Amino acid dipepetide frequency for Pandoravirus quercus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.307AlaAla: 22.307 ± 0.382
3.546AlaCys: 3.546 ± 0.112
8.343AlaAsp: 8.343 ± 0.153
4.812AlaGlu: 4.812 ± 0.118
3.092AlaPhe: 3.092 ± 0.087
8.932AlaGly: 8.932 ± 0.192
4.009AlaHis: 4.009 ± 0.116
5.234AlaIle: 5.234 ± 0.117
2.544AlaLys: 2.544 ± 0.089
13.17AlaLeu: 13.17 ± 0.225
3.156AlaMet: 3.156 ± 0.096
2.902AlaAsn: 2.902 ± 0.113
8.476AlaPro: 8.476 ± 0.204
3.76AlaGln: 3.76 ± 0.117
12.069AlaArg: 12.069 ± 0.194
8.779AlaSer: 8.779 ± 0.146
8.456AlaThr: 8.456 ± 0.142
10.321AlaVal: 10.321 ± 0.154
2.529AlaTrp: 2.529 ± 0.081
3.019AlaTyr: 3.019 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
4.084CysAla: 4.084 ± 0.103
0.548CysCys: 0.548 ± 0.039
1.788CysAsp: 1.788 ± 0.068
0.958CysGlu: 0.958 ± 0.052
0.455CysPhe: 0.455 ± 0.029
2.004CysGly: 2.004 ± 0.086
0.553CysHis: 0.553 ± 0.036
0.751CysIle: 0.751 ± 0.041
0.495CysLys: 0.495 ± 0.033
2.176CysLeu: 2.176 ± 0.101
0.591CysMet: 0.591 ± 0.036
0.499CysAsn: 0.499 ± 0.036
2.098CysPro: 2.098 ± 0.117
0.516CysGln: 0.516 ± 0.032
2.441CysArg: 2.441 ± 0.089
1.201CysSer: 1.201 ± 0.062
1.483CysThr: 1.483 ± 0.067
1.946CysVal: 1.946 ± 0.065
0.346CysTrp: 0.346 ± 0.028
0.429CysTyr: 0.429 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
10.594AspAla: 10.594 ± 0.161
1.425AspCys: 1.425 ± 0.073
9.291AspAsp: 9.291 ± 0.309
3.581AspGlu: 3.581 ± 0.119
1.366AspPhe: 1.366 ± 0.063
7.135AspGly: 7.135 ± 0.167
2.13AspHis: 2.13 ± 0.083
2.435AspIle: 2.435 ± 0.083
1.423AspLys: 1.423 ± 0.062
5.192AspLeu: 5.192 ± 0.1
1.637AspMet: 1.637 ± 0.067
2.535AspAsn: 2.535 ± 0.098
4.797AspPro: 4.797 ± 0.123
1.805AspGln: 1.805 ± 0.057
5.36AspArg: 5.36 ± 0.121
3.593AspSer: 3.593 ± 0.09
3.647AspThr: 3.647 ± 0.098
5.303AspVal: 5.303 ± 0.135
1.075AspTrp: 1.075 ± 0.047
1.289AspTyr: 1.289 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.894GluAla: 5.894 ± 0.149
0.962GluCys: 0.962 ± 0.048
2.211GluAsp: 2.211 ± 0.098
1.718GluGlu: 1.718 ± 0.092
0.772GluPhe: 0.772 ± 0.04
2.697GluGly: 2.697 ± 0.094
1.216GluHis: 1.216 ± 0.05
1.741GluIle: 1.741 ± 0.068
0.926GluLys: 0.926 ± 0.055
1.415GluLeu: 1.415 ± 0.06
0.847GluMet: 0.847 ± 0.044
0.73GluAsn: 0.73 ± 0.04
2.608GluPro: 2.608 ± 0.082
1.11GluGln: 1.11 ± 0.059
4.295GluArg: 4.295 ± 0.116
2.42GluSer: 2.42 ± 0.076
2.492GluThr: 2.492 ± 0.084
2.315GluVal: 2.315 ± 0.074
1.112GluTrp: 1.112 ± 0.056
0.828GluTyr: 0.828 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.218PheAla: 3.218 ± 0.091
0.736PheCys: 0.736 ± 0.04
1.982PheAsp: 1.982 ± 0.065
0.945PheGlu: 0.945 ± 0.048
0.886PhePhe: 0.886 ± 0.053
2.215PheGly: 2.215 ± 0.082
0.427PheHis: 0.427 ± 0.033
0.629PheIle: 0.629 ± 0.037
0.384PheLys: 0.384 ± 0.031
1.812PheLeu: 1.812 ± 0.067
0.536PheMet: 0.536 ± 0.039
0.461PheAsn: 0.461 ± 0.037
0.779PhePro: 0.779 ± 0.051
0.376PheGln: 0.376 ± 0.03
1.246PheArg: 1.246 ± 0.055
1.197PheSer: 1.197 ± 0.045
0.975PheThr: 0.975 ± 0.055
2.217PheVal: 2.217 ± 0.076
0.48PheTrp: 0.48 ± 0.029
0.702PheTyr: 0.702 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
10.025GlyAla: 10.025 ± 0.186
2.375GlyCys: 2.375 ± 0.123
6.12GlyAsp: 6.12 ± 0.132
2.435GlyGlu: 2.435 ± 0.095
1.588GlyPhe: 1.588 ± 0.061
7.673GlyGly: 7.673 ± 0.266
3.63GlyHis: 3.63 ± 0.158
2.375GlyIle: 2.375 ± 0.074
1.538GlyLys: 1.538 ± 0.072
5.689GlyLeu: 5.689 ± 0.131
1.321GlyMet: 1.321 ± 0.062
1.94GlyAsn: 1.94 ± 0.077
5.157GlyPro: 5.157 ± 0.189
2.505GlyGln: 2.505 ± 0.096
6.975GlyArg: 6.975 ± 0.116
4.814GlySer: 4.814 ± 0.141
4.95GlyThr: 4.95 ± 0.157
5.313GlyVal: 5.313 ± 0.117
1.317GlyTrp: 1.317 ± 0.054
1.632GlyTyr: 1.632 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
3.941HisAla: 3.941 ± 0.098
0.612HisCys: 0.612 ± 0.034
2.112HisAsp: 2.112 ± 0.072
1.302HisGlu: 1.302 ± 0.062
0.647HisPhe: 0.647 ± 0.033
3.344HisGly: 3.344 ± 0.134
1.103HisHis: 1.103 ± 0.059
0.99HisIle: 0.99 ± 0.046
0.634HisLys: 0.634 ± 0.044
2.697HisLeu: 2.697 ± 0.115
0.783HisMet: 0.783 ± 0.043
0.809HisAsn: 0.809 ± 0.037
1.647HisPro: 1.647 ± 0.067
0.792HisGln: 0.792 ± 0.039
2.605HisArg: 2.605 ± 0.081
1.02HisSer: 1.02 ± 0.048
1.59HisThr: 1.59 ± 0.063
2.347HisVal: 2.347 ± 0.075
0.467HisTrp: 0.467 ± 0.031
0.657HisTyr: 0.657 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
4.598IleAla: 4.598 ± 0.105
0.51IleCys: 0.51 ± 0.035
3.544IleAsp: 3.544 ± 0.082
2.245IleGlu: 2.245 ± 0.071
0.574IlePhe: 0.574 ± 0.034
2.364IleGly: 2.364 ± 0.065
0.785IleHis: 0.785 ± 0.044
1.131IleIle: 1.131 ± 0.053
0.802IleLys: 0.802 ± 0.043
2.625IleLeu: 2.625 ± 0.078
0.636IleMet: 0.636 ± 0.036
0.96IleAsn: 0.96 ± 0.046
1.261IlePro: 1.261 ± 0.052
0.751IleGln: 0.751 ± 0.042
1.79IleArg: 1.79 ± 0.066
1.415IleSer: 1.415 ± 0.058
1.652IleThr: 1.652 ± 0.06
3.352IleVal: 3.352 ± 0.076
0.363IleTrp: 0.363 ± 0.028
0.871IleTyr: 0.871 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
2.524LysAla: 2.524 ± 0.086
0.482LysCys: 0.482 ± 0.037
1.378LysAsp: 1.378 ± 0.065
0.954LysGlu: 0.954 ± 0.051
0.28LysPhe: 0.28 ± 0.026
1.75LysGly: 1.75 ± 0.098
0.687LysHis: 0.687 ± 0.045
0.561LysIle: 0.561 ± 0.038
1.184LysLys: 1.184 ± 0.109
0.604LysLeu: 0.604 ± 0.039
0.393LysMet: 0.393 ± 0.035
0.519LysAsn: 0.519 ± 0.034
1.09LysPro: 1.09 ± 0.054
0.585LysGln: 0.585 ± 0.036
2.518LysArg: 2.518 ± 0.099
1.199LysSer: 1.199 ± 0.059
1.295LysThr: 1.295 ± 0.052
1.097LysVal: 1.097 ± 0.043
0.546LysTrp: 0.546 ± 0.046
0.452LysTyr: 0.452 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
12.6LeuAla: 12.6 ± 0.184
2.859LeuCys: 2.859 ± 0.098
6.781LeuAsp: 6.781 ± 0.16
2.262LeuGlu: 2.262 ± 0.087
2.435LeuPhe: 2.435 ± 0.068
5.825LeuGly: 5.825 ± 0.12
2.014LeuHis: 2.014 ± 0.079
2.144LeuIle: 2.144 ± 0.066
1.306LeuLys: 1.306 ± 0.067
7.492LeuLeu: 7.492 ± 0.146
1.402LeuMet: 1.402 ± 0.057
1.308LeuAsn: 1.308 ± 0.058
5.539LeuPro: 5.539 ± 0.127
1.893LeuGln: 1.893 ± 0.084
5.326LeuArg: 5.326 ± 0.122
4.665LeuSer: 4.665 ± 0.102
3.692LeuThr: 3.692 ± 0.085
7.503LeuVal: 7.503 ± 0.146
1.995LeuTrp: 1.995 ± 0.063
2.181LeuTyr: 2.181 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
3.448MetAla: 3.448 ± 0.092
0.559MetCys: 0.559 ± 0.035
1.543MetAsp: 1.543 ± 0.074
0.886MetGlu: 0.886 ± 0.046
0.32MetPhe: 0.32 ± 0.025
1.549MetGly: 1.549 ± 0.057
0.565MetHis: 0.565 ± 0.036
0.615MetIle: 0.615 ± 0.04
0.28MetLys: 0.28 ± 0.024
1.579MetLeu: 1.579 ± 0.063
0.429MetMet: 0.429 ± 0.033
0.371MetAsn: 0.371 ± 0.027
1.53MetPro: 1.53 ± 0.06
0.649MetGln: 0.649 ± 0.037
2.01MetArg: 2.01 ± 0.066
1.291MetSer: 1.291 ± 0.055
1.336MetThr: 1.336 ± 0.051
1.157MetVal: 1.157 ± 0.06
0.412MetTrp: 0.412 ± 0.028
0.258MetTyr: 0.258 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.529AsnAla: 2.529 ± 0.084
0.326AsnCys: 0.326 ± 0.026
2.106AsnAsp: 2.106 ± 0.077
0.798AsnGlu: 0.798 ± 0.038
0.373AsnPhe: 0.373 ± 0.034
3.246AsnGly: 3.246 ± 0.121
0.544AsnHis: 0.544 ± 0.033
0.651AsnIle: 0.651 ± 0.041
0.627AsnLys: 0.627 ± 0.045
1.428AsnLeu: 1.428 ± 0.056
0.399AsnMet: 0.399 ± 0.029
1.41AsnAsn: 1.41 ± 0.09
1.267AsnPro: 1.267 ± 0.066
0.583AsnGln: 0.583 ± 0.034
1.615AsnArg: 1.615 ± 0.054
1.095AsnSer: 1.095 ± 0.047
1.069AsnThr: 1.069 ± 0.054
1.658AsnVal: 1.658 ± 0.058
0.25AsnTrp: 0.25 ± 0.025
0.435AsnTyr: 0.435 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
7.526ProAla: 7.526 ± 0.194
1.724ProCys: 1.724 ± 0.067
4.274ProAsp: 4.274 ± 0.12
2.39ProGlu: 2.39 ± 0.082
1.652ProPhe: 1.652 ± 0.07
3.866ProGly: 3.866 ± 0.132
2.008ProHis: 2.008 ± 0.077
1.982ProIle: 1.982 ± 0.067
1.253ProLys: 1.253 ± 0.071
5.759ProLeu: 5.759 ± 0.121
1.479ProMet: 1.479 ± 0.054
1.349ProAsn: 1.349 ± 0.054
6.329ProPro: 6.329 ± 0.195
1.897ProGln: 1.897 ± 0.089
4.974ProArg: 4.974 ± 0.117
5.083ProSer: 5.083 ± 0.133
5.198ProThr: 5.198 ± 0.132
4.477ProVal: 4.477 ± 0.121
1.816ProTrp: 1.816 ± 0.106
1.417ProTyr: 1.417 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
3.09GlnAla: 3.09 ± 0.103
0.681GlnCys: 0.681 ± 0.044
1.46GlnAsp: 1.46 ± 0.051
1.223GlnGlu: 1.223 ± 0.058
0.523GlnPhe: 0.523 ± 0.038
2.087GlnGly: 2.087 ± 0.084
0.881GlnHis: 0.881 ± 0.049
0.76GlnIle: 0.76 ± 0.038
0.681GlnLys: 0.681 ± 0.035
1.449GlnLeu: 1.449 ± 0.056
0.516GlnMet: 0.516 ± 0.035
0.44GlnAsn: 0.44 ± 0.033
2.093GlnPro: 2.093 ± 0.111
1.963GlnGln: 1.963 ± 0.145
3.115GlnArg: 3.115 ± 0.092
1.551GlnSer: 1.551 ± 0.054
1.628GlnThr: 1.628 ± 0.059
1.502GlnVal: 1.502 ± 0.058
1.21GlnTrp: 1.21 ± 0.076
0.553GlnTyr: 0.553 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
11.224ArgAla: 11.224 ± 0.174
2.061ArgCys: 2.061 ± 0.08
4.978ArgAsp: 4.978 ± 0.105
2.699ArgGlu: 2.699 ± 0.099
2.108ArgPhe: 2.108 ± 0.062
6.596ArgGly: 6.596 ± 0.133
3.269ArgHis: 3.269 ± 0.096
2.556ArgIle: 2.556 ± 0.079
1.647ArgLys: 1.647 ± 0.081
7.688ArgLeu: 7.688 ± 0.154
1.739ArgMet: 1.739 ± 0.055
1.391ArgAsn: 1.391 ± 0.048
5.864ArgPro: 5.864 ± 0.134
2.849ArgGln: 2.849 ± 0.087
9.641ArgArg: 9.641 ± 0.179
4.366ArgSer: 4.366 ± 0.107
4.411ArgThr: 4.411 ± 0.097
5.473ArgVal: 5.473 ± 0.105
2.255ArgTrp: 2.255 ± 0.08
1.903ArgTyr: 1.903 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
7.428SerAla: 7.428 ± 0.148
1.272SerCys: 1.272 ± 0.061
4.197SerAsp: 4.197 ± 0.109
1.784SerGlu: 1.784 ± 0.066
1.21SerPhe: 1.21 ± 0.051
4.803SerGly: 4.803 ± 0.117
1.502SerHis: 1.502 ± 0.064
1.933SerIle: 1.933 ± 0.071
1.073SerLys: 1.073 ± 0.053
4.94SerLeu: 4.94 ± 0.104
1.323SerMet: 1.323 ± 0.05
1.282SerAsn: 1.282 ± 0.055
4.443SerPro: 4.443 ± 0.129
1.299SerGln: 1.299 ± 0.058
4.302SerArg: 4.302 ± 0.098
5.083SerSer: 5.083 ± 0.304
4.379SerThr: 4.379 ± 0.114
4.344SerVal: 4.344 ± 0.101
0.967SerTrp: 0.967 ± 0.05
0.851SerTyr: 0.851 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
7.87ThrAla: 7.87 ± 0.154
1.575ThrCys: 1.575 ± 0.074
3.741ThrAsp: 3.741 ± 0.099
2.063ThrGlu: 2.063 ± 0.077
1.27ThrPhe: 1.27 ± 0.058
4.178ThrGly: 4.178 ± 0.108
1.615ThrHis: 1.615 ± 0.059
2.076ThrIle: 2.076 ± 0.064
1.349ThrLys: 1.349 ± 0.069
5.202ThrLeu: 5.202 ± 0.125
1.368ThrMet: 1.368 ± 0.057
1.37ThrAsn: 1.37 ± 0.063
4.398ThrPro: 4.398 ± 0.128
1.323ThrGln: 1.323 ± 0.055
4.577ThrArg: 4.577 ± 0.113
3.502ThrSer: 3.502 ± 0.108
5.638ThrThr: 5.638 ± 0.167
4.556ThrVal: 4.556 ± 0.116
1.112ThrTrp: 1.112 ± 0.058
1.306ThrTyr: 1.306 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
10.865ValAla: 10.865 ± 0.162
2.151ValCys: 2.151 ± 0.072
6.34ValAsp: 6.34 ± 0.11
3.269ValGlu: 3.269 ± 0.089
1.863ValPhe: 1.863 ± 0.066
5.759ValGly: 5.759 ± 0.127
1.94ValHis: 1.94 ± 0.057
2.422ValIle: 2.422 ± 0.064
1.139ValLys: 1.139 ± 0.053
6.436ValLeu: 6.436 ± 0.118
1.193ValMet: 1.193 ± 0.058
1.267ValAsn: 1.267 ± 0.062
4.807ValPro: 4.807 ± 0.117
1.784ValGln: 1.784 ± 0.065
5.97ValArg: 5.97 ± 0.111
3.775ValSer: 3.775 ± 0.099
3.527ValThr: 3.527 ± 0.109
6.293ValVal: 6.293 ± 0.137
1.208ValTrp: 1.208 ± 0.057
1.869ValTyr: 1.869 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
2.401TrpAla: 2.401 ± 0.087
0.525TrpCys: 0.525 ± 0.034
1.547TrpAsp: 1.547 ± 0.087
0.706TrpGlu: 0.706 ± 0.039
0.382TrpPhe: 0.382 ± 0.03
1.101TrpGly: 1.101 ± 0.06
0.738TrpHis: 0.738 ± 0.041
0.659TrpIle: 0.659 ± 0.036
0.346TrpLys: 0.346 ± 0.029
2.328TrpLeu: 2.328 ± 0.116
0.525TrpMet: 0.525 ± 0.037
0.363TrpAsn: 0.363 ± 0.034
1.302TrpPro: 1.302 ± 0.055
0.519TrpGln: 0.519 ± 0.031
2.08TrpArg: 2.08 ± 0.075
1.357TrpSer: 1.357 ± 0.063
1.536TrpThr: 1.536 ± 0.062
1.099TrpVal: 1.099 ± 0.053
0.41TrpTrp: 0.41 ± 0.031
0.363TrpTyr: 0.363 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.29TyrAla: 3.29 ± 0.094
0.431TyrCys: 0.431 ± 0.033
1.876TyrAsp: 1.876 ± 0.066
1.28TyrGlu: 1.28 ± 0.063
0.41TyrPhe: 0.41 ± 0.03
2.247TyrGly: 2.247 ± 0.091
0.482TyrHis: 0.482 ± 0.038
0.583TyrIle: 0.583 ± 0.037
0.467TyrLys: 0.467 ± 0.028
1.543TyrLeu: 1.543 ± 0.067
0.514TyrMet: 0.514 ± 0.034
0.504TyrAsn: 0.504 ± 0.032
0.967TyrPro: 0.967 ± 0.05
0.448TyrGln: 0.448 ± 0.037
1.807TyrArg: 1.807 ± 0.062
1.011TyrSer: 1.011 ± 0.045
1.133TyrThr: 1.133 ± 0.056
1.605TyrVal: 1.605 ± 0.065
0.418TyrTrp: 0.418 ± 0.027
0.587TyrTyr: 0.587 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1179 proteins (468644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski