.053 ± 1.416
2.137LysTrp: 2.137 ± 1.27
2.748LysTyr: 2.748 ± 1.457
0.0LysXaa: 0.0 ± 0.0
Leu
7.023LeuAla: 7.023 ± 0.811
0.916LeuCys: 0.916 ± 0.568
5.802LeuAsp: 5.802 ± 0.928
3.664LeuGlu: 3.664 ± 0.845
3.359LeuPhe: 3.359 ± 0.987
6.107LeuGly: 6.107 ± 0.725
2.443LeuHis: 2.443 ± 0.736
6.412LeuIle: 6.412 ± 0.828
6.718LeuLys: 6.718 ± 2.773
9.466LeuLeu: 9.466 ± 1.575
1.527LeuMet: 1.527 ± 0.412
4.885LeuAsn: 4.885 ± 1.458
8.55LeuPro: 8.55 ± 0.925
7.634LeuGln: 7.634 ± 0.99
3.969LeuArg: 3.969 ± 1.338
5.191LeuSer: 5.191 ± 1.523
6.718LeuThr: 6.718 ± 0.318
3.053LeuVal: 3.053 ± 0.638
1.527LeuTrp: 1.527 ± 0.412
3.053LeuTyr: 3.053 ± 1.057
0.0LeuXaa: 0.0 ± 0.0
Met
1.221MetAla: 1.221 ± 0.775
0.305MetCys: 0.305 ± 0.336
1.527MetAsp: 1.527 ± 0.575
0.916MetGlu: 0.916 ± 0.318
0.611MetPhe: 0.611 ± 0.348
2.443MetGly: 2.443 ± 0.939
0.0MetHis: 0.0 ± 0.0
0.916MetIle: 0.916 ± 0.652
0.305MetLys: 0.305 ± 0.217
1.527MetLeu: 1.527 ± 0.814
0.305MetMet: 0.305 ± 0.336
1.832MetAsn: 1.832 ± 0.445
0.611MetPro: 0.611 ± 0.348
1.527MetGln: 1.527 ± 0.595
0.305MetArg: 0.305 ± 0.347
0.305MetSer: 0.305 ± 0.217
2.137MetThr: 2.137 ± 0.944
0.611MetVal: 0.611 ± 0.225
0.0MetTrp: 0.0 ± 0.0
0.916MetTyr: 0.916 ± 0.402
0.0MetXaa: 0.0 ± 0.0
Asn
3.053AsnAla: 3.053 ± 0.729
0.611AsnCys: 0.611 ± 0.465
2.748AsnAsp: 2.748 ± 0.382
2.137AsnGlu: 2.137 ± 0.633
1.221AsnPhe: 1.221 ± 0.316
2.137AsnGly: 2.137 ± 0.314
0.916AsnHis: 0.916 ± 0.349
2.748AsnIle: 2.748 ± 0.891
2.137AsnLys: 2.137 ± 1.015
5.496AsnLeu: 5.496 ± 0.508
0.305AsnMet: 0.305 ± 0.423
2.748AsnAsn: 2.748 ± 0.714
3.053AsnPro: 3.053 ± 0.623
5.496AsnGln: 5.496 ± 2.666
2.443AsnArg: 2.443 ± 0.923
1.832AsnSer: 1.832 ± 0.413
3.053AsnThr: 3.053 ± 1.454
2.443AsnVal: 2.443 ± 0.623
0.611AsnTrp: 0.611 ± 0.435
1.527AsnTyr: 1.527 ± 0.541
0.0AsnXaa: 0.0 ± 0.0
Pro
5.802ProAla: 5.802 ± 2.701
0.611ProCys: 0.611 ± 0.225
2.748ProAsp: 2.748 ± 0.488
3.053ProGlu: 3.053 ± 1.587
1.527ProPhe: 1.527 ± 0.581
5.802ProGly: 5.802 ± 2.063
2.443ProHis: 2.443 ± 0.719
3.969ProIle: 3.969 ± 1.028
4.58ProLys: 4.58 ± 1.661
8.244ProLeu: 8.244 ± 0.759
0.916ProMet: 0.916 ± 0.22
4.275ProAsn: 4.275 ± 1.584
5.802ProPro: 5.802 ± 2.901
4.275ProGln: 4.275 ± 1.538
2.748ProArg: 2.748 ± 0.841
4.885ProSer: 4.885 ± 1.294
3.053ProThr: 3.053 ± 1.297
6.412ProVal: 6.412 ± 2.904
0.916ProTrp: 0.916 ± 0.493
3.053ProTyr: 3.053 ± 0.951
0.0ProXaa: 0.0 ± 0.0
Gln
3.359GlnAla: 3.359 ± 0.994
0.611GlnCys: 0.611 ± 0.451
1.832GlnAsp: 1.832 ± 0.528
5.191GlnGlu: 5.191 ± 0.827
1.527GlnPhe: 1.527 ± 0.314
3.053GlnGly: 3.053 ± 1.064
1.527GlnHis: 1.527 ± 0.609
3.359GlnIle: 3.359 ± 0.59
3.359GlnLys: 3.359 ± 1.407
6.718GlnLeu: 6.718 ± 0.832
1.832GlnMet: 1.832 ± 0.62
4.275GlnAsn: 4.275 ± 1.013
6.412GlnPro: 6.412 ± 3.131
4.885GlnGln: 4.885 ± 1.882
3.664GlnArg: 3.664 ± 2.627
3.053GlnSer: 3.053 ± 0.619
4.885GlnThr: 4.885 ± 1.193
2.137GlnVal: 2.137 ± 0.817
1.527GlnTrp: 1.527 ± 0.55
1.221GlnTyr: 1.221 ± 0.45
0.0GlnXaa: 0.0 ± 0.0
Arg
2.748ArgAla: 2.748 ± 0.889
1.221ArgCys: 1.221 ± 0.608
2.137ArgAsp: 2.137 ± 0.929
2.443ArgGlu: 2.443 ± 0.825
0.916ArgPhe: 0.916 ± 0.72
4.58ArgGly: 4.58 ± 2.774
1.527ArgHis: 1.527 ± 0.835
3.664ArgIle: 3.664 ± 0.572
3.053ArgLys: 3.053 ± 0.87
4.885ArgLeu: 4.885 ± 1.686
0.916ArgMet: 0.916 ± 0.402
2.748ArgAsn: 2.748 ± 1.269
3.053ArgPro: 3.053 ± 0.651
2.748ArgGln: 2.748 ± 1.875
5.496ArgArg: 5.496 ± 2.43
1.221ArgSer: 1.221 ± 0.902
3.969ArgThr: 3.969 ± 0.648
3.664ArgVal: 3.664 ± 1.534
1.527ArgTrp: 1.527 ± 0.526
2.137ArgTyr: 2.137 ± 0.633
0.0ArgXaa: 0.0 ± 0.0
Ser
2.137SerAla: 2.137 ± 0.98
0.611SerCys: 0.611 ± 0.38
4.885SerAsp: 4.885 ± 1.574
3.359SerGlu: 3.359 ± 0.683
0.611SerPhe: 0.611 ± 0.225
2.443SerGly: 2.443 ± 0.759
0.611SerHis: 0.611 ± 0.348
3.664SerIle: 3.664 ± 1.159
2.748SerLys: 2.748 ± 1.452
4.275SerLeu: 4.275 ± 1.521
1.527SerMet: 1.527 ± 0.78
2.137SerAsn: 2.137 ± 0.817
4.58SerPro: 4.58 ± 1.061
1.527SerGln: 1.527 ± 1.066
1.832SerArg: 1.832 ± 1.316
5.802SerSer: 5.802 ± 3.067
4.58SerThr: 4.58 ± 1.299
2.443SerVal: 2.443 ± 1.151
1.221SerTrp: 1.221 ± 0.651
3.053SerTyr: 3.053 ± 0.87
0.0SerXaa: 0.0 ± 0.0
Thr
4.885ThrAla: 4.885 ± 1.477
0.916ThrCys: 0.916 ± 0.474
3.053ThrAsp: 3.053 ± 0.571
3.359ThrGlu: 3.359 ± 0.852
2.137ThrPhe: 2.137 ± 0.889
4.58ThrGly: 4.58 ± 1.158
2.137ThrHis: 2.137 ± 0.98
3.053ThrIle: 3.053 ± 0.814
3.664ThrLys: 3.664 ± 0.85
6.718ThrLeu: 6.718 ± 1.689
0.916ThrMet: 0.916 ± 0.659
3.053ThrAsn: 3.053 ± 1.335
6.412ThrPro: 6.412 ± 2.052
2.137ThrGln: 2.137 ± 0.521
2.748ThrArg: 2.748 ± 0.308
4.275ThrSer: 4.275 ± 1.229
2.137ThrThr: 2.137 ± 1.015
3.969ThrVal: 3.969 ± 0.56
2.443ThrTrp: 2.443 ± 0.535
1.832ThrTyr: 1.832 ± 0.767
0.0ThrXaa: 0.0 ± 0.0
Val
1.527ValAla: 1.527 ± 0.513
0.916ValCys: 0.916 ± 0.513
3.359ValAsp: 3.359 ± 0.786
2.443ValGlu: 2.443 ± 0.535
1.527ValPhe: 1.527 ± 0.609
2.137ValGly: 2.137 ± 0.533
1.832ValHis: 1.832 ± 0.504
4.275ValIle: 4.275 ± 0.996
1.527ValLys: 1.527 ± 1.161
6.412ValLeu: 6.412 ± 1.005
1.832ValMet: 1.832 ± 0.706
3.359ValAsn: 3.359 ± 0.855
3.969ValPro: 3.969 ± 1.553
3.053ValGln: 3.053 ± 0.643
3.053ValArg: 3.053 ± 1.501
3.664ValSer: 3.664 ± 0.549
3.053ValThr: 3.053 ± 1.013
2.748ValVal: 2.748 ± 0.783
1.832ValTrp: 1.832 ± 0.767
3.359ValTyr: 3.359 ± 0.807
0.0ValXaa: 0.0 ± 0.0
Trp
0.611TrpAla: 0.611 ± 0.465
0.305TrpCys: 0.305 ± 0.347
0.916TrpAsp: 0.916 ± 0.922
2.137TrpGlu: 2.137 ± 0.558
0.611TrpPhe: 0.611 ± 0.694
0.305TrpGly: 0.305 ± 0.336
0.916TrpHis: 0.916 ± 0.678
0.916TrpIle: 0.916 ± 0.376
1.221TrpLys: 1.221 ± 0.45
2.137TrpLeu: 2.137 ± 0.533
0.611TrpMet: 0.611 ± 0.435
1.221TrpAsn: 1.221 ± 0.411
0.916TrpPro: 0.916 ± 0.376
1.527TrpGln: 1.527 ± 0.513
1.221TrpArg: 1.221 ± 0.437
1.221TrpSer: 1.221 ± 0.264
2.137TrpThr: 2.137 ± 0.786
0.611TrpVal: 0.611 ± 0.465
0.611TrpTrp: 0.611 ± 0.225
0.916TrpTyr: 0.916 ± 0.402
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.527TyrAla: 1.527 ± 0.576
0.611TyrCys: 0.611 ± 0.611
1.832TyrAsp: 1.832 ± 0.674
2.443TyrGlu: 2.443 ± 0.516
0.916TyrPhe: 0.916 ± 0.439
2.443TyrGly: 2.443 ± 0.729
0.916TyrHis: 0.916 ± 0.697
3.359TyrIle: 3.359 ± 1.363
1.527TyrLys: 1.527 ± 0.609
3.359TyrLeu: 3.359 ± 1.162
0.916TyrMet: 0.916 ± 0.376
1.527TyrAsn: 1.527 ± 0.595
2.748TyrPro: 2.748 ± 0.596
1.832TyrGln: 1.832 ± 0.528
3.053TyrArg: 3.053 ± 0.668
1.832TyrSer: 1.832 ± 0.5
2.748TyrThr: 2.748 ± 0.778
2.137TyrVal: 2.137 ± 1.015
0.611TyrTrp: 0.611 ± 0.225
1.832TyrTyr: 1.832 ± 0.45
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski