Amino acid dipepetide frequency for Mariniflexile sp. TRM1-10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.883AlaAla: 3.883 ± 0.072	0.575AlaCys: 0.575 ± 0.025	3.192AlaAsp: 3.192 ± 0.059	3.641AlaGlu: 3.641 ± 0.06	3.395AlaPhe: 3.395 ± 0.057	3.901AlaGly: 3.901 ± 0.064	1.064AlaHis: 1.064 ± 0.03	5.343AlaIle: 5.343 ± 0.078	4.43AlaLys: 4.43 ± 0.066	5.96AlaLeu: 5.96 ± 0.078	1.407AlaMet: 1.407 ± 0.04	3.653AlaAsn: 3.653 ± 0.062	1.893AlaPro: 1.893 ± 0.055	2.218AlaGln: 2.218 ± 0.043	1.824AlaArg: 1.824 ± 0.045	4.428AlaSer: 4.428 ± 0.066	3.778AlaThr: 3.778 ± 0.071	3.814AlaVal: 3.814 ± 0.058	0.654AlaTrp: 0.654 ± 0.02	2.616AlaTyr: 2.616 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.429CysAla: 0.429 ± 0.02	0.084CysCys: 0.084 ± 0.008	0.47CysAsp: 0.47 ± 0.025	0.472CysGlu: 0.472 ± 0.021	0.447CysPhe: 0.447 ± 0.018	0.603CysGly: 0.603 ± 0.025	0.193CysHis: 0.193 ± 0.012	0.62CysIle: 0.62 ± 0.024	0.535CysLys: 0.535 ± 0.021	0.643CysLeu: 0.643 ± 0.021	0.161CysMet: 0.161 ± 0.01	0.445CysAsn: 0.445 ± 0.022	0.328CysPro: 0.328 ± 0.021	0.199CysGln: 0.199 ± 0.012	0.193CysArg: 0.193 ± 0.011	0.566CysSer: 0.566 ± 0.025	0.447CysThr: 0.447 ± 0.033	0.43CysVal: 0.43 ± 0.018	0.071CysTrp: 0.071 ± 0.008	0.334CysTyr: 0.334 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.003AspAla: 4.003 ± 0.059	0.45AspCys: 0.45 ± 0.021	3.066AspAsp: 3.066 ± 0.059	3.524AspGlu: 3.524 ± 0.054	3.719AspPhe: 3.719 ± 0.054	3.875AspGly: 3.875 ± 0.07	0.849AspHis: 0.849 ± 0.025	4.715AspIle: 4.715 ± 0.059	4.139AspLys: 4.139 ± 0.055	5.156AspLeu: 5.156 ± 0.059	1.201AspMet: 1.201 ± 0.032	3.215AspAsn: 3.215 ± 0.052	1.624AspPro: 1.624 ± 0.04	1.273AspGln: 1.273 ± 0.035	1.71AspArg: 1.71 ± 0.042	3.182AspSer: 3.182 ± 0.047	2.843AspThr: 2.843 ± 0.046	3.725AspVal: 3.725 ± 0.052	0.821AspTrp: 0.821 ± 0.027	3.018AspTyr: 3.018 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.552GluAla: 4.552 ± 0.077	0.348GluCys: 0.348 ± 0.017	3.575GluAsp: 3.575 ± 0.059	4.114GluGlu: 4.114 ± 0.072	2.953GluPhe: 2.953 ± 0.047	3.581GluGly: 3.581 ± 0.059	1.223GluHis: 1.223 ± 0.03	5.05GluIle: 5.05 ± 0.063	5.475GluLys: 5.475 ± 0.077	5.966GluLeu: 5.966 ± 0.07	1.304GluMet: 1.304 ± 0.035	4.628GluAsn: 4.628 ± 0.065	1.629GluPro: 1.629 ± 0.039	2.111GluGln: 2.111 ± 0.045	2.339GluArg: 2.339 ± 0.05	3.424GluSer: 3.424 ± 0.045	4.057GluThr: 4.057 ± 0.053	4.077GluVal: 4.077 ± 0.059	0.627GluTrp: 0.627 ± 0.022	2.323GluTyr: 2.323 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.701PheAla: 2.701 ± 0.047	0.452PheCys: 0.452 ± 0.016	3.211PheAsp: 3.211 ± 0.046	3.419PheGlu: 3.419 ± 0.053	2.624PhePhe: 2.624 ± 0.055	3.598PheGly: 3.598 ± 0.059	0.869PheHis: 0.869 ± 0.027	4.003PheIle: 4.003 ± 0.062	4.081PheLys: 4.081 ± 0.06	4.563PheLeu: 4.563 ± 0.068	1.071PheMet: 1.071 ± 0.031	3.689PheAsn: 3.689 ± 0.064	1.724PhePro: 1.724 ± 0.035	1.526PheGln: 1.526 ± 0.034	1.538PheArg: 1.538 ± 0.035	3.974PheSer: 3.974 ± 0.069	3.167PheThr: 3.167 ± 0.063	2.968PheVal: 2.968 ± 0.051	0.611PheTrp: 0.611 ± 0.024	2.209PheTyr: 2.209 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.035GlyAla: 4.035 ± 0.06	0.61GlyCys: 0.61 ± 0.038	3.412GlyAsp: 3.412 ± 0.053	3.418GlyGlu: 3.418 ± 0.046	3.663GlyPhe: 3.663 ± 0.061	4.454GlyGly: 4.454 ± 0.077	1.218GlyHis: 1.218 ± 0.03	5.438GlyIle: 5.438 ± 0.064	4.728GlyLys: 4.728 ± 0.065	5.63GlyLeu: 5.63 ± 0.076	1.578GlyMet: 1.578 ± 0.037	3.898GlyAsn: 3.898 ± 0.071	1.308GlyPro: 1.308 ± 0.028	1.773GlyGln: 1.773 ± 0.037	2.002GlyArg: 2.002 ± 0.042	4.15GlySer: 4.15 ± 0.065	4.346GlyThr: 4.346 ± 0.077	4.213GlyVal: 4.213 ± 0.07	0.846GlyTrp: 0.846 ± 0.025	2.905GlyTyr: 2.905 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.05HisAla: 1.05 ± 0.031	0.182HisCys: 0.182 ± 0.01	0.908HisAsp: 0.908 ± 0.024	0.986HisGlu: 0.986 ± 0.031	1.137HisPhe: 1.137 ± 0.027	1.104HisGly: 1.104 ± 0.028	0.489HisHis: 0.489 ± 0.021	1.62HisIle: 1.62 ± 0.034	1.249HisLys: 1.249 ± 0.031	1.816HisLeu: 1.816 ± 0.036	0.356HisMet: 0.356 ± 0.017	1.008HisAsn: 1.008 ± 0.026	0.84HisPro: 0.84 ± 0.025	0.645HisGln: 0.645 ± 0.022	0.615HisArg: 0.615 ± 0.021	1.046HisSer: 1.046 ± 0.032	1.003HisThr: 1.003 ± 0.028	1.09HisVal: 1.09 ± 0.028	0.271HisTrp: 0.271 ± 0.016	0.898HisTyr: 0.898 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.299IleAla: 5.299 ± 0.073	0.627IleCys: 0.627 ± 0.026	5.025IleAsp: 5.025 ± 0.059	5.677IleGlu: 5.677 ± 0.07	3.549IlePhe: 3.549 ± 0.055	5.034IleGly: 5.034 ± 0.068	1.41IleHis: 1.41 ± 0.037	6.289IleIle: 6.289 ± 0.083	6.528IleLys: 6.528 ± 0.084	7.026IleLeu: 7.026 ± 0.087	1.436IleMet: 1.436 ± 0.037	5.224IleAsn: 5.224 ± 0.07	3.235IlePro: 3.235 ± 0.054	2.54IleGln: 2.54 ± 0.043	2.426IleArg: 2.426 ± 0.038	5.926IleSer: 5.926 ± 0.071	5.004IleThr: 5.004 ± 0.082	4.787IleVal: 4.787 ± 0.063	0.779IleTrp: 0.779 ± 0.024	3.04IleTyr: 3.04 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.925LysAla: 4.925 ± 0.071	0.34LysCys: 0.34 ± 0.015	4.601LysAsp: 4.601 ± 0.068	5.94LysGlu: 5.94 ± 0.081	2.904LysPhe: 2.904 ± 0.05	4.535LysGly: 4.535 ± 0.055	1.577LysHis: 1.577 ± 0.036	6.169LysIle: 6.169 ± 0.076	6.429LysLys: 6.429 ± 0.08	6.785LysLeu: 6.785 ± 0.084	1.936LysMet: 1.936 ± 0.041	5.578LysAsn: 5.578 ± 0.07	2.531LysPro: 2.531 ± 0.046	2.953LysGln: 2.953 ± 0.049	2.814LysArg: 2.814 ± 0.046	4.717LysSer: 4.717 ± 0.073	5.136LysThr: 5.136 ± 0.061	4.573LysVal: 4.573 ± 0.062	0.809LysTrp: 0.809 ± 0.024	3.108LysTyr: 3.108 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.393LeuAla: 5.393 ± 0.068	0.651LeuCys: 0.651 ± 0.026	4.944LeuAsp: 4.944 ± 0.061	5.936LeuGlu: 5.936 ± 0.07	4.81LeuPhe: 4.81 ± 0.076	5.56LeuGly: 5.56 ± 0.08	1.526LeuHis: 1.526 ± 0.038	6.977LeuIle: 6.977 ± 0.096	8.127LeuLys: 8.127 ± 0.101	8.327LeuLeu: 8.327 ± 0.082	1.925LeuMet: 1.925 ± 0.04	6.1LeuAsn: 6.1 ± 0.09	3.438LeuPro: 3.438 ± 0.048	3.081LeuGln: 3.081 ± 0.053	3.007LeuArg: 3.007 ± 0.053	6.589LeuSer: 6.589 ± 0.075	5.227LeuThr: 5.227 ± 0.066	5.251LeuVal: 5.251 ± 0.062	0.869LeuTrp: 0.869 ± 0.027	3.332LeuTyr: 3.332 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.587MetAla: 1.587 ± 0.041	0.145MetCys: 0.145 ± 0.01	1.093MetAsp: 1.093 ± 0.026	1.27MetGlu: 1.27 ± 0.033	0.902MetPhe: 0.902 ± 0.026	1.302MetGly: 1.302 ± 0.038	0.4MetHis: 0.4 ± 0.021	1.42MetIle: 1.42 ± 0.033	2.027MetLys: 2.027 ± 0.037	1.961MetLeu: 1.961 ± 0.041	0.532MetMet: 0.532 ± 0.022	1.312MetAsn: 1.312 ± 0.029	0.856MetPro: 0.856 ± 0.027	0.767MetGln: 0.767 ± 0.021	0.774MetArg: 0.774 ± 0.025	1.325MetSer: 1.325 ± 0.029	1.159MetThr: 1.159 ± 0.031	1.387MetVal: 1.387 ± 0.032	0.176MetTrp: 0.176 ± 0.012	0.774MetTyr: 0.774 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.966AsnAla: 3.966 ± 0.055	0.512AsnCys: 0.512 ± 0.023	3.692AsnAsp: 3.692 ± 0.058	3.912AsnGlu: 3.912 ± 0.054	3.129AsnPhe: 3.129 ± 0.055	4.363AsnGly: 4.363 ± 0.076	1.266AsnHis: 1.266 ± 0.032	5.306AsnIle: 5.306 ± 0.076	4.91AsnLys: 4.91 ± 0.058	5.662AsnLeu: 5.662 ± 0.081	1.354AsnMet: 1.354 ± 0.031	4.556AsnAsn: 4.556 ± 0.071	2.855AsnPro: 2.855 ± 0.045	2.314AsnGln: 2.314 ± 0.045	2.179AsnArg: 2.179 ± 0.043	4.047AsnSer: 4.047 ± 0.066	4.119AsnThr: 4.119 ± 0.07	3.626AsnVal: 3.626 ± 0.065	0.875AsnTrp: 0.875 ± 0.026	3.192AsnTyr: 3.192 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.751ProAla: 1.751 ± 0.04	0.223ProCys: 0.223 ± 0.014	1.985ProAsp: 1.985 ± 0.039	2.746ProGlu: 2.746 ± 0.053	1.88ProPhe: 1.88 ± 0.041	1.826ProGly: 1.826 ± 0.037	0.605ProHis: 0.605 ± 0.022	2.918ProIle: 2.918 ± 0.049	2.54ProLys: 2.54 ± 0.048	2.924ProLeu: 2.924 ± 0.045	0.722ProMet: 0.722 ± 0.023	2.517ProAsn: 2.517 ± 0.047	0.795ProPro: 0.795 ± 0.026	1.113ProGln: 1.113 ± 0.026	0.879ProArg: 0.879 ± 0.027	2.245ProSer: 2.245 ± 0.044	2.128ProThr: 2.128 ± 0.057	2.206ProVal: 2.206 ± 0.043	0.36ProTrp: 0.36 ± 0.015	1.477ProTyr: 1.477 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.879GlnAla: 1.879 ± 0.038	0.189GlnCys: 0.189 ± 0.01	1.716GlnAsp: 1.716 ± 0.033	2.09GlnGlu: 2.09 ± 0.037	1.665GlnPhe: 1.665 ± 0.033	1.837GlnGly: 1.837 ± 0.034	0.604GlnHis: 0.604 ± 0.023	2.69GlnIle: 2.69 ± 0.045	2.574GlnLys: 2.574 ± 0.052	3.294GlnLeu: 3.294 ± 0.05	0.739GlnMet: 0.739 ± 0.027	2.207GlnAsn: 2.207 ± 0.052	1.113GlnPro: 1.113 ± 0.03	1.352GlnGln: 1.352 ± 0.034	1.137GlnArg: 1.137 ± 0.032	1.985GlnSer: 1.985 ± 0.035	1.956GlnThr: 1.956 ± 0.043	1.897GlnVal: 1.897 ± 0.038	0.359GlnTrp: 0.359 ± 0.016	1.34GlnTyr: 1.34 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	1.936ArgAla: 1.936 ± 0.04	0.209ArgCys: 0.209 ± 0.012	1.721ArgAsp: 1.721 ± 0.037	1.906ArgGlu: 1.906 ± 0.04	1.863ArgPhe: 1.863 ± 0.035	1.868ArgGly: 1.868 ± 0.04	0.604ArgHis: 0.604 ± 0.02	2.772ArgIle: 2.772 ± 0.045	2.47ArgLys: 2.47 ± 0.046	3.121ArgLeu: 3.121 ± 0.051	0.817ArgMet: 0.817 ± 0.025	2.043ArgAsn: 2.043 ± 0.038	1.082ArgPro: 1.082 ± 0.027	1.046ArgGln: 1.046 ± 0.029	1.184ArgArg: 1.184 ± 0.03	1.743ArgSer: 1.743 ± 0.033	1.832ArgThr: 1.832 ± 0.043	1.943ArgVal: 1.943 ± 0.038	0.408ArgTrp: 0.408 ± 0.018	1.484ArgTyr: 1.484 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.57SerAla: 3.57 ± 0.056	0.686SerCys: 0.686 ± 0.025	3.519SerAsp: 3.519 ± 0.052	4.064SerGlu: 4.064 ± 0.058	3.689SerPhe: 3.689 ± 0.056	4.72SerGly: 4.72 ± 0.069	1.2SerHis: 1.2 ± 0.031	5.593SerIle: 5.593 ± 0.072	5.294SerLys: 5.294 ± 0.068	5.937SerLeu: 5.937 ± 0.085	1.297SerMet: 1.297 ± 0.028	4.392SerAsn: 4.392 ± 0.066	2.124SerPro: 2.124 ± 0.041	2.14SerGln: 2.14 ± 0.038	2.03SerArg: 2.03 ± 0.038	4.241SerSer: 4.241 ± 0.065	3.752SerThr: 3.752 ± 0.064	3.906SerVal: 3.906 ± 0.054	0.768SerTrp: 0.768 ± 0.025	2.878SerTyr: 2.878 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.856ThrAla: 3.856 ± 0.112	0.392ThrCys: 0.392 ± 0.019	3.385ThrAsp: 3.385 ± 0.05	3.391ThrGlu: 3.391 ± 0.056	3.184ThrPhe: 3.184 ± 0.059	4.199ThrGly: 4.199 ± 0.071	1.076ThrHis: 1.076 ± 0.027	5.331ThrIle: 5.331 ± 0.07	4.125ThrLys: 4.125 ± 0.049	5.584ThrLeu: 5.584 ± 0.065	1.006ThrMet: 1.006 ± 0.025	3.884ThrAsn: 3.884 ± 0.077	2.54ThrPro: 2.54 ± 0.049	1.895ThrGln: 1.895 ± 0.04	1.579ThrArg: 1.579 ± 0.031	4.124ThrSer: 4.124 ± 0.071	3.81ThrThr: 3.81 ± 0.071	3.919ThrVal: 3.919 ± 0.076	0.67ThrTrp: 0.67 ± 0.029	2.785ThrTyr: 2.785 ± 0.069	0.0ThrXaa: 0.0 ± 0.0
Val	3.691ValAla: 3.691 ± 0.058	0.535ValCys: 0.535 ± 0.019	3.507ValAsp: 3.507 ± 0.056	3.811ValGlu: 3.811 ± 0.058	3.476ValPhe: 3.476 ± 0.052	3.728ValGly: 3.728 ± 0.058	0.99ValHis: 0.99 ± 0.029	4.783ValIle: 4.783 ± 0.066	4.448ValLys: 4.448 ± 0.06	5.842ValLeu: 5.842 ± 0.071	1.228ValMet: 1.228 ± 0.028	3.717ValAsn: 3.717 ± 0.054	2.111ValPro: 2.111 ± 0.043	1.627ValGln: 1.627 ± 0.031	1.849ValArg: 1.849 ± 0.039	4.598ValSer: 4.598 ± 0.066	3.741ValThr: 3.741 ± 0.089	4.054ValVal: 4.054 ± 0.066	0.626ValTrp: 0.626 ± 0.022	2.502ValTyr: 2.502 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.672TrpAla: 0.672 ± 0.023	0.13TrpCys: 0.13 ± 0.009	0.667TrpAsp: 0.667 ± 0.02	0.773TrpGlu: 0.773 ± 0.024	0.579TrpPhe: 0.579 ± 0.02	0.766TrpGly: 0.766 ± 0.025	0.273TrpHis: 0.273 ± 0.014	0.764TrpIle: 0.764 ± 0.025	0.86TrpLys: 0.86 ± 0.024	0.993TrpLeu: 0.993 ± 0.033	0.294TrpMet: 0.294 ± 0.013	0.757TrpAsn: 0.757 ± 0.023	0.267TrpPro: 0.267 ± 0.013	0.449TrpGln: 0.449 ± 0.02	0.41TrpArg: 0.41 ± 0.019	0.719TrpSer: 0.719 ± 0.024	0.619TrpThr: 0.619 ± 0.029	0.699TrpVal: 0.699 ± 0.027	0.17TrpTrp: 0.17 ± 0.012	0.464TrpTyr: 0.464 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.49TyrAla: 2.49 ± 0.045	0.33TyrCys: 0.33 ± 0.015	2.419TyrAsp: 2.419 ± 0.042	2.265TyrGlu: 2.265 ± 0.038	2.429TyrPhe: 2.429 ± 0.044	2.774TyrGly: 2.774 ± 0.046	0.877TyrHis: 0.877 ± 0.025	3.059TyrIle: 3.059 ± 0.052	3.39TyrLys: 3.39 ± 0.057	3.882TyrLeu: 3.882 ± 0.065	0.806TyrMet: 0.806 ± 0.023	3.012TyrAsn: 3.012 ± 0.057	1.547TyrPro: 1.547 ± 0.036	1.602TyrGln: 1.602 ± 0.035	1.562TyrArg: 1.562 ± 0.037	2.772TyrSer: 2.772 ± 0.046	2.611TyrThr: 2.611 ± 0.062	2.296TyrVal: 2.296 ± 0.044	0.554TyrTrp: 0.554 ± 0.019	2.051TyrTyr: 2.051 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4002 proteins (1401172 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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